Discovery of LYA914, An Orally Bioavailable PROTAC Degrader Targeting the DNA Binding Domain of the Androgen Receptor for the Treatment of CRPC.

Prostate cancer is a common male malignancy. Although androgen deprivation therapy (ADT) is initially effective, it often leads to castration-resistant prostate cancer (CRPC) eventually. Second-generation androgen antagonists are the standard therapy for CRPC.

Biological applications of graphene-based nanomaterials in neurodegenerative diseases.

Neurodegenerative diseases (NDDs) have become a major challenge in global public health due to neurotoxicity caused by progressive neuronal degeneration and abnormal protein aggregation, which has attracted widespread attention. Graphene-based nanomaterials provide innovative solutions for the early diagnosis and precise treatment of NDDs by virtue of their ultra-high conductivity, large specific surface area and multifunctional properties. In this paper, we systematically discuss the key applications of these materials in the diagnosis and treatment of NDDs, and deeply analyze the technological breakthroughs and clinical translation challenges.

Efficacy and prognostic analysis of venetoclax combined with hypomethylating agents for induction therapy in acute myeloid leukemia: a multi-center real-world study on indication-specific stratification, molecular markers, and hematologic toxicities.

The combination of venetoclax and hypomethylating agents (VEN + HMAs) has shown significant progress in treating acute myeloid leukemia (AML), especially for patients not suitable for intensive chemotherapy. However, outcomes for relapsed/refractory AML remain uncertain, and factors influencing VEN + HMAs efficacy are not yet conclusively determined. A retrospective analysis of 181 AML patients treated with VEN + HMAs from October 2020 to January 2024 revealed a CR rate of 39.

Single-Cell Transcriptomics Unveils the Mechanistic Role of FOSL1 in Cutaneous Wound Healing.

The skin, a complex organ vital for protecting the body against environmental challenges, undergoes a multifaceted wound healing process involving hemostasis, inflammation, proliferation, and remodeling. The transcription factor FOSL1 has been implicated in various cellular processes crucial for wound healing, including cell cycle regulation, differentiation, and apoptosis. We hypothesize that FOSL1 is a key regulator of wound healing processes.

Report on Witteveen-Kolk syndrome caused by large fragment deletion in the 15q24.1 - q24.2 region in infants with early onset and literature review.

Background: WITKOS is a rare neurodevelopmental disorder caused by heterozygous loss-of-function variants in the 15q24.1 - q24.2 region, includeing switch-insensitive 3 transcription regulator family member A (SIN3 A).

Meta-analysis on the effectiveness and safety of venetoclax-based combination therapy with hypomethylation in acute myeloid leukemia.

The combined therapy strategy of venetoclax with hypomethylating agents (HMAs) has demonstrated encouraging efficacy in the treatment of acute myeloid leukemia (AML), particularly in elderly patients or those deemed unfit for standard treatments. However, due to differences in the research focuses of various research centers, the results have not yet comprehensively and systematically demonstrated the clinical significance of this treatment approach. Therefore, in this meta-analysis, we aimed to assess the effectiveness and safety of venetoclax in combination with HMAs for the treatment of AML.

Status and Influencing Factors of Discharge Readiness in Day Surgery Lung Cancer Patients Under a Fast-Track Rehabilitation Pathway.

Aim: To investigate the status of discharge readiness of patients undergoing daytime lung cancer surgery and analyse its influencing factors.

Design: This was a cross-sectional study.

Methods: In this study, patients who underwent daytime lung cancer surgery from August 2022 to February 2023 at a Tertiary Care Hospital in Shanghai were selected via the convenience sampling method.

Ethanol extract of L. mitigates atherosclerosis through modulation of cholesterol efflux and uptake pathways.

Background: Purslane () is a medicinal and edible plant. Purslane extract (POEE) exhibits lipid-lowering, anti-inflammatory, and antioxidant properties. Traditionally, this extract has been used to treat various inflammatory conditions, including skin inflammation, enteritis, and dysentery.

Decoding prognostic factors in SARS-CoV-2 complications among patients with hematological disorders.

Within the intricate tapestry of the global SARS-CoV-2 pandemic, this study delves into the intricate interplay of clinical data to elucidate prognostic factors associated with complications in patients concomitantly afflicted with hematological disorders and SARS-CoV-2. An exhaustive analysis of 71 individuals, spanning the period from November 2022 to March 2023, aims to unveil distinctive clinical characteristics and explicate the nuanced determinants steering the trajectory of the disease. The updated findings reveal a multi-faceted correlation, underscoring the complex interplay of clinical parameters.

Identification of Mood Disorders Causal Genes by Integrating the Brain Proteome and Transcriptome.

Genome-wide association analysis studies (GWAS) have revealed loci associated with mood disorders (MD). However, the mechanism of action of these loci on drug targets for MD remains uncertain. Therefore, in this study, our aim was to identify causal genes for MD by integrating brain transcriptomic and proteomic expression data.

Construction and verification of a nomogram model for the risk of death in sepsis patients.

At present, there is insufficient evidence to evaluate the prognosis of patients with sepsis. This study anazed the clinical data of 822 sepsis patients in the ICU of a tertiary Grade A hospital to construct and validate a nomogram model for predicting the 28-day mortality risk in sepsis patients. The model was constructed using multivariate logistic regression analysis to screen for independent risk factors affecting prognosis, and a mortality risk prediction model was built based on these independent risk factors.

A Cohort Clinical Study on the Efficacy of Topical Salicylic Acid/Piroctone Olamine Dandruff Pre-Gel and Cleanser in Improving Symptoms of Moderate to Severe Seborrheic Dermatitis of the Scalp.

Background: Scalp seborrheic dermatitis (SD) is a chronic, recurrent inflammatory skin condition associated with scalp sebum secretion and dysbiosis.

Aims: The aim of this study is to evaluate the efficacy and safety of a topical salicylic acid/piroctone olamine/zinc salt of L-pyrrolidone carboxylate (Zinc PCA) scalp pre-application gel in combination with a salicylic acid/piroctone olamine/antimicrobial peptide cleansing lotion for the treatment of moderate to severe scalp SD.

Patients/methods: In this prospective cohort study, 20 patients with moderate to severe scalp SD were treated with a combination of the scalp pre-application gel and cleansing lotion for 4 weeks (one tube of the pre-application gel per week and the cleansing lotion used every 1-3 days depending on the frequency of hair washing).

Primary angle-closed diseases recognition through artificial intelligence-based anterior segment-optical coherence tomography imaging.

Purpose: In this study, artificial intelligence (AI) was used to deeply learn the classification of the anterior segment-Optical Coherence Tomography (AS-OCT) images. This AI systems automatically analyzed the angular structure of the AS-OCT images and automatically classified anterior chamber angle. It would improve the efficiency of AS-OCT image analysis.

Secondary childhood glaucoma in neurofibromatosis type 1: an unusual corneal leukoma case report.

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder that affects the skin, eyes and peripheral nervous system. It is rarely associated with glaucoma, especially in pediatric patients. We herein report an unusual case of corneal degeneration in a child with NF1, characterized by peripheral corneal leukoma and a membrane under Descemet's membrane.

Rotenone adaptation promotes migration and invasion of p53-wild-type colon cancer through lipid metabolism.

Background: The association between mitochondrial dysfunction and multiple metabolic adaptations is increasingly being proven. We previously elucidated that mitochondrial complex I deficiency can promote glycolysis in mut-p53 SW480 cells. However, studies have revealed a phenotype with attenuated glycolysis but enhanced fatty acid oxidation (FAO) in invasive tumors.

Synergistic effect of venetoclax and ibrutinib on ibrutinib-resistant ABC-type DLBCL cells.

Despite the widespread use of R-CHOP therapy in diffuse large B-cell lymphoma (DLBCL), the therapeutic efficacy for this disease remains suboptimal, primarily due to the heterogeneity of refractory and/or relapsed diseases. To address this challenge, optimization of DLBCL treatment regimens has focused on the strategy of combining an additional drug "X" with R-CHOP to enhance efficacy. However, the failure of R-CHOP combined with the BTK inhibitor ibrutinib in treating ABC-type DLBCL patients has raised significant concerns regarding ibrutinib resistance.

Toxicological Analysis of Acetamiprid Degradation by the Dominant Strain Md2 and Its Effect on the Soil Microbial Community.

Microbial degradation is acknowledged as a viable and eco-friendly approach for diminishing residues of neonicotinoid insecticides. This study reports the dominant strain of Md2 that degrades acetamiprid was screened from soil and identified as , and the optimal degradation conditions were determined. Research indicated that the degradation of Md2 to 100 mg/L acetamiprid was 55.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma.

While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center, was first reported 27 years ago. Yet, its methyltransferase and role in translation remain unexplored.

Preparation of white rot fungal inoculum and its application to bioremediation of chlorimuron-ethyl-contaminated soil.

Chlorimuron-ethyl is currently the primary herbicide used for chemical weed control in a soybean field. In this study, a solid microbial inoculum (corn stalk-white rot fungus (W-1)) was prepared for the remediation of farmland soil contaminated by chlorimuron-ethyl. Firstly, the preparation method of the microbial inoculum was studied.

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism.

Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial mechanisms, especially the antibacterial mechanisms, remain elusive.

Management of experimental trabeculectomy filtering blebs via crosslinking of the scleral flap inhibited vascularization.

Purpose: The aim of this study was to evaluate whether UVA-light-activated riboflavin-induced collagen crosslinking (UVA-CXL) can maintain the function of filtering blebs after trabeculectomy (TRAB) in rabbits.

Methods: Thirty-six healthy rabbits were randomized to one of the following groups with 12 rabbits in each group: Trabeculectomy group (TRAB group), trabeculectomy combined with CXL group (CXL group), and trabeculectomy combined with MMC group (MMC group). Six rabbits of each group were performed with intraocular pressure (IOP), optical coherence tomography (OCT), and OCT angiography (OCTA).

Regulates Myogenesis in Sheep, and SNPs Located in Its Putative Promoter Region Are Associated with Growth and Development Traits.

Previously, was identified as a candidate gene associated with sheep growth traits. This study aimed to investigate the direct role of in regulating myogenesis in embryonic myoblast cells and to investigate the association between single-nucleotide polymorphisms (SNPs) in its promoter region and sheep growth traits. The function of in myoblast proliferation and differentiation was detected after small interfering RNAs (siRNAs) knocked down the expression of .

Effect of the COVID-19 Pandemic on Rates and Epidemiology of Infection in One VA Hospital.

The COVID-19 pandemic was associated with increases in some healthcare-associated infections. We investigated the impact of the pandemic on the rates and molecular epidemiology of infection (CDI) within one VA hospital. We anticipated that the potential widespread use of antibiotics for pneumonia during the pandemic might increase CDI rates given that antibiotics are a major risk for CDI.