METTL1-mediated m7G modification promotes colorectal cancer metastasis via stabilization of ICAM-1.

Colorectal cancer (CRC) is one of the most common tumors worldwide, and metastatic CRC is likely to have a poor prognosis. N7-methylguanosine (m7G) is a common methylation modification that is catalyzed primarily by methyltransferase 1 (METTL1). However, the role of m7G in metastatic CRC remains unclear.

m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19.

Background: In recent years, the emphasis has shifted to understanding the role of N1-methyladenosine (m1A) in tumor progression as little is known about its regulatory effect on mRNA and its role in the metastasis of colorectal cancer (CRC).

Methods: We performed methylated RNA immunoprecipitation sequencing of tumor tissues and tumor-adjacent normal tissues from three patients with CRC to determine the m1A profile of mRNA in CRC. The expression of diaphanous-related formin 3 (DIAPH3) and its correlation with clinicopathological characteristics of CRC were evaluated using immunohistochemistry and online datasets.

Two-sample Mendelian randomization analysis of the relationship between periodontitis and risk of upper gastrointestinal cancers.

Purpose: The aim of the present study is to explore the possible association between periodontitis and upper gastrointestinal (UGI) cancers, including esophageal and gastric cancers, utilizing the Mendelian randomization method.

Methods: In this research, we utilized the Mendelian randomization method to examine the causal association between periodontitis and UGI cancers. Genome-wide association studies data for periodontitis were obtained from the Gene-Lifestyle Interactions in Dental Endpoints consortium, while UGI cancers' data were accessed from FinnGen's Biobank.

SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1.

Metastasis accounts for the major cause of colorectal cancer (CRC) related mortality due to the lack of effective treatments. In this study, we integrated the single-cell RNA-seq (scRNA-seq) and bulk RNA-seq data and identified the transcriptional coactivator SUB1 homolog (Sac-Saccharomyces cerevisiae)/PC4 (positive cofactor 4) associated with CRC metastasis. Elevated SUB1 expression was correlated with advanced tumor stage and poor survival in CRC.

HIF-1α/METTL1/mG axis is involved in CRC response to hypoxia.

Background: In recent years, many studies have confirmed that hypoxia and hypoxia inducible factor (HIF)-1α drive the development of colorectal cancer (CRC). HIF-1α also modulates epitranscriptomic remodeling to regulate cancer development. However, the mechanism by which RNA methylation is altered under hypoxic conditions and the underlying regulatory mechanisms in CRC remain unclear.

Wood-based superblack.

Light is a powerful and sustainable resource, but it can be detrimental to the performance and longevity of optical devices. Materials with near-zero light reflectance, i.e.

MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3.

Background: Distant metastasis is the main cause of mortality in colorectal cancer (CRC) patients. N1-methyladenosine (m1A) is a type of epitranscriptome modification. While its regulatory effect on mRNA and its role in CRC metastasis remain unclear.

ALKBH1-mediated m A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m A RNA modification plays critical role in many biological processes. However, the role of m A modification in CRC remains unclear.

113 W Ho:YLF oscillator with good beam quality efficiently pumped by a Tm:YAP laser.

We demonstrate a linearly polarized Tm:YAP slab laser pumped by fiber-coupled laser diodes. The maximum output power is 202 W at 1937.5 nm with a slope efficiency of 47.

Thermal-birefringence-induced depolarization in a 450 W Ho:YAG MOPA system.

We demonstrated an efficient, high-power Ho:YAG master-oscillator power amplifier (MOPA) system and investigated its thermal-birefringence-induced depolarization. The maximum output power was 450 W with a depolarized power of 32.1 W and depolarization of 0.

Aberrant lipid metabolism in cancer cells and tumor microenvironment: the player rather than bystander in cancer progression and metastasis.

As the primary cause of cancer-induced fatality and morbidity, cancer metastasis has been a hard nut to crack. Existing studies indicate that lipid metabolism reprogramming occurring in cancer cells and surrounding cells in TME also endows the aggressive and spreading properties with malignant cells. In this review we describe the lipid metabolic reprogramming of cancer cells at different steps along the metastatic process, we also summarize the altered lipid metabolism of non-cancer cells in TME during tumor metastasis.

161 W middle infrared ZnGeP MOPA system pumped by 300 W-class Ho:YAG MOPA system.

We demonstrated a high-power -switched two-stage Ho:YAG master-oscillator power-amplifier (MOPA) system dual-end pumped by Tm:YLF lasers. A new method was introduced by rotating and swapping spatial axial directions of pump beams to improve the beam quality of the Ho:YAG oscillator and first-stage amplifier. Two parallel second-stage Ho:YAG amplifiers were employed to output high power.

Research on performance improvement technology of a BaGaSe mid-infrared optical parametric oscillator.

In this Letter, we demonstrate an average output power of 5.12 W at 3-5 µm from a type-I phase-matching (BGSe) optical parametric oscillator (OPO), which is pumped by a 2090 nm -switched Ho:YAG laser with pulse repetition frequency of 1 kHz. At maximum output level, the corresponding slope efficiency and optical-to-optical conversion efficiency are 30.

570 MHz harmonic mode-locking in an all polarization-maintaining Ho-doped fiber laser.

In this paper, we demonstrate a 570.0 MHz harmonically mode-locked all-polarization-maintaining Ho-doped fiber laser based on semiconductor saturable absorbed mirror. Firstly, the laser operates in the 15.

Opening a Window on Attention: Adjuvant Therapies for Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD), most commonly known as Crohn's disease (CD) and ulcerative disease (UC), is a chronic and relapsing intestinal disease which cannot be cured completely. The prevalence of IBD in Europe and in North America has increased over the past 20 years. As most IBD patients are young at onset, their quality of life (QOL) can be influenced to varying degrees.

Friend or Foe? An Unrecognized Role of Uric Acid in Cancer Development and the Potential Anticancer Effects of Uric Acid-lowering Drugs.

In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists. Mets has an intimate relationship with the incidence and development of various cancers. As a contributory factor of Mets, hyperuricemia actually plays an inseparable role in the formation of various metabolic disorders.

High-beam-quality 2.1 µm pumped mid-infrared type-II phase-matching BaGaSe optical parametric oscillator with a ZnGeP amplifier.

We firstly demonstrated a tunable 2.1 µm pumped mid-infrared type-II phase-matching (BGSe) optical parametric oscillator (OPO). A signal tuning range of 3.

Measurement of optical homogeneity of ZnGeP crystal using a 2.02 µm single-longitudinal-mode Tm:LuAG ring laser.

We demonstrate a single-longitudinal-mode Tm:LuAG unidirectional ring laser based on the Faraday effect and its application in measuring the optical homogeneity of (ZGP) crystal. The maximum single-longitudinal-mode power was 511 mW at 2022.4 nm, with a slope efficiency of 9.

11 µm, high beam quality idler-resonant CdSe optical parametric oscillator with continuous-wave injection-seeded at 2.58 µm.

We report an idler-resonant, continuous-wave (CW) seed injected, optical parametric oscillator (OPO) based on cadmium selenide (CdSe). The CdSe OPO was pumped by a 2.09 µm ns-pulsed laser and injection-seeded by a 2.

3.5 W long-wave infrared ZnGeP optical parametric oscillator at 9.8 µm.

We demonstrated a high-power long-wave infrared optical parametric oscillator at 9.8 µm based on a type-I phase-matching ${{\rm ZnGeP}_2}$ZnGeP crystal. By using a ${Q}$Q-switched 2091 nm Ho:YAG laser with pulse repetition frequency of 10 kHz as the pump source, the maximum average output power of 3.

1 W, 10.1 µm, CdSe optical parametric oscillator with continuous-wave seed injection.

We demonstrated a 2.1 µm nanosecond laser pumped, 2.6 µm continuous-wave (CW) seed injected, cadmium selenide (CdSe) signal singly resonant optical parametric oscillator (OPO).