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Article Abstract
A general and mild method for the synthesis of homoallylic 1,2-diamines from α-amino aldimines is reported. This method capitalizes on a low-loading iridium-catalyzed asymmetric umpolung allylation of imines and the following facile 2-aza-Cope rearrangement. The reagents are derived from readily available starting materials, and the catalytic system enables efficient construction of chiral vicinal diamines under mild conditions with broad functional group tolerance.
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