[Research and prospect of integrated traditional Chinese and western medicine in treatment of bronchiectasis].

Bronchiectasis(BE) is the third major chronic airway disease, and its incidence rate shows a continuously increasing trend. Bronchiectasis is a highly heterogeneous chronic airway disease. Due to structural alterations, airflow limitation, and mucus hypersecretion, clinical treatment faces many challenges.

Unveiling the role of cathepsins in depression: a Mendelian randomization study.

Objective: Depression is a prevalent psychological disorder involving complex pathogenesis mechanisms. Cathepsins may play a significant role in the pathogenesis of depression, yet the exact impact of cathepsins on the risk of developing depression remains unclear. The objective of this research was to examine the cause-and-effect link between cathepsins and the susceptibility to depression through the application of Mendelian randomization (MR) techniques.

Boron Supplementation and Phytohormone Application: Effects on Development, Fruit Set, and Yield in Macadamia Cultivar 'A4' (, ).

Macadamia (), and hybrids, a crop of high economic and nutritional importance, faces challenges with low fruit set rates and severe fruit drop. To address this, we investigated the effects of exogenous plant growth regulators (PGRs) and boron fertilizer on the development, fruit set, and yield of the A4 macadamia variety. The study was conducted in 2024 at the Lujiangba research base (China, Yunnan Province).

LDLR H3K27ac in PBMCs: An Early Warning Biomarker for Hypercholesterolemia Susceptibility in Male Newborns Treated with Prenatal Dexamethasone.

Dexamethasone, widely used as an exogenous glucocorticoid in clinical and animal practice, has recently been recognized as an environmental contaminant of concern. Existing evidence documents its ability to induce persistent dyslipidemia in adult offspring. In this study, plasma cholesterol levels in male rats exposed to dexamethasone prenatally (PDE) were increased.

Efficacy and safety of Qingbu Weijing decoction in treatment stable bronchiectasis: study protocol for a multicenter, double- blind, randomized and placebo-controlled trial.

Background: Bronchiectasis is characterized by persistent cough, excessive sputum production, and recurrent infections. Chronic cough and sputum are the primary manifestations of airway mucus hypersecretion, which leads to frequent acute exacerbations and severely impairs quality of life. Qingbu Weijing Decoction (QWD) has shown promising evidence for improving sputum production and reducing the inflammatory burden.

GIGANTEA-LATE ELONGATED HYPOCOTYL complex regulates citrus drought tolerance and drought induced flowering.

Drought severely impedes plant growth and production as a primary abiotic stress. GIGANTEA (GI) regulates flowering and responds to various stresses in model plants; however, its function remains poorly understood in non-model plants. In this study, a Citrus limon GI homologous (CiGI) was identified and two alternative splicing transcripts (CiGIα and CiGIβ) were found.

miR156-SPLs module regulates flowering and controls plant height by modulating gibberellin biosynthesis in citrus.

Plant height and optimal flowering time are key determinants of crop yield and economic value. However, the regulatory mechanisms governing these traits, particularly in woody plants, remain unclear. In this study, overexpression of a citrus microRNA156 (miR156) family member, Ci-miR156c, resulted in significant phenotypic changes in citrus, including reduced plant height and delayed flowering.

The regulatory module consisting of KNOTTED1-like homeobox 6, Homeobox-leucine zipper 14, and BLADE-ON-PETIOLE 2 is involved in shoot development and lateral branching in citrus.

KNOTTED1-like homeobox (KNOX) family transcription factors (TFs) are important regulatory factors in plant growth and development, participating in various aspects of developmental regulation. In this study, we demonstrate that the citrus KNOX gene 6 (CiKN6) regulates shoot branch development. Overexpression of CiKN6 in citrus plants resulted in a significant phenotype characterized by increased branching and shortened shoots.

Joint association of frailty index and biological age with chronic obstructive pulmonary disease: a cohort study from CHARLS.

Chronic Obstructive Pulmonary Disease (COPD) is associated with frailty and ageing, but there is insufficient evidence from existing longitudinal studies. This research explored the longitudinal association between frailty, ageing and COPD. We used the China Health and Retirement Longitudinal Study (CHARLS) data to perform a cohort study.

SHP1 and its downstream p38/SP1/PI3K/YAP/Notch-1 signaling in trophoblast cells suppressed the progression of Preeclampsia via inhibiting proliferation of SMCs.

Preeclampsia leads to high fetal morbidity and pregnancy-induced mortality. However, the detailed molecular pathology of PE is currently unknown. shp1 has been shown to be critical to the pathogenesis of several diseases, but their role in PE requires further validation.

Comparative Effects of Dietary Supplementations with Microencapsulated Sodium Butyrate, Glycerol Monolaurate and Tributyrin on Growth, Immunity, and Gut Health in Black Sea Bream.

This study investigates the effects of three dietary additives-microencapsulated sodium butyrate (MSB), glycerol monolaurate (GML), and tributyrin (TB)-on the growth performance, various physiological parameters, gene expression, intestinal morphology, and microflora in (black sea bream). The experiment utilized a 43.5% soybean meal (SBM) inclusion diet with four isonitrogenous and isoenergetic formulations: a control diet, and diets supplemented with MSB (0.

Genetic Prediction of the Phosphate-to-Glucose Ratio Mediates the Association Between CXCL5 and Vascular Dementia.

Background And Objectives: A variety of observational studies suggest a possible connection between C-X-C Motif Chemokine Ligand 5 (CXCL5) and vascular dementia (VaD), though the exact causal relationship is still uncertain. This research aims to investigate the causal connection between CXCL5 and VaD risk through a Mendelian randomization (MR) method and to examine the phosphate-to-glucose ratio as a possible mediator.

Methods: Using summary-level data from genome-wide association studies (GWAS), we conducted a two-sample MR analysis to investigate the genetic prediction of CXCL5 and VaD.

Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii.

The proliferation of multi-drug resistant (MDR) bacteria is driven by the global spread of epidemic lineages that accumulate antimicrobial resistance genes (ARGs). Acinetobacter baumannii, a leading cause of nosocomial infections, displays resistance to most frontline antimicrobials and represents a significant challenge to public health. In this study, we conduct a comprehensive genomic analysis of over 15,000 A.

Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets.

Background: Aflatoxins have been reported as a significant pollutant in feed, capable of causing harm to the liver, gastrointestinal tract and kidneys of piglets. However, research on the interactions among aflatoxin B1 (AFB1), bile acid (BA) metabolism and gut microbiota is limited.

Methods: In this study, piglets were treated with AFB1 and antibiotics (ABX) to evaluate the interaction between AFB1 and gut microbiota.

Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD.

Background: This study was designed to assess the efficacy of the Jieyu Guben Decoction (JYGBD), a novel formula that has not been reported, in treating rats with combined allergic rhinitis and asthma syndrome (CARAS) and the mechanism.

Methods: CARAS rats were induced by ovalbumin (OVA) sensitization and treated with JYGBD to analyze the allergic symptoms and the production of OVA-specific antibodies. Hematoxylin-eosin staining, periodic acid-Schiff staining, Toluidine blue staining, Giemsa staining, and MASSON staining were applied to examine the impact of JYGBD treatment on the histopathological damage of nasal mucosa and lungs.

Effect of dietary supplementation of lauric acid on growth performance, digestive enzymes, serum immune and antioxidant parameters, and intestinal morphology in black sea bream.

An eight-week feeding trial was conducted to examine the impact of dietary supplementation with lauric acid (LA) on juvenile black sea bream. A basal diet was formulated containing 19.9% fish meal, while five additional diets were prepared, each supplemented with varying levels of LA: LA1 (0.

Sarcopenia in trauma patients: A systematic review and meta-analysis.

Sarcopenia is associated with poor prognosis and mortality following injury. This systematic review and meta-analysis aimed to analyze diagnostic criteria for sarcopenia, as well as to assess its prevalence and impact on health outcomes among trauma patients. We conducted a literature search on MEDLINE, EMBASE, and the Cochrane Library from inception to June 2023.

The impact of Tanreqing injection on mucus hypersecretion and cough in bronchiectasis: A meta-analysis of randomized controlled trials.

Background: Bronchiectasis clinically manifests airway mucus hypersecretion as mucopurulent sputum production and chronic cough. In the past decade, Tanreqing injection (TRQ) has been often used in clinical practice as an add-on treatment for bronchiectasis in China. Several in vivo studies have indicated that TRQ is effective in improving sputum expectoration and cough in acute exacerbation of bronchiectasis but results of individual studies are inconsistent.

Fully integrated multi-mode optoelectronic memristor array for diversified in-sensor computing.

In-sensor computing, which integrates sensing, memory and processing functions, has shown substantial potential in artificial vision systems. However, large-scale monolithic integration of in-sensor computing based on emerging devices with complementary metal-oxide-semiconductor (CMOS) circuits remains challenging, lacking functional demonstrations at the hardware level. Here we report a fully integrated 1-kb array with 128 × 8 one-transistor one-optoelectronic memristor (OEM) cells and silicon CMOS circuits, which features configurable multi-mode functionality encompassing three different modes of electronic memristor, dynamic OEM and non-volatile OEM (NV-OEM).

Effect of Dietary Supplementation of Glycerol Monolaurate on Growth Performance, Digestive Enzymes, Serum Immune and Antioxidant Parameters, and Intestinal Morphology in Black Sea Bream.

An eight-week feeding trial was conducted to examine the impact of dietary supplementation with glycerol monolaurate (GML) on juvenile black sea bream. A basal diet was formulated containing 24% fish meal, while five additional diets were prepared, each supplemented with varying levels of GML: GML1 (0.01%), GML2 (0.

Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer.

Currently, only 20% to 40% of patients with cancer benefit from immune checkpoint inhibitors. Understanding the mechanisms underlying the immunosuppressive tumor microenvironment (TME) and characterizing dynamic changes in the immunologic landscape during treatment are critical for improving responsiveness to immunotherapy. In this study, we identified JNK signaling in cancer-associated fibroblasts (CAF) as a regulator of the immunosuppressive TME.

Discovery of SARS-CoV-2 papain-like protease (PL) inhibitors with efficacy in a murine infection model.

Vaccines and first-generation antiviral therapeutics have provided important protection against COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there remains a need for additional therapeutic options that provide enhanced efficacy and protection against potential viral resistance. The SARS-CoV-2 papain-like protease (PL) is one of the two essential cysteine proteases involved in viral replication.

The impact of tea consumption on the risk of depression: A Mendelian randomization and Bayesian weighting algorithm study.

Background And Objectives: The precise impact of tea consumption on the risk of depression remains unclear. This study aimed to explore the relationship between the consumption patterns of tea and the likelihood of depression onset, utilizing a two-sample Mendelian randomization (MR) methodology.

Methods And Study Design: We utilized available genome-wide association study (GWAS) datasets on tea intake and depressive disorders.