An ERP study on pre-attentive processing of emotional faces in individuals with high social anhedonia.

Expression-related visual mismatch negativity (EMMN) is encoded by prediction errors associated with facial emotion changes. Previous studies have shown that patients with psychiatric disorders (e.g.

Moderation Effect of Emotional Expressivity on the Associations Between Schizotypal Traits, Autistic Traits and Social Pleasure.

Diminished social pleasure has been reported in people with schizophrenia and autism spectrum disorder (ASD). Previous studies suggested that emotional expressivity is closely correlated with social pleasure. However, the underlying psychological mechanisms between traits related to schizophrenia and ASD, emotional expressivity, and social pleasure remain unclear.

Dephospho-dynamin 1 coupled to activity-dependent bulk endocytosis participates in epileptic seizure in primary hippocampal neurons.

Background And Purpose: Epilepsy is a severe neurological and mental disorder, and not all patients adequately respond to the current treatments. Dynamin 1 plays a key role in synaptic endocytosis and the modulation of neurological function.

Material And Methods: Cultured hippocampal neurons were used in the study.

Upregulated dynamin 1 in an acute seizure model and in epileptic patients.

Dynamin 1 is a neuron-specific guanosine triphosphatase (GTPase) that is an essential component of membrane fission during synaptic vesicle recycling and endocytosis. This study evaluated the dynamin 1 expression pattern in the acute lithium-pilocarpine rat model and in patients with temporal lobe epilepsy (TLE) and investigated whether altering the dynamin 1 expression pattern affects epileptic seizures in vivo and in vitro. The immunofluorescence, western blot analysis, and reverse transcription-PCR results show that the dynamin 1 expression level increased significantly in experimental rats from day 1 to day 7 after the onset of seizures and was significantly higher in TLE patients.