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Rapid Synthesis of 3,7a-Diazacyclohepta[]fluorenes via Cascade Michael Addition/Pictet-Spengler Reaction and Amidation Reaction. | LitMetric

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Article Abstract

In this article, a convenient method has been developed for the rapid and expedient diastereoselective synthesis of highly functionalized 3,7a-diazacyclohepta[]fluorenes from simple starting materials via a cascade Michael addition/Pictet-Spengler reaction and amidation reaction. In addition, the whole process, losing only one molecule of water and alcohol, has a high atomic economy.

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http://dx.doi.org/10.1021/acs.joc.5c00529DOI Listing

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