FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury.

Introduction: Intestinal ischemia-reperfusion injury (IRI) is a critical condition often requiring emergency intervention. Ferroptosis, a form of regulated cell death driven by phospholipid peroxidation, plays a central role in its pathogenesis.

Objective: This study aimed to explore whether CoQ10 could mitigate intestinal IRI by suppressing ferroptosis.

Novel insights into microbial strategies for antimony (Sb) transformation coupled with carbon utilization in groundwater ecosystem.

Microbial-mediated antimony (Sb) metabolism and its coupling with bio-essential elements cycles are not only crucial to the biogeochemistry of Sb-contaminated groundwater but also have potential implications for human health. However, the ways in which Sb contamination affects microbial carbon, nitrogen, and sulfur metabolism, particularly carbon-utilization strategies, remain poorly understood and lack direct experimental confirmation. Herein, well and spring water samples were collected from the Xikuangshan (XKS) mine to investigate microbial responses and functional adaptations.

Understanding the Degradation and Stress Response Mechanisms of Cypermethrin by J6 Isolated from Broiler Gastrointestinal Tract.

Pyrethroid residues in the environment and agricultural products have caused significant negative effects on food safety and human health. In this study, a novel strain of J6, isolated from the cecum of broilers, exhibited the ability to degrade cypermethrin and its major metabolite, 3-phenoxybenzoic acid. The identified intermediates indicated that J6 degrades cypermethrin through ester bond hydrolysis, benzene hydroxylation, and ether bond cleavage.

Bicontinuous Zinc Monoliths with a Protective Coating for Practical Zinc-Powder Anodes.

Zinc powder (ZnP) emerges as a competitive anode material for aqueous zinc-ion batteries (AZIBs) due to its scalable processability, and precise areal capacity control. However, ZnP anodes suffer from critical electrical failure due to exacerbated electrolyte corrosion, unstable point-contact networks, and strain-induced isolation. Herein, a bicontinuous monolithic ZnP anode with a protective coating is developed to ensure stable and robust electron transport.

The environmental adaptation of acidophilic archaea: promotion of horizontal gene transfer by genomic islands.

Acid mine drainage (AMD) is an extremely acidic leachate highly contaminated with metal ions, yet it harbors a significantly high abundance of archaea. Genomic islands (GIs), as one of the productions of horizontal gene transfer (HGT), play an important role in the environmental adaptation and evolutionary processes of archaea. However, the distribution, structure, and function of GI within the genomes of archaea remain poorly understood.

Tandem reaction-adsorption separation of perfluorinated cyclopropane/propane mixtures.

Separating perfluorinated cyclopropane/propane mixtures is critical yet challenging for sustainably producing high-purity perfluropropane in the advanced electronics industry. Conventional one-step adsorption separation methods lack proper selectivity due to similar molecular sizes and properties. We introduce a tandem reaction-adsorption approach with ultrahigh selectivity and low-pressure uptake.

Pollution sources, characteristics and environmental risk assessment of heavy metals in surface water and sediments of typical pyrite mine in Southwest China.

Abandoned mines, especially pyrite-rich ones, release acid mine drainage (AMD) with high acidity and excessive amounts of heavy metals, threatening regional ecosystems. Six samples of mine drainage, nine samples of surface water, and twelve samples of sediment were analyzed in this case study of the Dashu pyrite mine in southwest China. A comprehensive analysis of the pollution levels, pollution sources, and potential hazards of eight metals (Ni, Cd, Cu, Zn, Fe, Al, Pb, and Mn) that exceeded regulatory standards was conducted by monitoring 24 conventional and characteristic indicators.

Unlocking Precision in Biomass Conversion Through Functional Ligand Engineering of Lewis Acidic MOFs.

Glucose isomerization to fructose is a key factor in cellulosic biomass utilization. Thus, achieving highly efficient fructose production and understanding the dominant reaction route remain crucial goals. Hereby, this study refines a precise ligand engineering strategy applied to the typical metal-organic framework, UiO-66, generating a series of Lewis acidic UiO-66-based catalysts with only subtle structural adjustments.

Oxidative Stress-related Gene Signature: A Prognostic Tool for Predicting Survival in ST-elevation MI.

Background: This study aimed to identify differentially expressed oxidative stress-related genes (DEOSRGs) in ST-elevation MI (STEMI) patients and examine their connection to clinical outcomes.

Methods: We conducted a systematic review of Gene Expression Omnibus datasets, selecting GSE49925, GSE60993 and GSE61144 for analysis. DEOSRGs were identified using GEO2R2, overlapping across the selected datasets.

Medium-Band-Gap, Fully Nonfused Electron Acceptors with High for High-Efficiency Binary and Ternary Organic Solar Cells.

Fully nonfused electron acceptors (FNEAs) have shown a huge potential for organic solar cells (OSCs). Herein, two medium-band-gap FNEAs, namely, and , are developed based on the "benzene-dithiophene-benzene" skeleton, with the assistance of alkoxyl side chains to form S···O conformational locks. Two FNEAs exhibit medium optical gaps ( ≈1.

Distinct mechanisms of stibnite (SbS) oxidative dissolution mediated by acid-generating and alkali-generating microorganisms within a wide pH range.

Indigenous microorganisms in antimony mining areas facilitate stibnite dissolution over a wide pH range, yet their mechanisms remain poorly studied. Herein, the acid-generating Bosea sp. AS-1 and the alkali-generating Pseudomonas sp.

All-natural charge gradient interface for sustainable seawater zinc batteries.

Paring seawater electrolyte with zinc metal electrode has emerged as one of the most sustainable alternative solutions for offshore stationary energy storages owing to the intrinsic safety, extremely low cost, and unlimited water source. However, it remains a substantial challenge to stabilize zinc metal negative electrode in seawater electrolyte, given the presence of chloride ions and complex cations in seawater. Here, we reveal that chloride pitting initiates negative electrode corrosion and aggravates dendritic deposition, causing rapid battery failure.

Ferroptosis genes and ST-segment elevation myocardial infarction outcomes: A predictive signature.

Objective: The aim of this paper is to discover differentially expressed genes related to ferroptosis (DEFRGs) in patients with ST-segment elevation myocardial infarction (STEMI) and to construct a reliable prognostic signature that incorporates key DEFRGs and easily accessible clinical factors.

Methods: We did a systematic review of Gene Expression Omnibus datasets and picked datasets SE49925, GSE60993, and GSE61144 for analysis. We applied GEO2R to find DEFRGs and overlapped them among the picked datasets.

Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation.

The prognostic value of differentially expressed senescence-related genes(DESRGs) in ST-segment elevation myocardial infarction(STEMI) patients is unclear. We used GEO2R to identify DESRGs from GSE60993 and performed functional enrichment analysis. We built an optimal prognostic model with LASSO penalized Cox regression via GSE49925.

Personalized tourism recommendation model based on temporal multilayer sequential neural network.

Personalized tourism has recently become an increasingly popular mode of travel. Effective personalized route recommendations must consider numerous complex factors, including the vast historical trajectory of tourism, individual traveler preferences, and real-time environmental conditions. However, the large temporal and spatial spans of trajectory data pose significant challenges to achieving high relevance and accuracy in personalized route recommendation systems.

Nonnegative matrix factorization with Wasserstein metric-based regularization for enhanced text embedding.

Text embedding plays a crucial role in natural language processing (NLP). Among various approaches, nonnegative matrix factorization (NMF) is an effective method for this purpose. However, the standard NMF approach, fundamentally based on the bag-of-words model, fails to utilize the contextual information of documents and may result in a significant loss of semantics.

Biosorption of cypermethrin from aqueous solutions by Pediococcus acidilactici: kinetics, isotherms, and mechanisms.

Background: Pediococcus acidilactici is an effective adsorbent for removing of pyrethroid insecticides. This study investigated the biosorption characteristics and mechanisms of P. acidilactici D15 using adsorption measurement, scanning electron microscopy, and Fourier-transform infrared spectroscopy.

Leveraging Ligand Desymmetrization to Enrich Structural Diversity of Zirconium Metal-Organic Frameworks for Toxic Chemical Adsorption.

The discovery of metal-organic frameworks (MOFs) with novel structures provides significant opportunities for developing porous solids with new properties and enriching the structural diversity of functional materials for various applications. The rational design of building units with specific geometric conformations is essential to direct the construction of MOFs with unique properties. Herein, we leverage a ligand desymmetrization approach to construct a series of new MOFs.

A novel cold-adapted pyrethroid-degrading esterase from Bacillus subtilis J6 and its application for pyrethroid-residual alleviation in food matrix.

Prolonged and widespread use of pyrethroid pesticides a significant concern for human health. The initial step in pyrethroid bioremediation involves the hydrolysis of ester-bond. In the present study, the esterase genes est10 and est13, derived from Bacillus subtilis, were successfully cloned and expressed in Escherichia coli.

Fractionation of lignin and fermentable sugars from wheat straw using an alkaline hydrogen peroxide/pentanol biphasic pretreatment.

To breakthrough the delignification saturation point (DSP) of alkaline hydrogen peroxide (AHP) pretreatment, a biphasic AHP/pentanol (AHPP) pretreatment was proposed in this work. The temperature and HO concentration were evaluated. Under the optimal conditions (110 °C, 2 h, 4 % HO), 70.

Design and synthesis of triazolopyridine derivatives as potent JAK/HDAC dual inhibitors with broad-spectrum antiproliferative activity.

A series of triazolopyridine-based dual JAK/HDAC inhibitors were rationally designed and synthesised by merging different pharmacophores into one molecule. All triazolopyridine derivatives exhibited potent inhibitory activities against both targets and the best compound 4-(((5-(benzo[][1, ]dioxol-5-yl)-[1, 2, 4]triazolo[1, 5-]pyridin-2-yl)amino)methyl)--hydroxybenzamide (19) was dug out. 19 was proved to be a pan-HDAC and JAK1/2 dual inhibitor and displayed high cytotoxicity against two cancer cell lines MDA-MB-231 and RPMI-8226 with IC values in submicromolar range.

Molecular Insights into the Aroma Difference between Beer and Wine: A Meta-Analysis-Based Sensory Study Using Concentration Leveling Tests.

Beer and wine are popular beverages with clearly different aroma characters, the molecular background of which has not yet been systematically investigated. A comprehensive literature survey returned 14 845 concentration values obtained from 160 beer and 904 wine samples, covering 42 basic beer and 42 basic wine odorants, among which 40 were common to both beverages. Based on mean concentrations and a comparison with threshold data, 29 beer and 32 wine odorants were finally selected to build aroma base models that reflected the basic olfactory difference between beer and wine.

Standardized framework for assessing soil quality at antimony smelting site by considering microbial-induced resilience and heavy metal contamination.

Antimony smelting activities damage the soil and vegetation surroundings while generating economic value. However, no standardized methods are available to diagnose the extent of soil degradation at antimony smelting sites. This study developed a standardized framework for assessing soil quality by considering microbial-induced resilience and heavy metal contamination at Xikuangshan antimony smelting site.

Polymetallic contamination drives indigenous microbial community assembly dominated by stochastic processes at Pb-Zn smelting sites.

Indigenous microbial communities in smelting areas are crucial for maintaining fragile ecosystem functions. However, the community assembly process and their responses to polymetallic pollution are poorly understood, especially the taxa in each bin from the amplicons that contributed to the assembly process. Herein, microbial diversity, co-occurrence patterns, assembly process and the intrinsic mechanisms across contamination gradients at a typical PbZn smelting site were systematically unravelled by high-throughput sequencing.