The impact of peer effects on college students' sports normative behavior intention: a moderated mediation model.

This study investigates the mechanisms through which peer effects, attitudes toward sports policies, and formal institutional factors influence college students' intentions to engage in normative sports behaviors. The goal is to provide theoretical insights and practical guidance for enhancing students' adherence to normative sports conduct, fostering positive behavioral habits, and promoting holistic physical and mental development. A total of 2,340 college students from 20 universities across China participated in a structured questionnaire survey.

Using Deep Learning to Choose Optimal Smoothing Values for Equating.

Test developers typically use alternate test forms to protect the integrity of test scores. Because test forms may differ in difficulty, scores on different test forms are adjusted through a psychometrical procedure called equating. When conducting equating, psychometricians often apply smoothing methods to reduce random error of equating resulting from sampling.

[Fabrication and evaluation of dexmedetomidine hydrochloride microneedles based on 3D printing].

Compared with conventional transdermal drug delivery systems, dissolving microneedles significantly enhance drug bioavailability by penetrating the stratum corneum barrier and achieving intradermal drug delivery. In order to improve the transdermal bioavailability of dexmedetomidine hydrochloride, in this study, a novel microneedle delivery system was developed for dexmedetomidine hydrochloride based on 3D printing combined with micro-molding. By systematically optimizing the microneedle geometrical parameters, array arrangement, and preparation process parameters, we determined the optimal ratio of drug-carrying matrix as 15% PVP (polyvinyl pyrrolidone) K90.

Metabolic Reprogramming Shapes the Progression and Therapeutic Landscape of Ovarian Cancer.

Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies due to its asymptomatic progression, frequent late-stage diagnosis, and high rates of chemoresistance and recurrence. Beyond genetic alterations, recent studies highlight the central role of metabolic reprogramming in driving OC initiation, progression, and therapy resistance. OC cells exhibit dynamic metabolic reprogramming, enabling dynamic shifts between glycolysis and oxidative phosphorylation depending on environmental conditions and treatment pressures.

Rapid MS-Based Single-Cell Analysis Assisted by Photochemical Derivatization in Living Cell Membranes Reveals Lipidomic Patterns with Located C═C Bonds.

Traditional lipidomics methods are not well-suited for studying unsaturated lipids containing located C═C bonds in single cells. Here, we proposed a single-cell mass spectrometry (MS) platform assisted by a photochemical derivatization (PCD) method termed isible-light-activated u(bpy)-catalyzed inglet xygen-mediated ydroperoxidation (VRSOH), for the rapid and simultaneous detection of multiple lipid C═C location isomers in living cell membranes at the single-cell level. First, the VRSOH method combined with MS analysis achieved the localization of C═C bonds in mono- and polyunsaturated lipids and cellular lipid extracts.

Inequities in prenatal neonatology consultation in high-mortality neonatal populations.

Objectives: To explore inequities in prenatal consultation and parental resuscitation decisions across high-mortality conditions.

Study Design: We conducted a retrospective chart review of pregnant people whose liveborn neonates were diagnosed with high-mortality conditions. We examined two cohorts: periviable infants (22 0/7-24 6/7 weeks) and infants with severe congenital anomalies.

Combined Pharmacological Conditioning of Endothelial Cells for Improved Vascular Graft Endothelialization.

The development of functional endothelial monolayers on synthetic vascular grafts remains challenging, particularly for small-diameter vessels (<6 mm) prone to thrombosis. Here, we present a pharmacological strategy combining 8-(4-chlorophenylthio) adenosine 3',5'-cyclic monophosphate sodium salt (pCPT-cAMP, a tight junction promoter) with nitric oxide/cGMP pathway agonists 3-morpholinosydnonimine (SIN-1), captopril, and sildenafil) to enhance endothelialization. In human umbilical vein endothelial cells (HUVECs), this four-agent cocktail induced a flat, extended phenotype with a 3-fold increased cell area and 57.

Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type with Immune Thrombocytopenia as the First Primary Presentation.

Background: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare aggressive vari-ant of non-Hodgkin lymphoma (NHL). It is also clinically uncommon for NHL to primarily manifest as immune thrombocytopenia (ITP).

Methods: We report a rare case of PCDLBCL-LT, which was misdiagnosed as primary refractory ITP.

Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target.

Immunotherapy has emerged as a cornerstone strategy for augmenting therapeutic efficacy in acute myeloid leukemia (AML). The immunosuppressive AML microenvironment, characterized by profound immune dysfunction, critically impairs anti-leukemic immune surveillance. This immunologically hostile niche is principally governed by specialized immunosuppressive cell populations-notably regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), leukemia-associated macrophages (LAMs), and regulatory B cells (Bregs)-which collectively establish an immune-privileged sanctuary for leukemic cells.

Development and validation of a multi-platform LAMP system for rapid HAdV-3 and HAdV-7 detection.

Purpose: We developed a loop-mediated isothermal amplification (LAMP) multi-platform detection system that overcomes the limitations of traditional polymerase chain reaction (PCR) in timeliness and equipment dependency, establishing a rapid, accurate diagnostic framework for Human adenovirus types 3 and 7 (HAdV-3 and HAdV-7) across resource-varied clinical settings.

Methods: LAMP primers were designed based on the conserved regions of the Hexon genes of HAdV-3 and HAdV-7. The calcein, immunochromatography (IC), and fluorescence probe methods were used.

A CSDG photoelectronic transistor based on simulation model mimicking dopamine-facilitated synaptic plasticity for high energy-efficient neuromorphic system.

Charge-trap transistors are widely used for the simulation of biological synaptic functions. However, the unique structure of silicon-oxide-nitride-oxide-silicon (SONOS) makes it difficult to simulate short-term memory (STM). Based on simulation modeling, this work proposes a cylindrical surrounding double-gate (CSDG) nanowire synaptic transistor with a Si N charge trap layer in direct contact with the channel.

Exercise-induced lactate suppresses ccRCC via CNDP2-mediated depletion of intracellular amino acids.

Although epidemiological evidence has established a link between physical exercise and reduced risk and recurrence of multiple cancers, the association between physical exercise and cancer risk varies depending on the cancer site. Therefore, there is an urgent need to explore the molecular mechanisms underlying the antitumor effects of exercise to identify which types of cancers can benefit the most from physical exercise. Recent studies have shown that amino acids and exercise-induced lactate can be used by Carnosine Dipeptidase 2 (CNDP2) to synthesize lactoyl amino acids (Lac-AAs), which are then immediately secreted.

Regulating the Assembly of γ-Cyclodextrin Host and Polyoxometalate-Based Guests toward Light-Responsive Hybrid Rotaxanes.

The rational design of hybrid organic-inorganic rotaxanes is crucial for advancing molecular machines and functional nanomaterials, yet the integration of metal-oxo clusters into interlocked systems remains challenging. Herein, we present a precision synthesis strategy for hybrid rotaxanes combining γ-cyclodextrin (γ-CD) hosts with Anderson-type polyoxometalate (POM)-based guests. This approach utilizes covalent POM modification coupled with strategically anchored organic functionalities to control supramolecular assembly, enabling the construction of -[2]-, [3]-, and [4]rotaxanes with controlled structural variations.

The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines.

Thermo-sensitive genic male-sterile (TGMS) lines are fertile at lower temperatures but male sterile above a critical sterility-inducing temperature (CSIT), which varies substantially across TGMS lines. Such lines are valuable resources for breeding two-line hybrid rice (Oryza sativa). However, as their utility is restricted by the CSIT, understanding its regulatory mechanisms has crucial breeding-associated implications.

Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.

Background: Electroacupuncture (EA) has been reported to improve post-stroke dysphagia (PSD) effectively. However, the underlying afferent neural circuit and neurological mechanism involved in improving PSD remain poorly understood.

Methods: A PSD mouse model was established via the photochemical embolization method.

Optimization of crude protein production feed and process for semi-solid-state fermentation of brewing sorghum straw.

This study utilized alkali-assisted, high-temperature-pretreated brewing sorghum straw (BSS) for semi-solid-state fermentation to produce high-protein feed. Solid-state fermentation with for enzyme production was used to promote stalk biodegradation, and single-cell strains 26 and D3-1 were chosen for liquid-state fermentation and propagation to enhance crude protein content. Baijiu distiller's grains were added to balance the carbon-to-nitrogen ratio of BSS.

Prenatal repair of myelomeningocele is associated with lower need for long-term feeding support.

Objective: Infants with myelomeningocele (MMC) are at risk of brainstem dysfunction secondary to symptomatic Chiari II malformation with hindbrain herniation (HH), which can manifest as feeding difficulties including aspiration and dysphagia. This study aims to investigate whether prenatal repair of MMC is associated with improved feeding outcomes compared to postnatal repair.

Study Design: Retrospective observational study of 208 infants with MMC, 105 repaired prenatally and 103 repaired postnatally, from January 2011 to July 2022.

Preeclampsia: The silent catalyst for autism spectrum disorder in offspring.

Preeclampsia, a pregnancy-specific disorder characterized by hypertension and proteinuria, has been hypothesized to be associated with the development of autism spectrum disorder (ASD) in offspring. This review synthesizes epidemiological evidence and examines biological mechanisms, proposing a significant association between preeclampsia and ASD. The analysis demonstrates an increased risk of ASD in offspring of mothers with preeclampsia, with early-onset and severe preeclampsia likely exerting a more significant effect.

Reduced Neural Speech Tracking in Adolescents with Listening Difficulty.

Objective: To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).

Methods: Neural speech tracking (NST) was assessed using magnetoencephalography (MEG) in 21 adolescents with LiD and 25 typically developing (TD) peers, all with audiometrically normal hearing. Participants performed a cocktail party task involving target speech presented alone or alongside competitor speech streams differing in talker identity and spatial location.

A Comprehensive review of humoral immune defense in the silkworm, Bombyx mori: Mechanistic insights and responses to microbial pathogens.

The silkworm Bombyx mori L. is an economically valuable insect and an excellent model for investigating insect immunity. Its robust innate immune system shields it from numerous pathogens, such as viruses, bacteria, fungi, and microsporidia.

Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study.

Objectives: Most of the myelodysplastic syndromes (MDS) patients suffer from iron overload (IOL) due to ineffective hematopoiesis and repeated blood transfusions. IOL may affect the survival of MDS patients, but the related mechanism has not been fully clarified. We aimed to provide clinical evidence for the impact of IOL on the immunity and prognosis of MDS patients.

Combined serum IFN-γ and IL-22 levels as predictive biomarkers for hepatocellular carcinoma risk: A clinical investigation.

Hepatocellular carcinoma (HCC) is predominantly diagnosed at advanced stages due to a lack of reliable biomarkers for early detection. Consequently, identifying predictive biomarkers for HCC development in patients with chronic liver diseases holds significant potential for improving early diagnosis and clinical outcomes of this aggressive malignancy. Serum levels of immune checkpoint proteins and cytokines were quantified by ELISA in patients with chronic hepatitis B, liver cirrhosis, and HCC, with healthy subjects serving as controls.

Predicting and Validating the Regulation of Podocyte Injury and Treatment of Diabetic Kidney Disease by Yinhuo Tang.

Diabetic kidney disease (DKD) is a chronic kidney disease characterized by massive proteinuria and decreased glomerular filtration rate. The main pathological feature of DKD is renal microangiopathy, and ~40% of diabetic patients will develop DKD. The podocyte-associated proteins CD2AP and WT-1 play a crucial role in maintaining the normal function of podocytes and the integrity of the glomerular filtration barrier.

Tislelizumab (anti-PD-1) plus chemotherapy as neoadjuvant therapy for patients with stage IB3/IIA2 cervical cancer (NATIC): a prospective, single-arm, phase II study.

The clinical benefit of neoadjuvant immunochemotherapy in locally advanced cervical cancer (LACC) remains unclear. This single-arm, phase II study (Chinese Clinical Trial Registry, ChiCTR2200065392) aimed to evaluate the efficacy and safety of neoadjuvant anti-programmed cell death protein 1 (PD-1) antibody tislelizumab in combination with chemotherapy in treatment-naïve patients with stage IB3/IIA2 LACC. Enrolled patients received tislelizumab (200 mg, every 3 weeks) plus chemotherapy for 3 cycles before radical surgery.