ApCaleosin resists cadmium stress by regulating lipid droplet formation and intracellular oxidative stress levels in microalgae.

Microalgae are considered a promising candidate for cadmium biosorption material. However, the mechanisms behind their resistance to cadmium remain unclear. Here, we have uncovered that a lipid droplet (LD) protein caleosin of Auxenochlorella protothecoides regulates Cd tolerance in microalgae.

The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma.

Background: Immunotherapy has emerged as an effective treatment for lung adenocarcinoma (LUAD) in recent years. However, the ability of cancer cells to suppress antitumor immune responses through multiple mechanisms has become one of the major challenges for therapy. PYCR1 can reinforce the proliferation of LUAD cells, but the function of PYCR1 in LUAD against the tumor immune response has not been fully elucidated.

Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization.

In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the entire Y axis synapsed onto the X axis. This persistent Y-X NH synapsis did not interrupt meiotic sex chromosome inactivation, recombination, or sex body formation, but it disrupted X-Y loop-axis organization and homologous X-Y desynapsis, leading to spermatocyte death.

High-efficiency solar seawater evaporator by foam with hierarchically ordered channels based on carboxymethylated regenerated cellulose fibers.

Solar energy-driven water evaporation technology presents a sustainable method for seawater desalination and wastewater treatment. However, creating a biomass-based interfacial evaporator that achieves high salt resistance and rapid evaporation rates remains a significant challenge. In this study, we prepared a novel foam from carboxymethylated regenerated cellulose fibers, leveraging their natural orientation properties and excellent hydrophilicity.

Age-period-cohort analysis of syphilis epidemics in Eastern China, China, 2005-2024.

Background: Syphilis remains one of the serious public health challenges in China and worldwide. This study aims to assess the potential independent risks associated with age, period, and birth cohort for the reported incidence of syphilis in Eastern China.

Methods: Data on all syphilis cases from 2005 to 2024 in Zhejiang Province in Eastern China were collected from the China Information System for Disease Control and Prevention.

The lncRNA MAGI2-AS3 in peripheral blood mononuclear cells: a valuable biomarker for diagnosis and prognosis prediction of breast cancer.

Background: Existing research has shown that long non-coding RNA (lncRNA) MAGI2 antisense RNA3 (MAGI2-AS3) expression is significantly decreased in breast cancer tissues and can inhibit breast cancer progression. However, the relationship between MAGI2-AS3 expression levels in peripheral blood mononuclear cells (PBMCs) and breast cancer remains unclear. This study aimed to explore the clinical significance of MAGI2-AS3 expression in PBMCs for diagnosing breast cancer and predicting patient prognosis.

Spatial analysis and prediction of psittacosis in Zhejiang Province, China, 2019-2024.

Background: The emergence of advanced diagnostic techniques and improved disease surveillance have led to increased recognition of psittacosis cases in recent years. This study aimed to characterize the epidemiological patterns and spatiotemporal distribution of psittacosis in Zhejiang Province, China, and to identify high-risk clusters through predictive modeling.

Methods: We conducted a comprehensive analysis of reported psittacosis cases in Zhejiang Province from January 2019 to June 2024.

Short- and long-term exposure to ambient air pollution and greenness in relation to pulmonary tuberculosis incidence.

Epidemiological studies have found inconsistent relationships between air pollutants and the risk of pulmonary tuberculosis (PTB), possibly due to variations in exposure windows and limited attention to environmental modifiers such as greenness. However, few studies has systematically examined how short- and long-term exposure to air pollution may differentially impact PTB risk, and how greenness may modify these associations. We utilized comprehensive data, including daily PTB incidence, air pollutants, meteorological data, and the normalized difference vegetation index (NDVI) from Zhejiang Province, China, spanning from 2013 to 2019.

Mechanosensitive ion channels and inflammation: key links in cellular signal transduction.

Inflammation is a crucial pathological process in many diseases. Mechanosensitive ion channels, like the Piezo family and TRPV4, play a significant role in the inflammatory response. They sense mechanical stimuli and convert them into intracellular signals, regulating physiological processes.

A radiomics-clinical predictive model for difficult laparoscopic cholecystectomy based on preoperative CT imaging: a retrospective single center study.

Background: Accurately identifying difficult laparoscopic cholecystectomy (DLC) preoperatively remains a clinical challenge. Previous studies utilizing clinical variables or morphological imaging markers have demonstrated suboptimal predictive performance. This study aims to develop an optimal radiomics-clinical model by integrating preoperative CT-based radiomics features with clinical characteristics.

Parameter Identification and Transition Process Online Calibration Method of Pulsed Eddy Current Receiving Coil Based on Underdamped Dynamic Response Characteristics.

In order to solve the problem that the system parameters will be offset during the detection process of the pulsed eddy current receiving coil, this paper first analyzes the response signal of the receiving system and the deconvolution process of the response signal, and discusses the influence of various system parameters on the deconvolution accuracy. A method is proposed to change the system response characteristics and apply a step signal through the excitation coil to realize parameter identification through the response of the receiving coil system. The error of feature extraction under the change in each parameter is discussed, and the influence of increasing the matching resistance and switching the capacitor in parallel on the identification accuracy is analyzed and compared.

Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study.

Introduction: Syndecan-1 is one of cell surface proteoglycans that mediates the connection between cytoskeleton and interstitial matrix. The previous studies have demonstrated that syndecan-1 exerts an essential role in several pulmonary diseases. However, there are few researches about the relation of serum syndecan-1 with corona virus disease 2019 (COVID-19).

Spatiotemporal analysis of pulmonary tuberculosis in the central region of the Zhejiang Province, China (2016-2024).

Background: In recent years, Shaoxing City, located in central Zhejiang Province, has experienced a slow decline in the incidence of pulmonary tuberculosis (PTB). Therefore, there is an urgent need to elucidate the potential causes for this decline through spatiotemporal analyses to provide a scientific basis for targeted prevention and control. We aimed to explore the spatiotemporal distribution of PTB notification rates in Shaoxing City from 2016 to 2024 and identify high-incidence clusters, thereby offering data-driven insights to optimize regional PTB control strategies.

Photothermal-electrocatalysis interface for fuel-cell grade ammonia harvesting from the environment.

The development of sustainable artificial nitrogen recycling technologies enables ammonia extraction from ambient sources, facilitating zero-carbon Water-Energy-Food (WEF) Nexus integration. While electrochemical reduction of oxidized nitrogen offers promise for ammonia synthesis, purifying low-concentration products remains a challenge, limiting practical applications and undermining the Haber-Bosch process's viability. Here, we introduce a photothermal-electrocatalysis interface (PTEI) based on a Janus hybrid nanoarchitecture electrode, demonstrating synergistic enhancement in ammonia yield and evaporation performance.

Effective removal of naphthalene from water using bacteria and bacteria-load carrier materials.

The volatilization of naphthalene unavoidably poses significant risks to health, the environment, and safety. Traditional remediation approaches have been criticized for their inefficiency in removing naphthalene and transforming its toxicity. This study proposed a bacteria-loaded carrier material and evaluated its degradation efficiency compared to that of free bacteria.

Morphophysiological Reconfiguration and Antioxidant Networking Underpin Selenium-Mediated Drought Adaptation in Nicotiana tabacum.

Drought stress severely limits plant growth and productivity, prompting the need for suitable mitigation strategies. This study investigates the role of selenium in improving drought tolerance in Nicotiana tabacum (tobacco) through morphophysiological adjustments and a strengthened antioxidant defense system. Therefore, a pot experiment was conducted to investigate the effects of varying levels of sodium selenite (0, 5, 10, 15, 20 mg L) on morphophysiological growth, oxidative stress indicators, antioxidant enzyme activities, and quality attributes of tobacco exposed to different drought conditions, imposed by maintaining soil moisture at 80% (D: no stress), 50% (D: moderate stress), and 30% (D: severe stress) of field capacity.

[Corrigendum] Umbilical cord‑derived mesenchymal stem cells promote proliferation and migration in MCF‑7 and MDA‑MB‑231 breast cancer cells through activation of the ERK pathway.

Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that a pair of data panels appeared to contain overlapping data in each of Fig. 3A and C on p. 1473, showing the results of Transwell migration and scratch‑wound assay experiments respectively, where the data panels were intended to have shown the results from differently performed experiments; moreover, control GAPDH western blotting data featured in Fig.

Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification.

Background: The heterogeneity of bladder cancer (BLCA) is affected by its inherent transcriptional properties and tumor microenvironment (TME). Stromal transcriptional components in the TME significantly influence the transcriptional classification of BLCA, and the intrinsic biological transcriptional characteristics of cancer cells may be obscured by the dominant, lineage-dependent transcriptional components of stromal origin. This study aimed to explore the degree and mechanisms by which cancer-intrinsic gene expression profiles contribute to the classification and prognosis of BLCA patients.

Giant 64 m passive green laser gyroscope: solution in Earth rotation sensing and geophysical detection.

Large-scale laser gyroscopes with high resolution are widely used in Earth rotation sensing and geophysical detection. We demonstrate a giant 64 m green laser gyroscope in a passive running mode. By adopting a heterolithic architecture and using a 532 nm solid state laser as the light source, the gyroscope demonstrates a short wavelength, a large-scale factor, and currently the highest -factor of 6 × 10 among existing gyroscopes.

Operando Characterization of Uranium Dendrite Growth in High-Temperature Molten Salt Electrochemistry by Synchrotron X-Ray Tomography and Diffraction.

In this study, an innovative operando characterization methodology utilizing synchrotron radiation X-ray micro-computed tomography (SR-µCT) and high-energy X-ray diffraction (HEXRD) to investigate dendritic electrodeposition in high-temperature molten salt (HTMS) electrochemistry is presented. This approach enables the in-situ visualization and quantification of uranium dendrite growth and ion diffusion dynamics during the electrochemical reaction of LiCl-KCl-UCl molten salt. Through 3D reconstruction of uranium dendrite imaging and multiphysics simulations of the uranium electrolysis process, the underlying mechanisms of uranium dendrite formation are elucidated.

Prevalence, Progression, and Treatment of Asymptomatic Tuberculosis: A Prospective Cohort Study in Lanxi County, Zhejiang Province, China.

Background: Individuals with asymptomatic tuberculosis (TB) are considered a significant risk to the disease burden and transmission. However, the progression and treatment for asymptomatic TB remain incompletely described.

Methods: This prospective cohort study was embedded within a prevalence survey conducted in 2021 and 2022 in Lanxi County, China.

Microalgal glutaredoxin 1 interacts with transcription factor bZIP to resist cadmium stress via lipid metabolism alteration.

Triacylglycerol (TAG), a universal energy reserve and biodiesel feedstock, accumulates under stress in microalgae. However, the regulatory mechanisms linking stress signals to TAG synthesis remain unclear. In this study, we identified ApGRX1724, a novel glutaredoxin 1 family member found in Auxenochlorella protothecoides, that could translocate to the nucleus and interact with the transcription factor ApbZIP4896, which regulating TAG synthesis by interacting with the synthetase ApPAP6812.

Platelet aggregation rate serves as a significant predictive indicator for thromboembolic events in the context of stent-assisted embolization for unruptured arterial aneurysms.

Background: Perioperative cerebrovascular thromboembolic events are serious complications of stent-assisted embolization (SAE) for unruptured intracranial aneurysms (UIAs). To date, there have been no definitive clinical trial results to effectively predict and prevent the occurrence of this complication. This study aims to elucidate the correlation between platelet aggregation rate (PAR) and thromboembolic events (TEs), with the goal of predicting the occurrence of cerebrovascular TEs in these patients.

Health economic evaluation of newborn hepatitis B immunization prevention strategies in Ningbo: a Markov modeling study.

Background: Hepatitis B virus (HBV) infection poses a significant public health challenge in China. The Prevention of mother-to-child Transmission (PMTCT) strategy of combining universal hepatitis B vaccination with hepatitis B immunoglobulin (HBIG) for newborns is crucial in preventing widespread infection. In this study, we conduct health economic evaluation of three strategies: PMTCT, universal vaccination, and non-vaccination for newborns in Ningbo, China.

Gui-zhi-fu-ling-wan alleviates bleomycin-induced pulmonary fibrosis through inhibiting epithelial-mesenchymal transition and ferroptosis.

Background: Idiopathic pulmonary fibrosis (IPF) has a higher morbidity and poor prognosis. Gui-Zhi-Fu-Ling-Wan (GFW) is a traditional Chinese herbal formula which exerts anti-inflammatory and anti-oxidative effects. The goal was to determine the protective effect of GFW on bleomycin (BLM)-induced pulmonary fibrosis.