PdbNAC1 transcription factor confers salt tolerance by regulating stress-response and secondary wall biosynthesis genes in Populus davidiana × P. bolleana.

Soil salinity represents a major abiotic stress factor that inhibits plant growth and causes substantial yield losses. NAC transcription factors (TFs) play essential roles in plant biological processes and stress responses; however, their functions and underlying mechanisms in salt stress response remain inadequately understood. In this study, we characterized a PdbNAC1 TF from P.

Radical surgery versus definitive radiotherapy in treatment of locoregional upper esophageal squamous cell carcinoma.

Backgrounds: Current consensus guidelines lack robust evidence to advocate the optimal treatment approach for locoregional upper esophageal squamous cell carcinoma (L-UESCC). The purpose of this study was to conduct an in-depth investigation of the treatment patterns, outcomes, and prognostic factors among patients with L-UESCC.

Methods: Consecutive patients diagnosed with L-UESCC who underwent curative-intent treatment at two cancer centers from January 2013 to December 2018 were enrolled in this study.

Visible-Light-Driven Photoredox-Catalyzed Radical Cyclization via a TEMPO-Intercepted Cascade: Regioselective and Access to Cyclopentene Skeletons.

A visible-light-driven regioselective intramolecular cyclization and oxidation cascade of γ-alkynyl β-sulfonylester is developed. This metal-free approach efficiently affords synthetically useful cyclopentene and cyclohexene skeletons under mild conditions, with TEMPO acting as a dual electron and oxygen atom donor. Mechanism investigations support a radical cyclization/TEMPO-trapping cascade.

National trends in depressive symptoms, antidepressant use, and mental health consultations among US adults, 2005-2020.

Objectives: Depression significantly contributes to the global disease burden. This study aims to monitor national trends in depressive symptoms, antidepressant use and mental health consultations among American adults and identify key subgroups that require attention.

Study Design: Serial cross-sectional analysis.

Lipid-Modified Bilirubin Nanocrystals for the Repair of Ischemia-Reperfusion-Induced Acute Kidney Injury.

Ischemia-reperfusion (IR)-induced acute kidney injury (AKI) is a life-threatening form of AKI frequently observed in clinical settings, such as hemorrhagic shock, kidney transplantation, and cardiovascular surgery. Targeting renal antioxidant therapy may represent an effective strategy against IR-induced AKI. Bilirubin (BR), a specific superoxide anion scavenger, faces limitations in clinical application due to its poor water solubility and hepatic metabolism pathway.

Bioartificial liver: Where lies the path ahead-A review.

Despite its proven effectiveness in treating liver failure, liver transplantation is often impractical due to its high surgical risks involved and the limited availability of donor organs. Blood purification technologies used in non-bioartificial liver (NBAL) systems have improved clinical cure rates, but they do not substitute for the complex biosynthesis, detoxification, metabolism, and biological transformation roles of the liver. To overcome these challenges brought by NBAL systems, bioartificial liver (BAL) systems have been developed with repeated optimization of both hepatocyte sources and bioreactors to emulate a "fully functional liver".

[Modified scrotoscopic surgery for testicular hydrocele].

Objective: To explore the application of modified scrotoscopic surgery (MSS) in the treatment of testicular hydrocele.

Methods: We selected 45 cases of testicular hydrocele for this study, 22 treated by traditional scrotoscopic surgery (TSS) and the other 23 by MSS, which was performed with a pin-shaped electrode bent inward at an angle of 60° instead of a circular electrode used in TSS. We recorded the general clinical data, operation time, incision length, intraoperative injury, incision infection, scrotal edema, postoperative hospital stay and postoperative Visual Analogue Scale (VAS) scores of the patients and compared them between the two groups.

[Application of China-made Toumai Robot in laparoscopic radical prostatectomy].

Objective: To evaluate the safety and efficiency of China-made Toumai Robot-assisted laparoscopic radical prostatectomy (LRP).

Methods: This study included 40 cases of PCa treated from January 2023 to May 2023 by robot-assisted LRP with preservation of the bladder neck and maximal functional urethral length, 15 cases with the assistance of Toumai Robot (the TMR group) and the other 25 with the assistance of da Vinci Robot as controls (the DVR group). We recorded the docking time, laparoscopic surgery time, vesico-urethral anastomosis time, intraoperative blood loss and postoperative urinary continence, and compared them between the two groups.

Mixed infections and heteroresistance of among multidrug-resistant tuberculosis in China: a genomic epidemiology study.

Mixed infection refers to the presence of multiple strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes. Mixed infections and heteroresistance with can complicate drug resistance diagnosis, treatment options, and transmission inference. We conducted a population-based genomic epidemiological study of multidrug-resistant tuberculosis (MDR-TB) in Shanghai, China, between January 1, 2005, and December 31, 2018, to evaluate the prevalence and impact of mixed infection and heteroresistance on MDR-TB diagnosis and treatment outcomes.

Association between dyslexia and overweight/obesity among Chinese children: findings from a cross-sectional study.

Background: Extensive studies have consistently reported associations between neurodevelopmental disorders and overweight/obesity. However, limited research addressed the weight status of children with dyslexia. Therefore, this study aimed to explore the association between dyslexia and overweight/obesity among Chinese children.

Global research trends and hotspots in prognostic prediction models for pancreatic cancer: a bibliometric analysis.

Background: Pancreatic cancer is a highly aggressive malignancy of the digestive system, characterized by insidious onset and rapid progression. Most cases are diagnosed at advanced stages, complicating surgical resection and presenting significant challenges for clinical treatment. Recent advancements have emphasized individualized treatment strategies tailored to patients' specific conditions.

Porphyromonas gingivalis-induced HuR upregulation suppresses SLC39A10-derived hsa_circ_0057552 in esophageal squamous cell carcinoma.

Porphyromonas gingivalis (P. gingivalis) is one of the main risk factors of esophageal squamous cell carcinoma (ESCC). Circular RNAs (circRNAs) have been found to play a crucial role in many types of cancer.

Jasmonic acid enhances aluminum tolerance of rice by regulating detoxification genes.

Aluminum (Al) stress in acidified soils represents a critical limitation for rice productivity and sustainable cropping. Jasmonic acid (JA) plays a crucial role in plant responses to Al stress, yet its underlying molecular mechanisms remain poorly understood. This study aimed to elucidate the role and mechanisms of JA in mitigating Al toxicity in rice.

Isolated relapse of multiple myeloma in the central nervous system post autologous hematopoietic stem cell transplantation: a case report and literature review.

This case report retrospectively evaluated the diagnosis and treatment of a multiple myeloma (MM) patient with early relapse in the central nervous system (CNS) post autologous hematopoietic stem cell transplantation (AHSCT). We also performed a literature review of treatment options for patients with CNS myeloma. The patient was diagnosed with isolated CNS relapse of multiple myeloma one month after AHSCT, without other extramedullary lesions and with normal blood, urine, and bone marrow profiles.

Mediating role of systemic inflammation on the association between periodontitis and gestational diabetes mellitus: a cross-sectional study.

Objectives: This study aimed to explore the relationship between periodontitis and gestational diabetes mellitus (GDM) and to ascertain the role of systemic inflammation in mediating this association.

Methods: Data from 5,283 women of reproductive age ranging from 20 to 44 years were retrieved from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2009-2014 cycles. The female participants were categorized into three groups: non-diabetes, DM, and GDM.

Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis.

Senile osteoporosis (SOP) primarily arises from an imbalance between bone formation and bone resorption. The tightly regulated coupling between osteoblasts and osteoclasts limits the therapeutic efficacy of conventional anti-resorptive agents and anabolic agents. Anti-aging therapy offers a potential strategy to modify the senescent phenotype of bone-associated cells, restore cellular function, and re-establish homeostasis between bone resorption and formation.

Silica-Driven CO Reduction in Water Microdroplets.

Carbon dioxide (CO), the most notorious greenhouse gas responsible for global warming and ocean acidification, could persist in the atmosphere for 50 to 200 years, posing substantial long-term environmental challenges. However, its environmental fate remains not fully clear. This study reveals a previously unrecognized silica-driven CO reduction pathway in ubiquitous water microdroplets, enabling the efficient conversion of CO primarily into formic acid, along with other C and C products such as methanol, acetic acid, and ethanol, under ambient conditions.

Developmental toxicity and transcriptome analysis of zebrafish (Danio rerio) embryos exposed to anesthetic esketamine.

Esketamine (ESK), a novel intravenous general anesthetic, extensively utilized in obstetric and pediatric anesthesia. However, the potential in vivo toxicity of ESK to growth and development has not been comprehensively evaluated. In this study, we employed a zebrafish model to investigate the developmental toxicity and behavioral alterations induced by ESK in zebrafish embryos.

Ionic-Nanotube Array Membrane Generating Ultrahigh Osmotic Energy Conversion.

Ion exchange membranes (IEMs) are critical components in osmotic energy conversion. However, traditional IEMs suffer from disordered nanochannels due to the lack of precise control over the content and distribution of ionic groups, resulting in an inherent trade-off between ion selectivity and conductivity. One promising strategy is constructing high-density ion channels with minimal ionic groups.

The chromosome-level genome and multi-omics analysis provide new insights into the iridoids biosynthetic pathway.

Introduction: (Rubiaceae) is a medicinal herb with significant therapeutic potential, primarily attributed to its bioactive iridoid compounds. However, the molecular mechanisms governing iridoid biosynthesis in this species remain poorly characterized, limiting its biotechnological and pharmaceutical applications.

Methods: We generated a telomere-to-telomere (T2T) chromosomal-scale genome assembly of (∼482.

A monitoring network SIMNet for weld penetration status based on multimodal fusion.

This paper primarily addresses the challenges posed by the difficulties in directly measuring the fusion width at the bottom of the weld and in real-time monitoring of the penetration state during the groove welding process. It focuses on the research of online penetration state monitoring technology, which utilizes multi-modal signals such as sound and image during the welding process. The multimodal network proposed in this paper, SIMNet, first employs the short-time Fourier transform (STFT) to convert the original sound signal into the time-frequency domain for preliminary feature extraction.

Unveiling the diagnostic and pro-inflammatory role of crohn's disease: insights from 16 S-guided discovery and species-specific validation.

Background: The rising incidence of Crohn's disease (CD) in Asia underscores the need to explore its underlying mechanisms. The interaction between gut microbiota and the host is strongly linked to CD onset and progression, yet the precise mechanisms remain unclear. Previous studies have demonstrated that Ruminococcus gnavus (R.

Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop.

Triple-negative breast cancer (TNBC) represents the most malignant subtype of breast cancer. The clinical application of PARP inhibitors (PARPi) is limited by the low frequency of BRCA1/2 mutations in TNBC. Here, we identified that MTAP deletion sensitized genotoxic agents in our clinical cohort of metastatic TNBC.

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis.

Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls (HC).

The multiple roles of GM-CSF in autoimmune and autoinflammatory uveitis.

Uveitis is an inflammatory disorder of the eye that causes severe vision loss. In autoimmune and autoinflammatory diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA), granulocyte-macrophage colony-stimulating factor (GM-CSF) has been indicated to play a significant pathogenic role that depends on cellular immune responses. Emerging evidence from both experimental models and clinical studies of uveitis suggests that GM-CSF plays a far more complex role than its originally described function as a hematopoietic growth factor that promotes the differentiation of granulocytes and macrophages from progenitor cells.