Striatal GluN2A gene suppression reduces L-DOPA-induced abnormal involuntary movements in parkinsonian rats.

L-DOPA-induced dyskinesia (LID) is a common disabling complication of long-term L-DOPA therapy in Parkinson's disease (PD). LID development is associated with maladaptive plasticity mechanisms in striatal circuits contributed by dysregulated dopamine and glutamate signaling. Upregulation of the NMDAR subunit 2A (GluN2A) over chronic L-DOPA treatment is thought to play a role in corticostriatal synaptic changes.

Association between taurine transporter SLC6A6 and breast cancer development and prognosis: a Mendelian randomization analysis.

Background: Breast cancer is the most common malignancy among women worldwide, with early screening and diagnosis being crucial for improving patient prognosis. Taurine, as an important metabolite, shows significant changes during breast cancer development, while the taurine transporter SLC6A6 may play a key role in breast cancer progression.

Methods: This study systematically investigated the relationship between taurine level changes and breast cancer development through cell experiments, animal models, and clinical sample analysis.

The open sharing operation mechanism of health data in the digital healthcare era: A study based on grounded theory and interpretative structural modeling method.

Objective: In the evolving digital healthcare landscape, the strategic exploitation of open health data has become increasingly pivotal. The open sharing of health data is essential due to its irreplaceable role in digital health care. It is made feasible by the development of emerging technologies and the support of national policies.

Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace.

Objective: To visually analyze the current status, hotspots, and frontiers of irisin in the nervous system and to provide a reference for future clinical research.

Methods: Web of Science Core Collection (WoSCC), PubMed, Embase, and Cochrane Library databases were searched for studies on the mechanism of irisin on the nervous system published from January 1st, 2012 to April 15th, 2025. CiteSpace 6.

Differential effects of left DLPFC anodal and cathodal tDCS interventions on the brain in children with autism: A randomized controlled trial.

Background: Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder with few effective treatment options. In recent years, transcranial direct current stimulation (tDCS) has been applied in interventions for ASD, often targeting the left dorsolateral prefrontal cortex (DLPFC). However, studies investigating anodal and cathodal tDCS interventions have reported differing outcomes.

Construction of a new tool for predicting cancer-specific survival in papillary thyroid cancer patients who have not received surgery.

Background: The prevalence of papillary thyroid cancer is gradually increasing and the trend of youthfulness is obvious. Some patients may not be able to undergo surgery, which is the mainstay of treatment, due to physical or financial reasons. Therefore, the prediction of cancer-specific survival (CSS) in patients with non-operated papillary thyroid cancer is necessary.

[Corrigendum] (‑)‑Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase‑dependent pathway and Bcl‑2 family protein modulation.

Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 3 on p. 1510, the western blot images selected to portray the caspase 7 and PARP/cleaved PARP experiments were remarkably similar.

Genome-wide identification analysis in wild-type reveals some genes defending against .

exhibits strong resistance to late blight caused by but only an incomplete genome assembly based on short Illumina reads has been published. In this study, we generated the first chromosome-level draft genome for the wild-type potato species in China using Oxford Nanopore technology sequencing and Hi-C technology. The high-quality assembled genome size is 664 Mb with a scaffold N50 value of 49.

Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site.

Background: Allogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the transplanted cells remains a daunting task, as they are actively cleared by the recipient's immune system. Therefore, a detailed understanding of the innate or adaptive immune cells-derived responses against allogeneic transplanted hepatic cells is the key to rationalize cell-based therapies.

Fast needling combined with occupational therapy for hand dysfunction of spastic cerebral palsy : a randomized controlled trial.

Objectives: To compare the clinical effect of fast needling (without needle retaining), needle retaining acupuncture combined with occupational therapy and simple occupational therapy for hand dysfunction of spastic cerebral palsy in children.

Methods: A total of 75 children with spastic cerebral palsy were randomly divided into an occupational therapy group (25 cases), a fast needling group (25 cases, 1 case dropped out) and a needle retaining group (25 cases, 1 case dropped out). The patients in the occupational therapy group were only treated with occupational therapy for 20 min each time.

Development of EEG connectivity from preschool to school-age children.

Introduction: Many studies have collected normative developmental EEG data to better understand brain function in early life and associated changes during both aging and pathology. Higher cognitive functions of the brain do not normally stem from the workings of a single brain region that works but, rather, on the interaction between different brain regions. In this regard studying the connectivity between brain regions is of great importance towards understanding higher cognitive functions and its underlying mechanisms.

Risk prediction models for cardiovascular events in hemodialysis patients: A systematic review.

Objective: To perform a systematic review of risk prediction models for cardiovascular (CV) events in hemodialysis (HD) patients, and provide a reference for the application and optimization of related prediction models.

Methods: PubMed, The Cochrane Library, Web of Science, and Embase databases were searched from inception to 1 February 2023. Two authors independently conducted the literature search, selection, and screening.

SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.

Unlabelled: The DNA damage response (DDR) is essential for the maintenance of genomic stability. Protein posttranslational modifications play pivotal roles in regulating the DDR process. Here, we found that SUMOylated RNF168 undergoes liquid-liquid phase separation (LLPS), which restricts the recruitment of RNF168 to DNA damage sites, reduces RNF168-catalyzed H2A ubiquitination, restrains 53BP1 in nuclear condensates, and ultimately impairs nonhomologous DNA end joining repair efficiency.

Comparative genomics reveals intraspecific divergence of : insights from evolutionary adaptation.

serves as a model chemolithoautotrophic organism in extremely acidic environments, which has attracted much attention due to its unique metabolism and strong adaptability. However, little was known about the divergences along the evolutionary process based on whole genomes. Herein, we isolated six strains of from mining areas in China and Zambia, and used comparative genomics to investigate the intra-species divergences.

Insertion sequence contributes to the evolution and environmental adaptation of Acidithiobacillus.

Background: The genus Acidithiobacillus has been widely concerned due to its superior survival and oxidation ability in acid mine drainage (AMD). However, the contribution of insertion sequence (IS) to their biological evolution and environmental adaptation is very limited. ISs are the simplest kinds of mobile genetic elements (MGEs), capable of interrupting genes, operons, or regulating the expression of genes through transposition activity.

hCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex.

Cellular senescence is a major process affected by multiple signals and coordinated by a complex signal response network. Identification of novel regulators of cellular senescence and elucidation of their molecular mechanisms will aid in the discovery of new treatment strategies for aging-related diseases. In the present study, we identified human coilin-interacting nuclear ATPase protein (hCINAP) as a negative regulator of aging.

H-NMR-Based Metabonomics Study to Reveal the Progressive Metabolism Regulation of SAP Deficiency on ApoE Mice.

Atherosclerosis is the most common disease of the vascular system and the metabolic disorder is one of its important molecular mechanisms. SAP protein is found to be highly expressed in atherosclerotic blood vessels. Our previous study found that SAP deficiency can significantly inhibit the development of atherosclerosis.

Hepatic DKK1-driven steatosis is CD36 dependent.

Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide; about 25% of NAFLD silently progress into steatohepatitis, in which some of them may develop into fibrosis, cirrhosis and liver failure. However, few drugs are available for NAFLD, partly because of an incomplete understanding of its pathogenic mechanisms. Here, using in vivo and in vitro gain- and loss-of-function approaches, we identified up-regulated DKK1 plays a pivotal role in high-fat diet-induced NAFLD and its progression.

SRPX2 Promotes Tumor Proliferation and Migration via the FAK Pathway in Papillary Thyroid Carcinoma.

Thyroid cancer is the most common form of endocrine cancer around the world, and among which papillary thyroid carcinoma (PTC) is the most ubiquitous pathological sub-kind. Sushi repeat-containing protein X-linked 2 (SRPX2) was reported to be an independent prognostic factor and significantly overexpressed in advanced PTC patients. However, the biological functions of SRPX2 remain ambiguous in PTC.

Short-form development of the specific module of the QLICD-CRF(V2.0) for assessing the quality of life of patients with chronic renal failure.

Background: A short instrument would enhance the viability of a study. Therefore, we aimed to shorten the specific module (SPD-10) of the Quality of Life Instrument for Chronic Diseases - Chronic Renal Failure (QLICD-CRF) for assessing the quality of life of patients with chronic renal failure.

Methods: The 10-item SPD-10 was self-administered to 164 patients with chronic renal failure.

Exceeding 30 % External Quantum Efficiency in Non-doped OLEDs Utilizing Solution Processable TADF Emitters with High Horizontal Dipole Orientation via Anchoring Strategy.

Strategies to enhance the ratio of the molecular horizontal emitting dipole orientation (Θ ) for thermally activated delayed fluorescence (TADF) emitters have unlocked the full potential of efficiencies for the evaporated devices, which, however, remain elusive for the solution-processed ones. Here, a strategic molecular design for solution processable TADF emitters featuring high Θ s is proposed by attaching flexible chains ended with bipolar 9,9'-spirobi[fluorene] subunits as anchoring groups onto TADF emitting core. It's unveiled that the anchoring groups not only enhance the horizontal orientation via enlarging molecular planarity, but also benefit the high photoluminescence in pristine films.

Divergent prokaryotic microbial assembly, co-existence patterns and functions in surrounding river sediments of a Cu-polymetallic deposit in Tibet.

The exploitation of polymetallic deposits produces large amounts of mine drainage, which poses great challenges to the surrounding aquatic ecosystem. However, the prokaryotic microbial community assembly and co-existence patterns in the polluted area are poorly understood, especially in high-altitude localities. Herein, we investigated the prokaryotic microbial assembly, co-existence patterns and their potential functional responses in surrounding river sediments of a Cu-polymetallic deposit in Tibet.

Modeling MEN1 with Patient-Origin iPSCs Reveals GLP-1R Mediated Hypersecretion of Insulin.

Multiple endocrine neoplasia type 1 (MEN1) is an inherited disease caused by mutations in the gene encoding a nuclear protein menin. Among those different endocrine tumors of MEN1, the pancreatic neuroendocrine tumors (PNETs) are life-threatening and frequently implicated. Since there are uncertainties in genotype and phenotype relationship and there are species differences between humans and mice, it is worth it to replenish the mice model with human cell resources.

Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.

The DNA damage response (DDR) is critical for maintaining cellular homeostasis and genome integrity. Mounting evidence has shown that posttranslational protein modifications play vital roles in the DDR. In this study, we showed that deubiquitinase OTUD6A is involved in the DDR and is important for maintaining genomic stability.