Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Functional near-infrared spectroscopy (fNIRS) has emerged as a valuable tool for detecting brain functional activities. Motor imagery (MI) tasks have been employed to evoke brain responses in patients with disorders of consciousness (DOC), providing potential insights into their consciousness levels. However, the utility of brain functional characteristics for patient diagnosis and prognosis remains unclear.
Objective: This study aims to use fNIRS to investigate the characteristics of brain functional activities evoked by MI task in populations with varying levels of consciousness, and to explore the potential of these characteristics in the diagnosis and prognosis of DOC.
Methods: fNIRS was used to measure hemodynamic responses during MI tasks in a cohort of 63 DOC patients (26 vegetative states [VS] and 37 minimally conscious states [MCS]) and 70 healthy controls (HC). The mean values of hemodynamic responses in each brain region were extracted for inter-group and intra-group comparisons. Additionally, the correlation between hemodynamic responses and prognosis of DOC patients was investigated.
Results: Inter-group comparisons revealed that HC had significantly higher hemodynamic responses than both the MCS and VS groups across all brain regions. The MCS group demonstrated significantly higher responses than the VS group in the left premotor cortex, left primary motor cortex, right primary motor cortex, and left parietal cortex. In intra-group comparisons, 33 and 7 pairs of brain regions were significantly different in the HC and MCS group, while no significant differences were observed in the VS group. Furthermore, a significant correlation was found between the hemodynamic responses and the prognosis scores of DOC patients 6 months after the fNIRS examination.
Conclusions: Task-evoked functional activities in various brain regions among populations with varying levels of consciousness demonstrate significant intra-group and inter-group differences. The characteristics of brain functional activities provide valuable insights for the diagnosis and prognosis of DOC patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2025.138293 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Air-test for assessing gas exchange and the potential benefit of alveolar recruitment manoeuvre in anaesthetized dogs.
Vet Anaesth Analg
July 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Objective: To determine the use of Air-Test in ventilated, anaesthetized dogs for evaluating oxygen uptake and to determine its potential utility in guiding the decision to perform an alveolar recruitment manoeuvre (ARM).
Study Design: Retrospective cohort study.
Animals: A total of 25 client-owned dogs undergoing general anaesthesia.
Patients with cardiovascular compromise are likely to develop hypotension upon receiving even small doses of sedatives. On the other hand, patients with severe dental phobias or with intellectual disability who have a severe gag reflex often require deeper levels of anesthesia. Thus, achieving an optimal level of anesthesia can be difficult in patients with cardiovascular compromise because of the relatively narrow range of sedative dosing capable of providing sufficient sedation to prevent the gag reflex without compromising hemodynamics.
View Article and Find Full Text PDFInvestigating the Role of Gene Polymorphisms in Hypertension: Evidence from the Jordanian Population.
Vasc Health Risk Manag
September 2025
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Purpose: Hypertension (HTN) is a complex disorder regulated by multiple physiological systems. Each individual's underlying genetic architecture strongly influences inter-individual variability in therapeutic responses to HTN. Consequently, identifying candidate genes that contribute to the genetic basis of HTN remains a significant challenge.
View Article and Find Full Text PDFKounis Syndrome Triggered by Intravenous Co-Amoxiclav: A Case of Transient ST Elevation in the Context of Anaphylaxis.
Cureus
August 2025
Emergency Medicine, Stockport NHS Foundation Trust, Stockport, GBR.
Kounis syndrome, also known as allergic myocardial infarction, is a rare but potentially life-threatening condition in which acute coronary events are triggered by an allergic reaction. The pathophysiology involves mast cell degranulation and the release of inflammatory mediators such as histamine, leukotrienes, and platelet-activating factor, leading to coronary vasospasm, myocardial ischemia, or infarction. We present the case of a female patient in her 80s with no prior history of coronary artery disease who developed anaphylaxis shortly after intravenous administration of co-amoxiclav in the emergency department.
View Article and Find Full Text PDFImpact of centre experience on complete clinical and haemodynamic response after alcohol septal ablation for hypertrophic obstructive cardiomyopathy.
Int J Cardiol
September 2025
Department of Demography and Geodemography, Faculty of Science, Charles University, Prague, Czech Republic.
Background: Alcohol septal ablation (ASA) is an established therapy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) in patients unresponsive to medical treatment. However, comprehensive assessment of ASA outcomes remains challenging. This study aimed to evaluate the impact of institutional experience and patient characteristics on achieving complete clinical and haemodynamic response (CCHR), a novel composite outcome integrating long-term symptomatic, haemodynamic, safety, and major clinical endpoints, including survival and resuscitation.
View Article and Find Full Text PDF