Preeclampsia: The silent catalyst for autism spectrum disorder in offspring.

Preeclampsia, a pregnancy-specific disorder characterized by hypertension and proteinuria, has been hypothesized to be associated with the development of autism spectrum disorder (ASD) in offspring. This review synthesizes epidemiological evidence and examines biological mechanisms, proposing a significant association between preeclampsia and ASD. The analysis demonstrates an increased risk of ASD in offspring of mothers with preeclampsia, with early-onset and severe preeclampsia likely exerting a more significant effect.

Chinese herbal medicine improves the treating outcomes in advanced non-small cell lung cancer patients treated with iodine-125 seed brachytherapy: a 5-year follow-up study.

Brachytherapy based on iodine-125 (I-125) is becoming one of the alternative treatment option for advanced non-small cell lung cancer (NSCLC). Chinese herbal medicine (CHM) combined with radiotherapy reduces the complications. In the current study, we attempted to assess the outcomes of treating strategies using CHM, chemotherapy or I-125.

Biomimetic Visual System Implemented by a Two-Dimensional Plasmonic Photosensor Array for Processing Spatio-Temporal Information.

Compared to machine vision chips, the human visual system can continuously perceive and process static scene and dynamic motion from the ever-changing real world with extremely low power consumption in both spatial and temporal dimensions. However, current neuromorphic devices either only focus on preprocessing and recognizing images in spatial dimension, or only focus on encoding and discriminating specific partial information (such as event-driven information), lacking biological fidelity. An in-sensor spiking neural network (SNN) is presented, consisting of a 2D plasmonic photosensor array (PPSA) that mimics the human visual system's ability to efficiently perceive, preprocess, encode, and process frame-driven spatio-temporal information.

Osthole inhibits proliferation and induces autophagy-dependent ferroptosis of cervical cancer cells through induction of TFR1.

Osthole (OST), a natural coumarin, exerts its anticancer effects by inducing cancer cell necroptosis, apoptosis, pyroptosis or autophagy. In He La cells, OST cause mitochondrial atrophy, increased membrane density and reduced cristae, which are characteristics of ferroptosis. However, the mechanisms of OST-induced ferroptosis in cervical cancer cells remain unclear.

Active control of excitonic strong coupling and electroluminescence in electrically driven plasmonic nanocavities.

Enhancement and active control of light-matter interactions at the atomic scale is important for developing next-generation nanophotonic and quantum optical devices. Here, we demonstrate electric control of excitonic strong coupling and electroluminescence (EL) by integrating a semiconductor monolayer into a nanometer gap of single electrically driven nanocube-on-mirror plasmonic nanocavities, which provide unmatched optical and electrical confinement. In particular, in a strongly coupled system of nanocavity plasmons and tungsten diselenide (WSe) excitons, an ultrastrong electric field generated in the nanocavity gap enables reversible modulation of the Rabi splitting between ~108 and 102 milli-electron volts with a bias of only 2.

Enhancing sewer low-loss transportation by food waste microencapsulation treatment: Dual suppression of organic leaching and biofilm architecture-function for mitigating hazardous gases and blockage risks.

Food waste management posed a critical global sustainability challenge, with significant environmental, economic, and social impacts. The installation of food waste disposers emerged as a primary strategy for source-separated food waste transfer to wastewater treatment systems through municipal pipelines. However, this approach accelerated the transformation of sewer systems into bioreactors and induced sewer pipe deterioration.

Reconfigurable Phototransistor Based on the Interface Trap State of the WS/TaNiSe Heterostructure for Logic-in-Memory Operation.

In recent years, machine vision technology has experienced rapid growth, in which optoelectronic sensing plays a crucial role. With the rising demand for versatile integration of photoelectric sensors, sensors that combine sensing, storage, and computing capabilities are emerging as the next-generation paradigm for high-density, low-power visual processing. Here, with a simplified floating-gate structure based on the interface trap state of the WS/TaNiSe heterostructure, we demonstrate a self-driven logic-in-memory optoelectronic transistor with nonvolatile reconfigurable photoresponsivity by controlling the direction and magnitude of the built-in electric field, which can be used for image preprocessing, at the same time capable of achieving multifunctions such as neuromorphic computation, multicolor sensing, positive and negative light response switching, and polarization detection, highlighting the great potential for multifunctional reconfigurable vision devices.

Preparation and Performance Optimization of Fe:ZnSe Solid Solution by High-Pressure-High-Temperature Method.

In this paper, high-purity zinc selenide (ZnSe) prepared by the Chemical Vapor Deposition (CVD) method was used as the raw material, and iron ion-doped zinc selenide polycrystals were successfully fabricated through the thermal diffusion method at 1100 °C for 30 h. The results showed that iron ions (Fe) successfully penetrated into the zinc selenide crystals, but the concentration of iron ions inside the crystals was relatively low, and the crystals exhibited numerous defects. To address this issue, we performed secondary sintering and annealing on the samples under high-temperature and high-pressure (HPHT) conditions, with the annealing temperature range set at 900-1200 °C.

Enhancing sulfide mitigation via the synergistic dosing of calcium peroxide and ferrous ions in gravity sewers: Efficiency and mechanism.

Chemical dosing constitutes an effective strategy for sulfide control in sewers; however, its efficacy requires further optimization and enhancement. In this study, a novel dosing strategy using the synergistic dosing of calcium peroxide (CaO) and ferrous ions (Fe) for sulfide control was proposed, and its efficacy in controlling sulfides was evaluated using a long-term laboratory-scale reactor. The results showed that adding CaO-Fe improves the effect of sulfide control.

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.

Background: The association between mitochondrial dysfunction and multiple metabolic adaptations is increasingly being proven. We previously elucidated that mitochondrial complex I deficiency can promote glycolysis in mut-p53 SW480 cells. However, studies have revealed a phenotype with attenuated glycolysis but enhanced fatty acid oxidation (FAO) in invasive tumors.

Persistent Exciton Dressed by Weak Polaronic Effect in Rigid and Harmonic Lattice Dion-Jacobson 2D Perovskites.

The emerging two-dimensional (2D) Dion-Jacobson (DJ) perovskites with bidentate ligands have attracted significant attention due to enhanced structural stability compared with conventional Ruddlesden-Popper (RP) perovskites with monodentate ligands linked by van der Waals interactions. However, how the pure chemical bond lattice interacts with excited state excitons and its impact on the exciton nature and dynamics in 2D DJ-perovskites, particularly in comparison to RP-perovskites, remains unexplored. Herein, by a combined spectroscopy study on excitonic and structural dynamics, we reveal a persistent exciton dressed by a weak polaronic effect in DJ-perovskite due to their rigid and harmonic lattice, in striking contrast to significantly screened exciton polaron observed in RP-perovskites.

Robust excitonic light emission in 2D tin halide perovskites by weak excited state polaronic effect.

2D perovskites hold immense promise in optoelectronics due to their strongly bound electron-hole pairs (i.e., excitons).

Effect and mechanism of curcumin on colon cancer cell senescence through early growth response 1 (EGR1).

Background: The expression level of early growth response 1 (EGR1) is elevated in colon cancer (CC) tissues and is closely associated with poor prognosis in colorectal cancer. However, the role of EGR1 as a transcription factor (TF) influencing cell senescence in the progression of CC remains largely unexplored. This study aims to investigate the impact of curcumin on colorectal cancer cell senescence by modulating EGR1.

High power self-Q-switched Tm:YAP laser.

To the best of our knowledge, the output performance of a self-Q-switched Tm:YAP laser has been controlled by adjusting the cavity length for the first time. By using a concise concave-flat cavity, a pulsed laser emitting at 1993 nm is produced without any additional modulation device. Under a stable self-Q-switched mode, the maximum average output power of 9.

Patient-Controlled Subcutaneous Analgesia with Hydromorphone versus Oral Oxycontin for Opioid Titration of Cancer Pain: A Prospective Multicenter Randomized Trial.

Background: Studies have shown that oral oxycontin tablets can be used for opioid titration. The European Society for Medical Oncology (ESMO) guidelines for adult cancer pain recommend opioid titration through the parenteral route, usually the intravenous or subcutaneous route. Patient-controlled subcutaneous analgesia (PCSA) with hydromorphone needs further evaluation for opioid titration.

Large area single crystal gold of single nanometer thickness for nanophotonics.

Two-dimensional single crystal metals, in which the behavior of highly confined optical modes is intertwined with quantum phenomena, are highly sought after for next-generation technologies. Here, we report large area (>10 μm), single crystal two-dimensional gold flakes (2DGFs) with thicknesses down to a single nanometer level, employing an atomic-level precision chemical etching approach. The decrease of the thickness down to such scales leads to the quantization of the electronic states, endowing 2DGFs with quantum-confinement-augmented optical nonlinearity, particularly leading to more than two orders of magnitude enhancement in harmonic generation compared with their thick polycrystalline counterparts.

High performance artificial visual perception and recognition with a plasmon-enhanced 2D material neural network.

The development of neuromorphic visual systems has recently gained momentum due to their potential in areas such as autonomous vehicles and robotics. However, current machine visual systems based on silicon technology usually contain photosensor arrays, format conversion, memory and processing modules. As a result, the redundant data shuttling between each unit, resulting in large latency and high-power consumption, seriously limits the performance of neuromorphic vision chips.

Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis.

Mogroside V (MV) is a natural sweetener extracted from the edible plant that possesses anti-inflammatory bioactivity. It has been reported that microRNAs (miRNAs) play an important role in the inflammation response suppression by natural agents. However, whether the anti-inflammation effect of mogroside V is related to miRNAs and the underlying mechanism remains unclear.

Ultrabroadband High Photoresponsivity at Room Temperature Based on Quasi-1D Pseudogap System (TaSe ) I.

Narrow bandgap materials have garnered significant attention within the field of broadband photodetection. However, the performance is impeded by diminished absorption near the bandgap, resulting in a rapid decline in photoresponsivity within the mid-wave infrared (MWIR) and long-wave infrared (LWIR) regions. Furthermore, they mostly worked in cryogenic temperature.

Two-Dimensional Atomically Thin Titanium Nitride via Topochemical Conversion.

Titanium nitride as a typical transition metal nitride (TMN) has attracted increasing interest for its fascinating characteristics and widespread applications. However, the synthesis of two-dimensional (2D) atomically thin titanium nitride is still challenging which hinders its further research in electronic and optoelectronic fields. Here, 2D titanium nitride with a large area was prepared topochemical conversion of the titanate monolayer.

Conservative rehabilitation therapy for respiratory dysfunction due to phrenic nerve sacrifice during resection of massive mediastinal tumor: A case series study.

Rationale: Cases of respiratory dysfunction due to phrenic nerve sacrifice during resection of massive mediastinal tumor have rarely been studied in detail. Diaphragmatic dysfunction in such cases can lead to potentially fatal respiratory and circulatory disturbances. Therefore, timely diagnosis and intervention are important.

Neoadjuvant camrelizumab plus chemotherapy in locally advanced oesophageal squamous cell carcinoma: a retrospective cohort study.

Background: Neoadjuvant therapy is recommended to improve the prognosis of oesophageal squamous cell carcinoma (ESCC). As a PD-1 inhibitor developed in China, camrelizumab is more accessible and available for Chinese ESCC patients. Camrelizumab plus neoadjuvant chemotherapy has shown promising efficacy with acceptable toxicity for resectable ESCC in the NIC-ESCC2019 trial.