Characteristics and associated cognitive indicators of decision-making decline over time in older people with mild cognitive impairment.

Background: Impaired decision-making (DM) under uncertainty in mild cognitive impairment (MCI) increases financial vulnerability and suboptimal medical decision-making OBJECTIVE: This two-year longitudinal study characterized DM changes in MCI and identified modifiable cognitive correlates for functional preservation.

Methods: Fifty-two MCI and 49 cognitively normal (CN) participants underwent annual Iowa Gambling Task (IGT), modeled via Outcome-Representation Learning (ORL) to quantify reward/punishment learning rates (A/A), memory decay (K), and win/deck perseverance (β/β). Concurrent neuropsychological assessments measured six domains.

A 12-week cluster randomized controlled trial of the effectiveness of an AI-aided DICE algorithm for BPSD management in low-resource settings: a study protocol.

Background: The "Describe-Investigate-Create-Evaluate" (DICE) approach has been considered a guide for managing behavioral and psychological symptoms of dementia (BPSD). However, limited resources may limit the implementation of the DICE approach. With the development of AI technology, the effectiveness of the AI-aided DICE algorithm for BPSD management has yet to be determined.

Norms of Hong Kong Brief Cognitive Test and the Utility for Screening Cognitive Impairment Among Chinese Older Adults.

Objective: To establish the norms of the Hong Kong Brief Cognitive Test (HKBC) among Chinese older adults and to examine its utility for differentiating neurocognitive disorders from cognitively normal controls.

Methods: Two thousand three hundred twelve participants aged 40 years and above were recruited from six regions of China as the norm construction sample. 93 normal participants and 246 cognitive impairment patients were included for diagnostic test of HKBC.

Plasma amyloid-β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort.

Introduction: This study aimed to explore the association between plasma amyloid-β oligomerization tendency (OAβ) and cognitive performance in Alzheimer's disease (AD) and determine its predictive value for outcomes of mild cognitive impairment (MCI).

Methods: Plasma from 727 subjects (286 AD, 260 MCI, and 181 controls) in a case registry was analyzed using the multimer detection system (MDS) to measure plasma OAβ.

Results: Elevated plasma OAβ was strongly correlated with multidomain cognitive performance in patients with MCI and AD.

Attenuated neural activity in processing decision-making feedback in uncertain conditions in patients with mild cognitive impairment.

The present study aimed to explore the potential neural correlates during feedback evaluation during decision-making under risk and ambiguity in MCI. Nineteen individuals with MCI and twenty age-matched HCs were enrolled. Decision-making performance under risk and ambiguity was examined with the modified game of dice task (GDT) and an Iowa gambling task (IGT).

A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study.

Background: Dementia has become a major public health concern due to its heavy disease burden. Mild cognitive impairment (MCI) is a transitional stage between healthy aging and dementia. Early identification of MCI is an essential step in dementia prevention.

Characteristics and Potential Neural Substrates of Encoding and Retrieval During Memory Binding in Amnestic Mild Cognitive Impairment.

Background: Whether encoding or retrieval failure contributes to memory binding deficit in amnestic mild cognitive impairment (aMCI) has not been elucidated. Also, the potential brain structural substrates of memory binding remained undiscovered.

Objective: To investigate the characteristics and brain atrophy pattern of encoding and retrieval performance during memory binding in aMCI.

Heterogenous Subtypes of Late-Life Depression and Their Cognitive Patterns: A Latent Class Analysis.

Background: Late-life depression (LLD), characterized by cognitive deficits, is considered heterogeneous across individuals. Previous studies have identified subtypes with diverse symptom profiles, but their cognitive patterns are unknown. This study aimed to investigate the subtypes of LLD and the cognitive profile of each group.

Decision-Making Profiles and Their Associations with Cognitive Performance in Mild Cognitive Impairment.

Background: It is crucial for older adults, especially those with mild cognitive impairment (MCI), to make profitable decisions routinely. However, the results regarding decision-making (DM) remain inconsistent.

Objective: The present study assessed DM profiles under uncertainty conditions in individuals with MCI and their associations with multi-domain cognitive performance.