The long noncoding RNA SNHG12 defines KEAP1 stability and ferroptosis susceptibility by targeting E3 ligase TRIM25.

Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation. Targeted induction of ferroptosis holds great promise for cancer treatment. SNHG, a newly recognized lncRNA family, has been reported to implicate in the proliferation, invasion, migration or drug resistance of cancer cells.

A national survey on how to improve the integration of traditional Chinese medicine and artificial intelligence: Attitudes and perceptions from medical staff.

Background: With the significant development of artificial intelligence (AI) in recent years, the inheritance and innovation of traditional Chinese medicine (TCM) urgently require the help of AI technology. The present study was to evaluate the attitudes and perceptions of medical staff towards the integration of TCM and AI development.

Methods: A cross-sectional national survey was conducted at 13 medical institutions across China.

A national survey on the integration of traditional Chinese medicine and artificial intelligence: attitudes and perceptions from the individuals with health needs.

Background: Traditional Chinese medicine (TCM) plays an indispensable role in the healthcare system. Artificial intelligence (AI) opens a new pathway for TCM modernization, while also addressing critical healthcare challenges. The present national survey was conducted to assess the attitudes and perceptions of individuals with health needs regarding the integration of TCM with AI.

exports a mucin glycoprotein into the microvilli of intestinal epithelium.

causes severe diarrhea in humans and animals. Mucin-like glycoproteins play a critical role in parasite attachment and invasion and therefore serve as potential protective antigens against reinfection. Muc25 is a highly polymorphic mucin that has been associated with differences in host infectivity in comparative genomic analyses.

Flexible Tactile Sensing Systems: Challenges in Theoretical Research Transferring to Practical Applications.

Since the first design of tactile sensors was proposed by Harmon in 1982, tactile sensors have evolved through four key phases: industrial applications (1980s, basic pressure detection), miniaturization via MEMS (1990s), flexible electronics (2010s, stretchable materials), and intelligent systems (2020s-present, AI-driven multimodal sensing). With the innovation of material, processing techniques, and multimodal fusion of stimuli, the application of tactile sensors has been continuously expanding to a diversity of areas, including but not limited to medical care, aerospace, sports and intelligent robots. Currently, researchers are dedicated to develop tactile sensors with emerging mechanisms and structures, pursuing high-sensitivity, high-resolution, and multimodal characteristics and further constructing tactile systems which imitate and approach the performance of human organs.

Fusing wrist pulse and ECG data for enhanced identification of coronary heart disease and its complications.

Objectives: This study aimed to explore the potential of synchronously acquiring wrist pressure pulse wave (PPW) and limb lead electrocardiogram (ECG) signals for the development of an identification model for coronary heart disease (CHD) and its associated comorbidities.

Methods: A custom-designed device equipped with pressure and ECG sensors, was utilized to synchronously collect wrist PPW and limb-lead ECG signals from 748 participants (463 for modeling and 285 for external validation). Features were extracted from these two types of physiological signals to form distinct datasets, and RF models were built based on different datasets.

Using multichannel electrochemical constructed wetlands to treat wastewater containing a mixed herbicide: efficacy and mechanism analysis.

Cross-use of herbicides in agricultural production produces multiple herbicide residues in agricultural wastewater, which makes water treatment systems less stable and specific. A multichannel electroactive constructed wetlands (EWs) system was designed in this study to treat three types of agricultural wastewaters containing herbicides: glyphosate alone (PEW), atrazine alone (AEW), and a mixture of the two herbicides (MEW). The effect of the system on the treatment of different herbicide wastewaters and the corresponding mechanism were analyzed.

Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases.

Ocular diseases affect over 2.2 billion people globally, imposing a significant socioeconomic burden, with annual productivity losses estimated at US$411 billion. Conventional drug delivery methods-topical, local injection, and systemic administration-face challenges such as low bioavailability (<5%), rapid clearance, and physiological barriers like the cornea and blood-retinal barrier (BRB).

Balloon dilation therapy for managing anastomotic strictures subsequent to surgical correction of esophageal atresia.

Background: Anastomotic strictures (AS) following surgical repair of esophageal atresia (EA) are the most common cause of pediatric esophageal strictures. In this retrospective cohort study, we evaluated the safety and efficacy of balloon dilation in the treatment of AS following EA repair.

Methods: Balloon dilation was performed on 31 children with AS following EA repair (the diameter of the balloon ranged from 6-15 mm).

The salvage therapy utilizing human umbilical cord-derived mesenchymal stem cells for the treatment of critically ill patients with COVID-19.

Background: The therapeutic options for patients with coronavirus disease (COVID-19) are limited. Mesenchymal stem cells (MSCs) have immunomodulatory and regenerative properties that may inhibit excessive inflammatory responses, promote recovery from COVID-19-induced lung injury, and potentially serve as a therapeutic option.

Methods: An evaluation of the safety and efficacy of using human umbilical cord mesenchymal stem cells (hUC-MSCs) in 5 critically ill patients with COVID-19 was conducted in this study.

Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling.

Background: The proneural-to-mesenchymal transition (PMT) represents a crucial phenotypic transformation in glioblastoma. Glioma-associated mesenchymal stromal/stem cells (GaMSCs) play a significant role in diverse biological processes of gliomas. However, the impact of exosomes released from GaMSCs (GaMSCs-Exos) on the PMT of glioblastoma remains inadequately understood.

Interface-Engineered RuP/MnPO Heterojunction on N/P Co-Doped Carbon for High-Performance Alkaline Hydrogen Evolution.

Developing efficient and durable electrocatalysts for the alkaline hydrogen evolution reaction (HER) is crucial for sustainable hydrogen production. Herein, we report a novel RuP/MnPO heterojunction anchored on a three-dimensional nitrogen and phosphorus co-doped porous carbon (RuP/MnPO/NPC) framework as a high-performance HER catalyst, synthesized via a controlled pyrolysis-phosphidation strategy. The heterostructure achieves uniform dispersion of ultrafine RuP/MnPO heterojunctions with well-defined interfaces.

The role of indocyanine green fluorescence angiography in the perioperative period for patients after colorectal surgery: a meta-analysis of propensity score-matched studies with trial sequential analysis.

Introduction: The utilization of Indocyanine Green (ICG) Fluorescence Angiography (FA) in colorectal surgery is gaining increasing traction. This manuscript employs meta-analysis, propensity score-matched (PSM), and trial sequential analysis (TSA) to compare the perioperative outcomes between colorectal cancer patients who underwent surgery with and without ICG FA.

Materials And Methods: A thorough literature search was conducted across many databases, including PubMed, Embase, Cochrane Library, and Web of Science, from the foundation of each database to November 2024.

Case Report: A case report of the diagnosis of renal inflammatory myofibroblastic tumor.

Renal inflammatory myofibroblastic tumor is a very rare disease that primarily occurs in the renal parenchyma and may even involve the renal pelvis. This study presents a case of renal inflammatory myofibroblastic tumor with exophytic growth, whose imaging appearance resembles that of a solitary perirenal mass. A 75-year-old male patient was referred to our hospital for further treatment after a retroperitoneal lesion was discovered and suspected at another hospital.

Integrated peripheral blood multi-omics profiling identifies immune signatures predictive of neoadjuvant PD-1 blockade efficacy in head and neck squamous cell carcinoma.

Background: Neoadjuvant PD-1 inhibitor therapy has shown promise in locally advanced head and neck squamous cell carcinoma (HNSCC), but only a subset of patients achieves major pathological responses. Liquid biopsy, the analysis of tumor-derived biomarkers in readily accessible bodily fluids (primarily blood), offers significant advantages over traditional tissue biopsies for predicting cancer treatment outcomes. The aim of this study is to develop a predictive model for neoadjuvant PD-1 therapy response in HNSCC patients using exclusively liquid biopsy approaches-namely, peripheral blood immune profiling (CyTOF) and plasma cytokine panels (Olink).

Conductive and piezoelectric biomaterials: a comprehensive review of load-bearing soft tissue repair.

Load-bearing soft tissues, such as tendons, cartilage, and ligaments, withstand substantial mechanical stress and are susceptible to injury, particularly in athletes. The increasing prevalence of these injuries poses a significant challenge, exacerbated by the limitations of traditional treatments, which often lead to lengthy recovery periods and a high risk of recurrence. In recent years, researchers have harnessed the electrical properties of conductive and piezoelectric biomaterials to address challenges in load-bearing soft tissue engineering.

Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis.

Gliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases. Understanding the molecular mechanisms underlying glioma pathogenesis is crucial for developing novel and effective treatment strategies. In recent years, increasing attention has been directed toward the tripartite motif (TRIM) family of proteins, a class of E3 ubiquitin ligases, due to their significant roles in glioma development and progression.

A nomogram for predicting fracture of the sandwich vertebrae after percutaneous vertebral augmentation: a multicenter study with 1-year follow-up.

Purpose: This work aimed to investigate the risk factors for fractures in sandwich vertebrae (SDV; an unfractured vertebra located between 2 cemented vertebrae) formed after percutaneous vertebral augmentation (PVA) and to construct a predictive model from this.

Methods: This study retrospectively analyzed patients who underwent PVA with the formation of SDV from July 2018 to July 2023 at Affiliated Banan Hospital of Chongqing Medical University. Patients were divided into a fracture group and a control group according to the presence or absence of fracture of the SDV during the 1-year postoperative follow-up period.

Period of formation of and factors associated with perianchor cysts around Healicoil and Footprint polyetheretherketone anchors following arthroscopic rotator cuff repair.

Background: To investigate the factors associated with the formation of perianchor cysts (PCs) around Healicoil and Footprint polyetheretherketone (PEEK) anchors following arthroscopic rotator cuff (RC) repair and assess its association with clinical shoulder function and the incidence of RC retearing.

Methods: The data of patients who underwent arthroscopic RC repair with Healicoil and Footprint PEEK anchors were retrospectively analyzed. The incidence of PCs was evaluated on postoperative magnetic resonance imaging and compared across multiple follow-up points.

Foreign language enjoyment in language learning from a positive psychology perspective: a scoping review.

The language learning process is inherently rich in emotional experiences. With the affective turn toward positive emotions in second language acquisition (SLA), foreign language enjoyment (FLE) has gained increasing scholarly attention over the past decade due to its pivotal role in facilitating language learning and improving learners' emotional wellbeing. However, previous studies on FLE have largely adhered to ontological, epistemological, and methodological orthodoxy, often approaching FLE from a static, monolithic, and linear perspective.

A scoping review of effects of acute exercise on executive function: evidence from event-related potentials.

Background: Although the acute effects of exercise on executive function are extensively documented in the field of exercise psychology, a thorough assessment of neuroelectric brain activity that is underlying executive function following acute exercise is absent. This systematic review investigated the effects of acute exercise on event-related potentials through their amplitude and latency.

Methods: Six electronic databases were searched from their inception to April 15, 2024.

Exploring the regulatory mechanism of CCNA2 in colorectal cancer: Insights from multiomics and experimental analysis.

Colorectal cancer (CRC) is the third-most common cancer and the second leading of cancer-related deaths worldwide. The underlying regulatory mechanism of cyclin A2 (CCNA2) in CRC was explored through multiomics and experimental analyses, thus facilitating diagnosis, therapy, and prognosis. GSE9348 and GSE110223 were extracted from Gene Expression Omnibus.

Engineering the dimensionality of porous CoO for enhanced capacitive deionization performance.

The intricate network of pores within the material matrix is frequently underutilized during ion diffusion. Here, the spatial dimension of the ZIF-9 derived porous material was precisely controlled by strategic modification of the carboxyl functional groups on the ligand chains for deriving 2D-CoO architecture, which demonstrates substantially enhanced accessibility to its porous domains, and consequently leads to markedly improved desalination capacity.

A Nomogram Model for Prenatal Predicting Survival in Infants with Congenital Diaphragmatic Hernia.

The study aimed to combine prenatal risk factors associated with early survival of patients with prenatally diagnosed congenital diaphragmatic hernia (CDH) into a predictive nomogram.We retrospectively analyzed 217 neonates with prenatally diagnosed CDH. The patients who underwent surgery in an earlier period comprised the training cohort ( = 158) for nomogram development, while those who underwent surgery subsequently constituted the validation cohort ( = 59) to verify the model's performance.