Multimodal Intraoperative Neurophysiological Monitoring in Neurofibromatosis Type 1-Related Craniofacial Tumor Surgery.

Objective: This study summarized the application effect and clinical experience of multimodal intraoperative neurophysiological monitoring (IONM) technology in the surgery of neurofibromatosis type 1 (NF1)-related craniofacial tumors.

Materials And Methods: A retrospective study was conducted on NF1 patients who were admitted between January 2019 and December 2024 and treated with craniofacial tumor resection surgery assisted by multimodal IONM technology. Data from this study were analyzed regarding sex, age at surgery, surgical procedures, IONM parameters, preoperative and postoperative symptoms, follow-up period, as well as oncological outcome.

Machine Learning-Derived Neddylation Gene Signature for Predicting Prognosis and Immunotherapy Benefits in Colorectal Cancer.

Background: Colorectal cancer (CRC) is a major cause of cancer deaths globally, mainly due to treatment resistance. Neddylation, a key post-translational modification, is linked to tumor growth and immune response, offering potential therapeutic targets, though its role in CRC is not well-explored.

Methods: We examined neddylation-related genes (NRGs) across cell subtypes using CRC scRNA-seq data from the TISCH database.

Cell-laden printed hydrogel scaffolds with glutamic acid-modified hyaluronic acid/collagen concentration gradients for directional neural stem cell migration.

Biomimetic gradients are desirable features for hydrogel to improve their similarity to the three-dimensional cell culture environment. However, gradient hydrogel scaffolds for simulating heterogeneous tissue to regulate brain neural stem cells (NSCs) fate remain underexplored. Hydrogel scaffolds with concentration gradients were prepared by light-curing printing, guiding brain NSCs directional migration.

Attention-based deep learning network for predicting World Health Organization meningioma grade and Ki-67 expression based on magnetic resonance imaging.

Objectives: Preoperative assessment of World Health Organization (WHO) meningioma grading and Ki-67 expression is crucial for treatment strategies. We aimed to develop a fully automated attention-based deep learning network to predict WHO meningioma grading and Ki-67 expression.

Materials And Methods: This retrospective study included 952 meningioma patients, divided into training (n = 542), internal validation (n = 96), and external test sets (n = 314).

Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways.

African swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs), with a particular focus on viral evasion strategies that disrupt antigen presentation pathways.

A Minimally Invasive Double Live-Knot Technique for Myocardial Ischemia-Reperfusion Injury Modeling in Rats.

The myocardial ischemia-reperfusion injury (MI/RI) model is of great significance in exploring the pathophysiological mechanisms of myocardial infarction and facilitating the development of relevant drugs. However, among the commonly used modeling methods, the traditional polyethylene-tube-assisted coronary artery ligation method has significant drawbacks. It requires reopening the chest to untie the ligature, which is not only time-consuming but also causes substantial damage to the experimental animals and can easily lead to their death.

Influence of Polystyrene Microplastics on the Structural Stability of activated sludge microbial flocs in Sequencing Batch Reactors.

Polystyrene microplastics are commonly found in wastewater treatment plants, accumulating in activated sludge systems. However, their specific impact on the integrity and aggregation of microbial flocs-which are crucial for effective sludge settling and pollutant removal-remains poorly understood. This study uses sequencing batch reactors (SBR) to systematically investigate how environmentally relevant concentrations of polystyrene microplastics (0, 10, and 100 mg/L) affect microbial floc structure and function.

Abdominal cocoon syndrome in a 10-year-old young adolescent after abdominal operation: A case report and review of literature.

Background: Sclerosing encapsulating peritonitis (SEP), also known as abdominal cocoon syndrome, is rare in children. The etiology of primary SEP is believed to be associated with retrograde menstruation or viral peritonitis in young adolescent girls, whereas secondary SEP refers to SEP caused by other factors such as surgery, peritoneal dialysis, or tuberculosis. Secondary SEP is rare and lack diagnostic specificity in children.

Hypergraph-based Audio-Visual Fusion for Obstructive Sleep Apnea Severity Estimation During Wakefulness.

Obstructive sleep apnea (OSA) is associated with psychophysiological impairments, and recent studies have shown the feasibility of using speech and craniofacial images during wakefulness for severity estimation. However, the inherent limitations of unimodal data constrain the performance of current methods. To address this, we proposed a novel hypergraph-based multimodal fusion framework (HMFusion) that integrates psychophysiological information from audio-visual data.

Characterizations and transcriptional response of peroxiredoxin genes, TcPrx6a and TcPrx6b, to paraquat and deltamethrin exposures in Tribolium castaneum.

Prx6 attracts particular attention because of its ability to reduce the widest range of peroxidative substrates among the peroxiredoxin (Prx) family. In this study, TcPrx6a and TcPrx6b were cloned from Tribolium castaneum. RT-qPCR analysis revealed that TcPrx6a and TcPrx6b were highly expressed in fat body and head, respectively, and both were upregulated after exposure of the beetles to paraquat and deltamethrin.

Three-Dimensional Single-Shot CEST Imaging at 3T Based on True FISP Readout.

To simultaneously fit multiple-pool effects, spectrally selective 3D chemical exchange saturation transfer (CEST) imaging typically requires single-shot readouts to save time. However, to date, fast low angle shot (FLASH) and echo planar imaging (EPI) have been the primary pulse sequences used for this purpose. They suffer from low signal-to-noise ratio (SNR) or image distortion related to B0 field inhomogeneity.

Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression.

The detection of cytosolic viral nucleic acids via pattern-recognition receptors (PRRs) activates multiple signaling pathways, leading to the production of interferons (IFNs), which are essential for host survival during viral infection. Precise control of PRR gene expression is crucial for maintaining immune homeostasis. Here, we showed that Mediator complex subunit 23 (Med23) is required for the precise production of the innate immune receptor RIG-I in response to RNA virus infection.

Integrative analysis of thiamethoxam induced hepatocellular carcinoma toxicity mechanisms.

Neonicotinoid (NEO) pesticides play a crucial role in agricultural production. However, their potential risks to human health and the environment cannot be overlooked. To gain a comprehensive understanding of the toxicity and mode of action of NEOs, thiamethoxam (THX), which exhibits the highest potential for carcinogenicity and hepatotoxicity, was selected as the subject of this study.

A nomogram model integrating radiomics and clinical variables to predict napsin a expression in lung adenocarcinoma patients.

Background: Lung adenocarcinoma, a major subtype of non-small cell lung cancer, requires non-invasive diagnostic tools to improve early detection and differentiate primary from metastatic tumors. Napsin A, a key marker for primary lung adenocarcinoma, is traditionally assessed via invasive biopsy, limiting its utility in reflecting tumor heterogeneity. Radiomics, which extracts quantitative features from medical images, offers potential for non-invasive prediction of molecular markers like Napsin A.

Involvement of Cranial Nerve Ganglion as an Independent Risk Factor for Malignant Transformation of Head and Neck Plexiform Neurofibromas in Neurofibromatosis Type 1.

Background: Individuals with neurofibromatosis type 1 (NF1) are confronted with a 10% lifetime susceptibility to malignant peripheral nerve sheath tumors (MPNST). The majority of NF1-associated MPNST arise from pre-existing plexiform neurofibromas (PNF). Nevertheless, the precise subtypes of PNF susceptible to malignant transformation remain unclear.

Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome-mediated pyroptosis of alveolar macrophage.

Background: Pulmonary fibrosis (PF) is a progressive and irreversible pathological manifestation of fibrotic interstitial lung diseases, characterized by chronic inflammation, excessive extracellular matrix (ECM) deposition, and architectural distortion of lung parenchyma, ultimately leading to respiratory failure. Maiwei Yangfei Decoction (MWYF) has been clinically applied in PF treatment, and can effectively improve the lung function and life quality of PF patients. Nevertheless, the precise regulatory mechanisms underlying its anti-fibrotic effects require further investigation.

Machine learning-based prediction of antimicrobial resistance and identification of AMR-related SNPs in Mycobacterium tuberculosis.

Background: Mycobacterium tuberculosis (MTB) is a human-specific pathogen that primarily infects humans, causing tuberculosis (TB). Antimicrobial resistance (AMR) in MTB presents a formidable challenge to global health. The employment of machine learning on whole-genome sequencing data (WGS) presents significant potential for uncovering the genomic mechanisms underlying drug resistance in MTB.

Carbon storage change, driving mechanism, and scenario prediction in Beijing-Tianjin-Hebei region for regional carbon neutral target: From history to future.

Understanding the driving mechanisms and spatial heterogeneity of regional-scale ecosystem carbon storage (CS) is crucial for regional carbon cycle research and formulating climate change mitigation strategies. This study develops an integrated framework utilizing Optimal Parameters-based Geographical Detector (OPGD) for key driver identification and interaction analysis, Multi-scale Geographically Weighted Regression (MGWR) for quantifying spatial heterogeneity of driver influences, and the patch-generating land use simulation (PLUS) model to simulate future land use and land cover (LULC) scenarios, enabling CS assessment via InVEST. Applying this framework, spatio-temporal CS change (2000-2020) in the Beijing-Tianjin-Hebei (BTH) region was analyzed, key drivers and their spatially differentiated mechanisms were explored, and CS was projected for 2030.

Causal role of phenylalanine and cholesterol metabolism in bladder cancer Chemoresistance: Insights from mendelian randomization and targeted molecular docking.

Bladder cancer (BLCA) exhibits profound chemoresistance, partly mediated by metabolic dysregulation. This study investigated the roles of phenylalanine (Phe) and cholesterol metabolism in BLCA chemoresistance using integrated omics and computational modeling. Transcriptomic analysis of the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets revealed that elevated hexokinase 2 (HK2) and low-density lipoprotein receptor (LDLR) expression correlates with poor response to cisplatin.

Recent progress in the polysaccharides from okra (Abelmoschus esculentus L.): Preparation methods, structural characterization, pharmacological properties, and applications.

Abelmoschus esculentus L. (okra), as a medicine-food homology plant, has a long history of both medicinal and dietary use. Okra is rich in different types of compounds, such as flavonoids, proteins, phenolic acids, vitamins, and polysaccharides.

Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.

To explore the therapeutic effects of Nobiletin (NOB) on Idiopathic pulmonary fibrosis (IPF) and to identify its targets and molecular pathways. We verified the inhibitory effect of NOB on the senescence of A549 cells through in vitro experiments, and the inhibitory effect of NOB on the migration ability of fibroblasts was verified by the Transwell experiment. The inhibitory effects of NOB on Idiopathic IPF were subsequently assessed in a mouse model induced by bleomycin (BLM).

High-valent nickel oxyhydroxides self-derived through a low-temperature thermochemical strategy for an efficient oxygen evolution reaction.

High-valent Ni(Fe) metals are considered practical electroactive phases that can accelerate reaction kinetics and exhibit high inherent reactivity during the alkaline oxygen evolution reaction (OER). However, their formation and stabilisation are thermodynamically unfavourable. Oxyanions possess a unique polyanionic motif and suitable electronegativity, enabling them to share more dispersed electrons with adjacent metal cations and thereby balance the strong positive electronic fields of the metal cations.

Trimethylamine-N-Oxide Impedes Late Endothelial Progenitor Cell-Mediated Revascularization by Triggering Mitochondrial Apoptosis via Suppression of MnSOD.

Trimethylamine-N-oxide (TMAO) is recognized as a novel marker and mediator of atherosclerotic cardiovascular disease (ASCVD). Endothelial progenitor cells (EPCs) are crucial for maintaining vascular homeostasis. Impaired EPC numbers and function correlate with increased adverse cardiovascular events.

Did the reform of the public hospitals' pay system increase the physicians' pay in China? A cross-sectional study.

Background: In 2017, the government initiated a pilot program for the public hospitals' pay system (RPHPS) aimed at enhancing physician compensation. We investigated the extent to which the reform impacted the physicians' pay and analyzed the factors that determine their pay.

Methods: This cross-sectional study utilized China Public Hospitals' Compensation Reform Survey from 2017, which included a sample of 178,622 physicians.