MAP30 inhibits proliferation and metastasis of bladder cancer by increasing EGR1 expression and promoting the transcriptional activation of DUSP1.

The confirmed tumor-inhibitory effects of the 30 kDa Momordica anti-human immunodeficiency virus protein (MAP30) have yet to be complemented by an exploration into its mechanism of action on tumor development and metastasis. For this purpose, we delved into the intrinsic mechanism of MAP30 in bladder cancer (BC). Here, we demonstrated that MAP30 markedly suppressed the proliferation, migration, invasion, and angiogenic capabilities of human BC cells in vitro, and the tumor metastatic potential in vivo.

Efficacy of adjuvant therapy regimens administered during the perioperative period in resectable non-small cell lung cancer.

Background: We aimed to contribute to the ongoing discussion regarding adjuvant treatment strategies following neoadjuvant chemoimmunotherapy (NCIT) and adjuvant immunotherapy (AIT) after upfront surgery (US) in patients with resectable non-small cell lung cancer (NSCLC).

Methods: 317 patients were retrospectively included from 2019 to 2024. 285 received NCIT, while 32 received AIT after US.

Modulating MoS Substrate via d-p Orbital Hybridization Driven by π-Electron Feedback Effect for Dual-Site Adsorption Enhancement of Formaldehyde.

Two-dimensional transition metal chalcogenides (TMCs), such as MoS (MS), exhibit chemically inert basal planes due to saturated intralayer coordination. This inherent inertness limits their specific recognition and adsorption of target gas molecules as gas-sensitive materials. Based on density functional theory (DFT) calculations, we report a strategy to achieve efficient formaldehyde adsorption by enhancing d-p orbital hybridization within the MS lattice to establish a π-electron feedback mechanism.

No consistent size responses in radiolarians to the climatic changes and mass extinctions during the Paleozoic-Mesozoic transition.

Plankton are important indicators of ocean health and are crucial for the support of ecosystems. Few analyses have been carried out on the morphological responses of planktonic organisms to the greatest mass extinction in the Permian-Triassic transition. Here, we explore a large database on the middle Permian to Middle Triassic Radiolaria, which is one of the most important planktonic bio-indicators of primary productivity from those times.

Dyadic Associations of Parenting Stress, Family Resilience, and Coping Styles Among Parents and Grandparents in Intergenerational Co-Parenting Families.

This study examined the dyadic relationships among parenting stress, family resilience, and coping styles within Chinese intergenerational co-parenting households. A cross-sectional study was conducted in China from December 2022 to September 2023. The STROBE checklist was used to report the current study.

The effects of cognitive closure need and time pressure on individual risk decision making.

This study examined the effects of need for cognitive closure and time pressure on individual risky decision-making. Ninety-one college students were randomly selected to participate. Their risky decision-making behaviors were measured using a mixed experimental design with two levels of cognitive closure needs (high and low) and two levels of time pressure (pressured and unpressured), utilizing the Balloon Analog Risk Task (BART).

Early peripapillary neurovascular injury and its relevant systemic factors in type 2 diabetic patients without retinopathy: An OCTA based study.

Purpose: To determine the ability of peripapillary neurovascular units (NVU) to detect early changes in the retinal microvasculature and microstructure, and to explore systemic factors linked to the peripapillary NVU injury in type 2 diabetic patients without clinically detectable retinopathy (NDR).

Methods: Fifty-two NDR patients (mean age 51.08 ± 9.

Effects of flower flavonoids on cognitive function by regulating gut microbiota.

Background: As we get older, we experience a variety of symptoms such as memory and cognitive decline in learning. In the process of aging, neuroinflammatory response is one of the main reasons for the occurrence of cognitive dysfunction. flower flavonoids (DOFF) can effectively regulate the structure of intestinal microbiota, antioxidant and anti-inflammatory functions.

Research progress on the regulation of plant growth and development by TOR kinase.

The target of rapamycin (TOR) is a conserved serine/threonine protein kinase in eukaryotes. Numerous studies in yeast and animals have found that TOR kinase senses the status of intracellular nutrients and hormonal signals and participates in the regulation of diseases such as cancer through processes such as protein translation, gene transcription, material metabolism, and autophagy. The medical community has now identified TOR kinase as a key target for the treatment of the aforementioned diseases, conducting research and clinical trials for related drugs.

Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses.

Introduction: With the popularity of yoga increasing as a means to improve overall well-being, this umbrella review aimed to evaluate the potential effects of yoga on chronic disease outcomes by synthesizing previously published systematic reviews, including meta-analyses, of randomized controlled trials in adult populations.

Content: PubMed, Scopus, Cochrane, Web of Science, and CINAHL for systematic reviews published up to 31st March 2023. Systematic reviews examining the effectiveness of yoga interventions compared with controllable groups on chronic disease outcomes were searched from adults aged above 18 years old.

Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study.

Background: Although dietary patterns rich in plant-based food have been linked to lower frailty risk in older adults, the relationship between vegetarian diet and incident frailty has been understudied. Therefore, this study aimed to investigate the association between vegetarian diet and risk of frailty in a nationwide representative cohort of Chinese community-dwelling older adults (≥ 65 years old).

Methods: Included were 27,917 participants (age range: 65-122 years; mean age: 86.

Predictive value of machine learning for radiation pneumonitis and checkpoint inhibitor pneumonitis in lung cancer patients: a systematic review and meta-analysis.

Some studies have developed machine learning (ML) models for the prediction of pneumonitis following immunotherapy and radiotherapy for patients with lung cancer (LC). However, the prediction accuracy of these models remains a topic of debate. Thus, this study aims to summarize the advantages of ML methods in the early prediction of radiation pneumonitis (RP) and checkpoint inhibitor pneumonitis (CIP) in LC patients.

Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis.

In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrence and development of cancer has received increasing attention. This study aims to elucidate the role of m6A modification in colorectal cancer (CRC), focusing on the effect of METTL3 on STC2 expression and its effects on cell proliferation, drug resistance and metastasis. Using MeRIP-seq, mRNA-seq, EdU staining, CCK-8 (Cell Counting Kit-8) assay, Transwell assay, Western blot and flow cytometry, this study confirmed that RNA methylation was predominantly located in the CDS region and that STC2 was overexpressed in advanced cancer and 5-FU (5-Fluorouracil)-resistant cell lines.

A Two-Step Therapeutic Strategy in the Management of Critical Neonatal Hydrocephalus.

Aim: To identify novel therapeutic strategies to improve the outcomes of neonatal hydrocephalus.

Material And Methods: The treatment strategies for cases of neonatal hydrocephalus in our hospital between February 1, 2015, and February 1, 2024 reviewed and analyzed, with the aim of identifying valuable factors to assist in treating future patients with critical neonatal hydrocephalus. We further conducted literature searches and summarized the relevant treatment strategies.

Molecular imaging using F-FDG PET/CT and circulating inflammatory and immune indicators to predict pathological response to neoadjuvant camrelizumab plus chemotherapy in resectable stage IIIA-IIIB NSCLC.

Objective: This study aims to predict the pathological response of patients with non-small cell lung cancer (NSCLC) in prospective trials of neoadjuvant camrelizumab combined with chemotherapy by integrating the clinical characteristics, PET-associated parameters, and hematological indicators.

Methods: A prospective analysis was conducted among 24 patients undergoing surgery after neoadjuvant camrelizumab plus chemotherapy. F-Fluorodeoxyglucose (FDG) scans were performed before and after neoadjuvant therapy (pre-NAT, post-NAT).

Modeled Single-Atomic-Site Pt Catalyst with Well-Defined Coordination Structure for Hydrosilylation Reaction.

Single-atom-site (SAS) catalysts exhibit superior activity in catalytic reactions, and their isolated active sites are anticipated to serve as an ideal platform for mechanistic investigations. However, the coordination environment of SAS catalyst synthesized via pyrolysis is challenging to control, and the active sites are randomly distributed, posing challenges for structure-activity relationship studies. Therefore, the development of model catalysts featuring well-defined coordination structures remains highly desirable but challenging.

Preparation and characterization of κ-carrageenan/yam starch composite films incorporated with cinnamaldehyde Pickering emulsions.

Plastic packaging is highly resistant to degradation, leading to significant environmental pollution. Therefore, it is necessary to develop a new type of packaging material, especially natural polymer-based packaging materials. This study aimed to prepare a κ-carrageenan/yam starch (KC/YS) composite film incorporating cinnamaldehyde-based Pickering emulsions (CA-PE) to resolve the aforementioned issue and to investigate the impact of the CA-PE on the physicochemical characteristics and bioactivity of the composite films.

Comparison of incontinent characteristics between women with hypothyroid dysfunction and euthyroidism during pregnancy and the first year postpartum: A prospective observational study.

The aim of the study was to evaluate the occurrence and severity of gestational and postpartum urinary incontinence (UI) and the negative impact upon quality of life (QoL) among pregnant women with gestational hypothyroidism. After initial selection 522 eligible subjects with gestational UI were enrolled and distributed into the HUI (hypothyroid UI, n = 155) and EUI (euthyroid UI, n = 367) groups, respectively. Their demographic parameters, clinic characteristics and incontinent profiles evaluated by the validated International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF) questionnaire were collected during gestational and postpartum follow-ups.

Vegetarian diet and healthy aging among Chinese older adults: a prospective study.

Vegetarian diets are increasingly popular worldwide, but their impact on healthy aging in older adults remains unclear. This study examined the association between vegetarian diets and healthy aging among 2,888 healthy older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey. Dietary patterns (vegan, ovo-vegetarian, pesco-vegetarian, omnivorous) were derived from a simplified non-quantitative food frequency questionnaire.

Biological age construction for prediction of mortality in the Chinese population.

Efforts to increase health span bring to light the necessity of constructing biological age (BA) for measuring aging. However, universally adaptive BA needs further investigation, especially among the Chinese population. Therefore, this study aimed to construct BA using routine clinical markers for the Chinese population.

Study on the degradation characteristics of PCDD/Fs using Non-thermal Plasma (NTP) technology in full-scale medical waste incineration.

Flue gas from medical waste incineration is a major source of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Conventional treatment technologies exhibit limited effectiveness in purifying PCDD/Fs in flue gas, indicating the need for further research. Improvements to the existing medical waste incineration flue gas treatment process were implemented based on Non-thermal Plasma (NTP) technology.

Microalgae-based biodegradable embolic agent for the treatment of hepatocellular carcinoma through transarterial embolization.

Transarterial chemoembolization (TACE) serves as a locoregional therapy for hepatocellular carcinoma (HCC) patients. Nevertheless, the rapid dissociation of conventional TACE (cTACE) preparations, attributed to the instability of the emulsion, often leads to inadequate concentrations of chemotherapeutic agents within the tumor site. Consequently, there exists a pressing demand for an embolic agent that possesses facile injectability and the capacity to provide continuous delivery of chemotherapy drugs.

Effects of human disturbance on the landscape pattern in the mountainous area of western Henan, China.

Human disturbance, including agricultural development, urbanization, and resource exploitation, has become one of the important driving factors in the formation and evolution of mountain landscape patterns. Understanding the spatiotemporal changes of human disturbance and their impacts on landscape patterns is of great significance for sustainable development of mountainous areas. This study focuses on the mountainous areas of western Henan in China, dividing elevation zones based on vegetation distribution, using hemeroby index (HI) to evaluate the intensity and degree of human disturbance, and reflecting landscape spatial patterns such as fragmentation, complexity, aggregation, and diversity through four landscape pattern indices (AREA_MN, FRAC_MN, AI, SHDI).

Association between yoga and multimorbidity: a nationwide study of 279,885 middle-aged and older adults.

Background: The health benefits of exercise have been well-established, but the specific role of yoga in multimorbidity was less understood. This study aimed to examine the association between yoga and multimorbidity in comparison with other exercises or non-exercise.

Methods: This cross-sectional study pooled nationally representative surveys from Behavioral Risk Factor Surveillance System (BRFSS) (2015, 2017, and 2019), and classified 279,885 participants aged 45 + years as yoga practitioners, other exercisers, and non-exercisers.

Addition of thoracic radiotherapy to a PD-L1 inhibitor plus chemotherapy regimen delays brain metastasis onset in extensive-stage small cell lung cancer patients without baseline brain metastasis.

Background: With the application of immune checkpoint inhibitors (ICIs) and the discovery of the synergistic effect of radiotherapy and immunotherapy, the intracranial benefit of thoracic radiotherapy (TRT) is receiving signiffcant clinical attention. The purpose of this study was to analyze the cranial benefits of ICIs and TRT in patients with extensive-stage small cell lung cancer (ES-SCLC) without baseline brain metastases (BMs).

Materials And Methods: From August 2019 to August 2022, data from patients diagnosed with ES-SCLC without baseline BMs were retroactively recorded.