[Association among seminal oxidation-reduction potential, sperm DNA fragments and semen parameters in patients with varicocele].

Objective: To investigate the relationship among seminal oxidation-reduction potential (nORP), sperm DNA fragmentation (DFI) and semen parameters in patients with varicocele.

Methods: Clinical data of 522 patients treated in the reproductive andrology clinic of the Northern Theater General Hospital from November 2023 to December 2023 were retrospectively analyzed, including 435 men of childbearing age and 87 men of infertile age. The patients were divided into the varicocele group (n=116) and non-varicocele group (n=406) according to clinical diagnosis.

Tomato Roots Exhibit Development-Specific Responses to Bacterial-Derived Peptides.

To combat soilborne pathogens, roots activate pattern-triggered immunity (PTI) through pattern-recognition receptors (PRRs) that recognise microbe-associated molecular patterns (MAMPs). Root PTI pathways can differ from their above-ground counterparts and have been well-characterised in the model plant Arabidopsis thaliana but are not well-defined in crops. Gene repurposing coupled with differences in root tissues and root architecture in tomato species (Solanum lycopersicum and S.

Relationship Between Paralumbar Muscle Assessment Methods and Spinal Alignment in Adult Spinal Deformity.

Study designRetrospective cross-sectional study.ObjectivesParalumbar muscle degeneration is closely linked to adult spinal deformity (ASD). However, assessment methods vary widely, including quality via fat infiltration (FI) and quantity through paraspinal total cross-sectional area (PTCSA), psoas vertebral body index (PVBI), and normalized total psoas area (NTPA).

Response of Anammox Process to Chloroacetonitrile and Accelerated Recovery With Pulse Electric Field.

Chloroacetonitrile poses significant challenges to anaerobic ammonium oxidation (anammox) process due to its toxicity. This study evaluated the effects of chloroacetonitrile on anammox and further explored the potential of a 1.5 V and 1000 Hz pulsed electric field (PEF) in mitigating prolonged chloroacetonitrile stress.

The development and validation of postpartum hemorrhage prediction models for pregnancies with placenta previa totalis based on coagulation function indexes: a retrospective cohort study.

Background: The objective of this study is to establish and validate models that can accurately predict postpartum hemorrhage (PPH) in women with placenta previa totalis prior to undertaking cesarean delivery.

Methods: A retrospective cohort study was conducted on 306 pregnancies with placenta previa totalis delivered between January 2011 and June 2022. The pregnancies were classified into two groups, PPH group and non-PPH group, based on bleeding volume and red blood cell transfusion.

Short-term outcomes of repair vs. replacement for rheumatic mitral valve disease.

Background: The main types of surgery for rheumatic mitral valve disease are traditional percutaneous mitral balloon valvuloplasty (PMBV), mitral valve replacement (MVR) with removal of the original valve, and valve repair with preservation of the original valve. Some studies have shown that mitral valve repair (MVr) has certain advantages compared with replacement.

Methods: The clinical data of 166 patients with rheumatic mitral valve lesions admitted to the Department of Cardiac Macrovascular Surgery of the and the were retrospectively analyzed to compare the hemodynamic changes after mitral valve repair and replacement.

Feasibility of fully automatic assessment of cervical canal stenosis using MRI via deep learning.

Background: Currently, there is no fully automated tool available for evaluating the degree of cervical spinal stenosis. The aim of this study was to develop and validate the use of artificial intelligence (AI) algorithms for the assessment of cervical spinal stenosis.

Methods: In this retrospective multi-center study, cervical spine magnetic resonance imaging (MRI) scans obtained from July 2020 to June 2023 were included.

MZB1-Driven Endoplasmic reticulum stress model as a predictor of breast cancer progression and survival.

Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a crucial role in cancer's progression, but their prognostic significance in breast cancer (BC) remains unclear. In this study, a reliable ER-related gene signature was developed for the purpose of predicting BC prognosis and investigating the associated immune landscape. By utilizing public datasets and analytical methods, we developed a 16 ER-related gene risk signature and verified its efficacy in predicting prognosis in independent patient groups.

Exploring the Integration of Anthocyanins with Functional Materials in Smart Food Packaging: From Stabilization to Application.

Anthocyanins, the most ubiquitous water-soluble phytopigments in terrestrial flora, have garnered substantial attention in sustainable food packaging research owing to their exceptional chromatic properties, pH-responsive characteristics, and putative health-promoting effects. Nevertheless, their inherent chemical lability manifests as rapid chromatic fading, structural degradation, and compromised bioactivity/bioavailability, ultimately restricting industrial implementation and incurring significant economic penalties. Recent advances in stabilization technologies through molecular encapsulation within polymeric matrices or nanoscale encapsulation systems have demonstrated remarkable potential for preserving anthocyanin integrity while augmenting multifunctionality.

Applications of machine learning in high-entropy alloys: a review of recent advances in design, discovery, and characterization.

High-entropy alloys (HEAs) have attracted considerable attention due to their exceptional properties and outstanding performance across various applications. However, the vast compositional space and complex high-dimensional atomic interactions pose significant challenges in uncovering fundamental physical principles and effectively guiding alloy design. Traditional experimental approaches, often reliant on trial-and-error methods, are time-consuming, cost-prohibitive, and inefficient.

LDLR H3K27ac in PBMCs: An Early Warning Biomarker for Hypercholesterolemia Susceptibility in Male Newborns Treated with Prenatal Dexamethasone.

Dexamethasone, widely used as an exogenous glucocorticoid in clinical and animal practice, has recently been recognized as an environmental contaminant of concern. Existing evidence documents its ability to induce persistent dyslipidemia in adult offspring. In this study, plasma cholesterol levels in male rats exposed to dexamethasone prenatally (PDE) were increased.

Monitoring Chemical Reactions Induced by Filamentation with Air-Lasing-Based Coherent Raman Spectroscopy.

Simultaneous detection of multiple reaction products induced by filamentation is crucial for unraveling complex atmospheric chemistry but remains challenging technically. Herein, we employ air-lasing-based coherent Raman spectroscopy to simultaneously monitor the formation and evolution of O and NO after femtosecond laser filamentation in synthetic air. Simultaneous detection of the two species reveals their distinct reaction dynamics.

Global, regional and national burden of diabetes mellitus type 2 attributable to low physical activity from 1990 to 2021 and projections to 2050: a finding from the global burden of disease study 2021.

Background: This study aims to assess the global burden of type 2 diabetes mellitus (T2DM) attributable to low physical activity from 1990 to 2021 and forecast of its global burden by 2050 using GBD 2021 data.

Method: This study uses data from the GBD 2021 to examine the global burden of T2DM attributable to low physical activity, focusing on deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and Years of Life Lost (YLLs). Descriptive analysis was performed across gender, age, region, and country for 1990 and 2021, using age-standardized rates.

Hydroxyl-crosslinked polyvinyl alcohol films reinforced with nanocellulose and tea polyphenols for antibacterial preservation of dried tofu.

Conventional plastic packaging and chemical preservatives pose risks to both the environment and human health. Consequently, increasing research efforts are directed toward the development of environmentally friendly, non-toxic, and safe packaging materials. In this study, a polyvinyl alcohol (PVA) / pullulan (PUL) / soy hull nanocellulose (SHNC) composite film incorporating 2 % (w/w) tea polyphenols (TP) was prepared.

Correction: Research progress on nanomaterial-empowered electrochemical biosensors for the detection of cardiac troponin I.

[This corrects the article DOI: 10.1039/D5RA04555J.].

[Effect of moxibustion on SIRT1/eNOS signaling pathway in ApoE atherosclerotic mice].

Objectives: To observe the effect of moxibustion on pathological structure and ultrastructural changes of thoracic aorta, the expression of silent information regulator 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) in ApoE atherosclerosis (AS) mice, so as to explore its possible mechanism in preventing and treating AS.

Methods: Ten C57BL/6J mice were fed a normal diet as the control group, and 30 ApoE mice were fed a high-fat diet to establish the AS model, which were randomly divided into the model group, moxibustion group, and moxibustion+EX527 group, with 10 mice in each group. Mice in the moxibustion group received mild moxibustion treatment at "Danzhong"(CV17), "Shenque"(CV8), "Neiguan"(PC6, bilateral), and "Xuehai" (SP10, bilateral) for 30 min, the mice in the moxibustion+EX527 group were given intraperitoneal injection of EX527 (10 mg/kg) 30 min before moxibustion, with both treatments given once daily, 5 times a week, with a total intervention period of 12 weeks.

Solving the coupled Gerdjikov-Ivanov equation via Riemann-Hilbert approach on the half line.

In this research, the Fokas method is adopted to examine the coupled Gerdjikov-Ivanov equation within the half line interval [Formula: see text]. Meanwhile, the Riemann-Hilbert technique is engaged to work out the potential function associated with the equation. We initially partition the matrix into segments and identify the jump matrix linking each segment based on the positive feature of the segment.

Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.

Importance: With the programmed cell death protein 1 (PD-1) blockade toripalimab, omitting highly toxic concurrent cisplatin may be feasible for nasopharyngeal carcinoma (NPC) without compromising survival.

Objective: To evaluate the efficacy and safety of toripalimab incorporated into induction chemotherapy and radiotherapy, without concurrent cisplatin, for locoregionally advanced NPC.

Design, Setting, And Participants: Open-label, multicenter, randomized phase 3 clinical trial conducted from August 2021 to July 2022 at 13 hospitals in China, enrolling 532 patients with T4N1M0 or T1-4N2-3M0 NPC; 400 (75.

StMAPKK1 enhances drought and salt tolerance in potato via ROS scavenging and stomatal closure.

Drought and salt stress are among the main factors affecting agricultural productivity, seriously influencing the growth, development and yield of potatoes. The mitogen-activated protein kinase (MAPK) cascade is highly conserved in signal transduction under abiotic stress. However, studies on the expression patterns of the mitogen-activated protein kinase kinase (MAPKKs) gene under drought and salt stress are limited, and there is a lack of functional verification of it in supporting potato plant growth.

Non-targeted and suspect screening analysis of non-phthalate ester plasticizers in house and car dust.

Following restrictions on the use of phthalate esters (PAEs), the industry has increasingly manufactured non-PAE plasticizers (NPPs) to meet the continuous demand for plastic products. However, the environmental occurrence of NPP diversity remains insufficiently investigated. This study established a suspect and category-specific characteristic fragment-dependent non-targeted screening strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) to identify 14 categories of emerging NPPs in house and car dust.

[Functional and aesthetic evaluation of external fixator lengthening through plantar approach for fourth brachymetatarsia].

Objective: To evaluate the functional and aesthetic evaluation of external fixator lengthening through plantar approach for fourth brachymetatarsia.

Methods: A retrospective analysis was conducted on 20 patients (23 feet) with fourth brachymetatarsia who met the selection criteria between January 2016 and January 2024, including 3 males and 17 females, with 8 left, 9 right, and 3 bilateral cases. The mean age was 24.

Identification and immunological characterization of cuproptosis-related molecular clusters in cardioembolic stroke.

This study explored the molecular patterns and diagnostic biomarkers associated with cuproptosis in cardioembolic stroke (CES) using bioinformatics tools. GSE58294 expression profile data were downloaded from the Gene Expression Synthesis Database as a training dataset, and cuproptosis-related genes were extracted for analysis. We identified differentially expressed cuproptosis-associated genes (DECAGs) between CES and control samples.