Study on the relationship between homocysteine and general metabolic indexes in healthy population in Hebei Province, China.

Background: The aging problem is a significant issue and challenge currently faced by the whole world. Hyperhomocysteinemia (HHcy) is a common phenomenon among the older adult. Increasing evidence suggests a link between HHcy and multiple systemic issues in the older adult-related diseases.

Molecular Epidemiology of spp. in Aborted Livestock in the Ningxia Hui Autonomous Region, China.

Brucellosis is caused by spp.; it can result in fetal loss and abortion, resulting in economic losses and negative effects on human health. Herein, a cross-sectional study on the epidemiology of spp.

Hierarchical Assembly of Proteinosomes and Coacervates Communities into 3D Protocellular Networks.

Drawing inspiration from the living cells, various life-inspired assemblies have been developed to mimic their remarkable properties and functionalities, and offer valuable insights into the origin of life and the understanding of life behaviors. Advancing the design and construction of multi-compartmentalized hierarchical systems with more advanced structures and functions has always increasingly attracted attention in this field. Here, a type of 3D protocellular networks are designed and constructed, which is formed by the hybrid of two types of protocells communities based on phenylboronic acid-grafted proteinosomes and polysaccharide-based coacervate microdroplets.

Interpreting spatiotemporal dynamics of Ulva prolifera blooms in the southern yellow sea using an attention-enhanced transformer framework.

Harmful algal blooms dominated by Ulva prolifera have posed recurring ecological and economic challenges in the southern Yellow Sea. To better understand and predict the complex spatiotemporal dynamics of these blooms, we developed an enhanced Transformer-based deep learning framework, incorporating multi-head self-attention mechanisms. This model dynamically captures spatial dependencies, providing a comprehensive understanding of bloom dynamics.

The value of dual-energy spectral CT in differentiating the pathological grades of T1-size lung adenocarcinoma.

Background: Accurate preoperative diagnosis of pathological grades in T1-sized lung adenocarcinoma (LUAD) is crucial for clinical decision-making. The study aimed to investigate the value of dual-energy computed tomography (DECT) in distinguishing pathological grades in newly diagnosed LUAD lesions ≤3 cm in size.

Methods: From October 2018 to January 2022, 137 patients with 161 pathologically confirmed LUAD lesions (≤3 cm) having received DECT were retrospectively enrolled with clinical information collected (low-grade: high-grade =41:120).

The phytochemistry, pharmacology and modern applications of Cotinus coggygria Scop.-A comprehensive review with future perspectives.

Ethnopharmacological Relevance: Cotinus coggygria Scop. (syn Rhus cotinus L.), a plant with a longstanding medicinal history, has been traditionally employed in Asian ethnomedicine for the management of hepatic disorders and gastrointestinal ailments.

Introducing metal-sulfur active sites in metal-organic frameworks via post-synthetic modification for hydrogenation catalysis.

Metal-sulfur active sites play a central role in catalytic processes such as hydrogenation and dehydrogenation, yet the majority of active sites in these compounds reside on the surfaces and edges of catalyst particles, limiting overall efficiency. Here we present a strategy to embed metal-sulfur active sites into metal-organic frameworks (MOFs) by converting bridging or terminal chloride ligands into hydroxide and subsequently into sulfide groups through post-synthetic modification. We apply this method to two representative MOF families: one featuring one-dimensional metal-chloride chains and another containing discrete multinuclear metal clusters.

Mechanism and regulation of mitophagy in liver diseases: a review.

Mitochondria are vital for the proper operation of healthy eukaryotic cells. Mitophagy, a specialized form of autophagy that targets damaged or surplus mitochondria, plays a key role in both the normal functioning and disease-related processes within the liver. This review aims to explore the main mechanisms underlying the initiation of mitophagy and its importance in various liver conditions, such as alcoholic liver disease, drug-induced liver injury, non-alcoholic fatty liver disease, viral hepatitis, and cancer.

Decitabine regulates the resistance of HCC to sorafenib through demethylation.

Purpose: To evaluate the efficacy of sorafenib in combination with the DNA methylation inhibitor decitabine (DAC) for the treatment of hepatocellular carcinoma (HCC), and to investigate the mechanism of sorafenib resistance from an epigenetic perspective, aiming to provide new insights and strategies for HCC therapy.

Methods: The GEPIA2 database was used to analyze the expression of solute carrier organic anion transporter family member 1B3 (SLCO1B3) in various tumors and adjacent normal tissues. The Kaplan-Meier method was applied to assess the relationship between SLCO1B3 expression and overall survival.

Highly Conductive Liquid Metal Emulsion Gels for Three-Dimensionally Printed Stretchable Electronics.

Gallium-based liquid metals are promising for stretchable electronics due to their inherent deformability and excellent conductivity. However, the lack of a scalable and automated fabrication process has limited their practical applications. This study introduces a two-step method to create liquid metal emulsion gels suitable for 3D printing, characterized by densely packed liquid metal microcapsules within polymer matrices.

Tryptophan-Rich Diet Improves High-Fat Diet-Induced Cognitive Dysfunction and Blood-Brain Barrier Disruption in C57BL/6 Mice through FFAR3 Activation.

Increasing evidence indicates that high-fat diets (HFDs) are strongly associated with cognitive deficits. Tryptophan (Trp), an essential amino acid, has been implicated in regulating metabolic and neurological pathways, but its role in mitigating HFD-induced cognitive dysfunction remains insufficiently explored. We hypothesized that enhancing Trp availability (0.

In Situ Encapsulation of Cationic [2]Catenane in a Stable Zirconium Metal-Organic Framework.

As an emerging class of porous supports, metal-organic frameworks (MOFs) can host multifarious guests to realize diverse applications. Among the guest-introducing approaches, the in situ encapsulation method is unique in its ability to incorporate a diverse range of guests, from small organic molecules and metal clusters to proteins and even more complicated guests. Previous investigations have focused on guests that are either neutral or negatively charged.

Liquid-liquid phase separation-boosted transmembrane delivery in interactive protocell communities.

Stress stimulation-mediated liquid-liquid phase separation is a key activity in living organisms, but its biophysical characteristics are poorly understood. Here, we report a UV-light stress stimulation behaviour in a binary community of synthetic protocells of condensates and proteinosomes, showing that condensates could behave like Condensate Pumps to enable a stepwise controlled transmembrane mass transfer regardless of the permeability barrier of proteinosomes. The stimulation mechanism of interfacial tension-induced proteinosome deformation and transient high osmotic pressure arisen by the dissociation of condensate is proposed.

Solvent-Directed Assembly of π-Stacked 3D Metal-Organic Frameworks with Tunable Conductivity Enhanced by C Encapsulation.

Metal-organic frameworks (MOFs) with tunable structures and unique host-guest chemistry have emerged as promising candidates for conductive materials. However, the tunability of conductivity and porosity in conductive MOFs, as well as their interrelationship, still lacks a systematic study. Herein, we report the synthesis of a series of 3D copper MOFs (NU-4000 to NU-4003) using a triphenylene-based hexatopic carboxylate linker.

Evaluating the neuroprotective effects of the novel Kv2.1 blocker Zj7923 against ischemic stroke in vitro and in vivo.

The voltage-dependent potassium channel Kv2.1 correlates closely to the regulation of neuronal excitability and cellular apoptosis. Ischemia or oxidative treatment were known to stimulate the surge of Kv2.

RIP2/NF-κB/PD-L1 signaling pathway is involved in temozolomide resistance by inducing autophagy in glioblastoma cells.

Autophagy is an important factor in temozolomide (TMZ) resistance in glioblastoma (GBM). Receptor-interacting protein 2 (RIP2) is associated with autophagy, but its role and mechanism in regulating autophagy in GBM cells remain unclear. To analyze RIP2 expression in GBM in The Cancer Genome Atlas (TCGA) dataset.

Impact of Renal Function Eligibility Criteria on Clinical Trials and Real-World Survival Outcomes Among Patients With Metastatic Renal Cell Carcinoma.

Background: Registration trials of first-line (1L) therapies in metastatic renal cell carcinoma (mRCC) employed strict renal function criteria, which may not reflect real-world patients. We evaluated the impact of trial-based renal function eligibility criteria on real-world outcomes.

Methods: Using a nationwide, deidentified electronic health record-derived database, we included patients diagnosed with mRCC between January 2011 and April 2023 who received 1L systemic therapy.

Reticular Structural Diversification of Zirconium Metal-Organic Frameworks Through Angular Ligand Configuration Control.

Reticular chemistry offers practical guidelines for enlarging and enriching the arsenal of metal-organic frameworks (MOFs). However, reticular expansion to access mesoporous structures remains challenging due to limitations in achieving precise control over both the size and configuration during building units' extension. Herein, we combine ligand isomerization and functionalization strategies to regulate the ligand configuration by systematically replacing aryl C-H groups with N atoms, resulting in angular dicarboxylate ligands with various symmetries.

Synergistic Boiling Enhancement on Hierarchical Micro-Pit/Carbon Nanotube Surfaces.

Pool boiling offers exceptional heat transfer performance, making it crucial for advanced thermal management. However, simultaneously optimizing both critical heat flux (CHF) and heat transfer coefficient (HTC) is challenging due to the inherent trade-off between promoting bubble nucleation and mitigating detrimental bubble coalescence. This study presents a micro/nano-hierarchical surface architecture designed to overcome this limitation.

Heterogeneity of cardiometabolic and hepatic fibrosis risks in nonalcoholic fatty liver disease among lean, overweight, and obese populations: a multicenter cross-sectional study.

Objective: Given that cardiovascular events induced by metabolic disorders are the leading cause of death in nonalcoholic fatty liver disease (NAFLD), this study aimed to explore the heterogeneity of cardiometabolic and liver fibrosis risks among lean, overweight, and obese NAFLD individuals.

Methods: A multicenter cross-sectional study was conducted across three hospitals in Pudong from July 2022 to June 2023. Health checkup data were obtained and stratified by BMI categories.

Osmotic Pressure Induced Morphological Transformation of Membranized Coacervates.

The stimulus-response behavior of protocells under environmental osmotic pressure changes has long been a subject of scientific inquiry. Herein, we demonstrate a way to membranized coacervate microdroplets based on cholesterol anchoring of phospholipids, which provides enhanced stability, enabling morphological transformations instead of dissociation during subsequent osmotic pressure changes. In hypotonic environments, these membranized coacervates equilibrate osmotic pressure through transient internal vacuole formation, concomitant with a transmembrane substrate influx that triggers enzymatic reaction acceleration.

Cell-Permeable Microprotein from Panax Ginseng Protects Against Doxorubicin-Induced Oxidative Stress and Cardiotoxicity.

(1) Background: Doxorubicin (DOX) is a frontline chemotherapeutic, but its side-effects from oxidative stress, leading to cardiotoxicity, pose significant challenges to its clinical use. We recently discovered a novel family of proteolysis-resistant, cystine-dense, and cell-penetrating microproteins from that we term ginsentides. Ginsentides, such as the 31-residue TP1, coordinate multiple biological systems to prevent vascular dysfunction and endoplasmic reticulum stress induced by internal and external stressors.

Spatio-Temporal Processes of Diffusion-Controlled Communication in Hierarchical Multi-Compartments.

Exploring the synergy of feedback behavior and molecular communication between micro- and nanocompartments is of great implication for the development of advanced hierarchical living-like materials. Non-covalent interactions are the driving forces for dynamic and temporal events in biomimetic structures. Herein, pH-responsive hierarchical multi-compartments (HMC) are constructed via hydrophobic-hydrophobic interactions between azobenzene units and phospholipid layers through the integration of two distinct structural units: phospholipid-membranized coacervates (Coa@DMPC) and azobenzene-functionalized polymersomes (Azo-Psomes).

Comparative analysis of endoscopic-assisted burr hole craniostomy and two burr hole craniostomy in the treatment of septated chronic subdural hematoma.

Objective: To conduct a retrospective comparative analysis of endoscopic-assisted burr hole craniostomy (EBHC) vs. two burr hole craniostomy (TBHC) in the management of septated chronic subdural hematoma (sCSDH).

Methods: This study employed a retrospective cohort design, encompassing 87 patients diagnosed with sCSDH who were admitted for EBHC or TBHC between January 2018 and December 2023.

Glassy ionogels with high compressibility and strength for impact protection.

Solvents within gels enhance the mobility of polymer chain segments while concurrently diminishing interchain interactions, thereby facilitating the ductility of glassy polymers at the cost of their mechanical strength. Here, we develop a solvent toughening strategy for the preparation of highly compressible and high-strength ionogels in the glassy state. This approach leverages the synergistic effects of the slow dissociation-shift kinetics of solvent ionic liquids and polymer crystallization.