Pesticide-fertilizer interactions: nutrient effects on wheat detoxification of prothioconazole.

Background: Prothioconazole (PTC), a triazole fungicide, and its metabolite prothioconazole-desthio (dPTC) present potential phytotoxic risks in crops. However, the mechanisms governing their uptake and detoxification in wheat remain unknown. This study aimed to determine how macronutrients and endogenous signaling compounds regulate PTC absorption and metabolism in wheat seedlings.

Individualized supplement of water-soluble vitamins: the influence of inflammation and renal function on circulating concentrations in critically digestive disease patients.

Background: Existing studies have shown the association of circulating vitamin and disease outcome. The study aimed to elucidate individual response of plasma water-soluble vitamins after supplement by PN in critically digestive disorder patients.

Methods: We measured the plasma levels of nine water-soluble vitamins (i.

Breaking immune evasion in breast cancer by targeting COX-2/PGE2 pathway.

The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a pivotal role in breast cancer (BC) progression by promoting immune suppression, tumor growth, and metastasis. PGE2 mediates these effects through EP receptors (EP1-EP4), suppressing anti-tumor immunity while fostering an immunosuppressive tumor microenvironment (TME). This includes the recruitment and activation of tumor-associated macrophages (TAMs), dendritic cells (DCs), cancer-associated fibroblasts (CAFs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs), ultimately impairing cytotoxic T lymphocyte and natural killer (NK) cell function.

Porphyromonas gingivalis-induced HuR upregulation suppresses SLC39A10-derived hsa_circ_0057552 in esophageal squamous cell carcinoma.

Porphyromonas gingivalis (P. gingivalis) is one of the main risk factors of esophageal squamous cell carcinoma (ESCC). Circular RNAs (circRNAs) have been found to play a crucial role in many types of cancer.

Dual Targeting of Inflammatory and Immune Checkpoint Pathways to Overcome Radiotherapy Resistance in Esophageal Squamous Cell Carcinoma.

Esophageal squamous cell carcinoma (ESCC) is characterized by chronic inflammation, immune evasion, and resistance to RT. Inflammatory pathways such as nuclear factor-kappa B (NF-κB) and signal transducer and activator of transcription 3 (STAT3), and cyclooxygenase 2 (COX-2) promote tumor progression and reduce radiosensitivity. RT activates pro-inflammatory cytokines and upregulates immune checkpoints including programmed death 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which contribute to immune suppression and treatment failure.

A nano-pesticide with low toxicity for earthworms obtained by immobilizing avermectin onto Mg/Al layered double hydroxides.

Nanopesticides offer significant advantages, such as enhancing pesticide bioactivity, increasing efficacy, and reducing overall usage. However, knowledge gaps regarding their environmental risks to non-target organisms hinder the industrial adoption of nanopesticides. In this study, abamectin was selected as a model pesticide, and earthworms (Eisenia foetida) were employed as representative non-target organisms to evaluate the environmental behavior and ecotoxicity mechanisms of abamectin-loaded layered double hydroxides nanopesticide (Mg/Al LDHs-AVM) in soil systems.

Photothermal-responsive curcumin-loaded copper-based nanocomposites for targeted drug release and combined immunotherapy.

The integration of photothermal therapy (PTT) with chemotherapy and immunotherapy holds great promise for improving cancer treatment efficacy, yet achieving precise control over drug release and synergistic modulation of the immunosuppressive tumor microenvironment (TME) remains challenging. Herein, we report a hollow CuS-based nanoplatform that synergistically combines NIR-triggered photothermal-chemotherapy with PD-L1 suppression for enhanced antitumor immunity. The hollow CuS nanoparticles exhibit exceptional photothermal conversion efficiency under 980 nm irradiation, while the phase-change material (PCM) of lauric acid enables controlled release of curcumin (Cur) in response to localized hyperthermia.

Mediating Effect of Self-Efficacy Between Self-Perceived Burden and End-of-Life Communication Difficulties in Cancer Patients.

The purpose of this study is to explore the role of cancer patient self-efficacy in linking self-perceived burden to end-of-life communication difficulties. The participants and setting are conveniently selected cancer patients from three hospitals in Shiyan City, Hubei Province, from December 2022 to May 2023 as the study subjects. Questionnaires were administered using the General Information Questionnaire, Self-Perceived Burden (SPBS), Self-Efficacy Scale (SUPPH), and Difficulties in End-of-Life Discussions-Family Inventory (DEOLD-FI).

Dietary isobutyric acid supplementation improves intestinal mucosal barrier function and meat quality by regulating cecal microbiota and serum metabolites in weaned piglets.

This study aimed to provide evidence for the effects of isobutyric acid on the intestinal mucosal barrier and gut microbiota in weaned piglets. In this study, 30 piglets were divided into two groups: one group was fed a standard diet (CON group), and the other group was fed a diet supplemented with 0.5% isobutyric acid (IB group) for 21 days.

NIR-responsive CuSe@Fc nanoparticles for photothermal- ferroptosis combination therapy in esophageal cancer.

Esophageal cancer (EC) represents a highly recurrent and aggressive malignancy within the digestive system. However, conventional therapeutic strategies exhibit notable limitations in their clinical applications. Photothermal therapy (PTT), combined with ferroptosis, has attracted considerable attentions, emerging as a promising novel strategy for EC treatment.

A Review of Pesticide Residues in Pears: Current Status, Dissipation Pattern and Detection Methods.

Pears are pome fruits widely cultivated and consumed globally due to their unique taste and flavor. The application of pesticides is a significant practice to combat pear pests and diseases across the world; however, pesticide use during production frequently results in undesirable residues in postharvest pear products, raising concerns about potential health impacts. Thus, the monitoring of pesticide residues (PRs) in pears has always been of great importance.

Sensitive and Ultrafast Perovskite/Organic Hybrid Photodetectors With a Broad Spectral Response From Ultraviolet to the Telecommunication Band.

Fast and sensitive photodetectors (PDs) with broadband spectral responses are crucial in numerous fields, including image sensing, optical communication, and biochemical applications. While organic PDs offer broadband spectral responses, their response speed is typically limited to the microsecond range. This study demonstrates a sensitive, ultrafast PD with a broad spectral response by combining a 2D perovskite layer with an organic heterojunction of poly[(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b;4,5-b'] dithiophene-2,6-diyl-alt-(4-(2-ethylhexyl)-3-fluorothieno[3,4-b]thiophene-)-2-carboxylate-2-6-diyl)] (PTB7-Th) and (2,20-((2Z,20Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,30':4',50]thieno[20,30:4,5]pyrrolo[3,2-g]thieno[20,30: 4,5]thieno[3,2-b]indole-2,10-diyl)bis(me-thanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dima-lononitrile) (Y6) as the active layer.

Janus-Structured Micro/Nanomotors: Self-Propelled Mechanisms and Biomedical Applications.

Self-propelled micro/nanomotors (MNMs), which can convert other energy into mechanical motion, have attracted considerable attention due to their potential applications in diverse fields. Due to the asymmetric structures and 2 or more chemically discrepant composites constructed in the Janus nanoparticles, asymmetrical forces can be created in the physical environment. Thus, MNMs with Janus structures have been widely studied for revealing possible driving mechanisms.

Direct synthesis of high quantum yield lead-free CsCuI powder in water and its application in yellow LED.

Yellow light-emitting diodes (LEDs) with a wavelength of 570-590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection.

[AgSe nanoparticles suppress growth of murine esophageal cancer allograft in mice by eliminating ].

Objectives: To investigate the efficacy of AgSe nanoparticles for eliminating intracellular () in esophageal cancer and examine the effect of clearance on progression of esophageal cancer.

Methods: AgSe nanoparticles were synthesized a chemical synthesis method. The effects of AgSe nanoparticles on viability and colony-forming ability were assessed using fluorescence staining and colony formation assays.

Data-Driven Molecular Typing: A New Frontier in Esophageal Cancer Management.

Background: Esophageal squamous cell carcinoma (ESCC) is a predominant and highly lethal form of esophageal cancer, with a five-year survival rate below 20%. Despite advancements, most patients are diagnosed at advanced stages, limiting effective treatment options. Multi-omics integration, encompassing somatic genomic alterations, inherited genetic mutations, transcriptomics, proteomics, metabolomics, and single-cell sequencing, has enabled the identification of distinct molecular subtypes of ESCC.

Rhodamine B-Derived Low-Toxicity Full-Color Carbon Dots with Wide Tunable High-Stable Liquid-State Lasers.

Carbon dots (CDs) serve as a novel, non-toxic, cost-effective, and highly-stable solution-processable nanolaser material. However, compared to commonly used commercial laser dyes, CDs exhibit lower photoluminescence quantum yields (PLQYs), radiation transition rates, and gain coefficients. Consequently, this leads to higher laser thresholds that significantly impede the expansion of practical applications for CDs.

YOLOv8s-Longan: a lightweight detection method for the longan fruit-picking UAV.

Introduction: Due to the limited computing power and fast flight speed of the picking of unmanned aerial vehicles (UAVs), it is important to design a quick and accurate detecting algorithm to obtain the fruit position.

Methods: This paper proposes a lightweight deep learning algorithm, named YOLOv8s-Longan, to improve the detection accuracy and reduce the number of model parameters for fruitpicking UAVs. To make the network lightweight and improve its generalization performance, the Average and Max pooling attention (AMA) attention module is designed and integrated into the DenseAMA and C2f-Faster-AMA modules on the proposed backbone network.

Near 1050 nm laterally coupled DFB laser with tightened-ridge-waveguide for improving grating coupling capability and controlling lateral modes.

We report our design and fabrication of a laterally coupled tighten-ridge-waveguide distributed feedback (LC-TRWG-DFB) laser with 37th-order sidewall gratings and 30 µm ridge width. Unlike the LC-DFB lasers with narrow ridge waveguides, our proposed LC-TRWG-DFB improves the output power by widening the width of the ridge waveguide. Simultaneously, the reduction of grating coupling ability and the emergence of high-order lateral modes caused by the widening are mitigated by the tighten structure at the rear of the ridge waveguide.

CDKN3 as a key regulator of G2M phase in triple-negative breast cancer: Insights from multi-transcriptomic analysis.

Triple-negative breast cancer (TNBC) remains a significant global health challenge, emphasizing the need for precise identification of patients with specific therapeutic targets and those at high risk of metastasis. This study aimed to identify novel therapeutic targets for personalized treatment of TNBC patients by elucidating their roles in cell cycle regulation. Using weighted gene co-expression network analysis (WGCNA), we identified 83 hub genes by integrating gene expression profiles with clinical pathological grades.

Synergistic photothermal and chemo-therapeutic platform utilizing CuSe/PDA/AIPH nanoparticles for targeted tumor eradication.

In this study, we developed an innovative CuSe/PDA/AIPH nanoparticle platform that combines photothermal therapy and chemotherapy for effective tumor treatment. The CuSe nanoparticles, known for their strong near-infrared (NIR) absorption, were encapsulated within a polydopamine (PDA) and 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) matrix. Upon NIR irradiation, the platform triggers localized heating and subsequent thermal decomposition of AIPH, releasing ROS to induce significant oxidative damage in tumor cells.

Permeation enhancer decorated nanoparticles for oral delivery of insulin: manipulating the surface density of borneol and PEG for absorption barriers.

Oral protein drugs' delivery faces challenges due to multiple absorption barriers for macromolecules. Co-administration with permeation enhancers and encapsulation in nano-carriers are two promising strategies to enhance their oral absorption. Herein, the poly(lactic--glycolic acid) nanoparticles (PLGA NPs) are decorated with polyethylene glycol (PEG) and a traditional Chinese medicine-derived permeation enhancer borneol (BO) for oral insulin delivery.

Minimally invasive treatment of grade I and II gluteal muscle contracture using a self-made special cutter combined with a specialized compression hemostasis device.

Background: To explore the method and curative effect of minimally invasive treatment of gluteal muscle contracture (GMC) with self-made special cutter combined with special compression hemostasis device.

Methods: The data of 88 patients with GMC treated in our hospital from May 2017 to January 2021 were analyzed retrospectively. They were divided into two groups according to different surgical instruments and hemostatic devices.

Nurses' knowledge, attitude, and practice of low-flow oxygen therapy and humidification.

Objective: Nurses are key in administering oxygen therapy and managing its potential adverse effects in medical settings. This study aimed to investigate the knowledge, attitudes, and practices (KAP) regarding low-flow oxygen therapy and humidification among nurses.

Methods: This cross-sectional study was conducted from January 2024 to March 2024 at Shanghai Xuhui Central Hospital.