Imaging indicators and fusion analysis of percutaneous endoscopic posterior lumbar interbody fusion and modified posterior lumbar interbody fusion for the treatment of lumbar degenerative diseases.

Background: Although numerous studies have confirmed percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) as a safe and effective minimally invasive technique for lumbar degenerative diseases (LDDs), existing research primarily focuses on clinical outcomes and involves limited imaging analysis. This study aimed to quantitatively compare PE-PLIF and modified posterior lumbar interbody fusion (MPLIF) through comprehensive radiographic evaluation and clinical outcomes.

Methods: We conducted a retrospective analysis of 75 consecutive LDD patients who underwent surgical treatment at our institution between January 2018 and October 2023.

Effect of bispectral index-guided anaesthesia versus standard practice on recovery after general anaesthesia in children: A systematic review and meta-analysis.

Background And Aims: Accurate assessment of anaesthesia depth in children is essential for individualised anaesthetic monitoring and remains a considerable challenge in clinical practice. The bispectral index (BIS), a widely used clinical tool for monitoring anaesthesia depth, has been subject to controversy regarding its effectiveness in improving recovery quality in children after anaesthesia. This meta-analysis aimed to compare the impact of BIS-guided anaesthesia versus traditional anaesthesia depth monitoring on postoperative recovery quality in children undergoing general anaesthesia.

Developing Intravenous Delivery of Water-Soluble Prodrugs of Idebenone for the Treatment of Acute Ischemic Stroke.

Ischemic stroke (IS) represents a substantial global health threat, but only a few effective medicines exist to treat IS, with a huge unmet clinical need. Idebenone (IDB), a coenzyme Q10 analogue, has multitarget effects, including enhancing mitochondrial energy metabolism, scavenging free radicals, and anti-inflammation, which is approved in Europe for treating Leber's hereditary optic neuropathy (LHON). However, IDB has poor water solubility and oral bioavailability, resulting in insufficient therapeutic plasma concentrations, even following high-dose oral administration, and limiting its use for brain diseases and acute-phase interventions.

Diagnostic value of the iron apoptosis-related gene in recurrent miscarriage.

Background: The early diagnosis and treatment of recurrent miscarriage are essential for preventing adverse pregnancy outcomes. This study explores the value of iron apoptosis-related gene in the diagnosis of recurrent pregnancy loss (RPL).

Methods: We obtained ferroptosis-related differentially expressed genes (DEGs) associated with RPL from the GEO database and the FerrDb database.

Microbes Under Climate Refugia: Equable Subcommunity Rank Dynamics in Large-River Deltaic Estuaries.

Microorganisms, similar to macroorganisms, can be sheltered by climate refugia-a property overlooked due to their speciose nature. Using the latent Dirichlet allocation model to categorize microbial communities into ecologically distinct subcommunities, we conducted a 2-year survey of large-river deltaic estuaries (LDEs), recognized as refugial hotspots, and established rank hierarchies with the continuous time dynamic model to monitor temporal changes. We found that, consistent with macroecology, LDEs harbor distinct microbial community structures, with the abundance distribution of subcommunities exhibiting resilience against environmental perturbations, persisting on an annual cycle.

CuSO protects hepatocytes from lipotoxicity by promoting autophagic degradation of lipid droplets to attenuate oxidative stress.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition that often progresses to Metabolic Dysfunction-Associated Steatohepatitis (MASH), ultimately leading to liver fibrosis and hepatocellular carcinoma (HCC). Consequently, the early diagnosis and treatment of MASLD are particularly crucial. Currently, the pathogenic mechanisms underlying MASLD remain incompletely understood, and there is no optimal therapy available for this condition.

Palmitic acid and palmitoylation in cancer: Understanding, insights, and challenges.

Nutrients from dietary foods not only provide energy and building blocks, but also play critical roles in modulating diverse pathophysiological functions. They achieve these, in part, by accelerating cell signaling transduction processes via modulating various types of protein post-translational modifications (PTMs). Notably, accumulating evidence has identified palmitic acid (PA), a major component of high-fat diets, as a significant contributor to various human disorders, including diabetes and cancer.

Establishment of chromatin architecture interplays with embryo hypertranscription.

After fertilization, early embryos undergo dissolution of conventional chromatin organization, including topologically associating domains (TADs). Zygotic genome activation then commences amid unusually slow de novo establishment of three-dimensional chromatin architecture. How chromatin organization is established and how it interplays with transcription in early mammalian embryos remain elusive.

Dose-response associations of accelerometer-measured physical activity with mortality across frailty levels: A prospective cohort study.

Background: Limited evidence, majorly based on questionnaire-derived measurements, was available to reflect long-term benefits of physical activity (PA) across different frailty levels.

Methods: We included 81,219 UK Biobank participants (mean age 61.88 years; 41.

Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors.

Chronic stress exposure is a potent risk factor for anxiety, disrupting adaptive responses and increasing vulnerability. Astrocytes, as essential regulators of synaptic function and neuroimmune homeostasis, are implicated in mood regulation and neuropsychiatric pathogenesis. However, the precise molecular mechanisms of astrocytes involved in stress-induced anxiety remain poorly understood.

The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking.

Background: Asthma remains a significant public health challenge globally, particularly among older adults who face diagnostic complexity, atypical symptom profiles, and frequent comorbidities. Despite global advances in asthma control, little attention has been paid to the evolving composition and geographic disparity of modifiable risk factors in this age group.

Methods: We utilized data from the Global Burden of Disease Study 2021 to evaluate the long-term trends (1990-2021) in asthma burden attributable to high body-mass index (BMI), smoking, and occupational asthmagens among adults aged 60 years and older.

USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4.

In mouse, minor zygotic genome activation (ZGA) precedes and is essential for major ZGA in two-cell (2C) embryos. A subset of ZGA genes (known as "2C" genes) are also activated in a rare population of embryonic stem cells (ESCs) (2C-like cells). However, the functions of the 2C genes are not fully understood.

Causal Effects of Gut Microbiome on Tinnitus: A Mendelian Randomization Study.

Background: Previous studies have identified a clinical association between gut microbiota (GM) and tinnitus; however, the potential causal relationship remains unclear. Therefore, we conducted a Mendelian randomization(MR) study to evaluate the potential causal effects of 412 gut microbiome features on tinnitus risk.

Methods: In the study, we used pooled data from a genome-wide association study(GWAS) of gut microbes from a Dutch population.

Oral Prodrug of a Novel Glutathione Surrogate Reverses Metabolic Dysregulation and Attenuates Neurodegenerative Process in Transgenic Alzheimer's Mice.

Glycation-induced oxidative stress underlies the numerous metabolic ravages of Alzheimer's disease (AD). Reduced glutathione levels in AD lead to increased oxidative stress, including glycation-induced pathology. Previously, we showed that the accumulation of reactive 1,2-dicarbonyls such as methylglyoxal, the major precursor of nonenzymatic glycation products, was reduced by the increased function of GSH-dependent glyoxalase-1 enzyme in the brain.

Multidimensional diagnostic strategies for managing primary aldosteronism with false bilateral AVS due to a duplicated right adrenal vein: A case report.

Rationale: Primary aldosteronism can be categorized into 2 main subtypes: aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism. The treatment strategies for these 2 subtypes differ markedly: APA requires surgical removal of the adenoma, whereas idiopathic hyperaldosteronism is managed with pharmacological therapy. Adrenal venous sampling (AVS) is the most widely used technique for diagnosing APA, but its results can be influenced by abnormal adrenal or tumor venous drainage.

Case Report: A patient presenting primarily with psychosis of NPSLE treated with telitacicept, corticosteroids, and immunosuppressants.

Therapeutic strategies for neuropsychiatric systemic lupus erythematosus (NPSLE) primarily target underlying pathogenic mechanisms and typically include corticosteroids, immunosuppressants, anticoagulation, and adjunctive treatments. B-cell-targeted biologics are an emerging option for NPSLE. Although telitacicept is approved for systemic lupus erythematosus (SLE) treatment in China, evidence supporting its use in NPSLE remains limited.

Observation of *NH Intermediates by In Situ Electrochemical SERS: New Pathway of Ammonia Oxidation on High-Durability PtIr Catalysts.

The electrochemical ammonia oxidation reaction (AOR) is a cornerstone technology for sustainable on-site hydrogen production and clean energy conversion. While Pt-based alloys such as PtIr have emerged as promising AOR electrocatalysts to address the rapid deactivation of pure Pt systems, the atomic-level mechanisms governing their superior stability remain unresolved. Here, we employ in situ electrochemical surface-enhanced Raman spectroscopy to directly track the evolution of intermediates on Pt and PtIr catalysts during the AOR.

A Systematic Review of User Attitudes Toward GenAI: Influencing Factors and Industry Perspectives.

In the era of GenAI, user attitude-shaped by cognition, emotion, and behavior-plays a critical role in the sustainable development of human-AI interaction. Human creativity and intelligence, as core drivers of social progress, are important factors influencing user attitudes. This paper systematically reviews 243 peer-reviewed studies on GenAI user attitudes published since 2019, identifying major research methods and theoretical perspectives, including the Technology Acceptance Model (TAM), the Unified Theory of Acceptance and Use of Technology (UTAUT), and the AI Device Use Acceptance (AIDUA) model.

Neuroprotective Mechanisms of -Derived Bioactive Compounds in Alzheimer's Disease: An Overview of Novel Insights.

Alzheimer's disease (AD) is characterized by β-amyloid plaques, neurofibrillary tangles, neuroinflammation, and oxidative stress-pathological features that pose significant challenges for the development of therapeutic interventions. Given these challenges, this review comprehensively evaluates the neuroprotective mechanisms of bioactive compounds derived from , including polysaccharides and phycobiliproteins, which are considered a promising source of natural therapeutics for AD. constituents exhibit neuroprotective activities through multiple mechanisms.

Metabolic regulation of key developmental events during mammalian embryogenesis.

Metabolic regulation is critical in embryonic development and influences key processes such as fertilization, zygotic genome activation, cell compaction, implantation, gastrulation and organ development. Here we explore the interplay between metabolism and embryonic development in the context of important sequential key embryonic events, highlighting the orchestration of developmental processes by various metabolites and signalling molecules. Key metabolites, including glucose, fatty acids and amino acids, act as modulators of developmental processes, while also serving as energy sources and building blocks for cellular structures.

Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients.

Inflammation has been recognized as a pivotal factor in the pathophysiology of diabetes. The aggregate index of systemic inflammation (AISI) has recently been proposed as a novel biomarker for evaluating inflammatory status and predicting clinical outcomes. However, evidence on the association between AISI and mortality in diabetic patients remains limited.

LARS2 DNA methylation predicts the prognosis in colon cancer.

Colon cancer is a highly aggressive solid tumor. Because most studies have focused on the intrinsic oncogenic pathways of tumors, we focused on the relationship between DNA methylation genes in the tumor immune microenvironment and colon cancer prognosis. We download RNA-seq data from the TCGA dataset.

The connection between peripheral inflammation links and functional prognosis in patients with acute ischemic stroke.

Objective: Investigate the peripheral inflammation links (PIL) as predictors of acute ischemic stroke (AIS) severity and long-term outcomes.

Methods: Analyzing AIS patient data, linear mixed and logistic regression was employed for PIL with National Institute of Health stroke scale (NIHSS) and 3, 6 and 12 months prognosis outcomes. Restricted cubic splines (RCS) were utilized to visualize the relationships between inflammation and outcomes.