miRNA biomarkers for prognosis and therapy monitoring in a multi-ethnic cohort with SARS-CoV-2 infection.

This study aimed to identify miRNA-based biomarkers in a multi-ethnic cohort of SARS-CoV-2-infected individuals to enhance preparedness for future variants of concern. A total of 31 healthy controls and 154 infected patients were enrolled, from which 13 matched controls and 38 infected nasal swab samples were analyzed using miRNA sequencing, followed by qRT-PCR validation. Among the 1788 miRNAs detected, 14 differentially expressed miRNAs and four novel miRNAs were identified, with novel-miR-264-5p showing a ≥ 2-fold change.

Emotional labor and empathic concern as predictors of exhaustion and disengagement in college teachers.

Emotional labor has been widely studied in organizational settings, but its impact on job burnout, particularly within educational contexts, remains underexplored. This study examines how emotional labor influences the distinct dimensions of job burnout-exhaustion and disengagement-with empathetic concern as a potential mediator and gender as a moderating factor. In this cross-sectional study conducted in both private and public colleges in Rawalpindi, Pakistan, data was collected from 1,128 college teachers using three validated scales: the Oldenburg Burnout Inventory (OLBI) to assess burnout, the Emotional Labor Questionnaire (ELQ) for emotional labor, and the Interpersonal Reactivity Index (IRI) to evaluate the empathic concern.

Effect of work schedule flexibility as a moderator in the relationship between job stress and wellbeing in pharmacy practice.

Hospital pharmacists frequently face significant job stress, adversely impacting their well-being. Work schedule flexibility is often proposed as a potential buffer against job stress, yet its effectiveness among hospital pharmacists remains understudied. This study investigates the moderating effect of work schedule flexibility on the relationship between job stress and well-being among hospital pharmacists in Punjab, Pakistan.

The buffering effects of mindfulness and organizational support on the mental health of hospital pharmacists in high-workload environments.

The present research aims to explore the impact of workload on the mental well-being of hospital pharmacists, focusing on the mediating roles of mindfulness and perceived organizational support (POS). Utilizing a cross-sectional design, data were collected from 411 hospital pharmacists in Punjab, Pakistan, during July-September 2023 via stratified sampling. Mental well-being was assessed using the Patient Health Questionnaire (PHQ-9), the workload was assessed by the NASA Task Load Index (NASA-TLX), mindfulness using the Five Facet Mindfulness Questionnaire-Short Form (FFMQ-SF), and POS using a modified version of the Survey of Perceived Organizational Support (SPOS).

The mediating role of cognitive arousal in the relationship between impulsivity and sleep quality among college students: a random intercept cross-lagged panel analysis.

Impulsivity, cognitive arousal, and sleep quality are critical factors affecting college students' well-being and academic performance. While impulsivity negatively influences sleep quality, the mediating role of cognitive arousal remains underexplored. The present study assesses how impulsivity affects sleep quality through cognitive arousal.

Exploring the interplay of academic stress, motivation, emotional intelligence, and mindfulness in higher education: a longitudinal cross-lagged panel model approach.

Students in higher education often encounter significant academic pressure, which can have profound implications for their mental health and academic performance. The current study employs a two-wave longitudinal design to investigate the dynamic interrelationships among academic stress, academic motivation, emotional intelligence, and mindfulness. The study employed a cross-lagged panel model to investigate the temporal interactions among these four constructs and their influence on the academic experiences of doctoral students.

The Mediating Roles of Self-Compassion and Emotion Regulation in the Relationship Between Psychological Resilience and Mental Health Among College Teachers.

Background: The compromised well-being of educators engenders a range of educational, social, and economic issues that cannot be adequately addressed through the mere awareness of risk factors. The present research explores the mediating roles of self-compassion and emotion regulation strategies (cognitive reappraisal and expressive suppression) on the relationship between academic teachers' psychological resilience and mental health.

Methods: A total of 405 academic teachers from four colleges in Tabuk City, Saudi Arabia, participated in the study between September and November 2023.

Digital literacy as a catalyst for academic confidence: exploring the interplay between academic self-efficacy and academic procrastination among medical students.

Background: Digital literacy influences academic behaviors, especially in medical education, where students encounter considerable academic challenges. However, the effects of this phenomenon on academic self-efficacy and procrastination remain inadequately understood.

Objectives: This research explores the relationships between digital literacy and academic self-efficacy, emphasizing the mediating role of academic procrastination and its various dimensions among medical students.

Leveraging digital skills to reduce cognitive strain: Implications for academic self-efficacy in medical education.

Background: Digital literacy influences academic behaviors, especially in medical education, where students encounter considerable academic challenges. However, the effects of this phenomenon on academic self-efficacy and cognitive load remain inadequately understood.

Objectives: This research explores the relationships between digital literacy and academic self-efficacy, emphasizing the mediating role of cognitive load and its various dimensions among medical students in Islamabad, Pakistan.

Psychological dynamics of pandemic resilience: a tale of two cultures.

The present work endeavours to explore the experiences of university-level students from Pakistan and Nepal after the COVID-19 outbreak. A comprehensive electronic survey was carried out utilising a meticulous cluster sampling technique encompassing two distinct populations, i.e.

Potential Correlation Between Self-Compassion and Bedtime Procrastination: The Mediating Role of Emotion Regulation.

Purpose: The present research aims to investigate the potential correlations between self-compassion and bedtime procrastination, a significant behavior related to sleep. In this research, we put forward the hypothesis that a reduction in negative affect and the implementation of adaptative emotion regulation strategies can elucidate the established connections between self-compassion and a decreased tendency for bedtime procrastination.

Methods: Two cross-sectional online surveys (Survey I: n=241 and Survey II: n=546) were carried out via a convenient sampling method.

Potential determinants of vaccine hesitancy among celiac disease patients: a single cohort analysis.

Introduction: Though researchers and scholars have greatly emphasized addressing the influencing factors of vaccination hesitancy, little attention has been paid to patients with celiac disease. Addressing the variables hampering attitudes might help direct appropriate patient advocacy and doctor-patient communication endeavors to encourage vaccination among celiac disease patients. The present investigation seeks to explore the coverage against vaccine-preventable diseases, vaccination attitudes, and related possible factors among celiac disease patients in the Pakistani setting.

COVID-19 vaccine reluctance and possible driving factors: A comparative assessment among pregnant and non-pregnant women.

The coronavirus disease of 2019 (COVID-19) constitutes a serious threat to pregnant women. One of the key strategies for preventing and managing the COVID-19 epidemic is vaccination. Herd immunity is significantly hampered by COVID-19 vaccine reluctance, which poses a potential threat to population health.

Inflammatory biomarkers and cardiac injury in COVID-19 patients.

Introduction: Cardiac injury has received considerable attention due to the higher risk of morbidity and mortality associated with coronavirus disease. However, in a developing country, there is a scarcity of data on cardiac injury in COVID-19 patients related to inflammatory biomarkers.

Methods: Therefore, the present research retrospectively analyzes data from three territorial hospitals in Pakistan's Punjab province to investigate the potential impact of the cardiac injury on the mortality and severity of COVID-19-infected patients.

Particulate air pollution and metabolic risk factors: Which are more prone to cardiac mortality.

This study explored multiplex, country-level connections between a wide range of cardiac risk factors and associated mortality within the South Asian Association for Regional Cooperation (SAARC) countries. The grey relational analysis (GRA) methodology is used to evaluate data from 2001 to 2018 to compute scores and rank countries based on cardiac mortality. Subsequently, we used the conservative (Min-Max) technique to determine which South Asian country contributes the most to cardiac mortality.

Uptake of COVID-19 booster shot among healthcare workers: A mediation analysis approach.

Since the thrust of previous research investigations has been on people's willingness to get immunized against the COVID-19 infection, the underpinning principle of compliance has received very little attention. Addressing the possible drivers and mechanisms influencing vaccine acceptance may provide significant insights for limiting the pandemic. In response, we intend to investigate the influence of decision regret and the consequences of post-vaccination adverse effects on the inclination to undertake booster shots.

Cardiovascular Disease Mortality and Potential Risk Factor in China: A Multi-Dimensional Assessment by a Grey Relational Approach.

This study aims to investigate the impact of hypertension, diabetes, and high blood cholesterol on increased mortality from cardiovascular diseases such as coronary heart disease, stroke, and pulmonary heart disease in a multi-dimensional way. The grey relational analysis methodology is adopted to assess the connection between cardiac risk factors and related mortality. The Hurwicz and the Conservative (Min-Max) criterion approach are also utilized to identify the prospective risk factor that contributes the most to increased cardiac mortality.

Impact of Environmental Degradation on Human Health: An Assessment Using Multicriteria Decision Making.

Air pollution has emerged as a major global concern in recent decades as a result of rapid urbanization and industrialization, leading to a variety of adverse health outcomes. This research aims to investigate the influence of exposure to ambient and household particulate matter pollution (PM), and ground-level ozone (O) pollution on respiratory and cardiac mortality in Pakistan. We used grey incidence analysis (GIA) methodology to estimate the degree of proximity among selected variables and rank them based on mortality.

Socioeconomic Influence on Cardiac Mortality in the South Asian Region: New Perspectives from Grey Modeling and G-TOPSIS.

Background: Measuring the potential socioeconomic factors of cardiac mortality is fundamental to identifying treatments, setting priorities, and effectively allocating resources to minimize disease burden. The study sought to present a methodology that explores the connections between urbanization, population growth, human development index (HDI), access to energy, unemployment, and cardiovascular disease (CVD) mortality within the South Asian Association for Regional Cooperation (SAARC) nations to mitigate the cardiac disease burden.

Methods: This investigation uses multiple-criteria decision-making methodologies to analyze data between 2001 and 2017 commencing with a mathematical grey incidence analysis (GIA) methodology to estimate weights and rank nations based on CVD mortality.

Cardiovascular disease (CVD): assessment, prediction and policy implications.

Background: The study aims to predict and assess cardiovascular disease (CVD) patterns in highly affected countries such as Pakistan, India, China, Kenya, the USA, and Sweden. The data for CVD deaths was gathered from 2005 to 2019.

Methods: We utilized non-homogenous discrete grey model (NDGM) to predict growth of cardiovascular deaths in selected countries.

Sectoral-based CO emissions of Pakistan: a novel Grey Relation Analysis (GRA) approach.

Global warming regarded as the major global issue over the past few decades, whereas carbon dioxide (CO) emissions have been cited as one of the main causes of this problem. Therefore, this study aims to investigate the effect of energy consumption, economic development, and population growth on high CO emitting sectors of Pakistan such as transportation, industrial, and household. The data used in this study was taken from multiple databases from 2000 to 2018.

Quality of Care for Patients with Acute Myocardial Infarction (AMI) in Pakistan: A Retrospective Study.

A wide variation exists in the practice patterns of acute myocardial infarction (AMI) care worldwide, leading to differences in clinical outcomes. This study aims to evaluate the quality of process care and its impact on in-hospital outcomes among AMI patients in Pakistan, as no such study has been conducted in Pakistan thus far based upon recommended guidelines. We investigated a sample of 2663 AMI patients across 11 territory hospitals in Punjab province of Lahore, Faisalabad, Multan, Rawalpindi, and Islamabad from January 1, 2016 to December 31, 2017, with an in-hospital mortality rate of 8.