Efficacy of adjuvant therapy regimens administered during the perioperative period in resectable non-small cell lung cancer.

Background: We aimed to contribute to the ongoing discussion regarding adjuvant treatment strategies following neoadjuvant chemoimmunotherapy (NCIT) and adjuvant immunotherapy (AIT) after upfront surgery (US) in patients with resectable non-small cell lung cancer (NSCLC).

Methods: 317 patients were retrospectively included from 2019 to 2024. 285 received NCIT, while 32 received AIT after US.

Integrating network pharmacology, pharmacokinetics and experimental validation to reveal the potential mechanism of Physochlaina physaloides (L.) G. Don in chronic atrophic gastritis.

Ethnopharmacological Relevance: Physochlaina physaloides (L.) G. Don, abbreviated as P.

Individuals with High Social Anhedonia but not Schizophrenia Exhibited Altered Empathy in Daily Life.

Background And Hypothesis: Despite empathic abnormalities exhibited in both clinical and subclinical samples of schizophrenia (SCZ) in the laboratory, understanding of their empathy in the real world remains limited. This study applied the experience sampling method (ESM) to investigate empathy in people with SCZ and high social anhedonia (SocAnh), as well as its associations with social pleasure and emotional states in daily life.

Study Design: Thirty-one participants with SCZ, 31 individuals with high SocAnh, and 32 healthy controls completed a 7-day ESM survey (10 surveys per day) to assess empathy, social pleasure, and emotional states in daily life.

Association between cardiac dysfunction and late gadolinium enhancement confined to the LV intramural region in patients with hypertrophic cardiomyopathy.

Aim/introduction: There are two major distributions of late gadolinium enhancement (LGE) in the context of hypertrophic cardiomyopathy (HCM): intramural LGE and LGE at right ventricular insertion points (RVIPs). However, the clinical significance of intramural LGE has not been well established.

Materials And Methods: A total of 117 consecutive patients with HCM (61 male; median age, 58.

A novel and safe SmartCap SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans.

We have developed a 5'-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5'-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied. This is the first report to describe the proven safety of the novel cap analogue, SmartCap SC101, in humans and emphasize the importance of cap selection.

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Coordinating transcription and replication via transcription factors (TFs) is a conserved mechanism in higher eukaryotes. The role of TFs in regulating these processes in cancers remains unclear. Here, it is shown that oncogenetic ETS transcription factor ETV4 controls DNA replication through both transcriptional and non-transcriptional mechanisms in non-small cell lung cancer (NSCLC).

Microenvironment-Activatable Long-Wavelength NIR-II Visualization and Synergistic Treatment of Pulmonary Embolism.

Pulmonary embolism (PE) is a life-threatening thrombotic condition, yet its precise diagnosis and effective treatment remain a major clinical challenge. In this study, we report the development of a microenvironment-activatable nanoplatform that enables hypoxia-triggered long-wavelength second near-infrared (NIR-II) fluorescence imaging for accurate thrombus visualization, combined with photothermal therapy (PTT) and controlled hydrogen sulfide (HS) release for synergistic therapeutic intervention. We first synthesize an -oxide-based molecular probe that undergoes hypoxia-induced structural transition, thereby activating both NIR-II fluorescence and photothermal properties.

Targeting Dicer reprograms tumor-associated macrophages to promote anti-tumoral immunity in colorectal cancer liver metastasis.

Background: Tumor-associated macrophages (TAMs) contribute significantly to immunosuppression in colorectal cancer liver metastasis (CRLM), leading to high aggressiveness and poor prognosis. However, the key molecules involved in shaping TAMs toward the pro-tumoral phenotype in CRLM remain unclear, limiting the development of macrophage-mediated immunotherapies for CRLM.

Results: In this study, we showed that DICER1 was highly expressed in TAMs and closely associated with M2 polarization in CRLM.

Role of super-enhancer-associated miRNAs and histone modifications in intramuscular fat deposition in yak.

Intramuscular fat (IMF) content is a crucial factor in determining meat quality, yet yak meat is typically characterized by low IMF levels. The epigenetic mechanisms underlying IMF deposition, particularly the role of super-enhancers (SEs), remain poorly understood. RNA-seq identified 66 differentially expressed (DE) miRNAs and 56 DE pri-miRNAs in yak longissimus dorsi with varying IMF contents.

Identification and regulation of EMT cells by laser stimulation.

Cells undergoing epithelial-to-mesenchymal transition (EMT) exhibit significant plasticity, making them more tumorigenic, invasive, and stem-like. PLCG2 has been identified as being linked to EMT. Specifically, the PLCG2-high subpopulation of tumor cells shows strong correlations with metastasis.

Efficacy and safety of the R2-MTX regimen in primary central nervous system lymphoma (PCNSL): a single-center retrospective analysis.

Purpose: Primary central nervous system lymphoma (PCNSL) has a poor prognosis, mainly because of the significant challenges with the efficacy and tolerability of induction chemotherapy. This retrospective study aimed to evaluate the efficacy and safety of the R2-MTX regimen in PCNSL patients.

Methods: We conducted a retrospective analysis of 39 PCNSL patients treated with the R2-MTX regimen, focusing on treatment outcomes and adverse events (AEs).

Rapid Synthesis of 3,7a-Diazacyclohepta[]fluorenes via Cascade Michael Addition/Pictet-Spengler Reaction and Amidation Reaction.

In this article, a convenient method has been developed for the rapid and expedient diastereoselective synthesis of highly functionalized 3,7a-diazacyclohepta[]fluorenes from simple starting materials via a cascade Michael addition/Pictet-Spengler reaction and amidation reaction. In addition, the whole process, losing only one molecule of water and alcohol, has a high atomic economy.

Structural insights into the activation of the human prostaglandin E receptor EP1 subtype by prostaglandin E.

Prostaglandin E (PGE) mediates diverse physiological processes through four G protein-coupled receptor subtypes (EP1-EP4). While structures of EP2, EP3, and EP4 have been determined, the structural basis for PGE recognition and activation of the EP1 receptor subtype has remained elusive due to its inherent instability. Here, we present the cryoelectron microscopy structure of the human EP1 receptor in complex with PGE and heterotrimeric Gq protein at 2.

Molecular imaging using F-FDG PET/CT and circulating inflammatory and immune indicators to predict pathological response to neoadjuvant camrelizumab plus chemotherapy in resectable stage IIIA-IIIB NSCLC.

Objective: This study aims to predict the pathological response of patients with non-small cell lung cancer (NSCLC) in prospective trials of neoadjuvant camrelizumab combined with chemotherapy by integrating the clinical characteristics, PET-associated parameters, and hematological indicators.

Methods: A prospective analysis was conducted among 24 patients undergoing surgery after neoadjuvant camrelizumab plus chemotherapy. F-Fluorodeoxyglucose (FDG) scans were performed before and after neoadjuvant therapy (pre-NAT, post-NAT).

Three Criteria of M-Type Spectrometers for Engineering.

Researchers frequently utilize the method of optical initial structure (MOIS) of Czerny-Turner (C-T) spectrometers for aberration-correction studies based on the coma-free equation. While effective, this method has limitations: small numerical apertures at slits (0.05-0.

METTL1-mediated m7G modification promotes colorectal cancer metastasis via stabilization of ICAM-1.

Colorectal cancer (CRC) is one of the most common tumors worldwide, and metastatic CRC is likely to have a poor prognosis. N7-methylguanosine (m7G) is a common methylation modification that is catalyzed primarily by methyltransferase 1 (METTL1). However, the role of m7G in metastatic CRC remains unclear.

An ERP study on pre-attentive processing of emotional faces in individuals with high social anhedonia.

Expression-related visual mismatch negativity (EMMN) is encoded by prediction errors associated with facial emotion changes. Previous studies have shown that patients with psychiatric disorders (e.g.

Uranium immobilization via sulfur-modified Fe nanoparticles: U(VI) trapping kinetics and long-term stability evaluation.

The modification of nanoscale zero-valent iron (nZVI) by loading or incorporating sulfur into the iron crystal lattice can augment their efficacy in the removal of hydrophobic contaminants from wastewater. Nevertheless, the reactivity of sulfur-embedded nZVI (SnZVI) in immobilizing hydrophilic uranyl ions and the long-term stability of the sequestered uranium has received little attention. This study employed NaSO to modify the nZVI with different S/Fe molar ratios (0.

Clinical Impact of Primary Sclerosing Cholangitis on Outcomes of Inflammatory Bowel Disease Hospitalization: A Propensity Score Matching Analysis of the Nationwide Inpatient Sample.

Objective: We aimed to evaluate the effect of primary sclerosing cholangitis (PSC) on hospitalization outcomes of inflammatory bowel disease (IBD) patients.

Methods: This retrospective study used data from the Nationwide Inpatient Sample (NIS) database from January 1, 2019, to December 31, 2020, including adults (≥ 18 years) admitted and diagnosed with IBD. Key outcomes included length of hospital stay (LOS), in-hospital mortality, hospitalization cost, and complications.

Effects of indoor biophilic environments on cognitive function in elderly patients with diabetes: study protocol for a randomized controlled trial.

Background: The prevalence of cognitive impairment in elderly diabetic patients is increasing, highlighting the importance of exploring strategies to prevent and ameliorate cognitive impairment in this population. Previous studies have focused mostly on improving cognition in elderly diabetic patients through three methods: medication, cognitive training, and lifestyle intervention. However, few studies have investigated the role of indoor biophilic environments in improving cognition.

Addition of thoracic radiotherapy to a PD-L1 inhibitor plus chemotherapy regimen delays brain metastasis onset in extensive-stage small cell lung cancer patients without baseline brain metastasis.

Background: With the application of immune checkpoint inhibitors (ICIs) and the discovery of the synergistic effect of radiotherapy and immunotherapy, the intracranial benefit of thoracic radiotherapy (TRT) is receiving signiffcant clinical attention. The purpose of this study was to analyze the cranial benefits of ICIs and TRT in patients with extensive-stage small cell lung cancer (ES-SCLC) without baseline brain metastases (BMs).

Materials And Methods: From August 2019 to August 2022, data from patients diagnosed with ES-SCLC without baseline BMs were retroactively recorded.

Review of advancement in aggregation-induced emission-based fluorescent biosensors for enzyme detection: Mechanisms and biomedical applications.

Background: Enzymes, primarily proteins produced by living organisms, exhibit high substrate selectivity and catalytic efficiency. Many are crucial for normal biological processes and are closely associated with the onset of various diseases. As such, developing methods for detecting disease-related enzymes is essential.

Plasma amyloid-β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort.

Introduction: This study aimed to explore the association between plasma amyloid-β oligomerization tendency (OAβ) and cognitive performance in Alzheimer's disease (AD) and determine its predictive value for outcomes of mild cognitive impairment (MCI).

Methods: Plasma from 727 subjects (286 AD, 260 MCI, and 181 controls) in a case registry was analyzed using the multimer detection system (MDS) to measure plasma OAβ.

Results: Elevated plasma OAβ was strongly correlated with multidomain cognitive performance in patients with MCI and AD.

Leaf Vein-Inspired Programmable Superstructure Liquid Metal Photothermal Actuator for Soft Robots.

Asymmetric-expansion photothermal actuators have attracted the attention of researchers owing to their simple structure, superior stability, rapid response, and precise controllability. However, their response speed, deformation capacity, and load-carrying capacity are mutually constrained by their thickness. Inspired by the veins and pulp in plant leaves, this study uses laser etching to apply a superstructure of ordered grooves to liquid metal (LM) photothermal actuators.

Nurses' work value patterns and their relationship with burnout: a cross-sectional study based on latent profile analysis.

Background: There is a significant association between work values and burnout. However, most studies have tended to focus on a single influencing factor or rely only on total scale scores to assess nurses' work values, lacking a comprehensive consideration of differences within groups of nurses. As a result, the specific relationship between different work value patterns and burnout has not been clarified.