Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage.

Intracerebral hemorrhage (ICH) is a severe form of stroke with high mortality and disability, where early hematoma expansion (HE) critically influences prognosis. Previous studies suggest that revised hematoma expansion (rHE), defined to include intraventricular hemorrhage (IVH) growth, provides improved prognostic accuracy. Therefore, this study aimed to develop a deep learning model based on noncontrast CT (NCCT) to predict high-risk rHE in ICH patients, enabling timely intervention.

Case Report: Secukinumab for the treatment of severe psoriasis in a patient with hereditary hemochromatosis.

There are several comorbidities associated with psoriasis, including genetic disorders such as hereditary hemochromatosis, which can lead to organ damage secondary to iron overload. Herein, we report the case of a 38-year-old Chinese man with hereditary hemochromatosis who received secukinumab for the treatment of severe psoriasis. Follow-up after 3 months showed that the patient's lesions had almost resolved and remained well-controlled for 2 years without any reported side effects.

Correlation between umbilical cord concentration of the growth hormone-IGF axis and small for gestational age: A single-center retrospective, observational study.

Objective: To ascertain the association between small for gestational age (SGA) and growth hormone (GH)-insulin-like growth factor (IGF) system status.

Methods: This retrospective, observational single-center study at a tertiary hospital classified 175 newborns into two groups based on their gestational age and birth weight: SGA (n = 87) or appropriate for gestational age (AGA; n = 88). Umbilical cord blood samples were collected during delivery, and GH, IGF-1, and IGF-binding protein-3 (IGFBP-3) levels were measured using electrochemiluminescence immunoassay, liquid chromatography-tandem mass spectrometry, and chemiluminescence immunoassay, respectively.

A bacteriophage protein-driven platform for rapid and precise diagnosis of bacterial pathogens from blood samples.

The rapid emergence of antibiotic-resistant pathogens underscores the urgent need for fast, accurate, and accessible diagnostics to guide targeted therapy and mitigate resistance. Conventional methods for identifying bacterial infections are slow, labor-intensive, and costly, necessitating alternative approaches. Here, we developed an integrated diagnostic platform that employs bacteriophage-derived receptor-binding proteins (RBPs) and endolysin cell wall-binding domains (CBDs) for rapid bloodstream pathogen detection.

Time from waking to first cigarette, accelerated biological aging, and risk of premature mortality.

Background: The relationship between the time from waking to first cigarette (TWFC) and premature mortality remains unclear. This study aims to assess the association between TWFC and the risk of premature mortality, and to explore the role of accelerated biological aging in this relationship.

Methods: A total of 309,308 participants from the UK Biobank were included in this study.

Isolation, identification, and characterization of a marine strain with antimicrobial activity against .

, an opportunistic pathogen commonly found in the food and cosmetics industries, has serious potential to cause severe human infections and industrial contamination. However, compared to traditional physical or chemical antimicrobial treatment, the novel biological antimicrobial strategies against have not been extensively explored. In this study, a strain with antimicrobial activity against was isolated from a marine grouper aquaculture pond and identified as Dys01.

YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion.

Intestinal ischemia reperfusion (II/R) injury is a common critical disease with high morbidity and mortality. The mechanism of II/R-induced acute lung injury (ALI) is not fully elucidated. Yes-associated protein (YAP), a downstream transcriptional coactivator of the Hippo signaling pathway, plays a central role in controlling organ development and cell proliferation.

Lactobacillus gallinarum improves broiler performance by enhancing antioxidant capacity and regulating intestinal microbiota.

The predominant objective in large-scale poultry farming has consistently been to enhance broiler. In this context, the supplementing of probiotics, specifically Lactobacilli, has emerged as a promising strategy to improve production efficiency. Numerous studies have demonstrated that Lactobacilli could modulate intestinal microbiota.

EBV-Derived miR-BART20-3p Influences Proliferation and Migration in EBV-Positive Gastric Cancer Models by Suppressing PPARα.

Epstein-Barr virus (EBV) is the first oncogenic DNA virus known to encode microRNAs (miRNAs) and has been implicated in the pathogenesis of multiple malignancies, including a distinct subset of gastric cancers (EBV-associated gastric cancer, EBVaGC). However, the functional roles of individual EBV-encoded miRNAs in EBVaGC remain poorly defined. In this study, we integrate bioinformatic and experimental analyses to uncover a novel oncogenic axis driven by EBV-encoded miR-BART20-3p.

Aldolase A accelerates hepatocarcinogenesis by refactoring c-Jun transcription.

Hepatocellular carcinoma (HCC) expresses abundant glycolytic enzymes and displays comprehensive glucose metabolism reprogramming. Aldolase A (ALDOA) plays a prominent role in glycolysis; however, little is known about its role in HCC development. In the present study, we aim to explore how ALDOA is involved in HCC proliferation.

Research Progress on the Preparation and Application of Decellularized Tendons.

Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years.

Topical Gel/Microsphere Eyedrop for Combined Delivery of Brimonidine and Timolol: A Comparative Study With Traditional Eye Drops in Rabbits.

Purpose: Topical eye drops combining multiple antiglaucoma agents are often required when monotherapy fails to reduce intraocular pressure (IOP). However, their effectiveness is compromised by low bioavailability and poor patient compliance. To address these issues, we developed a novel gel/microsphere eye drop (GME) containing brimonidine and timolol, aimed at enhancing ocular bioavailability, reducing dosing frequency, and improving patient compliance.

Astragaloside IV Alleviates HO-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.

Oxidative stress and mitochondrial dysfunction play critical roles in the pathology of cardiovascular diseases. However, the effects of Astragaloside IV (As-IV) on mitochondrial function remain unclear. This study is aimed at evaluating the protective effects and mechanism of As-IV against HO-induced mitochondrial dysfunction in H9c2 cells.

Topography-guided subconjunctival oblique limbus incisions (SCOLI) in manual cataract surgery for astigmatism correction.

Purpose: To assess the safety and efficacy of two SCOLI designs (Yang's I/II) for astigmatism correction in manual cataract surgery and define incision size-astigmatism relationships.

Methods: A total of 72 eyes from 64 cataract patients who accept manual cataract extraction surgery via a SCOLI technique. The two different types of incision: Yang's I and II incisions were applied in this study.

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis.

Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategies.

Learning With Self-Calibrator for Fast and Robust Low-Light Image Enhancement.

Convolutional Neural Networks (CNNs) have shown significant success in the low-light image enhancement task. However, most of existing works encounter challenges in balancing quality and efficiency simultaneously. This limitation hinders practical applicability in real-world scenarios and downstream vision tasks.

Genetic skeletal disorders: phenotypic-genotypic characteristics and RhGH therapy responses of a pediatric cohort.

This study aimed to explore the genotype-phenotype correlations in individuals with Genetic Skeletal Disorders (GSD), evaluate the efficacy of recombinant human Growth Hormone (rhGH) therapy. The retrospective analysis of the medical records of 80 pediatric patients with GSD diagnosed via whole-exome sequencing was conducted. The therapeutic effects of rhGH treatment were analyzed in 30 of these patients who received rhGH therapy.

A novel necroptosis related prognostic signature for skin cutaneous melanoma based on transcriptome and single cell sequencing analysis.

Necroptosis is a novel programmed cell death that affects the tumor heterogeneity, microenvironment, and prognosis, which is not well elucidated in skin cutaneous melanoma (SKCM). The SKCM-TCGA, GSE65904, and GSE215120 datasets were downloaded from the TCGA and GEO databases, respectively. The necroptosis-related genes were identified by weighted co-expression network analysis (WGCNA) and single-cell sequencing analysis.

Regulative synthesis of capsular polysaccharides in the pathogenesis of .

() is an important zoonotic pathogen causing substantial economic losses in the swine industry. serotype 2 (SS2) is often isolated from the diseased. expresses capsular polysaccharide (CPS), a virulence factor crucial for their survival in the blood.

Beyond energy metabolism: ketogenic diet and β-hydroxybutyrate protect against intestinal ischemia-reperfusion injury through anti-inflammatory and barrier-preserving effects.

Intestinal ischemia-reperfusion injury (IRI) is a significant clinical challenge with limited effective treatments. This study investigated the protective effects of ketogenic diet (KD) and β-hydroxybutyrate (BHB) against intestinal IRI using mouse models and intestinal organoids. Following two weeks of KD or BHB administration, mice were subjected to superior mesenteric artery occlusion (60 min) and reperfusion (4 h).

Sex Differences in the Effects of Cadmium and Uric Acid Levels on Hypertension Risk: A Dose-Response Relationship and Synergistic Effect Study.

Objective: This study explored the independent and synergistic effects of cadmium (Cd) and uric acid (UA) levels on hypertension risk, with a focus on sex differences.

Methods: Data from 8043 National Health and Nutrition Examination Survey participants were analyzed using logistic regression, restricted cubic spline (RCS), and interaction effect models. A meta-analysis of eight studies was also conducted.

Clinical significance of elevated tumor markers in patients with biliary pancreatitis.

Objective: This study explores the clinical significance of elevated tumor markers in patients with biliary pancreatitis. It aims to develop a machine learning-based clinical prediction model to facilitate early intervention and improve outcomes in acute biliary pancreatitis (ABP).

Methods: We collected data from patients admitted with biliary pancreatitis to the Department of General Surgery at Jiangsu University Hospital from January 1, 2016, to December 31, 2023.

Klotho Regulates the Extracellular Matrix Metabolism via TGF-β1/Wnt Signaling Pathway of Fibroblasts in Pelvic Organ Prolapse.

Pelvic organ prolapse (POP) is a gynecological disease frequently diagnosed in middle-aged and elderly women. Klotho is an antiaging protein. This study aimed to investigate the regulatory role and potential molecular mechanism of Klotho in the pathological process of POP.

Progress in the application of fludeoxyglucose positron emission tomography computed tomography in biliary tract cancer.

Biliary tract cancer (BTC) is a group of heterogeneous sporadic diseases, including intrahepatic, hilar, and distal cholangiocarcinoma, as well as gallbladder cancer. BTC is characterized by high invasiveness and extremely poor prognosis, with a global increased incidence due to intrahepatic cholangiocarcinoma (ICC). The 18F-fludeoxyglucose positron emission tomography (PET) computed tomography (18F-FDG PET/CT) combines glucose metabolic information (reflecting the glycolytic activity of tumor cells) with anatomical structure to assess tumor metabolic heterogeneity, systemic metastasis, and molecular characteristics noninvasively, overcoming the limitations of traditional imaging in the detection of micrometastases and recurrent lesions.

Research status and progress of deep learning in automatic esophageal cancer detection.

Esophageal cancer (EC), a common malignant tumor of the digestive tract, requires early diagnosis and timely treatment to improve patient prognosis. Automated detection of EC using medical imaging has the potential to increase screening efficiency and diagnostic accuracy, thereby significantly improving long-term survival rates and the quality of life of patients. Recent advances in deep learning (DL), particularly convolutional neural networks, have demonstrated remarkable performance in medical imaging analysis.