The Association Between Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio With Psoriasis: A Cross-Sectional Survey and Genetic Approach.

This study utilised NHANES data from 2003 to 2006 and 2009 to 2014 to explore the association between the non-high-density lipoprotein to high-density lipoprotein cholesterol ratio (NHHR) and psoriasis. A total of 15 437 U.S.

A Small-Molecule Organic Cathode with Two Electron-Withdrawing Cyano Bonds for Li-Ion Batteries.

Perylene-3,4,9,10-tetracarboxylic dianhydride [PTCDA, theoretical specific capacity (C) = 130 mAh g] is an efficient n-type organic cathode in Li-ion batteries with the median potential of ≈2.5 V (vs. Li).

CO Sequestration Potential and Soil Improvement Effects by Carbon-Fixing Bacteria Isolated From Degraded Soils in Shendong Coal Mining Area Located in Northwest China.

Efficient carbon-sequestering microorganisms are crucial for enhancing soil quality and reducing carbon emissions, particularly in semiarid coal mining areas. In this study, we analyzed the soil carbon-fixing microbial taxa and pathways in the Shendong mining area via high-throughput sequencing, and concluded that their main carbon sequestering pathway is the reduced citrate cycle (rTCA cycle), which has the potential for microbial carbon sequestration. Bacterial strains with high CO sequestration efficiency were isolated and identified, and their potential for improving soil carbon storage and quality was assessed.

Boosting external quantum efficiency of green flip-chip mini-LEDs by nanoimprinting hemisphere-shaped microstructure on sapphire substrate.

High-efficiency GaN-based green miniaturized light-emitting diodes (mini-LEDs) are of great significance to the development of full-color high-resolution displays. Here, a double-sided hemisphere-shaped patterned sapphire substrate (PSS) was fabricated for improving the external quantum efficiency (EQE) of green flip-chip mini-LEDs using nanoimprint lithography (NIL). We find that the hemisphere-shaped microstructures are more effective at extracting light into the air compared to the frustum-shaped and cone-shaped microstructures.

Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study.

Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder. Acupuncture therapy demonstrates significant efficacy in alleviating KOA symptoms. However, the central neuroimaging mechanisms underlying acupuncture's therapeutic effects remain incompletely elucidated.

Overweight and POMC methylation: epigenetic associations with adolescent depression.

Introduction: To evaluate whether BMI status influences POMC methylation levels and subsequently affects the course of adolescent depression. This study examined the relationship between the methylation levels of different CpG sites in the POMC gene and clinical symptoms across various BMI categories in adolescent depression.

Methods: A total of 108 adolescent patients with depressive disorders including 68 with unipolar depression and 40 with bipolar depression participated in the study.

Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.

Background: Electroacupuncture (EA) has been reported to improve post-stroke dysphagia (PSD) effectively. However, the underlying afferent neural circuit and neurological mechanism involved in improving PSD remain poorly understood.

Methods: A PSD mouse model was established via the photochemical embolization method.

Correction: A comprehensive review of rehabilitation approaches for traumatic brain injury: efficacy and outcomes.

[This corrects the article DOI: 10.3389/fneur.2025.

Curcumin as a therapeutic agent in liver cancer: a systematic review of preclinical models and mechanisms.

Background: Curcumin, a bioactive compound derived from Curcuma longa, has gained attention for its potential therapeutic effects in liver cancer. We reviewed current literature to evaluate the efficacy of curcumin in liver cancer models, such as anti-proliferative, pro-apoptotic, anti-inflammatory, or anti-metastatic roles. This systematic review focused on experimental methods, dosages, and underlying mechanisms.

High-Performance GaN-Based Green Flip-Chip Mini-LED with Lattice-Compatible AlN Passivation Layer.

The GaN-based green miniaturized light-emitting diode (mini-LED) is a key component for the realization of full-color display. Optimized passivation layers can alleviate the trapping of carriers by sidewall defects and are regarded as an effective way to improve the external quantum efficiency (EQE) efficiency of mini-LEDs. Since AlN has a closer lattice match to GaN compared to other heterogeneous passivation materials, we boosted the EQE of GaN-based green flip-chip mini-LEDs through the deposition of a lattice-compatible AlN passivation layer through atomic layer deposition (ALD) and a SiO passivation layer through plasma-enhanced chemical vapor deposition (PECVD).

A comprehensive review of rehabilitation approaches for traumatic brain injury: efficacy and outcomes.

Traumatic Brain Injury (TBI), particularly in moderate-to-severe cases, remains a leading cause of long-term disability worldwide, affecting over 64 million individuals annually. Its complex and multifactorial nature demands an integrated, multidisciplinary rehabilitation approach to address the diverse physical, cognitive, behavioral, and psychosocial impairments that follow injury. We conducted a structured literature search using PubMed, Scopus, and Web of Science databases for suitable studies.

Interfacial Heating in Membrane Distillation: Advances, Optimization Strategies, and Industrial Applications for Desalination.

Interfacial heating (IH) membrane distillation (MD) is a promising MD variation with significant potential for freshwater production from brine and seawater. Unlike conventional MD, IH-MD heats locally between the hydrophobic membrane and saline water to enhance the vapor flux and minimize heat loss. However, a unified understanding of the performance of various IH-MD systems remains lacking.

An experimental study on the optimal timing of modified pharyngeal electrical stimulation for the treatment of dysphagia after stroke in rats.

As a novel neuroregulatory technique, modified pharyngeal electrical stimulation (mPES) has demonstrated clinical potential in improving swallowing function. However, there is a notable lack of animal studies exploring this approach. While our previous research validated the optimal parameters for post-stroke dysphagia (PSD) in rats, it did not establish the ideal timing for initiating treatment.

An artificial intelligence malnutrition screening tool based on electronic medical records.

Background & Aims: Nutrition screening is a fundamental step to ensure appropriate intervention in patients with malnutrition. An automatic tool of nutritional risk screening based on electronic health records will improve efficiency and elevate the malnutrition diagnosis rate. We aimed to develop an artificial intelligence (AI) malnutrition screening tool based on electronic medical records and compare it with the patient interview-based tool.

EIF2B5 promotes malignant progression of hepatocellular carcinoma by activating the PI3K/AKT signaling pathway through targeting RPL6.

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with limited treatment options and poor prognosis. In this study, we demonstrated the critical role of EIF2B5 in driving HCC progression. We found EIF2B5 expression is significantly upregulated in HCC tumor tissues in several bioinformatics datasets, including The Cancer Genome Atlas, and that high expression of EIF2B5 predicts poor prognosis for HCC patients.

Cooking Increased the Postprandial Glycaemic Response but Enhanced the Preload Effect of Air-Dried Jujube.

Randomised controlled trials involving healthy participants were conducted to investigate the impact of cooking and ingestion patterns on the physiological response and preloading effect of air-dried jujube (AJ). The participants' postprandial glycaemic and insulinemic responses were tested after ingestion of cooked or uncooked air-dried jujube containing 50 g (as a sole food source) or 15 g (as a preload food prior to a rice meal) of available carbohydrates. Compared with the uncooked AJ, the cooked air-dried jujube (CAJ) induced a 34.

USP28 knockdown and small molecule inhibitors promote KRT1 destabilization and sensitize hepatocellular carcinoma cells to sorafenib.

Background: Hepatocellular carcinoma (HCC) is a significant malignant tumor that is typically diagnosed late and has a poor prognosis. USP28 (Ubiquitin-specific protease 28), a deubiquitinating enzyme within the ubiquitin-specific proteases (USPs) family, plays a pivotal role in various biological processes, especially in cancer progression. However, its functions and molecular mechanisms in HCC are still unknown.

Efficacy of psychological interventions for complex post-traumatic stress disorder in adults exposed to complex traumas: A meta-analysis of randomized controlled trials.

Introduction: Effective treatments for post-traumatic stress disorder (PTSD) have been established, but their applicability in complex post-traumatic stress disorder (CPTSD) is largely unknown.

Methods: We searched Pubmed, Web of Science, PsycInfo, Embase, CNKI, wanfang data, and SinoMed databases to seek out studies assessing the impact of psychological therapies on CPTSD among individuals with complex trauma. The quality of studies was assessed using the Cochrane Risk of Bias tool, and the moderating influence of study characteristics on the effect was examined.

NH-Induced Challenges in CO Hydrogenation over the Cu/ZnO/AlO Catalyst.

Gas sources rich in CO derived from biomass/waste gasification, anaerobic digestion, or industrial carbon capture often contain impurities such as HS, HO, and NH, which can significantly hinder catalyst performance. Here, we show the role of NH on the reverse water-gas shift (RWGS) reaction over a commercial Cu/ZnO/AlO catalyst, examining its effects on both the catalytic activity and the catalyst structure. We found that NH reversibly decreases CO conversion immediately by suppressing carbonate hydrogenation and CO desorption.

Local-region treatment comparison following conversion therapy of hepatocellular carcinoma: a period and age-dependent analysis.

Background: Transarterial chemoembolization (TACE) is a potential conversion therapeutic strategy for unresectable hepatocellular carcinoma (uHCC). However, therapeutic options following conversion therapy are still controversial.

Objectives: This study aimed to compare the efficacy and safety of surgical resection (SR) and microwave ablation (MWA) after TACE conversion therapy for uHCC.

Association Between Cognitive Impairment and Dysphagia: A Two-Sample Mendelian Randomization Study.

Introduction: Previous observational studies have implied a correlation between cognitive impairment and dysphagia, but some have indicated no correlation between the two. Such contradictory findings may have been influenced by small sample sizes and potential confounders. In this Mendelian randomization (MR) analysis, we genetically estimated a causal relationship between cognitive impairment and dysphagia.

Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle through TRPA1 Activation on Mast Cells in Atopic Dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the itch-scratch cycle. Itching, induced by irritants or allergens that stimulate pruriceptive neurons, triggers uncontrollable mechanical scratching, leading to epidermal barrier disruption, immune response activation, inflammatory mediator release, and further stimulation of pruritus conduction. Although oxidative stress and immune cells can exacerbate this cycle, the correlation between mechanical scratching, epidermal oxidative stress, and dermal mast cell activation in AD remains unclear.

Deciphering the N-substituent effects on biodegradation of sulfonamides: Novel insights revealed from molecular biology and computational chemistry approaches.

Elucidating biodegradation mechanisms and predicting pollutant reactivities are essential for advancing the application of biodegradation engineering to address the challenge of thousands of emerging contaminants. Molecular biology and computational chemistry are powerful tools for this purpose, enabling the investigation of biochemical reactions at both the gene and atomic levels. This study employs the biodegradation of ten sulfonamide antibiotics as a case study to demonstrate the integration of genomics and quantum chemistry approaches in exploring the biodegradation behavior of emerging contaminants.

Fresh-Cooked but Not Cold-Stored Millet Exhibited Remarkable Second Meal Effect Independent of Resistant Starch: A Randomized Crossover Trial.

It is well established that cold storage results in increased resistant starch and a reduced glycemic index in carbohydrate food. However, the effects of cold storage on the glycemic response of the second meal of cereals remain unclear. The aim of this study was to compare the postprandial glycemic responses between the paired glutinous and non-glutinous grains, either fresh-cooked or refrigerated, after both the first and second meals.