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Accurate diagnosis and severity estimation of gastrointestinal tract (GT) lesions are crucial for patient care and effective treatment plan decisions. Traditional methods for diagnosing lesions face challenges in accurately estimating severity due to requiring interpretable biomarkers, inter-observer variability, and overlapping lesions. Moreover, existing deep-learning models treat lesion classification and severity estimation as separate tasks, complicating diagnosis. To address these gaps, we propose a deep multi-task learning framework that aims to improve accuracy by simultaneously addressing classification and severity estimation. The proposed framework is designed in three stages utilizing four multi-class GT datasets. The first stage involves multi-scale feature representation using the convolutional vision transformer (CViT) blocks. The CViT with enhanced multi-head attention employs a deep multi-task learning approach extracting shared features in a unified manner. In the second stage, the extracted features are combined with the features from the first stage. In a subsequent stage, task-specific enhanced multi-head attentions are applied to the concatenated features to facilitate efficient learning between global and local information features. Our approach enhances fine-grained image features by incorporating semantic image features and focusing on representation subspace. Extensive experimental results demonstrate significant performance, validating the proposed model's effectiveness across various datasets in lesion diagnosis and severity estimation.
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http://dx.doi.org/10.1038/s41598-025-09587-7 | DOI Listing |
JAMA Neurol
September 2025
Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy.
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September 2025
Department of Social Epidemiology, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan.
Importance: Previous studies have suggested that social participation helps prevent depression among older adults. However, evidence is lacking about whether the preventive benefits vary among individuals and who would benefit most.
Objective: To examine the sociodemographic, behavioral, and health-related heterogeneity in the association between social participation and depressive symptoms among older adults and to identify the individual characteristics among older adults expected to benefit the most from social participation.
Turk Kardiyol Dern Ars
September 2025
Department of Cardiology, Dicle University School of Medicine, Diyarbakır, Turkiye.
Objective: Originally designed to evaluate stroke risk in individuals with atrial fibrillation unrelated to valvular disease, the CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age ≥ 75 years, Diabetes mellitus, prior Stroke/transient ischemic attack/systemic embolism, Vascular disease, Age 65-74 years, and Sex category - female) is now additionally utilized for the prognostic evaluation of cardiovascular diseases. This study aimed to evaluate the predictive role of the CHA2DS2-VASc score for lesion severity and long-term survival outcomes in individuals with peripheral artery disease (PAD).
Method: This retrospective analysis included 784 patients diagnosed with PAD via computed tomography (CT) angiography, consecutively enrolled from two medical centers.
Case Rep Hematol
August 2025
Central Diagnostic Laboratories, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Factor XIII (FXIII) deficiency is a rare coagulopathy with an estimated prevalence of approximately 1 in 1 to 2 million, affecting males and females with equal frequency. FXIII plays a critical role in hemostasis by stabilizing fibrin clots through covalent cross-linking of fibrin monomers, thereby conferring mechanical resistance and durability to the clot structure. Clinically, FXIII deficiency presents with a spectrum of hemorrhagic manifestations including bleeding from the umbilical cord, intracranial hemorrhage, recurrent miscarriages, menorrhagia, epistaxis, gingival bleeding, and poor wound healing.
View Article and Find Full Text PDFFront Psychol
August 2025
Center for Applied Statistics, Renmin University of China, Beijing, China.
Introduction: Existing studies have consistently demonstrated a positive association between social capital and subjective well-being; however, systematic evidence on this relationship among disabled veterans remains limited. This study investigates how structural social capital-captured by the breadth of social support networks-affects the subjective well-being of disabled veterans in China. It further examines the mediating roles of perceived effectiveness of government assistance (institutional resource utilization) and comrade trust (relational social capital), as well as the moderating role of policy awareness in shaping these relationships.
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