Relationship Between Paralumbar Muscle Assessment Methods and Spinal Alignment in Adult Spinal Deformity.

Study designRetrospective cross-sectional study.ObjectivesParalumbar muscle degeneration is closely linked to adult spinal deformity (ASD). However, assessment methods vary widely, including quality via fat infiltration (FI) and quantity through paraspinal total cross-sectional area (PTCSA), psoas vertebral body index (PVBI), and normalized total psoas area (NTPA).

Objective assessment of gait and posture symptoms in Parkinson's disease using wearable sensors and machine learning.

Objective: Gait and posture symptoms-such as gait impairments, postural instability, and posture deformations-are common in Parkinson's disease (PD) and closely linked to falls. Traditional assessments using clinical scales are time-consuming and prone to subjective bias. This study aims to predict the severity of gait and posture symptoms using data collected from wearable sensors during a single laboratory-based walking assessment, providing an objective, efficient, and automated evaluation approach.

Fibroblast growth factor 19 in combination with liver fibrosis markers for non-invasive diagnosis of primary biliary cholangitis-associated cirrhosis.

Background And Aims: Primary biliary cholangitis (PBC) is an autoimmune liver disease that can progress to cirrhosis. However, reliable non-invasive tools for early cirrhosis risk stratification are still lacking. This study aimed to assess the diagnostic performance of fibroblast growth factor 19 (FGF19) in combination with the conventional liver fibrosis markers-aspartate aminotransferase-to-platelet ratio index(APRI), fibrosis-4 index(FIB-4), hyaluronic acid (HA), procollagen III N-terminal propeptide (PIIINP), collagen type IV (CIV), and laminin (LN) in PBC-associated cirrhosis.

Cross-modal adaptive reconstruction of open education resources.

Matching vast online resources to individual learners' needs remains a major challenge, especially for adults with diverse backgrounds. To address this challenge, we proposed a Dynamic Knowledge Graph-enhanced Cross-Modal Recommendation model (DKG-CMR) to solve the problem. This model utilizes a dynamic knowledge graph-a structure organizing information and relationships-that continuously updates based on learner actions and course objectives.

Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC.

Immune checkpoint inhibitors (ICIs) combined with chemotherapy (Chemo+ICI) have shown variable benefit in patients with epidermal growth factor receptor ()-mutant non-small cell lung cancer (NSCLC) whose disease progressed following tyrosine kinase inhibitors (TKIs) therapy. This retrospective study evaluated treatment outcomes between Chemo+ICI and chemotherapy alone, and developed a lymphocyte subset model (LSM) using pre-treatment blood samples to predict survival outcome. Patients receiving Chemo+ICI showed significantly improved overall response rates (34.

Effects of COVID-19 vaccination on irAEs and prognosis in lung cancer patients receive PD-(L)1 inhibitors.

The influence of COVID-19 vaccination on the efficacy and safety of immune checkpoint inhibitors (ICIs) in lung cancer treatment is not well understood. A cohort of 394 lung cancer patients treated with PD-1/PD-L1 inhibitors was analyzed. The incidence and types of irAEs were recorded, and the relationship between COVID-19 vaccination and progression-free survival (PFS) was assessed using univariate and multivariate analyses.

Oxygen Plasma-Treated Hard Carbon for High-Rate and Durable Sodium-Ion Storage.

Tuning of oxygen functional groups in hard carbon (HC) is significant for optimizing sodium storage performance, but achieving precise modulation through effective strategies remains challenging. Herein, we introduce an oxygen plasma treatment strategy to enrich targeted carbonyl groups (C═O) on litchi wood-derived HC (OHC-1400). This surface modification method simultaneously regulates the electron conductivity and interface kinetics.

An ovary-targeted nucleic acid delivery system, OT-NADPS, efficiently mediates the generation of transgenic silkworms.

Transgenic technology is crucial for advancing various areas of biological research. In silkworms, the traditional transgenic method relies on embryo microinjection, which is a labor-intensive process with limited efficiency and high technical barriers. To overcome these challenges, we developed an Ovary-Targeted Nucleic Acid Delivery Peptide, OT-NADPS, based on the Receptor-Mediated Ovary Transduction of Cargo system (ReMOT) by innovative integration.

Prediction of the mortality rate in the intensive care unit for early sepsis patients with combined hypoalbuminemia based on machine learning.

This study aims to predict the mortality rate among septic patients with early-onset hypoalbuminemia in the intensive care unit (ICU) using machine learning algorithms. Utilizing patient data from the MIMIC-IV and eICU databases, we divided MIMIC-IV samples into training and internal validation sets, with eICU samples serving as an external validation set. We developed the predictive model using various feature selection techniques and machine learning algorithms, and evaluated its performance using metrics such as AUC, accuracy, precision, recall, and F1 score.

Comprehensive first-in-human phase I/II study of FHND-9041 in patients with EGFR-mutated advanced non-small cell lung cancer.

Introduction: FHND-9041 is a novel third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI). This first-in-human study is a single-arm, multi-center, open-label, non-randomized phase Ⅰ/II trial that aims to evaluate the tolerability, safety, pharmacokinetics, and anti-tumor activity of FHND-9041 in patients with EGFR-mutated non-small cell lung cancer (NSCLC).

Methods: The phase I study enrolled 87 patients with previously-treated EGFR T790M-positive NSCLC.

Predicting progression to renal replacement therapy in children with posterior urethral valves: international validation of the secondary use of the posterior urethral valve risk of chronic kidney disease (PURK) score.

Introduction: Congenital lower urinary tract obstruction due to posterior urethral valves (PUV) often results in chronic kidney disease (CKD) and renal replacement therapy (RRT). The Posterior Urethral Valve Risk of Chronic Kidney Disease (PURK) score, a validated prognostic tool, uses clinical variables at presentation to predict development of CKD stage 3 or higher. However, its role in predicting progression to RRT remains unexplored.

Mechanism of KDM5C-Mediated H3K4me3 Demethylation of HOXC-AS3 in the Proliferation of Colorectal Cancer Cells.

Colorectal cancer (CRC) ranks as the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide. This study explored the role of lysine-specific histone demethylase 5C (KDM5C) in CRC progression. Expression levels of KDM5C, HOXC-AS3, and discs large MAGUK scaffold protein 4 (DLG4) were evaluated.

Synthesis of Lightweight and High-Strength Polyimide/Gelatin Composite Aerogels: A Thermal Insulation Material for Preventing the Thermal Runaway of Lithium Batteries.

Gelatin (GA) was used as a reinforced material in the study to enhance the thermal-mechanical properties of the polyimide (PI) aerogel. The effects of the content and the freezing rate on the thermal-mechanical properties of the composite aerogels were investigated. The internal structure and chemical composition of the composite aerogels were analyzed by using characterization methods.

Identification of inflammation-related biomarkers and therapeutic targets for neurogenic bladder fibrosis via multi-omics analysis.

Inflammatory responses play a crucial role in the progression of pediatric neurogenic bladder (NB)-associated fibrosis; however, their specific contributions remain poorly understood. This study aimed to identify inflammation-related biomarkers for diagnosing NB fibrosis and to explore potential therapeutic drugs. The NB rat model was established by spinal nerve severing, followed by single-cell and bulk RNA sequencing of bladder tissues.

Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson's disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study.

Background: Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson's disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate the optimal DNH assessment method as a biomarker for PD, idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson-plus syndromes, and to explore the nigral iron deposition patterns in these diseases.

Methods: Three-dimensional gradient-echo T2*-weighted images were acquired by 7T MRI from a total of 402 patients and 100 healthy controls (HCs) in two independent cohorts (development and validation cohorts).

Single-cell RNA sequencing reveals the potential role of estrogen in tuberous sclerosis complex related renal angiomyolipoma.

Purpose: Tuberous sclerosis complex (TSC) is a kind of rare genetic disorder caused by TSC1/TSC2 gene mutations and presented as angiomyolipoma (AML) in kidney. Previous studies have indicated the presence of estrogen-related heterogeneity in TSC, but this aspect has not been extensively explored.

Methods: In the present study, we employed single-cell RNA sequencing (scRNA-seq) to investigate the estrogen-related heterogeneity in TSC-AML.

Impact of Molecular Tumor Board on Clinical Outcomes in Patients with Refractory Solid Tumor: a Real-World Study.

Introduction: Providing precise oncologic treatment for patients with refractory solid tumor is still an unmet need in clinical practice. This study aimed to assess whether treatments recommended by a molecular tumor board (MTB) can improve clinical outcomes in patients with refractory solid tumors.

Methods: We screened all patients with refractory solid tumor during the period from 2017 to 2022 at the authors' center.

Knowledge, attitude, and practice of osteoporosis prevention in elder patients following lumbar fusion surgery: a cross-sectional study.

Purpose: To assess the knowledge, attitudes, and practices (KAP) regarding osteoporosis prevention among older adult patients following lumbar fusion surgery and identify associated factors.

Patients And Methods: A cross-sectional study was conducted with participants aged ≥50 years. Data on demographic characteristics, KAP related to osteoporosis prevention, and lifestyle behaviors were collected using structured questionnaires.

Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification.

Background: The heterogeneity of bladder cancer (BLCA) is affected by its inherent transcriptional properties and tumor microenvironment (TME). Stromal transcriptional components in the TME significantly influence the transcriptional classification of BLCA, and the intrinsic biological transcriptional characteristics of cancer cells may be obscured by the dominant, lineage-dependent transcriptional components of stromal origin. This study aimed to explore the degree and mechanisms by which cancer-intrinsic gene expression profiles contribute to the classification and prognosis of BLCA patients.

Association between nonstandard work schedules and employees' self-rated mental health with perceived work stress, work-family conflict and job satisfaction as psychosocial mediators: a national study in China.

Background: Nonstandard work schedules are prevalent across the industrialized world. While prior research indicates nonstandard work schedules lead to poor mental health, little research has explored the psychosocial pathways underlying the association between work schedule and mental health. This study aimed to fill this gap by testing for the mediating roles of perceived work stress, perceived work-family conflict and perceived job satisfaction in the association between nonstandard work schedules and employees' self-rated mental health.

Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.

Background: Traditional Chinese medicine and food deer antler has been extensively used in bone regeneration, but its molecular mechanisms remain poorly understood. Preliminary investigations suggest deer antler contains bioactive compounds that influence osteogenic differentiation and immune microenvironments.

Purpose: To elucidate the molecular mechanisms of deer antler in promoting human mesenchymal stem cell (hMSC) osteogenic differentiation, focusing on JUN downregulation and immune microenvironment modulation using bioinformatics and molecular docking approaches.

Gut microbiome signatures predict 5-ASA efficacy in ulcerative colitis.

Ulcerative colitis (UC) prevalence is rising globally, yet fewer than 50% of patients achieve mucosal healing (MH) with first-line 5-aminosalicylic acid (5-ASA) therapy. We aimed to identify microbial signatures that could predict the treatment efficacy of 5-ASA. Active UC patients on standardized 5-ASA treatment were prospectively enrolled.

Epidemiology and disease burden of fractures in Asia, 1990-2021: An analysis for the Global Burden of Disease Study 2021.

Background: Fractures are a significant global public health concern, imposing a substantial economic burden, particularly among the elderly. However, research on the fracture burden in Asia remains limited, highlighting the need for comprehensive and up-to-date studies to support the effective planning and allocation of healthcare resources across the region.

Methods: Using the Global Burden of Disease (GBD) 2021 database, we analyzed the age-standardized rates (ASRs) of incidence (ASIR), prevalence (ASPR), and years lived with disability (YLDs) (ASYR) associated with fracture burden across Asia.

Comparison of efficacy and safety between robotic-assisted and open surgery in treating neurogenic bladder: a systematic review and meta-analysis of comparative studies.

The safety and effectiveness of robotic-assisted surgery versus traditional open surgery for neurogenic bladder treatment remains uncertain, with no definitive conclusion drawn. This systematic review and meta-analysis aims to evaluate the differences between the two methods, offering additional insights to inform clinical decision-making. A detailed analysis of existing literature was carried out, referencing key databases such as EMBASE, Cochrane Library, Web of Science, PubMed, and Google Scholar, with data collection extending to February 2025.