Targeting ARPC1B Cancer Stem Cells to Sensitise Pancreatic Cancer to Gemcitabine Treatment.

ARPC1B cancer stem cells (CSCs) in pancreatic cancer are identified as a subpopulation resistant to gemcitabine. In our study, drug repositioning, molecular docking, and surface plasmon resonance (SPR) technique jointly revealed that CK-636 can directly target ARPC1B protein with high affinity. In vitro cytotoxicity, ex vivo organoid cultures, in vivo xenograft and orthotopic gemcitabine-resistant pancreatic cancer model demonstrated that combination therapy of gemcitabine plus CK-636 showed a superior anti-tumor effect compared with gemcitabine monotherapy.

Integrated lithium niobate photonic computing circuit based on efficient and high-speed electro-optic conversion.

The surge in artificial intelligence applications calls for scalable, high-speed, and low-energy computation methods. Computing with photons is promising due to the intrinsic parallelism, high bandwidth, and low latency of photons. However, current photonic computing architectures are limited by the speed and energy consumption associated with electronic-to-optical data transfer, i.

Leptin receptor signaling mediates the distinct tendon-bone interface reconstruction in rotator cuff tears and osteoporosis-comorbid rotator cuff tears.

Background: The intact tendon-bone interface (TBI) consists of four histological layers-tendon, fibrocartilage, calcified fibrocartilage, and bone-that gradually merge into each other, making complete structural restoration after injury challenging. Osteoporosis poses a significant risk for rotator cuff tears (RCTs) and re-tears after arthroscopic rotator cuff repair (ARCR). Activating Leptin receptor (Lepr) mediated Stat3 signaling transduction facilitates the transcription of Runx2 and Sox9, respectively, and promotes osteogenesis and chondrogenesis.

METTL3 mediates mA methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension.

Introduction: Features of hypertension include imbalance between vascular relaxation and constriction along with vascular remodeling caused by endothelial dysfunction, further increasing peripheral resistance and blood pressure (BP). While N-methyladenosine (mA) modifications of RNA mediated by methyltransferase-like 3 (METTL3) regulates certain endothelial function, its roles and mechanisms in hypertension remain unknown.

Objectives: This study was to examine roles of METTL3-mA and its regulating targets on BP, cardiovascular function, and remodeling in hypertensive mice.

Equilibrium Mechanics in Fracture Reduction of Tibial Plateau.

Background: Tibial plateau fracture is one of the common fractures in the lower limb, mostly caused by high-energy injuries, which may be accompanied by different degrees of compression and displacement of the joint surface, affecting the knee joint alignment, stability, and sports function, and improper treatment may cause various complications, which are a more difficult problem in the clinic. The objective of this study was to investigate the biomechanical mechanisms underlying effective closed reduction in the treatment of tibial plateau fractures, particularly focusing on the performance of the homeopathic double reverse traction repositor compared to traditional traction table methods.

Methods: We developed a biomechanical model to analyze the equilibrium mechanics during tibial plateau fracture reduction.

Apical Positioned Flap with a Combination of Mucograft and Fibro-Gide for Augmenting Keratinized Gingiva with Thin Gingival Phenotype: A Case Report.

The width and thickness of keratinized gingiva play a crucial role in the periodontal health and long-term stability of natural teeth. Noncrosslinked xenogeneic collagen matrix (Mucograft) has demonstrated favorable outcomes in augmenting keratinized gingival width (KGW), though its effect on increasing gingival thickness remains suboptimal. In contrast, crosslinked xenogeneic collagen matrix (Fibro-Gide) effectively enhances keratinized gingival thickness (KGT) but is unable to increase KGW.

Research letter: the global clinical trial landscape for non-alcoholic fatty liver disease (NAFLD) current status and future prospects.

Purpose: This study comprehensively analyzed the global clinical trials and depicted a landscape for non-alcoholic fatty liver disease (NAFLD) therapy.

Methods: Using the Trialtrove database, we collected trial information of 2,242 clinical trials. Using molecular docking analysis, we investigated the pharmacological properties of glucagon-like peptide-1 receptor (GLP-1 R) agonist such as semaglutide and its binding affinity to GLP-1 R protein.

Facile synthesis of 1-silaacenaphthenes by transition metal-catalyzed intramolecular C(sp)-H silylation.

We report a general strategy for synthesizing novel fused aromatic 1-silaacenaphthenes by iridium or rhodium-catalyzed intramolecular C(sp)-H silylation. Both methods showed similar activity and broad substrate scope, producing a variety of 1-silaacenaphthenes with high functional group tolerance. We found that C-H cleavage was not the rate-determining step and that the reaction was first-order with respect to the initial concentrations of substrate, catalyst and ligand.

Enantioselective Synthesis of Acenaphthene-Type Monohydrosilanes.

Acenaphthene and its analogues are privileged frameworks in medicinal chemistry and material science. However, the properties of silicon-substituted acenaphthene-type scaffolds are poorly understood. Here, we report a rhodium-catalyzed intramolecular C(sp)-H silylation for enantioselective synthesis of acenaphthene-type scaffolds with excellent enantioselectivity and broad substrate scope.

Facet-Selective Growth of Dots-on-Plate II-VI Heterostructures for Efficient Photocatalytic Hydrogen Evolution.

High-level control over the surface and interface of II-VI heterostructures is crucial for enhancing charge separation and optimizing active sites, thus improving photocatalytic performance. However, due to variations in surface energy and atomic arrangement among different crystal facets, achieving selective growth of specific facets remains a significant challenge. Herein, we have achieved the selective growth of CdSe or ZnSe dots on the lateral facets or basal facets of two-dimensional CdS or ZnS nanoplates by carefully selecting Se source precursors with different reaction activities.

Minimally invasive treatment strategies for submucosal tumors of the upper gastrointestinal tract: Advances in innovative endoscopy-based therapies.

The increasing detection of submucosal tumors (SMTs) in the upper gastrointestinal tract (UGI) is due to the increased clinical use of endoscopy and imaging technology. Some of these SMTs have malignant potential and may cause clinical symptoms. Thus, it is recommended in clinical guidelines to consider resection of these SMTs.

A comparative quantitative assessment of 3D-printed PEKK and PEEK thin meshes in customized alveolar bone augmentation.

Objective: Customized nonabsorbable membranes are widely used in severe alveolar bone defects and provide sufficient and precise regenerated bone tissue for subsequent dental implant placement. Although 3D-printed polyetheretherketone (PEEK) meshes have confirmed successful use in clinical cases, the performance of a PEEK mesh is not satisfactory. Compared with PEEK, polyetherketoneketone (PEKK) has better mechanical and processing properties.

Effects of Dynamic Neuromuscular Stabilization/Vojta Therapy on Pain Intensity and Physical Function in Individuals with Low Back Pain: A Systematic Review and Meta-Analysis.

Background: Low back pain (LBP) is a prevalent health issue that imposes heavy burdens on personal health status and social healthcare. Dynamic Neuromuscular Stabilization (DNS)/Vojta therapy has demonstrated effectiveness in managing conditions related to musculoskeletal system. However, its effects on individuals with LBP remain incompletely understood.

Octave-spanning Kerr soliton frequency combs in dispersion- and dissipation-engineered lithium niobate microresonators.

Dissipative Kerr solitons from optical microresonators, commonly referred to as soliton microcombs, have been developed for a broad range of applications, including precision measurement, optical frequency synthesis, and ultra-stable microwave and millimeter wave generation, all on a chip. An important goal for microcombs is self-referencing, which requires octave-spanning bandwidths to detect and stabilize the comb carrier envelope offset frequency. Further, detection and locking of the comb spacings are often achieved using frequency division by electro-optic modulation.

Corrigendum: Influences of cognitive load on center of pressure trajectory of young male adults with excess weight during gait initiation.

[This corrects the article DOI: 10.3389/fbioe.2023.

Influences of cognitive load on center of pressure trajectory of young male adults with excess weight during gait initiation.

Falls and fall-related injuries in young male adults with excess weight are closely related to an increased cognitive load. Previous research mainly focuses on analyzing the postural control status of these populations performing cognitive tasks while stabilized walking progress but overlooked a specific period of walking known as gait initiation (GI). It is yet unknown the influences of cognitive load on this population's postural control status during GI.

Electron transfer coupled spin transition in cyano-bridged mixed-valence {FeIII2FeII2} molecular squares.

The research on electron transfer coupled spin transition regulating the valence state and spin state transition of metal ions is promising and challenging. Herein, we report a cyano-bridged {FeIII2FeII2} molecular square complex, {[Fe(Tp)(CN)] [Fe(bnbpen)]}(ClO)·8CHOH (1·8CHOH, bnbpen = ,'-bis-(2-naphthylmethyl)-,'-bis(2-picolayl)-ethylenediamine), and its free of solvents form (1). Combined single-crystal X-ray diffraction, temperature-dependent infrared (IR) spectra, magnetic measurements, and Mössbauer spectra reveal that 1·8CHOH and 1 exhibit reversible one-step and two-step electron transfer coupled spin transition (ETCST) with temperature change, between the low-temperature state {Fe(μ-CN)Fe} (LS = low spin, HS = high spin) and the high-temperature state {Fe(μ-CN)Fe}, respectively.

Observation of protonation-induced intra-molecular metal-to-metal charge transfer in cyano-bridged [Fe-CN-Mn/Ni] dinuclear complexes.

A key challenge in the design of magnetic molecules with intramolecular charge transfer behavior is to obtain reversible magnetic bistability triggered by external stimuli. Here, we show that two dinuclear metal complexes, [(bbp)Fe(CN)Mn(PyMe)]·2.5CHOH (4) and [(bbp)Fe(CN)Ni(PyMe)]·2.

Daily walking kinematic characteristics of the elderly in different residential settings: experimental study on Chinese community-living elderly and long-term nursing home residents.

Background: Long-term nursing home (NH) care helps NH residents with their daily activities and improves their quality of life, but negatively affects their independent physical activities and increases the risk of dangerous events. Dangerous events in the elderly usually occur in the conversion of walking periods when forward striding has already happened, but the body has not yet entered a completely steady walking.

Objectives: Compare the gait characteristics in Chinese long-term NH residents and community-living elderly during the walking Transitional Period (TP) and Stabilization Period (SP).

The treatment of dispersion terms for solution systems.

DFT calculations of reaction mechanisms in solution have always been a hot topic, especially for transition-metal-catalyzed reactions, in which the traditional DFT-D3 method has been extensively employed. The overestimation of the dispersion from the traditional DFT-D3 method leads to a quite low activation free-energy barrier, so it is worth finding a proper way to deal with the dispersion for solution systems. The solvent-solute dispersion is also important for solution systems, and thus it should be calculated together with the solute dispersion.

Stiffness changes in internal rotation muscles of the shoulder and its influence on hemiplegic shoulder pain.

Background: Hemiplegic shoulder pain (HSP) is a common complication in patients with stroke. The pathogenesis of HSP is complex, and muscle hypertonia, especially the hypertonia of internal rotation muscles of the shoulder, may be one of the important causes of shoulder pain. However, the relationship between muscle stiffness and HSP has not been well studied.

The efficacy and safety of lenvatinib plus transarterial chemoembolization in combination with PD-1 antibody in treatment of unresectable recurrent hepatocellular carcinoma: a case series report.

Purpose: To explore the safety and efficacy of lenvatinib in combination with trans-arterial chemoembolization (TACE) and programmed death receptor 1 (PD-1) antibody in the treatment of unresectable recurrent hepatocellular carcinoma (urHCC).

Patients And Methods: The clinical data of 16 patients with unresectable recurrent hepatocellular carcinoma admitted to the Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, and received the conversion therapy of lenvatinib + TACE + PD-1 antibody between January 2019 and January 2022 were retrospectively analyzed.

Results: There were 25% (4/16) patients suffering from grade 3 adverse events and no patients suffering from grade 4 or higher adverse events.