Dose-response associations of accelerometer-measured physical activity with mortality across frailty levels: A prospective cohort study.

Background: Limited evidence, majorly based on questionnaire-derived measurements, was available to reflect long-term benefits of physical activity (PA) across different frailty levels.

Methods: We included 81,219 UK Biobank participants (mean age 61.88 years; 41.

Association of clonal hematopoiesis of indeterminate potential with cardiometabolic multimorbidity progression and mortality: a prospective study of UK Biobank.

Background: Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the aging-related clonal expansion of preleukemic mutations in hematopoietic stem cells. While CHIP has been studied in cardiometabolic diseases (CMDs), its role in the long-term progression from the absence of CMD to the development of a single CMD, cardiometabolic multimorbidity (CMM), and eventual mortality remains uncertain. This study aimed to investigate the association between CHIP and gene-specific CHIP subtypes with the progression of CMD transitions.

KAT2A-mediated H3K79 succinylation promotes ferroptosis in diabetic nephropathy by regulating SAT2.

Background: Diabetic nephropathy (DN) remains difficult to treat due to its complex mechanisms. This study explores the ferroptosis mechanism in DN, focusing on the regulation of SAT2 expression by KAT2A-mediated H3K79 succinylation (H3K79succ).

Methods: A DN rat model was created using streptozotocin (STZ) and a high-fat diet (HFD).

Methyltransferase-like 16 drives diabetic nephropathy progression via epigenetic suppression of V-set pre-B cell surrogate light chain 3.

Aims: This study aims to elucidate how Methyltransferase-like 16 (METTL16), as a key m6A methyltransferase, contributes to the pathogenesis of diabetic nephropathy by regulating oxidative stress and gene expression through epigenetic mRNA methylation.

Materials And Methods: In the present study, in vivo and in vitro DN models were established to investigate the role of METTL16 in disease progression. RNA-seq and m6A-seq were employed to identify downstream targets of METTL16 and validate its regulatory mechanisms.

Association of single and multiple cardiometabolic diseases with atrial fibrillation: a prospective cohort study.

Background: Individual cardiometabolic diseases (CMDs) increase atrial fibrillation (AF) risk; however, whether multiple CMDs exert a cumulative effect on AF risk remains unclear. Our objective was to examine the link between coexisting CMDs and AF, as well as their cumulative impact.

Methods: This UK Biobank-based prospective cohort study included data from participants with information related to CMDs and AF.