Long-Acting In Situ Cancer Vaccines by Oncolytic STING-Activating Microgels.

In situ cancer vaccines exploiting endogenous multiple antigens directly from tumors to elicit broad immune responses hold great potential in cancer treatment. However, the feeble antigen presentation and hostile immune microenvironments pose severe challenges to acquiring clinical benefits. Here, oncolytic STING-activating microgels (OSAM) that release oncolytic peptide LTX-315 and STING adjuvant diABZI in a sustained manner (>4 weeks) have been developed to elicit long-acting and powerful antitumor immunity.

Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis.

Background: Breast cancer is the most common malignancy among women worldwide, with early screening and diagnosis being crucial for improving patient prognosis. Taurine, as an important metabolite, shows significant changes during breast cancer development, while the taurine transporter SLC6A6 may play a key role in breast cancer progression.

Methods: This study systematically investigated the relationship between taurine level changes and breast cancer development through cell experiments, animal models, and clinical sample analysis.

Nickel-Catalyzed Three-Component Carboamination of Internal Alkynes toward Tetrasubstituted Enamines and α,β-Unsaturated Imines.

A nickel-catalyzed three-component carboamination strategy has been developed for the regio- and stereoselective synthesis of tetrasubstituted enamines from internal alkynes, organoboronic acids, and anthranils. This system also enables chemodivergent access to α,β-unsaturated imines by employing propargyl alcohols as versatile substrates.

Silica-Driven CO Reduction in Water Microdroplets.

Carbon dioxide (CO), the most notorious greenhouse gas responsible for global warming and ocean acidification, could persist in the atmosphere for 50 to 200 years, posing substantial long-term environmental challenges. However, its environmental fate remains not fully clear. This study reveals a previously unrecognized silica-driven CO reduction pathway in ubiquitous water microdroplets, enabling the efficient conversion of CO primarily into formic acid, along with other C and C products such as methanol, acetic acid, and ethanol, under ambient conditions.

Oncolytic microgels with regulated antibody release augment tumor immunotherapy.

The inhibition of immune checkpoints has emerged as a most successful immunotherapy strategy for cancers; however, it bears a modest clinical response rate and certain cases severe systemic adverse reactions. Here, oncolytic microgels (OMG) that possess similar antitumor activity and immune activation to oncolytic peptide LTX-315 and are capable of sustained release of immune checkpoint inhibitors have been developed to potentiate cancer immunotherapy. Of note, antibodies including anti-PD-1, anti-PD-L1, and anti-CTLA-4 all could be quantitatively loaded into OMG while being gradually released over a couple of weeks in vitro and in tumor as well.

Relationship Between the Drop Rate of Standing Blood Pressure and Major Adverse Cardiovascular Events.

Orthostatic hypotension (OH) is defined as a decrease of ≥20 mm Hg systolic blood pressure (SBP) or ≥10 mm Hg diastolic blood pressure (DBP) within 3 min after standing. OH was associated with an increased risk of major adverse cardiovascular events (MACEs) and mortality. As an indicator reflecting the characteristics of orthostatic blood pressure (BP) changes, there is currently no research available on the relationship between the orthostatic BP drop rate and MACEs or mortality.

Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance.

Background: Liver cirrhosis (LC) affect millions of people worldwide. The pathogenesis of cirrhosis involves complex interactions between immune responses and gut microbiota. Recent studies have highlighted the role of the interleukin-36 (IL-36) subfamily in inflammation and immune regulation.

Effectiveness of Emotional Freedom Techniques in Alleviating Symptoms Associated with Posttraumatic Stress Disorder: A Systematic Review and Meta-analysis.

Introduction: Energy psychology, particularly emotional freedom techniques (EFT), has gained attention as a non-pharmacological treatment for posttraumatic stress disorder (PTSD). We conducted a meta-analysis to assess the efficacy of EFT in alleviating PTSD symptoms.

Methods: This meta-analysis follows PRISMA guidelines.

China's social fake news database release with brain structural, functional, and behavioural measures.

Fake news poses significant societal risks by spreading rapidly on social media. While existing research predominantly examines its propagation patterns and psychological drivers, the neural underpinnings remain insufficiently understood. Moreover, current studies often focus on Western political contexts, overlooking cultural variations where social-lifestyle fake news may be more prevalent, such as in China.

Drug-Target Affinity Prediction Based on Topological Enhanced Graph Neural Networks.

Graph neural networks (GNNs) have achieved remarkable success in drug-target affinity (DTA) analysis, reducing the cost of drug development. Unlike traditional one-dimensional (1D) sequence-based methods, GNNs leverage graph structures to capture richer protein and drug features, leading to improved DTA prediction performance. However, existing methods often neglect to incorporate valuable protein cavity information, a key aspect of protein physical chemistry.

Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study.

In recent years, bipolar disorder (BD), a multifaceted mood disorder marked by severe episodic mood fluctuations, has been shown to have an impact on disability-adjusted life years (DALYs). The increasing prevalence of BD highlights the need for better diagnostic tools, particularly those involving genetic insights. Genetic association studies can play a crucial role in identifying variations linked to BD, shedding light on its genetic underpinnings and potential therapeutic targets.

Homeschooling and child maltreatment: A review of the regulatory context and research evidence in the United States.

An increasing number of families in the United States have opted for homeschooling as an alternative to the formal schooling system. Estimates suggest that in the United States, between 5 % and 11 % of the school-age population participates in homeschooling each year-more than 1.5 million students across the country.

Accelerated peptide bond formation at air-water interfaces.

Peptides and proteins, essential components of living organisms, are composed of amino acids linked by peptide bonds. However, the mechanism of peptide bond formation during the prebiotic era remains unclear. In this study, advanced Born-Oppenheimer molecular dynamics (BOMD) simulations were used to investigate the mechanisms and kinetics of peptide bond formation at air-water interfaces using diglycine, the simplest dipeptide, as a model molecule.

Low-dose Spironolactone Combined with ACEIs/ARBs May Reduce Cardiovascular Events in Patients with CKD Stages 3b-5: A Nationwide Population-Based Cohort Study in Taiwan.

ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly prescribed for hypertension and chronic kidney disease (CKD) management, but they can increase the risk of renal function deterioration and hyperkalaemia. Spironolactone, known for reducing cardiovascular events in CKD patients, faces limited use due to the risk of hyperkalaemia. This study evaluates the potential efficacy and complications of low-dose spironolactone as an adjunct therapy in patients with CKD stages 3b to 5 who are maintained on ACEIs or ARBs.

Correction: Zhao et al. Recombinant Abelson Tyrosine Protein Kinase (rAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells. 2025, , 179.

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Recombinant Abelson Tyrosine Protein Kinase (rAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells.

can modulate host immune mechanisms through excretory-secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite-host immune interaction. To investigate the immunoregulatory function of Abl in , we cloned and expressed the gigantica Abl protein and assessed its effect on specific immune functions of buffalo peripheral blood mononuclear cells (PBMCs).

Arrests among adolescents with a history of foster care placements in group home settings.

Background: Approximately 5 % of children and adolescents in foster care are placed in group home settings, with adolescents making up the largest age group in these placements. Group home placement is designed to support individuals with high acuity or specialized needs that cannot be met in a family-based setting. Prior research has highlighted the vulnerabilities of adolescents in group homes, including behavioral issues, mental health concerns, and juvenile justice system involvement.

Therapeutic Effects of Theta Burst Stimulation on Cognition Following Brain Injury.

This case report explores the therapeutic potential of theta burst stimulation (TBS) for cognitive enhancement in individuals with brain injuries. The study presents a 38-year-old male suffering from an organic mental disorder attributed to a traumatic brain injury (TBI), who demonstrated notable cognitive improvements following an intensive TBS protocol targeting the left dorsal lateral prefrontal cortex. The treatment led to significant enhancements in impulse control, irritability, and verbal comprehension without adverse effects.

Atomically Dispersed FeMo Dual Sites for Enhanced Electrocatalytic Nitrogen Reduction.

The electrocatalytic nitrogen reduction reaction (eNRR) is an attractive strategy for the green and distributed production of ammonia (NH); however, it suffers from weak N adsorption and a high energy barrier of hydrogenation. Atomically dispersed metal dual-site catalysts with an optimized electronic structure and exceptional catalytic activity are expected to be competent for knotty hydrogenation reactions including the eNRR. Inspired by the bimetallic FeMo cofactor in biological nitrogenase, herein, an atomically dispersed FeMo dual site anchored in nitrogen-doped carbon is proposed to induce a favorable electronic structure and binding energy.

Dual-Targeted Assembled Nanodrugs for Near-Infrared Photothermal Immunotherapy of Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is known for its poor prognosis and aggressive behavior, being highly prone to recurrence and metastasis, and currently has limited effective treatment options. Photothermal therapy (PTT) is an emerging, minimally invasive, low-drug-resistance, and precisely controllable therapeutic method for cancer treatment, offering hope to break through the bottleneck in TNBC therapy. The antitumor efficiency of PTT is predominantly contingent upon the performance of the photothermal drugs.

Impacts of Fruit Frosting Coverage on Postharvest Softening of Prunes under Vibration Stress.

The surface of prune fruit has a thick layer of frosting, which is easily damaged and lost during prunes harvest or postharvest handling, and there is no clear information on the effect of prune surface frost on postharvest storage quality. To investigate the effect of fruit frosting on the softening of prune fruits during storage under vibration stress, prunes were divided into three grades according to fruit frosting in this study and were vibrated for 8 h at a frequency of 5 Hz at 4 °C; then, samples were selected once every 8 d. The results showed that the heavy fruit frosting (HFF) group maintained higher hardness (21.