Ten-Year Cognitive Trajectories and Determinants in Chinese Older Adults Without Formal Schooling: Chinese Longitudinal Healthy Longevity Survey 2008-2018.

Objectives: Lack of formal schooling remains prevalent among older adults in China, particularly in rural areas. This study investigates the cognitive function trajectory and influencing factors in older adults without formal schooling from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Methods: The study included 2159 individuals without formal schooling (NFS) and 2234 individuals with formal schooling (FS), all cognitively healthy and aged over 60 at the first observation from the 2008 - 2018 CLHLS cohort.

The Association Between Childhood Trauma and Selective Serotonin Reuptake Inhibitor Treatment Outcomes in Adult Patients With Major Depressive Disorder.

Objective: The relationship between childhood trauma (CT) and the outcomes of selective serotonin reuptake inhibitor (SSRI) treatment for major depressive disorder (MDD) remains uncertain. The objective of this study is to investigate the overall association between CT and treatment outcomes in patients with MDD and the associations of different CT subtypes with the treatment outcomes of various MDD symptom dimensions.

Methods: A post hoc analysis of 285 adult patients with MDD from a multicenter, prospective study in China.

Phosphorus Incorporation Increases the Oxygen Electrocatalytic Activity of Co-N Catalysts.

Transition metal and nitrogen codoped graphitic carbon materials with Co-N bonds serve as key non-noble-metal catalysts for the oxygen evolution reaction (OER). To enhance catalytic efficiency, we explore the anchoring of Co-N bonds on nitrogen-doped graphitic carbon (NC) substrates with varied phosphorus content. The catalyst is synthesized through a straightforward sintering and phosphating process of ZIF@DCA in a tube furnace.

Exploring the photothermal effect in the photocatalytic water splitting over Type II ZnInS/CoFeS composites.

Hydrogen is increasingly acknowledged as a viable alternative to traditional fossil fuels. However, the photothermal properties of CoFeS, a photocatalyst displaying metal-like behavior, have not been adequately explored in the context of photocatalytic H generation. To improve photocatalytic hydrogen evolution, it is crucial to understand how to expedite the transfer of photogenerated electrons and the dissociation of H-OH bonds for enhanced hydrogen ion release.

Sensory impairments associated with cognitive impairment among older adults in China: A community-based, 10-year prospective cohort study.

Background: To address an existing gap in knowledge due to limited and inconclusive evidence, we aimed to investigate the association between sensory impairments and cognitive decline among older Chinese individuals.

Methods: We retrieved data on 6862 adults aged ≥65 years that were collected through the Chinese Longitudinal Healthy Longevity Study (CLHLS), a nationwide, prospective, community-based elderly cohort study. Visual or hearing impairment in the CLHLS were identified through self-reported questionnaire.

Attenuated neural activity in processing decision-making feedback in uncertain conditions in patients with mild cognitive impairment.

The present study aimed to explore the potential neural correlates during feedback evaluation during decision-making under risk and ambiguity in MCI. Nineteen individuals with MCI and twenty age-matched HCs were enrolled. Decision-making performance under risk and ambiguity was examined with the modified game of dice task (GDT) and an Iowa gambling task (IGT).

Co-occurrence of depressive and anxious symptoms and their influence on self-rated health: a national representative survey among Chinese older adults.

Objectives: The prevalence of the co-occurrence of depressive and anxious symptoms (CO) and their influence on perceived overall health were not clear in community dwelling Chinese older adults. The aims of the study were to investigate the prevalence of CO and to explore its influence on self-rated health (SRH).

Method: This study included 12301 individuals aged ≥65 years from the 2018 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a nationally representative survey of older adults in mainland China.

Sex differences in cognitive function trajectories and their determinants in older adults: Evidence from the Chinese longitudinal healthy longevity survey.

Objectives: To examine sex differences in the cognitive trajectories of a nationally representative sample of older people living in China and to explore potential determinants of these trajectories.

Methods: The study included 2230 women and 2171 men who were cognitively healthy and aged over 60 at the first observation from the Chinese Longitudinal Healthy Longevity Survey based on the 2008-2018 cohort. Cognitive function was measured using the Chinese version of the Mini-Mental State Examination (MMSE).

Development and validation of a stacking ensemble model for death prediction in the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Objective: This study aimed to develop and validate a mortality risk prediction model for older people based on the Chinese Longitudinal Healthy Longevity Survey using the stacking ensemble strategy.

Material And Methods: A total of 12,769 participants aged 65 or more at baseline were included. Ensemble machine learning models were applied to develop a mortality prediction model.

Self- and interviewer-reported cognitive problems in relation to cognitive decline and dementia: results from two prospective studies.

Background: Little is known regarding the association of interviewer-reported cognitive problems (ICP) with age-related cognitive decline. We aimed to investigate the independent associations of ICP and the combined associations of ICP and self-reported cognitive problems (SCP) with subsequent cognitive decline and dementia in two prospective cohort studies.

Methods: We included 10,976 Chinese (age = 57.

A Stable and Scalable Digital Composite Neurocognitive Test for Early Dementia Screening Based on Machine Learning: Model Development and Validation Study.

Background: Dementia has become a major public health concern due to its heavy disease burden. Mild cognitive impairment (MCI) is a transitional stage between healthy aging and dementia. Early identification of MCI is an essential step in dementia prevention.

Dietary factors in relation to the risk of cognitive impairment and physical frailty in Chinese older adults: a prospective cohort study.

Purpose: The study aimed to investigate the independent associations of dietary factors with cognitive impairment (CI) and physical frailty (PF) among Chinese older adults.

Methods: This study included 10,734 participants (mean age = 78.7 years) free of CI and PF at baseline from the Chinese Longitudinal Health Longevity Survey.

Proinflammatory phenotype in major depressive disorder with adulthood adversity: In line with social signal transduction theory of depression.

Background: The social signal transduction theory of depression proposes that life stress can be transformed into inflammatory signals, and ultimately lead to the development of major depressive disorder (MDD). The hypotheses of this study were: (1) The pro-inflammatory effect of life stress was only seen in patients with MDD, but not in healthy controls (HCs); (2) Inflammation can mediate the relationship between life stress and depressive symptoms.

Methods: This study included 170 MDD patients and 196 HCs, and 13 immune-inflammatory biomarkers closely related to MDD were measured, principal component analysis (PCA) was adopted to extract the inflammatory index.

Characteristics and Potential Neural Substrates of Encoding and Retrieval During Memory Binding in Amnestic Mild Cognitive Impairment.

Background: Whether encoding or retrieval failure contributes to memory binding deficit in amnestic mild cognitive impairment (aMCI) has not been elucidated. Also, the potential brain structural substrates of memory binding remained undiscovered.

Objective: To investigate the characteristics and brain atrophy pattern of encoding and retrieval performance during memory binding in aMCI.

Adverse effects of 21 antidepressants on sleep during acute-phase treatment in major depressive disorder: a systemic review and dose-effect network meta-analysis.

Study Objectives: Sleep-related adverse effects during acute treatment with antidepressants undermine adherence and impede remission. We aimed to address subtypes of sleep-related adverse effects and depict the relationship between dose and sleep-related adverse events.

Methods: We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science for double-blind randomized controlled trials of depression published before April 30th, 2023.

Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.

Context: Weight loss among middle-aged and older adults has been associated with a higher risk of subsequent dementia. However, most studies have limited follow-up durations or suboptimal control for the potential influence of physical frailty (PF).

Objective: Our study aimed to investigate the long-term and temporal relations of weight change to risk of dementia among middle-aged and older adults in the United States.

Features of cognitive impairment and related risk factors in patients with major depressive disorder: A case-control study.

Background: Cognitive impairment (CI) is a common symptom contributing to functional loss in major depressive disorder (MDD). However, the features of CI and its related risk factors in young and middle-aged MDD patients remain unclear.

Methods: In this case-control study, 18- to 55-year-old acute-onset MDD patients and healthy controls (HCs) were recruited from nine centers in China.

The effect of China's Clean Air Act on cognitive function in older adults: a population-based, quasi-experimental study.

Background: Air pollution might accelerate cognitive ageing; it is unclear whether large-scale interventions, such as China's Clean Air Act (CCAA), can mitigate cognitive deterioration. We aimed to evaluate the effect of CCAA on changes in cognitive function in older adults.

Methods: In this population-based, quasi-experimental study, we did a difference-in-differences analysis of the data collected during the 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Major depressive disorder comorbid with general anxiety disorder: Associations among neuroticism, adult stress, and the inflammatory index.

Accumulating evidence shows that higher neuroticism and adult stress may be potential risk factors for major depressive disorder (MDD) comorbid with generalized anxiety disorder (GAD). Studies have shown that anxious and depressed patients have significantly more neurobiological abnormalities than non-anxious depressed patients. However, the biological mechanism of comorbidity remains unknown.