Glycosyl Radicals Induced Ultrafast and Homogeneous Gelation for Mechanically Robust Hydrogels.

Rapid gelation remains essential in maintaining uniform network structures and mechanical properties under mild conditions. Here, we report a strategy based on a glycosyl radical to achieve rapid gelation within tens of seconds. Mechanistically, glycosyl sulfinates serve as efficient precursors to glycosyl radicals upon treatment with potassium persulfate (KPS) through a single-electron transfer process.

Meningitis caused by Aspergillus fumigatus: a case report.

Background: is a common pathogen that causes intracranial aspergillosis. intracranial infection mainly occurs in the brain parenchyma. Head CT or MRI examination showed aspergillous abscess, which is extremely rare to caused meningitis alone.

Novel homozygous variants in ASTL and WEE2 responsible for female infertility characterized by abnormal fertilization.

Purpose: To identify the disease-causing gene behind infertile couples with female infertility and abnormal fertilization.

Methods: Whole-exome sequencing and Sanger sequencing were used to identify variants in disease-causing genes in 119 infertile couples with abnormal fertilization. Molecular modeling and functional analysis were used to evaluate the pathogenic effects of the variants.

Neural Canonical Transformations for Quantum Anharmonic Solids of Lithium.

Lithium is a typical quantum solid, characterized by cubic structures at ambient pressure. As the pressure increases, it forms more complex structures and undergoes a metal-to-semiconductor transformation, complicating theoretical and experimental analyses. We employ the neural canonical transformation approach, a variational method based on probabilistic generative models, to investigate the quantum anharmonic effects in lithium solids at finite temperatures.

Asymmetric Synthesis of Chiral Diamines via a Low-Loading Ir-Catalyzed Umpolung Allylation of Imines.

A general and mild method for the synthesis of homoallylic 1,2-diamines from α-amino aldimines is reported. This method capitalizes on a low-loading iridium-catalyzed asymmetric umpolung allylation of imines and the following facile 2-aza-Cope rearrangement. The reagents are derived from readily available starting materials, and the catalytic system enables efficient construction of chiral vicinal diamines under mild conditions with broad functional group tolerance.

Diagnosis and treatment for anal fistula: a systematic review of clinical practice guidelines and consensus statements.

Background: Anal fistula constitutes a pathological channel originating either from the anal canal or rectum to the skin surrounding the anus, primarily characterized by recurrent pain, purulent discharge, and pruritus. This study aims to compare and standardize the recommendations for the diagnosis and treatment of anal fistula, drawing on contemporary clinical practice guidelines.

Methods: A comprehensive search was conducted across multiple databases including PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, and Chinese Biological Medicine Database, from their inception through April 1, 2024.

The initial stage of alveolar echinococcosis is a diagnostic challenge: a case report.

Background: Alveolar echinococcosis is a rare, potentially fatal parasitosis with the main manifestation site in the liver. Diagnosis already in the initial stage of the disease is important to prevent further exacerbation and possible secondary complications by early targeted therapy. Identifying alveolar echinococcosis lesions on imaging can be difficult, and making the diagnosis can be an interdisciplinary challenge, even in a specialized center.

Pathogenic variants in DLGAP5 cause female infertility characterized by oocyte maturation arrest and embryonic arrest.

Study Question: Can new genetic factors responsible for oocyte defects be identified in infertile women, especially for those with spindle assembly defects?

Summary Answer: We identified homozygous and compound heterozygous variants of DLGAP5 in three infertile individuals from two independent families.

What Is Known Already: Some genes have been found to be responsible for female infertility with oocyte maturation defects. During mitosis, DLGAP5 is involved in promoting microtubule polymerization and spindle formation.

Alterations in miR-151a-3p of plasma-derived exosomes and associated multimodal neuroimaging patterns in major depressive disorder.

Magnetic resonance imaging (MRI) has been recognized as a valuable tool for achieving 'reification of clinical diagnosis' of major depressive disorder (MDD). However, the reliability and validity of MRI results are often compromised by genetic, environmental, and clinical heterogeneity within test samples. Here, we combined MRI with other clinical findings using multimodal MRI fusion algorithm to construct a data-driven, bottom-up diagnostic approach.

Systematic review and meta-analysis of Transanal Opening of Intersphincteric Space (TROPIS) versus conventional treatments for anal fistula.

Transanal Opening of Intersphincteric Space (TROPIS) has emerged as a promising surgical approach for anal fistula management over recent years. This meta-analysis comprehensively evaluates the comparative efficacy and safety of TROPIS versus conventional treatments through systematic analysis of 24 clinical studies involving 2813 patients. Through systematic searches across 7 major biomedical databases (including PubMed, EMBASE, and Chinese repositories) from inception to March 2024, we identified comparative studies assessing TROPIS against six established interventions: incision-thread-drawing, seton placement, LIFT, EAFR, fistulotomy, and incision-suture techniques.

Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts.

Purpose: This study aims to construct a single-cell transcriptomic atlas of the developing rabbit sclera to elucidate fibroblast heterogeneity, differentiation trajectories, matrisome expression patterns, and intercellular communication, while revealing conserved molecular features of scleral cells through cross-species analysis.

Methods: Single-cell RNA sequencing (scRNA-seq) was performed on scleral tissues from New Zealand rabbits at embryonic day 25 (E25) and postnatal days 7 (P7), 21 (P21), and 180 (P180). Libraries were prepared using the DNBelab C Series Kit and sequenced on the BGISEQ-2000 platform.

Machine learning-based prediction of carotid intima-media thickness progression: a three-year prospective cohort study.

Background: Early detection of subclinical atherosclerosis progression is crucial for preventing atherosclerotic cardiovascular disease (ASCVD). Carotid intima-media thickness (CIMT) is a recognized surrogate marker for atherosclerosis, but accurate prediction of its progression remains challenging. This study aimed to develop and validate machine learning models for predicting CIMT progression via routine clinical biomarkers.

Pou2af1 Deficiency Aggravates DSS-Induced Colitis via Impaired Germinal Center Responses and Altered Gut Microbiota.

Background: Bob1 plays a critical role in immune system regulation, particularly in the function of B cells. Its deficiency in the context of colitis remains underexplored. This study investigates the effects of Bob1 (Pou2af1) deficiency on colitis, particularly focusing on immune responses and gut microbiota alterations in a murine model.

Dietary exposure to per- and polyfluoroalkyl substances and health risk assessment in 7-year-old children in Shandong, China.

Background: Dietary intake, especially foods of animal-origin, is an important source of per- and polyfluoroalkyl substances (PFAS) exposure to the general population. However, the distribution of legacy and emerging PFAS in different food categories is unclear, as well as their potential health risk for children.

Objectives: To investigate dietary sources of PFAS and evaluate the risk for 7-year-old children in Laizhou Wan, a region with high PFAS exposure in Shandong, China.

Efficacy and Safety of Electroacupuncture on Insomnia in Parkinson's Disease: A Multicentre, Randomized, Controlled Trial.

Background: Sleep disturbances, particularly insomnia, are prevalent and debilitating non-motor symptoms of Parkinson's disease (PD), significantly impacting quality of life. Current treatment options are limited by side effects and accessibility. Electroacupuncture (EA), a non-pharmacological approach, has shown promise in insomnia, while its specific impact on insomnia in PD remains unexplored.

Postoperative analgesic effects of combined transversus abdominis plane block and anterior approach of sacral plexus block in patients undergoing laparoscopic radical prostatectomy: A randomized controlled trial.

Study Objective: This study aimed to evaluate the efficacy of the combination of ultrasound-guided transversus abdominis plane block (TAPB) and a novel anterior approach of sacral plexus block (SPB) on postoperative pain following laparoscopic radical prostatectomy.

Design: Double-blinded, prospective, randomized study.

Setting: University-affiliated tertiary care hospital.

Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.

Introduction: Researchers have reported an association among amyloid beta (Aβ), tau deposition, and functional networks. Nevertheless, whether plasma biomarkers mediate this process remains unclear.

Methods: Three hundred and forty-eight participants with available plasma biomarkers, Aβ positron emission tomography (PET), and resting-state functional magnetic resonance imaging were obtained from two independent cohorts: SILCODE (n = 147) and ADNI (n = 201).

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: and studies.

Background: (L.) DC (Chinese name Shegan) has been widely used because of its pharmacological activity and remarkable therapeutic effects in sore throat. Tectorigenin, irigenin, and irisflorentin have been recognized as important quality indicators in Shegan.

Effect of magnetic field-assisted thawing on the quality and microstructure of Portunus trituberculatus meat.

The objective of this study was to examine the impact of magnetic field-assisted thawing (MFT) on the quality and microstructure of Portunus trituberculatus meat, in comparison to other thawing methods (Air thawing, AT; Hydrostatic thawing, HT; Microwave thawing, MT). A comprehensive comparative analysis was conducted on different physicochemical and flavor properties of crab meat. MFT significantly reduced thawing loss by 18.

Integration of single-cell RNA sequencing and network pharmacology to elucidate the effect of Yantiao Formula on alleviating ALI by regulating the polarization of alveolar macrophages.

Ethnopharmacological Relevance: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) has a high mortality rate and often occurs in sepsis. Yantiao Formula (YTF) is used effectively in clinic but its mechanism in the treatment of ALI induced by sepsis remains unelucidated.

Aim Of The Study: This study aims to explore the potential molecular mechanisms of YTF in the treatment of sepsis-induced ALI.

Modified versus traditional subcostal anterior quadratus lumborum block for postoperative analgesia after laparoscopic nephrectomy: a randomized-controlled study.

Purpose: To examine the ramifications of both the modified and traditional subcostal anterior quadratus lumborum block (SQLB) on postoperative analgesia in individuals undergoing laparoscopic nephrectomy.

Methods: Forty-six individuals slated for elective laparoscopic nephrectomy under general anesthesia were randomly assigned to acquire either traditional or modified SQLB using 20 mL of 0.5% ropivacaine.

Differences of longitudinal plasma biomarkers between single memory domain and multidomain subject cognitive decline: Evidence from SILCODE.

Background: Plasma biomarkers demonstrated potential in identifying amyloid pathology in early Alzheimer's disease. Different subtypes of subjective cognitive decline (SCD) may lead to different cognitive impairment conversion risks.

Objective: To investigate the differences of plasma biomarkers in SCD subtypes individuals, which were unclear.

A microenvironment-adaptive GelMA-ODex@RRHD hydrogel for responsive release of HS in promoted chronic diabetic wound repair.

Chronic diabetic wounds present significant treatment challenges due to their complex microenvironment, often leading to suboptimal healing outcomes. Hydrogen sulfide (HS), a crucial gaseous signaling molecule, has shown great potential in modulating inflammation, oxidative stress and extracellular matrix remodeling, which are essential for effective wound healing. However, conventional HS delivery systems lack the adaptability required to meet the dynamic demands of different healing stages, thereby limiting their therapeutic efficacy.

Asymmetrical patterns of β-amyloid deposition and cognitive changes in Alzheimer's disease: the SILCODE study.

The asymmetric pattern of β-amyloid plaque distribution across Alzheimer's disease clinical progression stages remains unclear. In this study, 66 participants with normal cognition, 59 with subjective cognitive decline, 12 with mild cognitive impairment, and 11 with Alzheimer's disease dementia were included in the Sino Longitudinal Study on Cognitive Decline (SILCODE) cohort. A regional asymmetry index, denoting the left-right asymmetry of β-amyloid plaques, was derived for each region based on the Anatomical Automatic Labeling atlas.

DNA damage caused by chemotherapy has duality, and traditional Chinese medicine may be a better choice to reduce its toxicity.

Background: DNA damage induced by chemotherapy has duality. It affects the efficacy of chemotherapy and constrains its application. An increasing number of studies have shown that traditional Chinese medicine (TCM) is highly effective in reducing side-effects induced by chemotherapy due to its natural, non-toxic and many sourced from food.