Association between hemoglobin albumin lymphocyte and platelet (HALP) score and psoriasis: Evidence from NHANES.

Background: The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is a novel indicator that measures systemic inflammation and nutritional status. This study aimed to investigate the association between HALP score and psoriasis in US participants.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) (2003-2006, 2009-2014) were utilized.

The efficacy and safety of pharmacotherapy for girls with central precocious puberty or early normal puberty: a retrospective cohort study.

The Chinese Expert Consensus on central precocious puberty (CPP) defines girls' rapid sexual development before age 8 as CPP; while after age 8 as early normal puberty (ENP). And the use of recombinant human growth hormone (rhGH) for CPP and ENP is off-label and lacks reliable evidence for clinical practice. This study only included girls due to the low prevalence among boys.

Optimizing pureed diets via texture analysis: A study on the impact of different energy levels and ingredient ratios on nasogastric tube patency.

Objective: This study aimed to investigate the impact of different energy levels and ingredient ratios on the nasogastric tube patency of pureed diets, optimizing the formulations to meet the nutritional requirements of elderly nasogastric feeding patients while minimizing tube blockage risk.

Methods: The study followed the guidelines of the "Chinese Resident's Balanced Diet Pyramid" and formulated five different energy levels of pureed diets (900 kcal, 1200 kcal, 1500 kcal, 1800 kcal, and 2100 kcal) using natural food groups. The diets consisted of seven major food categories: cereals and tubers, vegetables, meats, milk, oil, salt, and fruits.

Associations of prenatal and postnatal exposure to air pollution with hand, foot, and mouth disease: Key pollutants and sensitive exposure windows.

Background: The long-term association between exposure to air pollution-particularly during early life-and hand, foot, and mouth disease (HFMD) remains unclear. Moreover, evidence is lacking regarding the potentially differential effects of PM constituents on HFMD.

Methods: We included 41,256 children aged 0-6 years from a nationwide survey covering 15 Chinese provinces in 2013.

SZC-6 Promotes Diabetic Wound Healing in Mice by Modulating the M1/M2 Macrophage Ratio and Inhibiting the MyD88/NF-χB Pathway.

: The prolonged M1-like pro-inflammatory polarization of macrophages is a key factor in the delayed healing of diabetic ulcers (DU). SIRT3, a primary mitochondrial deacetylase, has been identified as a regulator of inflammation and represents a promising new therapeutic target for DU treatment. Nonetheless, the efficacy of existing SIRT3 agonists remains suboptimal.

PRDM2-The Key Research Targets for the Development of Diseases in Various Systems.

PR/SET domain 2 (PRDM2)/RIZ is a member of the histone/protein methyltransferases (PRDMs) superfamily. Discovered to have the ability to bind retinoblastoma in the mid-1990s, PRDM2 was assumed to play a role in neuronal development. Like other family members characterized by a conserved N-terminal PR structural domain and a classical C2H2 zinc-finger array at the C-terminus, PRDM2 encodes two major protein types, the RIZ1 and RIZ2 isoforms.

Exploring the relationship between metabolic syndrome and vestibular dysfunction: NHANES data and Mendelian randomization analysis.

Metabolic syndrome (MetS) is associated with an increased risk of various health issues, with emerging evidence suggesting a potential connection to vestibular dysfunction. However, the nature of this relationship remains unclear. This study aims to evaluate the association between MetS and vestibular dysfunction using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian Randomization (MR) analysis.

The effects of L-carnitine in children with kidney failure undergoing dialysis: a systematic review.

Background: Patients on dialysis often suffer from carnitine deficiency due to reduced intake, reduced synthesis in the kidneys, and clearing through dialysis. Carnitine deficiency may lead to anemia, cardiomyopathy, hypotension, and so on. Several studies have shown that supplementing with L-carnitine can diminish the above symptoms in adult dialysis patients, but whether children can benefit from L-carnitine remains unclear.

The multidimensional impact mechanism of treatment convenience, threat assessment, and coping evaluation on medication adherence in pediatric epilepsy patients.

Purpose: This study constructs a multidimensional impact mechanism model of "treatment convenience → threat assessment → coping evaluation → medication adherence," systematically revealing the various factors affecting medication adherence in pediatric epilepsy.

Methods: This cross-sectional study selected pediatric epilepsy patients and their caregivers from three institutions: West China Second University Hospital (Jinjiang and West China campuses) and Sichuan Provincial Children's Hospital. Data were collected through a questionnaire survey.

Effects of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SPH3348: A Single-Center, Randomized, Open-Label, Single-Dose, 2-Period, 2-Sequence Crossover Study.

This randomized, open-label, 2-period crossover study evaluated food effects on SPH3348 pharmacokinetics (PK) and safety in 16 healthy participants receiving a single 480-mg dose under fasting and high-fat fed conditions. PK profiling involved serial blood sampling at 15 predefined time points per period, while safety assessments included continuous monitoring of adverse events throughout the study. PK analysis revealed pronounced food-dependent alterations.

The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta-Analysis.

Objective: To evaluate zinc supplementation's efficacy in pregnancy, addressing gaps in previous reviews regarding high-risk subgroups and combination therapies.

Methods: Systematic review of six databases through March 27, 2025 for randomized controlled trials (RCTs) on prenatal zinc supplementation. Risk of bias was assessed using the Cochrane Risk of Bias 2.

Natalizumab for multiple sclerosis.

Rationale: Natalizumab (NTZ) is the first monoclonal antibody approved for the treatment of highly active relapsing-remitting multiple sclerosis (RRMS). Since 2010, several new studies on NTZ for MS have emerged.

Objectives: To evaluate the benefits and harms of NTZ alone or associated with other treatments in people with any form of MS.

Pharmacotherapy for children with central precocious puberty or early puberty: A systematic review and meta-analysis.

Background: The intervention of gonadotropin-releasing hormone agonist or in combination with recombinant human growth hormone (rhGH) is still controversial for children with central precocious puberty (CPP) or early puberty (EP). This study aimed to systematically review and compare the efficacy and safety of current therapeutic regimens for CPP or EP based on different timings of intervention.

Methods: We searched 7 databases and 2 registers for available studies from inception until December 2023.

Progress of smart biofilms in intelligent and sustainable meat preservation.

Smart biofilms offer an innovative solution for meat preservation by enabling responsive control over microbial growth and oxidation. This review systematically analyzes the development of biopolymer and synthetic polymer-based films with enhanced mechanical, barrier, and stimulus-responsive properties. These smart films enable targeted release of active agents, outperforming conventional methods in extending shelf life and preserving quality.

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury.

Traumatic brain injury (TBI), which refers to damage caused by external forces to the brain, significantly affects systemic organs and tissues, especially bone homeostasis. An increasing number of studies have revealed bidirectional crosstalk between the brain and bone, and the interactions between these systems in the context of TBI remain unclear. Here, existing research on the relationship between the brain and bone is summarized to explore their interactions and underlying mechanisms in TBI.

Sex-specific trajectories of adolescent brain development and behavioral health in relation to family environments.

Background: The associations of family environment with adolescent behavioral health are well established, yet insights into how these associations are moderated by sex, particularly through changes in brain structure, are limited.

Methods: This cohort study included over 9000 children aged 9-12 from the Adolescent Brain and Cognitive Development (ABCD) study. We used structural equation modeling to create a composite measure of family environment, incorporating factors such as family conflict, acceptance, parental monitoring and socioeconomic status, as reported by both children and parents.

A survey of availability, price, and affordability of innovative negotiated anticancer medicines: a retrospective study in Jiangsu Province, eastern China.

Background: The emergence of innovative anticancer medicines has revitalized cancer treatment prospects, and improving the accessibility of innovative anticancer medicines is a key goal of national pharmaceutical policies. Despite significant efforts by the National Medical Security Administration to reform the National Reimbursement Drug List (NRDL), concerns regarding the utilization of these newly included anticancer drugs persist. This study aims to assess the accessibility of 23 Innovative Negotiated Anticancer Medicines (INAMs) in Jiangsu Province, a developed region in eastern China.

The effect of caregiver anxiety on medication adherence in children with epilepsy: The mediating effect of medication beliefs.

Background: We used structural equation modelling to analyze the effect of caregiver anxiety on medication adherence and the mediating effect of medication beliefs in children with epilepsy in China.

Methods: Convenience sampling was used to continuously select children with epilepsy who met the inclusion criteria from January 2021 to June 2024. We generated a theoretical model of the interactions between medication beliefs, anxiety, and medication adherence.

Evaluating the Impact of the COVID-19 Pandemic on Telepharmaceutical Service Effectiveness: Systematic Review and Meta-Analysis.

Background: Telepharmaceutical services (TPS) led by pharmacists, an emerging telehealth service, improve access to medical services and enable patients to receive specialized services in areas with limited resources. With a lower risk of infection and no restriction of isolation measures, TPS showed great potential during the COVID-19 pandemic. However, whether the effectiveness of TPS changed before and after the outbreak of the COVID-19 pandemic remained unclear.

Parental psychopathology, family conflict, brain function, and child autistic-like traits in early adolescents.

Background: Parental psychopathology is a known risk factor for child autistic-like traits. However, symptom-level associations and underlying mechanisms are poorly understood.

Methods: We utilized network analyses and cross-lagged panel models to investigate the specific parental psychopathology related to child autistic-like traits among 8,571 adolescents (mean age, 9.

Effect of Second Sigmoid Colon Intubation During Colonoscopy on Adenoma Detection Rate in Overweight and Obese Patients: A Prospective Randomized Controlled Trial.

Introduction: The sigmoid colon is the most tortuous part of the large intestine and is often the most easily compressed during intubation and more easily missed during withdrawal observation. This study aimed to ascertain whether a second sigmoid colon intubation could enhance the adenoma detection rate (ADR).

Methods: We conducted a randomized controlled trial of patients 45 years and older with a body mass index over 24 who underwent colonoscopy.

Exercise-Mediated Skeletal Muscle-Derived IL-6 Regulates Bone Metabolism: A New Perspective on Muscle-Bone Crosstalk.

Skeletal muscles and bones maintain musculoskeletal system function through their collaborative interaction, whereby muscles regulate bone metabolism via mechanical coupling. An increasing number of studies have shown that various cytokines secreted by skeletal muscles during exercise closely regulate the balance of bone homeostasis. Interleukin-6 (IL-6), one of the first muscle-secreted factors to be discovered, not only plays an important role in regulating the function of the muscle itself but also regulates bone metabolic processes in a bidirectional manner through multiple complex signal transduction pathways, thereby affecting the balance between bone formation and bone resorption.

Role of SOST in Response to Mechanical Stimulation in Bone and Extraosseous Organs.

Sclerostin (SOST) is a specific osteocyte protein. During the differentiation and proliferation of osteoblasts and osteoclasts, the high expression of SOST can inhibit bone formation and contribute to osteoporosis and the bone metastasis of malignant tumors. Most of the research on SOST has focused on bone cells, but studies have found that SOST is not a specific product of bone cells but that it is also expressed by articular chondrocytes.

Muscle Stem Cell Microenvironment and Functions in Muscle Regeneration.

Muscle stem cells (MuSCs) are the key to muscle regeneration. The activation and maintenance of MuSCs require the precise regulation of their microenvironments. Myofibers and other cells including endothelial cells, fibroblasts, and immune cell populations constitute the cell components of the MuSC niche.

Advances in preparation techniques and antimicrobial properties of Aloe vera extract.

Aloe vera has a long history of use in traditional medicine for its diverse medicinal properties, especially its antibacterial effects. This review comprehensively analyzes various extraction techniques of A. vera, including traditional hand-filleted processing, whole leaves processing, and modern methods like hot water extraction, centrifugation-based gel extraction, freeze-drying, and solvent extraction.