Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank.

Plasma amyloid-β(Aβ)42/40 ratio, glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and phosphorylated tau181(p-tau181) are promising biomarkers for Alzheimer's disease (AD)-related pathology. We aimed to explore the longitudinal trajectories of these biomarkers in association with changes in structural brain markers and cognition, and the impact of cognitive reserve on their associations with cognitive function. This cohort study included 1270 individuals (mean age 59.

Enlarged choroid plexus is associated with reduced gray matter volumes and increased plasma amyloid-beta: a population-based study of older adults.

Objectives: To characterize brain structures and plasma Alzheimer's-related biomarkers associated with enlarged choroid plexus (ChP) among rural older adults in China.

Methods: This population-based cross-sectional study included 1115 older adults (age ≥ 60 years) derived from the Multimodal Interventions to delay Dementia and disability in rural China, who underwent structural brain MRI scans (3.0 T) in 2018-2020; of these, plasma biomarkers for Alzheimer's disease and neurodegeneration, i.

Associations of sleep characteristics with all-cause, cardiovascular and non-cardiovascular mortality among rural Chinese older adults: a cohort study.

Study Objectives: The longitudinal associations of sleep timing and time in bed (TIB) with all-cause, cardiovascular and non-cardiovascular mortality are unclear in Chinese rural populations.

Methods: This population-based cohort study included 2468 participants who were aged ≥60 years and residing in rural communities in western Shandong Province. Sleep timing and TIB were assessed using standard questionnaires at baseline in 2014.

Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study.

Introduction: We sought to examine the associations of physical frailty (PF) and biopsychological frailty (BF) with dementia and mild cognitive impairment (MCI) among Chinese older adults and further to explore neuropathological mechanisms underlying the associations.

Methods: This population-based cross-sectional study included 5149 participants in the MIND-China baseline examination (2018); of these, we measured plasma amyloid-β (Aβ), neurofilament light chain (NfL), and total tau in 1371 persons and phosphorylated tau 217 (p-tau217) and glial fibrillary acidic protein (GFAP) in 3387 persons.

Results: PF and BF were significantly associated with increased likelihoods of dementia, Alzheimer's disease (AD), vascular dementia (VaD), and MCI.

Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study.

Background: Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population.

Methods: This population-based prospective cohort study included 1004 rural residents (age ≥40 years) who were free of carotid plaque and had no history of clinical stroke and transient ischemic attack at baseline (2017).

Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults.

[This corrects the article DOI: 10.3389/fnagi.2025.

Cerebral small vessel disease among rural-dwelling Chinese older adults: prevalence, distribution, and associated factors.

Epidemiological characteristics of cerebral small vessel disease (cSVD) in the general population, especially among rural older adults, are poorly defined. Here, we reported the prevalence, distribution, and associated factors of cSVD in a rural-dwelling older population in China. This population-based cross-sectional study included 1272 older adults (age ≥60 years; mean age 69.

Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults.

Background: The mechanisms underlying olfactory decline in aging need further investigation. Noticeably, the longitudinal relationship of biological markers with olfaction remains underexplored. We investigated whether baseline levels and progression of microvascular lesions and brain atrophy are associated with odor identification (OID) decline.

Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study.

Background: The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies have thus far examined the association of ChP with physical function in older people.

Methods: This population-based cross-sectional study included 1217 participants (age ≥ 60 years; 57.

Characterization of brain morphology associated with metabolic dysfunction-associated steatotic liver disease in the UK Biobank.

Background: Emerging evidence has linked metabolic dysfunction-associated steatotic liver disease (MASLD) with accelerated cognitive decline and dementia. We aimed to investigate the associations of MASLD with volumes of total brain tissue and subcortical grey matter, and white matter microstructures in the UK Biobank.

Methods: This cross-sectional study included 29,195 individuals (aged 45-82 years) from the UK Biobank who undertook a magnetic resonance imaging (MRI) sub-study between 2014 and 2022.

Blood-based biomarkers of Alzheimer's disease and incident dementia in the community.

Evidence regarding the clinical validity of blood biomarkers of Alzheimer's disease (AD) in the general population is limited. We estimated the hazard and predictive performance of six AD blood biomarkers for incident all-cause and AD dementia-the ratio of amyloid-β 42 to amyloid-β 40 and levels of tau phosphorylated at T217 (p-tau217), tau phosphorylated at T181 (p-tau181), total tau, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP)-in a cohort of 2,148 dementia-free older adults from Sweden, who were followed for up to 16 years. In multi-adjusted Cox regression models, elevated baseline levels of p-tau181, p-tau217, NfL, and GFAP were associated with a significantly increased hazard for all-cause and AD dementia, displaying a non-linear dose-response relationship.

Development and internal validation of a risk prediction model for dementia in a rural older population in China.

Introduction: We sought to develop a practical tool for predicting dementia risk among rural-dwelling Chinese older adults.

Methods: This cohort study included 2220 rural older adults (age ≥ 65 years) who were dementia-free at baseline (2014) and were followed in 2018. Dementia was diagnosed following the DSM-IV criteria.

Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND-China study.

Background: Motoric cognitive risk syndrome (MCR) has been associated with dementia, functional dependence, and mortality. We sought to describe the prevalence and distribution of MCR and to explore the clinical, biological, and neuroimaging profiles for MCR in rural-dwelling Chinese older adults.

Methods: This population-based study included 5021 dementia- and disability-free participants (mean age 70.

Association of Abdominal Volume Index with Asymptomatic Intracranial Arterial Stenosis in Rural Chinese Adults: A Population-Based Study.

Introduction: The abdominal volume index (AVI), a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis (aICAS) in a rural Chinese population.

Methods: The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or transient ischemic attack.

Estimated pulse wave velocity associated with cognitive phenotypes in a rural older population in China: A cohort study.

Introduction: To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population.

Methods: This population-based study included 1857 dementia-free participants (age ≥60 years) who were examined in 2014 and followed in 2018. ePWV was calculated using age and mean blood pressure (MBP).

Associations between lifelong cognitive reserve, Alzheimer's disease-related plasma biomarkers, and cognitive function in dementia-free older adults: A population-based study.

Background: Cognitive reserve (CR), typically measured through socio-behavioral proxies, can partially explain better cognitive performance despite underlying brain aging or neuropathology.

Objective: To examine the associations of CR with mild cognitive impairment (MCI) and cognitive function while considering Alzheimer's disease (AD)-related plasma biomarkers.

Methods: This population-based cross-sectional study included 4706 dementia-free individuals from MIND-China.

Prevalence of Atrial Fibrillation and Long-Term Survival of Older Adults; Findings from the SNAC Study.

This study examined the prevalence and long-term survival of atrial fibrillation (AF) in the older population. Data was recruited from the longitudinal SNAC study from baseline (2001-2004) for up to 10 years. The population comprised 6,904 persons (59% women) (mean age 73.

Cardiometabolic and panvascular multimorbidity associated with motoric cognitive risk syndrome in older adults.

Background: Motoric cognitive risk (MCR) syndrome as a pre-dementia syndrome often co-occurring with chronic health conditions. This study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorbidity among older people living in rural China.

Methods: This population-based study included 1450 participants who were aged ≥ 60 years (66.

Mapping grey matter and cortical thickness alterations associated with subjective cognitive decline and mild cognitive impairment among rural-dwelling older adults in China: A population-based study.

Background: The structural brain alterations for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are poorly defined. We sought to characterize grey matter volume (GMV) and cortical thickness associated with SCD and MCI among rural-dwelling older adults in China.

Methods: This population-based cross-sectional study included 1072 dementia-free participants from the brain MRI sub-study of MIND-China (2018-2020).

Association of dementia with impaired kidney function and plasma biomarkers: A population-based study.

Background And Purpose: Emerging evidence has linked impaired kidney function with dementia in older adults, but the neuropathological pathways underlying their association remain poorly understood. We sought to examine the relationships of kidney function with dementia and plasma biomarkers in a Chinese rural population.

Methods: This population-based study used data from the baseline examination of the Multimodal Interventions to Delay Dementia and Disability in rural China (MIND-China) cohort (March-September 2018; n = 5715).

Association of polygenic risk scores with Alzheimer's disease and plasma biomarkers among Chinese older adults: A community-based study.

Introduction: We examined the associations of polygenic risk score (PRS) with Alzheimer's disease (AD) and plasma biomarkers in the Chinese population.

Methods: This population-based study used baseline data from MIND-China (2018; n = 4873) and follow-up data from dementia-free individuals (2014-2018; n = 2117). We measured AD-related plasma biomarkers in a subsample (n = 1256).

Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis.

Background: We aimed to explore the association of sleep duration with depressive symptoms among rural-dwelling older adults in China, and to estimate the impact of substituting sleep with sedentary behavior (SB) and physical activity (PA) on the association with depressive symptoms.

Methods: This population-based cross-sectional study included 2001 rural-dwelling older adults (age ≥ 60 years, 59.2% female).