Knowledge, Attitudes, and Practices Regarding Post-Cardiac Arrest Syndrome Among Chinese Physicians: A Dual-Center Cross-Sectional Study.

Background: Post-cardiac arrest syndrome (PCAS) occurs after cardiac arrest resuscitation, causing cardiac and neurological sequelae if not well treated. In China, physicians are vital in PCAS management from early diagnosis, therapeutic treatment to individualized care. Physicians' knowledge, attitudes, and practices (KAP) towards the condition significantly affect such process, which remain understudied in China.

Development of a predictive model for metachronous liver metastasis in gastric cancer.

Background: Patients with metachronous liver metastasis (MLM) in gastric cancer generally have a poor prognosis. Early detection and accurate prediction of MLM are crucial for improving clinical outcomes. This study aims to identify the risk factors for MLM through clinical pathological parameters and develop a predictive model for MLM in gastric cancer.

Pain-Free and Wireless Luminescent Microneedle Sensor Array for In Situ Monitoring Tissue Oxygenation Status in Diabetic Foot Ulcers.

Diabetic foot ulcers (DFUs) is a severe complication of diabetes, progressing insidiously at early stages but eventually leading to amputation. Therefore, to effectively bring DFUs under control, early diagnosis is crucial. Recent researches have shown that DFUs progression correlates with tissue oxygenation.

Effects of aerobic exercise on executive function in children and adolescents with attention deficit hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials.

Background: The benefits of aerobic exercise on the executive function of children and adolescents have been confirmed to a certain extent. However, the effects of such interventions on the executive function of children and adolescents with attention deficit hyperactivity disorder (ADHD) require further exploration. This study is a systematic review of randomized controlled trials (RCTs) of aerobic exercise interventions for children and adolescents with ADHD, aiming to provide valuable intervention suggestions to enhance the executive function of children and adolescents with ADHD.

ARID1A-Deficient and 11q13-Amplified Metastatic Pancreatic Cancer Initially Presenting as Retroperitoneal Fibrosis in a Patient with Familial CHEK2 Variant.

: Retroperitoneal fibrosis (RPF), a rare fibroinflammatory disorder, is classified into idiopathic (iRPF) and secondary (sRPF) forms, with the latter posing significant diagnostic challenges in routine clinical pathway due to atypical presentations, especially in malignancy-associated (maRPF) cases. : Here, we report a 38-year-old female with congenital pancreatic hypoplasia presenting with elusive hypometabolic retroperitoneal masses, initially suggestive of iRPF. Persistent CA19-9 elevation prompted histopathological evaluation, revealing poorly differentiated adenocarcinoma of indeterminate origin.

Zn-Bi Catalytic Pair Enables Selective Superoxide Radical Generation for Simultaneous Removal of Organic Pollutants and Heavy Metals.

Manipulating exciton dissociation and charge-carrier transfer processes to selectively generate redox-capable superoxide (O ) for the removal of antibiotic-heavy metal-combined pollutants is challenging. To address this issue, a Zn-Bi catalytic pair with a dual d electronic configuration is constructed. The incorporation of Zn atoms into the lattice results in the formation of a Zn-O-Bi defect structure, thereby enhancing the built-in electric field by 5.

High-Safety Design of Organic Electrolytes for Sodium-Ion Batteries.

The pursuit of intrinsically safe sodium-ion batteries (SIBs) with high energy density has spurred significant research into developing nonflammable organic liquid electrolytes, given their wide electrochemical stability window and excellent compatibility with electrodes. As safety requirements grow increasingly stringent, electrolyte design must comprehensively address both internal risks such as dendrite growth, parasitic reactions, and high flammability, and external abuses including overcharging and short circuits. In this review, the critical role of electrolytes in suppressing thermal runaway in SIBs is systematically elucidated, and contemporary methodologies for electrolyte safety assessment are summarized.

A multicenter single-arm clinical study of Chinese children's cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol.

The Realgar-Indigo Naturalis formula (RIF) is a proprietary Chinese medicine, which is one of the important drugs in the treatment of pediatric acute promyelocytic leukemia (APL). However, the dose of RIF in clinical application is not uniform and the long-term effectiveness and safety of combining RIF with all-trans retinoic acid (ATRA) in a larger population of pediatric APL patients remains undocumented. We conducted a multicenter single-arm clinical trial (ChiCTR-OIC-16010014) in China.

Temporal Features of Gamma Activity of Hyper-direct Pathway Regulated by Dopamine Receptors in the Dyskinetic Rat.

Cortico-thalamic projections (the hyper-direct pathway) are implicated in levodopa-induced dyskinesia (LID), a challenging complication in the advanced stages of Parkinson's disease (PD). Excessive beta and gamma activity in PD and LID has frequently been reported in recent cross-sectional studies. We aimed to investigate the temporal features of beta and gamma activity in the hyper-direct pathway during the development of PD and LID in rats, as well as the regulatory role of the dopamine receptors DI (D1Rs) and DIII (D3Rs) in these disorders.

CropPhenoX: high-throughput automatic extraction system for wheat seedling phenotypic traits based on software and hardware collaboration.

Accurately quantifying wheat seedling phenotypic traits is crucial for genetic breeding and the development of smart agriculture. However, existing phenotypic extraction methods are difficult to meet the needs of high-throughput and high-precision detection in complex scenarios. To this end, this paper proposes a high-throughput automated extraction system for wheat seedling phenotypic traits based on software and hardware collaboration, CropPhenoX.

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach.

Relatively little is known about the microbial variations within the human appendix niche. To overcome this knowledge gap, we employed endoscopic retrograde appendicitis treatment (ERAT) technology to collect microbial samples from the appendix lumen, followed by shotgun metagenomic sequencing on participants with acute appendicitis without antibiotic treatment. Compared to the cecum and terminal ileum, the appendix had a higher abundance at the genus level of Sphingobium, Leptotrichia and Oribacterium, as well as a significant increase in species-level abundance of oral bacteria, including Streptococcus sanguinis, Streptococcus australis, Streptococcus sp.

Robotic gastrointestinal surgery using the weigao surgical robot system: a single-centre prospective analysis.

Background: The Weigao surgical robot system (WG-NST600S) was successfully developed in China. In this study, we presented our single-centre experience and the short-term outcomes of gastrointestinal surgeries performed using the WG-NST600S system.

Materials And Methods: Between April 2024 and February 2025, consecutive gastrointestinal surgeries were performed using the WG-NST600S system at the participating institution.

Divergent residues influence PHYTOENE SYNTHASE isozyme interactions with GGPPS and the resulting enzyme activities in peach.

Carotenoids serve critical biological functions through their essential contributions to organismal survival and health. As a widely consumed fruit species, peach (Prunus persica) provides humans with valuable carotenoid sources, and these compounds also substantially enhance the aromatic properties of peach fruits. The synthesis of phytoene, catalyzed by phytoene synthase (PSY), constitutes a key rate-limiting step in carotenoid biosynthesis.

Optimal number of the examined lymph nodes for different N stages in colorectal cancer.

The National Comprehensive Cancer Network (NCCN) recommends that at least 12 lymph nodes (LNs) should be harvested during radical surgery of colorectal cancer (CRC). This study aims to clarify the optimal number of LNs that should be examined during the radical surgery for CRC patients with each N stage. The SEER database (n = 48,331) served as the primary cohort, while the Xijing cohort (n = 4447) was used for external validation.

Three-stage dynamics of nonlinear pulse amplification in an ultrafast mid-infrared fiber amplifier with anomalous dispersion.

Nonlinear pulse amplification in optical fiber, with the capability of breaking the gain-bandwidth limitation, is a key technique for high-energy, ultrafast pulse generation. In the longer wavelength region (including 1.55 μm, 2 μm and 2.

Modulating the nonlinear refractive index through F/O ratio to reduce the self-focusing effect of fluorophosphate glasses.

In this study, we systematically investigated the relationship between the F/O ratio and the nonlinear refractive index of fluorophosphate glass, revealing that the nonlinear refractive index decreased exponentially as the F/O ratio increased. A formula for calculating the nonlinear refractive index based on the composition of fluorophosphate glasses was proposed. Since the nonlinear refractive index is directly related to self-focusing damage, we demonstrated through femtosecond laser-induced damage experiments that the F/O ratio can effectively modulate the self-focusing damage properties of fluorophosphate glass.

Electro-optical sampling-based frequency response characterization of photodetectors beyond 120 GHz using a fiber-optic frequency comb.

With the rapid development of high-speed data transmission and fiber-optic communication, the frequency response range of high-speed photodetectors is gradually moving towards higher frequencies. The electro-optical sampling-based frequency response characterization technique is considered a terahertz-band-oriented characterization technique with the advantages of wide bandwidth, high accuracy, high spatial resolution, and the possibility of simultaneous time-frequency-domain measurements. To further expand the measurement capability and optimize the measurement stability, in this work, electro-optical sampling-based frequency response characterization of high-speed photodetectors at 90, 100, and 145 GHz is conducted using a femtosecond fiber-optic frequency comb and a electro-optic crystal coplanar waveguide.

Joint optimization technique of image enhancement and object detection based on a genetic algorithm for underwater target detection.

Underwater images often suffer from severe degradation issues such as color distortion and haze, significantly impacting object detection performance. Most existing approaches treat image enhancement and object detection as two separate tasks, first enhancing the image, then performing object detection. However, the enhancement process does not necessarily improve the detection accuracy due to the lack of effective interaction between these two tasks.

A Rare Case of Uterine Embryonal Rhabdomyosarcoma.

Background: Uterine sarcoma is a rare mesenchymal malignancy, and its preoperative diagnosis presents significant challenges, often resulting in the so-called occult sarcoma following surgery, based on the pathological diagnosis. Embryonal rhabdomyosarcoma of the female genital tract most commonly presents in pediatric patients and occurs in the uterine cervix. A pure uterine embryonal rhabdomyosarcoma presenting in an older adult patient is exceedingly rare.

Hydrogen/solvent-free plastic valorization loosely coordinated ruthenium sites steering selective aromatization.

The development of hydrogen- and solvent-free catalytic systems for plastic valorization requires precise control over metal speciation to enhance both catalytic efficiency and selectivity. Ru atomic clusters (ACs) on HZSM-5 zeolite show a turnover frequency of 52.71 mg mg h in low-density polyethylene (LDPE) conversion, a fivefold increase compared to traditional nanoparticles (NPs) at 10.

Development of a versatile chassis for the efficient production of diverse type II polyketides.

Type II polyketides (T2PKs) exhibit a wide range of structural diversity and potent pharmacological activities. However, the optimal chassis for the synthesis of T2PKs remains elusive, impeding the effective mining and production of these compounds. In this study, we identify Streptomyces aureofaciens J1-022, a high-yield producer of chlortetracycline, as a promising chassis for T2PKs synthesis.

Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement.

Background: Myeloid cells, such as resident microglia (MG), infiltrating monocytes (Mo), macrophages (MΦ), and CNS border-associated macrophages (BAM) in the brain, participate in aged brain injury. Aged microglial replacement is protective against brain injury in aged mice; however, whether/how the molecular changes in myeloid cells are affected by this replacement in injured brains remains unclear.

Methods: Aged microglia in mice were eliminated by PLX3397 for 21 consecutive days and repopulated following withdrawal for 21 days; then, intracerebral hemorrhage (ICH) models were constructed.

Cellulose nanocrystals reinforced polyvinyl alcohol hydrogel with thermal, mechanical, and ionic responsive behavior.

Conventional polyvinyl alcohol (PVA) hydrogels with isotropic polymer networks usually lack selective responses to external stimuli, which significantly limits their applications in smart devices. In this work, a series of double network (DN) composite PVA hydrogels reinforced with cellulose nanocrystal (CNC) were prepared by in situ photopolymerization of functional monomers and freeze-thawing (F-T). The incorporation of CNC and the DN structure resulted in the high tensile strength of the hydrogel (1.

Integrated omics identifies molecular networks of brain-body interactions of brain injury.

The molecular mechanisms of brain-body interactions in the progression of brain diseases remain unknown. Through integrative analysis of multi-organ proteomic, metabolomic, and transcriptomic data following ischemic stroke, we identified dynamic molecular signatures across organs. The heart exhibited the highest number of differentially expressed proteins (DEPs), followed by spleen and intestine.

Utilizing multiplex reverse transcription-multiple cross displacement amplification-lateral flow biosensor technology for detecting H1N1, H3N2 and H7N9 influenza A virus subtypes.

Respiratory infections caused by influenza A viruses (IAVs) pose a global threat annually, leading to significant mortality in severe cases. IAVs are classified into various subtypes, and a combination of multiplex reverse transcription-multiple cross displacement amplification (mRT-MCDA) and lateral flow biosensor (LFB) has been developed to detect three subtypes (H1N1, H3N2, and H7N9) that have been frequently observed in recent years. This technology simultaneously reverse transcribes and amplifies two target genes, hemagglutinin (HA) and neuraminidase (NA), at a constant temperature of 63 °C in just 40 min.