CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation.

Background: Myocardial ischemia/reperfusion (I/R) injury contributes significantly to cardiac dysfunction following myocardial infarction, mainly due to excessive oxidative stress and mitochondrial injury. Despite advances in reperfusion therapies, secondary injuries remain a challenge, necessitating deeper insight into the molecular mechanisms underlying I/R injury. In the present study, we aim to investigate the roles of circular ribonucleic acid (circRNA) RERE (circRERE) in myocardial I/R injury.

Association between age and malnutrition in oldest-old and centenarian populations.

Background: As the pace of social aging accelerates, mitigating malnutrition has emerged as a pressing public health imperative. This study aimed to assess the association between age and malnutrition in Chinese oldest-old and centenarian populations.

Methods: This population-based survey investigated 1768 adults in 18 cities and counties using a standardized protocol.

Plates versus headless screws for fixation of Mason Type 3 radial head fractures: A systematic review.

Objectives: In this review, we discuss the clinical outcomes of plates and headless screws (HSs) for Mason Type 3 radial head fractures to determine the superior approach.

Materials And Methods: A comprehensive literature search was conducted across multiple databases for studies on internal fixation of Mason Type 3 radial head fractures, covering publications from inception to December 2024. Literature was screened, and data were extracted according to predefined inclusion criteria.

Unveiling Hidden Genetic Architectures: Molecular Diagnostic Yield of Whole Exome Sequencing in 50 Children With Autism Spectrum Disorder Negative for Copy Number Variations.

Autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental conditions with complex genetic etiologies. Recent advances in whole exome sequencing (WES) have enabled comprehensive detection of clinically relevant variants, particularly single-nucleotide variations (SNVs) and InDels, in ASD genetic diagnostics. Here, we performed WES on 50 Chinese children with ASD who tested negative for copy number variants (CNVs).

Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine.

This up-to-date review focused on the recent advances in the concept, interrelationship, and mechanisms of the polytrauma clinical triad (PCT), and intervention knowledge and approaches to its prevention and treatment from the perspective of military pain medicine, hoping to provide a scientific basis and reference of PCT. Many soldiers suffering from chronic pain coexist with post-traumatic stress disorder and traumatic brain injury. If the above three diseases exist, it is called PCT.

Bibliometric Analysis of Classroom Engagement: A Review Based on Web of Science Database.

Classroom engagement, a critical factor in enhancing learning outcomes and personal development, serves as a direct manifestation of students' agency in learning. Understanding its developmental trajectory facilitates the efficient implementation of pedagogical activities. It also promotes students' holistic development.

Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians.

The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.

Teacher punishment intensity and parental trust in rural China: a moderated mediation of violation severity and trustworthiness.

Teacher discipline functions as an essential instrument not only for promoting the healthy development of adolescents but also for cultivating the trust relationship between parents and educators. Based on signaling theory and just deserts theory, this study explore the effects of teacher discipline intensity, student violation severity, and perceived trustworthiness on parental trust in rural China. A total of 1,206 parents residing in rural areas of Yichuan County, Henan Province, China, completed an online questionnaire.

Teacher Punishment Intensity and Parental Trust: A Moderated Moderation Effect Based on CEPS 2013-2014 Survey Data.

Teacher punishment serves as a critical tool not only for fostering the healthy development of adolescents but also for shaping the trust relationship between parents and teachers. Drawing on signaling theory and just deserts theory, this study examines baseline data from the China Education Panel Survey (CEPS 2013-2014) to explore the effects of teacher discipline intensity, student violation severity, and teacher gender on parental trust. The findings indicate the following: (1) There is a significant positive correlation between disciplinary intensity and violation severity, while both exhibit a significant negative correlation with parental trust.

SiN Nanoparticle Reinforced SiN Nanofiber Aerogel for Thermal Insulation and Electromagnetic Wave Transmission.

Traditional nanoparticle aerogels suffer from inherent brittleness and thermal instability at elevated temperatures. In recent years, ceramic nanofiber aerogels, utilizing flexible nanofibers as structural units, have emerged as mechanically resilient alternatives with ultrahigh porosity (>90%). However, their thermal insulation capabilities are compromised by micron-scale pores (10-100 μm) and overdependence on ultralow density, which exacerbates mechanical fragility.

Unmet long-term care needs and their association with health-related quality of life among Chinese oldest-old population.

Background: Entering the age of 80 or 100, individuals' functional decline and the need for assistance in daily activities increase dramatically, resulting in an inevitable increase in unmet long-term care (LTC) needs. Understanding unmet LTC needs in late life and their association with quality of life is essential for effective health planning and resource allocation. We aim to estimate the prevalence of unmet needs for LTC and the association of unmet needs for LTC and Health-related Quality of life (HRQOL), among the Chinese oldest-old population.

Associations of the triglyceride-glucose index and triglyceride-glucose/body mass index with all-cause mortality in Chinese centenarians.

Background: The triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.

Methods: Data from the China Hainan Centenarian Cohort Study (CHCCS) were analyzed.

Quantitative Analysis of Orbital Soft Tissues Using Three-Dimensional Fast Spin Echo With 2-Point Dixon-Based Fat Suppression Sequence: Its Association With Methylprednisolone Pulse Therapy Treatment Efficacy in Thyroid-Associated Ophthalmopathy.

Background: Three-dimensional fast spin echo with 2-point Dixon-based fat suppression (3D-FSE-Dixon) sequence may assess volume and water fraction (WF) of orbit.

Purpose: To explore the association between 3D-FSE-Dixon based parameters and methylprednisolone pulse therapy (MPPT) efficacy in active moderate-to-severe thyroid-associated ophthalmopathy (TAO).

Study Type: Retrospective.

White matter integrity mediated the effect of plasma uric acid levels on cognitive function in ALS patients.

Objective: To investigate the association between plasma uric acid levels and white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) patients and to explore the potential mediating role of white matter microstructural alterations in the protective effect of plasma uric acid on cognitive function in ALS patients.

Methods: 73 right-handed ALS patients were recruited for this study. Plasma uric acid levels were measured, diffusion tensor imaging scans were performed to assess white matter integrity, and cognition was evaluated using the Edinburgh Cognitive and Behavioral Screen.

Dynamic Load Identification of Thin-Walled Cabin Based on CNN-LSTM-SA Neural Network.

Spacecraft are subjected to various external loads during flight, and these loads have a direct impact on the structural safety and functional stability of the spacecraft. Obtaining external load information can provide reliable support for spacecraft health detection and fault warning, so accurate load identification is very important for spacecraft. Compared with the traditional time-domain load identification method, the neural network-based time-domain load identification method can avoid the establishment of the inverse model and realize the response-load time-sequence mapping, which has a broad application prospect.

Coverage of surfactants on polyoxometalate tunes the selectivity of alkene epoxidation.

Self-assembled nanosheets were formed through the interaction between polyoxometalate (POM) and dodecyltrimethylammonium bromide (DTB), which has hydrophilic groups at both ends of the carbon chain and serves as a "bridge" connecting the POMs. The resulting POM assemblies demonstrated high efficiency in the epoxidation of cyclohexene, with the selectivity of the reaction being tunable by adjusting the coverage of DTB on the POM.

[AgSe nanoparticles suppress growth of murine esophageal cancer allograft in mice by eliminating ].

Objectives: To investigate the efficacy of AgSe nanoparticles for eliminating intracellular () in esophageal cancer and examine the effect of clearance on progression of esophageal cancer.

Methods: AgSe nanoparticles were synthesized a chemical synthesis method. The effects of AgSe nanoparticles on viability and colony-forming ability were assessed using fluorescence staining and colony formation assays.

Risk factors and an interpretability tool of in-hospital mortality in critically ill patients with acute myocardial infarction.

Objective: We aim to develop and validate an interpretable machine-learning model that can provide critical information for the clinical treatment of critically ill patients with acute myocardial infarction (AMI).

Methods: All data were extracted from the multi-centre database (training and internal validation cohorts: MIMIC-III/-IV, external validation cohort: eICU). After comparing different machine-learning models and several unbalanced data processing methods, the model with the best performance was selected.

Macrocarpal I induces immunogenic cell death and synergizes with immune checkpoint inhibition by targeting tubulin and PARP1 in colorectal cancer.

Colorectal cancer (CRC) presents an obstacle to immunotherapy, primarily because most cases are microsatellite stable (MSS) tumors, which are often described as "cold tumors" with limited immunogenicity. Recent studies have indicated that several therapeutic approaches, such as chemotherapy and targeted therapies, can elicit immunogenic cell death (ICD) and stimulate immune responses. However, challenges such as target affinity and in vivo pharmacokinetics limit the efficacy and immune response of current targeted therapies.

Redox-Driven Magnetic Regulation in a Series of Couplers in Bridged Nitroxide Diradicals.

Redox-induced magnetic regulation in organic diradicals is distinctly attractive. In this work, taking nitroxide radicals as spin sources, we predict the magnetic properties of 9, 10-anthraquinone, 9, 10-phenaquone, 9, 10-diazanthracene and 9, 10-diazepine-bridged molecular diradical structures in which the couplers are prone to dihydrogenation reduction at positions 9 and 10. As evidenced at both the B3LYP and M06-2X levels of theory, the calculations confirm that the magnetic transitions between ferromagnetism and antiferromagnetism can take place for 9, 10-anthraquinone and 9, 10-diazanthracene-bridged diradicals after dihydrogenation.

Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma.

Background: FCER1G as an immune-associated protein, which belongs to the immunoglobulin superfamily and is involved in mediating and executing antibody-mediated immune responses. However, the role of FCER1G in cancers remains controversial. Our objectives were to study the association between FCER1G and tumor- infiltrating immune cells (TIICs) as well as the predictive significance of FCER1G.

Associations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults.

Background: Sleep disturbance is an immune-related disease, and the gut-brain axis is an important regulatory pathway. This cross-sectional study was designed to address these associations between complement C4, habitual constipation, and sleep disturbance and presents a reference for prevention and treatment of sleep disturbance.

Methods: Based on the China Hainan Centenarian Cohort Study, Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep disturbance following standard procedure.

Isolated Langerhans cell histiocytosis of the stomach in adults: An analysis of clinicopathologic characteristics and molecular genetics.

Isolated gastric Langerhans cell histiocytosis (LCH) occurs extremely rarely in adults. We characterized the clinicopathological and molecular genetics of this rare entity. We retrospectively analyzed the clinicopathologic and prognostic features of 3 patients with isolated gastric LCH during the past 10 years, with a review of an additional 20 patients from the literature.

Exploring the interplay of academic stress, motivation, emotional intelligence, and mindfulness in higher education: a longitudinal cross-lagged panel model approach.

Students in higher education often encounter significant academic pressure, which can have profound implications for their mental health and academic performance. The current study employs a two-wave longitudinal design to investigate the dynamic interrelationships among academic stress, academic motivation, emotional intelligence, and mindfulness. The study employed a cross-lagged panel model to investigate the temporal interactions among these four constructs and their influence on the academic experiences of doctoral students.

Preparation of an FeO Nanoparticle/Carbonized Hemp Fiber Composite with Superior Microwave Absorption Performance.

The increasing concern over the negative impact of electromagnetic radiation and interference on humans has led to a growing interest in microwave-absorbing materials that are cost-effective, have a wide frequency range, and have high efficiency. In this paper, an FeO nanoparticle/carbonized hemp fiber composite was successfully prepared using hemp fibers as the primary material and template. By carefully regulating the concentration of the iron nitrate impregnation solution, accurate loading of FeO nanoparticles onto the carbonized hemp fiber was achieved.