Ultrabroadband Photosensitivity and Frequency-Mixing in Anisotropic Weyl Semimetal NbNiTe.

Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).

Research Trends and Hotspots of Gut Microbiota and Its Metabolites in Cardiovascular Diseases: A Bibliometric Analysis.

Purpose: This study leverages quantitative analysis to delve into the current state, key focal points, and developmental trajectory of research on gut microbiota and its metabolites in relation to cardiovascular diseases, offering guidance for future exploration.

Methods: Utilizing software tools such as VOSviewer, CiteSpace, and Scimago Graphica, we conducted a multidimensional analysis. This analysis aimed to accurately evaluate the current research landscape and emerging focal points in the field of gut microbiota and cardiovascular disease research, both domestically and internationally.

Equilibrium Mechanics in Fracture Reduction of Tibial Plateau.

Background: Tibial plateau fracture is one of the common fractures in the lower limb, mostly caused by high-energy injuries, which may be accompanied by different degrees of compression and displacement of the joint surface, affecting the knee joint alignment, stability, and sports function, and improper treatment may cause various complications, which are a more difficult problem in the clinic. The objective of this study was to investigate the biomechanical mechanisms underlying effective closed reduction in the treatment of tibial plateau fractures, particularly focusing on the performance of the homeopathic double reverse traction repositor compared to traditional traction table methods.

Methods: We developed a biomechanical model to analyze the equilibrium mechanics during tibial plateau fracture reduction.

A Minimally Invasive Double Live-Knot Technique for Myocardial Ischemia-Reperfusion Injury Modeling in Rats.

The myocardial ischemia-reperfusion injury (MI/RI) model is of great significance in exploring the pathophysiological mechanisms of myocardial infarction and facilitating the development of relevant drugs. However, among the commonly used modeling methods, the traditional polyethylene-tube-assisted coronary artery ligation method has significant drawbacks. It requires reopening the chest to untie the ligature, which is not only time-consuming but also causes substantial damage to the experimental animals and can easily lead to their death.

A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic hydrogen/photothermal therapy.

Herein, we report a nanoscale composite COF material loaded with Pd nanoparticles and H a stepwise post-synthetic modification. The obtained PdH@COF was shown to affect mitochondrial function by disrupting the intracellular redox balance and thus down-regulating the expression of heat shock proteins (HSPs), thereby enhancing the photothermal therapy of tumors.

UV-B Responsive Flavonoid Synthesis Contributes to Tartary Buckwheat High-Altitude Adaption.

High-altitude environments expose plants to increased levels of UV-B radiation, necessitating the evolution of protective mechanisms to mitigate stress. Buckwheat is a flavonoid-rich pseudocereal naturally adapted to high-altitude environments with elevated UV-B exposure. Although flavonoid biosynthesis is thought to contribute to this adaptation, the molecular and metabolic basis underlying flavonoid-mediated UV-B tolerance remains largely uncharacterized.

Chromosome-level genome assembly of finger millet (Eleusine coracana) provides insights into drought resistance.

Finger millet (Eleusine coracana Gaertn.), a nutritionally rich and drought-resilient C4 cereal, possesses exceptional grain storage longevity (up to 50 years). Here, we report a high-quality genome assembly of the allotetraploid cultivar C142, revealing extensive structural rearrangements between its two subgenomes (subA and subB), which are associated with asymmetric gene expression and subgenome dominance favoring subA.

Deep multi-task learning framework for gastrointestinal lesion-aided diagnosis and severity estimation.

Accurate diagnosis and severity estimation of gastrointestinal tract (GT) lesions are crucial for patient care and effective treatment plan decisions. Traditional methods for diagnosing lesions face challenges in accurately estimating severity due to requiring interpretable biomarkers, inter-observer variability, and overlapping lesions. Moreover, existing deep-learning models treat lesion classification and severity estimation as separate tasks, complicating diagnosis.

Comparison of the efficacy of acupoint stimulation therapy in the treatment of pain in musculoskeletal diseases: A network meta-analysis based on randomized controlled trials.

BackgroundOrthopedic patients often present with significant pain symptoms, which can impact both the physical and mental well-being of patients, emerging as a significant concern. Given its safety, effectiveness, and absence of side effects, acupoint therapy is being increasingly utilized in the pain management of orthopedic patients. This study conducted a network meta-analysis to compare analgesic efficacy, safety, and effectiveness of acupuncture (AP), electroacupuncture (EA), moxibustion, and acupressure, so as to provide a reference for the clinical application of acupoint therapies in managing orthopedic pain.

Insights into the preparation, properties, application in food of polysaccharide-based edible films and coatings: An updated overview.

Polysaccharide-based edible films and coatings (PEFCs), as an innovative technology in the food industry, are increasingly receiving extensive attention due to their non-toxic, strong biodegradability, and excellent biocompatibility. Numerous studies have demonstrated that PEFCs could effectively regulate water migration and oxygen permeability, thereby prolonging the shelf life of food, mitigating spoilage, and minimizing nutrient loss. Hence, PEFCs are widely used in packaging for fruits, vegetables, fish, meat, and dairy products.

Global burden of urinary tract infections in older women from 1990 to 2021 with projections to 2040: a trend analysis of the Global Burden of Disease Study 2021.

Background: Comprehensive estimations regarding the worldwide burden of urinary tract infections (UTIs) in older women aged ≥ 65 years are lacking. This study first explored the trends in the burden of UTIs among older women from 1990 to 2021 with projections to 2040.

Methods: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 analytical tool was adopted to calculate the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life-years (DALYs) rate (ASDR).

Recent progress in the polysaccharides from okra (Abelmoschus esculentus L.): Preparation methods, structural characterization, pharmacological properties, and applications.

Abelmoschus esculentus L. (okra), as a medicine-food homology plant, has a long history of both medicinal and dietary use. Okra is rich in different types of compounds, such as flavonoids, proteins, phenolic acids, vitamins, and polysaccharides.

Spatiotemporal analysis of pulmonary tuberculosis in the central region of the Zhejiang Province, China (2016-2024).

Background: In recent years, Shaoxing City, located in central Zhejiang Province, has experienced a slow decline in the incidence of pulmonary tuberculosis (PTB). Therefore, there is an urgent need to elucidate the potential causes for this decline through spatiotemporal analyses to provide a scientific basis for targeted prevention and control. We aimed to explore the spatiotemporal distribution of PTB notification rates in Shaoxing City from 2016 to 2024 and identify high-incidence clusters, thereby offering data-driven insights to optimize regional PTB control strategies.

Onset of cavitation and vapor bubble development over hydrophilic and hydrophobic surfaces.

Cavitation, the formation of vapor bubbles as the liquid pressure is reduced below the saturated vapor pressure, often requires a substantial negative relative pressure in a pure liquid. Classical nucleation theory (CNT) provides an estimate for the rate of cavitation but there is often a disconnect between the predictions at the molecular scale compared to observations at the macroscale. We report on mesoscale simulations of cavitation based on many-body dissipative particle dynamics (mDPD), a coarse-grained molecular dynamics (MD), which bridges the two scales.

Risk prediction and clinical utility analysis of postoperative pancreatic fistula: a comparative study of multivariable logistic regression and random forest models.

Objective: Compare the performance of the Multivariable logistic regression (LR) model based on traditional statistical methods and the Random Forest (RF) model in machine learning for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD).

Background: CR-POPF is a common and severe complication following PD. Traditional statistical models are widely used to predict it, but the rise of machine learning has garnered attention for its potential in predictive medicine.

Constructing high-quality enhanced 4D-MRI with personalized modeling for liver cancer radiotherapy.

Background: For magnetic resonance imaging (MRI), a short acquisition time and good image quality are incompatible. Thus, reconstructing time-resolved volumetric MRI (4D-MRI) to delineate and monitor thoracic and upper abdominal tumor movements is a challenge. Existing MRI sequences have limited applicability to 4D-MRI.

Tunable Electronic Bandgaps and Optical and Magnetic Properties in Antiferromagnetic MPS/GaN (M = Mn, Fe, and Ni) Heterobilayers.

Research on two dimensional (2D) antiferromagnetic materials and heterobilayers is gaining prominence in spintronics. This study focuses on MPS monolayers and their van der Waals heterobilayers with GaN monolayers. We systematically investigated the structural stability, electronic properties, and magnetic characteristics of MPS (M = Mn, Fe, and Ni) monolayers via first-principles calculations, and explored their potential applications in optoelectronics and spintronics.

Current-Driven Collective Control of Helical Spin Texture in van der Waals Antiferromagnet.

Electrical control of quantum magnetic states is essential in spintronic science. Initial studies on the ferromagnetic state control were extended to collinear antiferromagnets and, more recently, noncollinear antiferromagnets. However, electrical control mechanisms of such exotic magnetic states remain poorly understood.

Reconfigurable terahertz optoelectronic logic through charge-density-wave phase engineering.

Charge density waves, manifestations of strongly correlated electronic states in low-dimensional materials, exhibit collective quantum phenomena that enable phase-coherent electronic manipulation. Conventional approaches face limitations in integrating sensing and computing functions, particularly at terahertz frequencies where traditional semiconductors struggle. We achieve deterministic switching between resistive and dissipationless states in 1T-TaS through synergistic thermal, electrical, and optical modulation of metastable charge-density-wave configurations.

The association between urinary cadmium exposure levels and overactive bladder syndrome in the U.S. adults from NHANES database.

The relationship between urinary cadmium exposure levels and overactive bladder (OAB) has not been fully elucidated. The purpose of this study was to further investigate the correlation between urinary cadmium exposure levels and OAB risk in adults. Laboratory data on urinary cadmium exposure levels were obtained from the National Health and Nutrition Examination Survey (NHANES) database for the period 2007-2016.

USP28 knockdown and small molecule inhibitors promote KRT1 destabilization and sensitize hepatocellular carcinoma cells to sorafenib.

Background: Hepatocellular carcinoma (HCC) is a significant malignant tumor that is typically diagnosed late and has a poor prognosis. USP28 (Ubiquitin-specific protease 28), a deubiquitinating enzyme within the ubiquitin-specific proteases (USPs) family, plays a pivotal role in various biological processes, especially in cancer progression. However, its functions and molecular mechanisms in HCC are still unknown.

The influence of surface cover change on solar radiation absorption in China.

Under the context of climate change, the energy exchange mechanisms between terrestrial ecosystems and the atmosphere are highly complex. This study investigates the impact of land cover changes on solar radiation using China's land cover data and surface solar radiation absorption data. We analyze the data changes over two adjacent periods and integrate additional factors to explore the impacts of surface cover changes on solar radiation.

Molecular Dynamics Simulation of Polymer Concrete Enhanced by Carbon Nanoparticles: Effect of Surface Functional Groups.

Polymer concrete (PC) has attracted considerable interest for its excellent deformation resistance and durability. However, the mechanical drawbacks of polymers, particularly their limited compressive strength, constrain the wider application and design flexibility of PC. While experimental techniques such as X-ray diffraction and scanning electron microscopy provide insights into nanoparticle interactions within the polymer matrix, they lack the resolution to fully elucidate nanoscale mechanisms.

Manipulations of a transmon qubit with a null-biased electro-optic fiber link.

In recent years, significant progress has been made in the field of superconducting quantum circuits, particularly in improving the complexity of quantum processors for large-scale quantum computing and quantum simulation tasks. To enable the execution of quantum information processing tasks on large-scale quantum circuits containing millions of qubits, it is essential to minimize thermal effects on control and measurement lines, ensuring that circuit components are superconducting and that qubits are not significantly thermally excited. Recent studies have shown that a quadrature-biased electro-optic fiber link can operate qubits with a much reduced thermal load, thereby facilitating the simultaneous operation of a large number of qubits.

Genome-Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat.

Tartary buckwheat (Fagopyrum tataricum) is esteemed as a medicinal crop due to its high nutritional and health value. However, the genetic basis for the variations in Tartary buckwheat grain ionome remains inadequately understood. Through genome-wide association studies (GWAS) on grain ionome, 52 genetic loci are identified associated with 10 elements undergoing selection.