ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis.

Introduction: Nanoplastics (NPs) have become a ubiquitous environmental pollutant that exhibits a tendency to accumulate in large quantities in the tissues of the host body (enteritis patients) with intestinal damage and poses a serious health risk, for which there is currently no suitable method for clearance. Studies have found that lactic acid bacteria has the potential to eliminate pollutants from the body.

Methods: In this study, we investigated the capacity of ZP-6, a strain isolated from human feces with demonstrated microplastic-binding activity, to alleviate the physiological toxicity of polystyrene nanoplastics (PS-NPs) in healthy and colitic murine models.

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Glioblastoma multiforme (GBM) shows profound inter- and intratumoral heterogeneity, but differences across ancestries remain understudied. We assemble the largest cohort of GBMs from East Asian patients (EAS-GBM) and perform genomic and transcriptomic analyses. Transcriptomic clustering reveals distinct EAS-GBM molecular subtypes-proliferative (PL), neurosynaptic (NS), metabolic (MB), and immunomodulatory (IM)-based on activated biological pathways.

Tomato flowering depends on overlapping functions of AP1/FUL-like genes in reproductive meristem specification.

AP1/FUL-clade transcription factors (TFs) are essential for the initiation and regulation of flowering and have clearly separated functions in Arabidopsis. However, how these functions have diverged across eudicots remains unclear. Here, we performed a detailed analysis to unravel the distinct and overlapping functions of the tomato AP1-ortholog MACROCALYX (MC) and the FUL-like genes FRUITFULL2 (FUL2) and MADS-BOX PROTEIN 20 (MBP20) through integrated molecular, genetic, and genomic approaches.

Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging.

Unlabelled: The paravertebral muscles play a critical role in maintaining dynamic spinal stability and physiological function. With aging, these muscles undergo senescence and degeneration, contributing to spinal instability and the development of low back pain. Age-related cellular death further accelerates chronic, low-grade inflammation termed “inflammaging” and disrupts the extracellular matrix (ECM), representing a key pathogenic mechanism driving paravertebral muscle degeneration (PMD).

Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling.

Background: The proneural-to-mesenchymal transition (PMT) represents a crucial phenotypic transformation in glioblastoma. Glioma-associated mesenchymal stromal/stem cells (GaMSCs) play a significant role in diverse biological processes of gliomas. However, the impact of exosomes released from GaMSCs (GaMSCs-Exos) on the PMT of glioblastoma remains inadequately understood.

Molecular Networking Combined with MALDI-MSI Reveals New Lanostane-Type Triterpenoids with Anti-Hepatocellular Carcinoma Activity and Their Spatial Distribution in the Fruit Body of .

Guided by the MS/MS metabolome-based molecular networking, 50 compounds, including 18 new triterpenoid metabolites (ganoleucocontins A-R, ), were obtained from Ganoderma leucocontextum. The chemical structures of these novel metabolites were determined based on comprehensive spectroscopic methods and chemical derivation. Compounds , and represent a new class of triterpenoid dimers linked by 3-hydroxy-3-methylglutaryl (HMG), which were reported for the first time.

Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform.

Background: Extracellular vesicles (EVs) have emerged as a promising pharmacotherapeutic modality for glioblastoma (GBM) drug delivery. However, the clinical translation of EVs remains restricted due to their low yield and demanding extraction steps. Therefore, extracellular vesicle mimetics (EVMs), as alternatives to EVs, have received much attention.

Targeted suppression of glioma by ultralow-dose x-ray-induced photodynamic therapy and gold-based nanoclusters in preclinical models.

The diffuse and infiltrative nature of high-grade gliomas poses ongoing challenges in treatment and management. Radiotherapy is an important glioma treatment, with a standard radiotherapy dose of 60 gray. However, high-dose radiotherapy is associated with radiation-induced side effects on normal tissue.

PDCL3 promotes the vasculogenic mimicry of glioma-associated mesenchymal stem cells through VEGFR-2 in glioma environment.

Glioma-associated mesenchymal stem cells (GA-MSCs), as a critical component of the glioma microenvironment, play an essential role in the development and invasion of glioma. Recent studies have shown that GA-MSCs can differentiate into pericytes under certain conditions, thereby promoting angiogenesis. However, the biological properties and molecular mechanisms underlying this process remain poorly understood.

Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis.

Gliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for developing novel and effective treatment strategies. In recent years, increasing attention has been directed toward the tripartite motif (TRIM) family of proteins, a class of E3 ubiquitin ligases, due to their significant roles in glioma development and progression.

Role of disturbance coefficient in monitoring and treatment of cerebral edema in patients with cerebral hemorrhage.

Background: At present, the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography (CT) and magnetic resonance imaging (MRI), which can evaluate the location and degree of peripheral cerebral edema, but cannot realize quantification. When patients have symptoms of diffuse cerebral edema or high cranial pressure, CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time. Intracranial pressure monitoring is the gold standard, but it is an invasive operation with high cost and complications.

Luteolin alleviates estrogen deficiency-induced muscle atrophy via targeting SLC7A11-mediated ferroptosis.

Background: Skeletal muscle atrophy, which is a debilitating condition exacerbated by estrogen deficiency, lacks effective therapeutic interventions. Although ferroptosis (an iron-dependent form of cell death driven by lipid peroxidation) has emerged as a contributor to muscle degeneration, its regulatory mechanisms remain poorly defined. In this study, we identified luteolin, which is a natural flavonoid, as a potent inhibitor of ferroptosis that mitigates estrogen deficiency-induced muscle atrophy by targeting SLC7A11.

Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.

Background: The origin of intervertebral disc degeneration (IDD) is highly complex, where both cartilage endplate remodeling and vertebral osteoporosis are of utmost importance. Myristic acid (MA), a saturated fatty acid derived from nutmeg, a traditional Chinese herb, has been shown to boost memory. Additionally, its isomers have been verified to have anti-osteoporotic characteristics.

Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via mA modification of CSF1.

Malignant glioma is the most common primary malignant tumor of the brain in adults, with glioblastoma (GBM) being the most aggressive subtype. Mesenchymal stem/stromal cells (MSCs) have been shown to fuse with tumor cells in various cancers including glioma, thereby regulating tumor progression. However, there has been no systematic research on the fusion of glioma-associated MSCs (GA-MSCs) with glioma cells.

Management and survival trends for diffuse gliomas diagnosed at a single neurooncology center in China during 2000 to 2020.

Currently reported survival outcomes for gliomas exhibit significant variability and controversy. In this study, we aim to provide survival data in Chinese populations by conducting a retrospective analysis of management and survival trends in a large cohort of glioma patients from a single institute in China. A total of 1206 patients with newly diagnosed gliomas treated between 2000 and 2020 were enrolled, including 537 glioblastoma (WHO grade 4), 450 astrocytomas (grade 2/3) and 219 oligodendroglial tumors (grade 2/3).

STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence.

Glioblastoma (GBM) is the most lethal type of brain tumor. Recent studies have indicated that cellular senescence-targeted therapy is a promising approach for cancer treatment. However, the underlying mechanisms remain to be clarified.

Preoperative CT attenuation value classification assesses cage subsidence risk in 112 OLIF surgery cases.

Retrospective Study. This study investigates the effectiveness of preoperative vertebral computed tomography (CT) attenuation value classification in predicting cage subsidence in Oblique lumbar interbody fusion (OLIF) surgeries. This study aims to evaluate the feasibility of using CT attenuation value classification to predict cage subsidence.

mNGS technique was used to analyze the microbiome structure of intervertebral disc tissue in 99 patients with degenerative disc disease.

Objective: Whether bacterial hypotoxic infection in the intervertebral disc is the cause of disc degenerative disease (DDD) is controversial. The mNGS technique can provide valuable insights by obtaining more comprehensive evidence of the presence of bacteria in the intervertebral disc. This study was designed to analyze the characteristics of intervertebral microbiome structure in patients with lumbar disc degenerative disease and its correlation with clinical indicators.

[Correlation analysis between preoperative C slope and effectiveness at 2 years after short-segment anterior cervical discectomy and fusion].

Objective: To investigate correlation between preoperative C slope (C2S) and effectiveness at 2 years after short-segment anterior cervical discectomy and fusion (ACDF), with the aim of providing reliable indicators for predicting effectiveness.

Methods: One hundred and eighteen patients with cervical spondylotic myelopathy, who received short-segment ACDF between January 2018 and December 2022 and met the selection criteria, were enrolled in the study. There were 46 males and 72 females, aged from 26 to 80 years, with a mean age of 53.

Reimagining cancer tissue classification: a multi-scale framework based on multi-instance learning for whole slide image classification.

In cancer pathology diagnosis, analyzing Whole Slide Images (WSI) encounters challenges like invalid data, varying tissue features at different magnifications, and numerous hard samples. Multiple Instance Learning (MIL) is a powerful tool for addressing weakly supervised classification in WSI-based pathology diagnosis. However, existing MIL frameworks cannot simultaneously tackle these issues.

Unveiling the oncogenic role of SLC25A13: a multi-omics pan-cancer analysis reveals its impact on glioma progression.

SLC25A13, a pivotal component of the mitochondrial aspartate-glutamate carrier, is integral to cellular metabolism and has been linked to various diseases. However, its role in cancer biology remains largely unexplored. In this study, we employed multi-omics data to elucidate the genetic landscape, expression profile, and prognostic value of SLC25A13 in a pan-cancer context.

LINC01088 prevents ferroptosis in glioblastoma by enhancing SLC7A11 via HLTF/USP7 axis.

Background: Glioblastoma multiforme (GBM)is a highly aggressive malignancy of the central nervous system characterized by poor survival rates. Ferroptosis, an iron-dependent cell death pathway, is a promising therapeutic target for GBM. However, current treatments targeting cell death pathways have not yielded expected results.

USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5.

: Glioblastoma (GBM) is the most aggressive type of primary brain cancer and contains self-renewing GBM stem cells (GSCs) that contribute to tumor growth and therapeutic resistance. However, molecular determinants governing therapeutic resistance of GSCs are poorly understood. : We performed genome-wide analysis of deubiquitylating enzymes (DUBs) in patient-derived GSCs and used gene-specific shRNAs to identify an important DUB gene contributing to GSC survival and radioresistance.