Impact of Oxygen Vacancies in LiCoO on the Electrochemical Performance of Garnet-Based All-Solid-State Li-Metal Batteries.

Garnet-structured LiLaZrO (LLZO) is considered as one of the most promising solid electrolytes for high safety all-solid-state Li batteries (SSLBs) applications. However, this type of SSLB utilizing LiCoO/LLZO as composite cathode faces high capacity degradation because of delamination between LiCoO (LCO) and LLZO and possible oxygen vacancy-driven microcrack formation within LCO. Herein, a pure oxygen atmosphere is used for sintering the composite cathode to limit oxygen vacancy formation in LCO.

Identification of a 10-species microbial signature of inflammatory bowel disease by machine learning and external validation.

Genetic and microbial factors influence inflammatory bowel disease (IBD), prompting our study on non-invasive biomarkers for enhanced diagnostic precision. Using the XGBoost algorithm and variable analysis and the published metadata, we developed the 10-species signature XGBoost classification model (XGB-IBD10). By using distinct species signatures and prior machine and deep learning models and employing standardization methods to ensure comparability between metagenomic and 16S sequencing data, we constructed classification models to assess the XGB-IBD10 precision and effectiveness.

Application of 5G robotic telesurgery in urology: a multicenter study in the real world.

Background: The current literature still lacks robust real-life evidence to support the practical implications of telesurgery. We conduct the current study to evaluate the safety and effectiveness of telesurgery over a high-speed remote communication network (the 5G network) in the real world.

Methods: A total of 37 patients were enrolled across the participating hospitals from December 2023 to June 2024.

Stable Na Deposition/Dissolution Enabled by 3D Bimetallic Carbon Fibers with Artificial Solid Electrolyte Interface.

3D bimetallic carbon nanofibers (CNFs) are promising interlayers for regulating Na deposition/dissolution on the Na metal or directly on current collectors like Cu. However, uncontrollable solid electrolyte interface (SEI) growth on the interlayer during the repeated Na plating/stripping process leads to low initial Coulombic efficiency (CE), impeding the practical applications of such a protective layer in Na metal batteries. Herein, an artificial SEI-coated interlayer decorated with sodiophilic Ag and sodiophobic Cu on CNF is applied on Cu foil to regulate the Na deposition/dissolution behavior.

Unravelling CYP4V2: Clinical features, genetic insights, pathogenic mechanisms and therapeutic strategies in Bietti crystalline corneoretinal dystrophy.

Inherited retinal dystrophies (IRDs) comprise a spectrum of disease phenotypes with genetic heterogeneity and clinical phenotypic diversity. Bietti crystalline corneoretinal dystrophy (BCD) represents a distinct IRD subtype characterized by crystalline deposits in the retina. Although rare in Western populations, BCD ranks among the most prevalent IRDs in East Asia, affecting an estimated 124,000 to 377,000 individuals worldwide.

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation.

Disruption of the circadian clock is associated with the development of inflammatory bowel disease (IBD), but the underlying mechanisms remain unclear. Here, we observe that mice in the early active phase (Zeitgeber time 12, ZT12) of the circadian clock are more tolerant to dextran sodium sulfate (DSS)-induced colitis, compared to those in the early resting phase (ZT0). The expression of the circadian gene Bmal1 peaks in the early resting phase and declines in the early active phase.

Gut microbiota dysbiosis in patients with Alzheimer's disease and correlation with multiple cognitive domains.

Background: Accumulating evidence suggested that Alzheimer's disease (AD) was associated with altered gut microbiota. However, the relationships between gut microbiota and specific cognitive domains of AD patients have yet been fully elucidated. The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.

Specific gut microbiome signatures predict the risk of acute ischemic stroke.

Introduction: Numerous studies have reported alterations in the composition of gut microbiota in patients with acute ischemic stroke (AIS), with changes becoming more pronounced as the disease progresses. However, the association between the progression of transient ischemic attack (TIA) and AIS remains unclear. This study aims to elucidate the microbial differences among TIA, AIS, and healthy controls (HC) while exploring the associations between disease progression and gut microbiota.

Identification of feature genes in intestinal epithelial cell types.

The intestine, is responsible for food digestion, nutrient absorption, endocrine secretion, food residue excretion, and immune defense. These function performances are based on the intricate composition of intestinal epithelial cells, encompassing differentiated mature cells, rapidly proliferative cells, and intestinal stem cells. Although the characteristics of these cell types are well-documented, in-depth exploration of their representative markers and transcription factors is critical for comprehensive cell fate trajectory analysis.

Erratum: Improved Measurement of the Differential Polarizability Using Co-trapped Ions [Phys. Rev. Lett. 133, 033001 (2024)].

This corrects the article DOI: 10.1103/PhysRevLett.133.

Application of Mendelian randomization analysis in investigating the genetic background of blood biomarkers for colorectal cancer.

Colorectal cancer (CRC), a malignancy affecting the colon and rectum, ranks as the third most common cancer worldwide and the second leading cause of cancer-related deaths. Early detection of CRC is crucial for preventing metastasis, reducing mortality, improving prognosis, and enhancing patients' quality of life. Genetic factors play a significant role in CRC development, accounting for up to 35% of the disease risk.

BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells.

Lgr5 intestinal stem cells (ISCs) are crucial for the intestinal epithelium renewal and regeneration after injury. However, the mechanism underlying the interplay between Wnt and BMP signaling in this process is not fully understood. Here we report that Bcl11b, which is downregulated by BMP signaling, enhances Wnt signaling to maintain Lgr5 ISCs and thus promotes the regeneration of the intestinal epithelium upon injury.

Spatiotemporal analysis of tuberculosis in the Hunan Province, China, 2014-2022.

Background: Pulmonary tuberculosis (PTB) is a major infectious disease that threatens human health. China is a high tuberculosis-burden country and the Hunan Province has a high tuberculosis notification rate. However, no comprehensive analysis has been conducted on the spatiotemporal distribution of PTB in the Hunan Province.

Improved Measurement of the Differential Polarizability Using Co-Trapped Ions.

We present a novel approach for measuring the differential static scalar polarizability of a target ion utilizing a "polarizability scale" scheme with a reference ion co-trapped in a linear Paul trap. The differential static scalar polarizability of the target ion can be precisely extracted by measuring the ratio of the ac Stark shifts induced by an add-on infrared laser shed on both ions. This method circumvents the need for the calibration of the intensity of the add-on laser, which is usually the bottleneck for measurements of the polarizability of trapped ions.

Effects of Bony Pelvic and Prostate Dimensions on Surgical Difficulty of Robot-Assisted Radical Prostatectomy: An Original Study and Meta-analysis.

Background: Due to the deep location of the prostate within the pelvic cavity, procedures of robot-assisted radical prostatectomy (RARP) might be challenged by the prostate size and the limited pelvic cavity space. This study aimed to investigate the roles of bony pelvic and prostate dimensions in RARP procedures by an original study coupled with a meta-analysis.

Methods: In the original study, patients undergoing multiport RARP between 2021 and 2022 were consecutively assessed.

Electrochemical Activation of LiGaO: Implications for Ga-Doped Garnet Solid Electrolytes in Li-Metal Batteries.

Ga-doped LiLaZrO garnet solid electrolytes exhibit the highest Li-ion conductivities among the oxide-type garnet-structured solid electrolytes, but instabilities toward Li metal hamper their practical application. The instabilities have been assigned to direct chemical reactions between LiGaO coexisting phases and Li metal by several groups previously. Yet, the understanding of the role of LiGaO in the electrochemical cell and its electrochemical properties is still lacking.

Chemical Prelithiated 3D Lithiophilic/-Phobic Interlayer Enables Long-Term Li Plating/Stripping.

The up-to-date lifespan of zero-excess lithium (Li) metal batteries is limited to a few dozen cycles due to irreversible Li-ion loss caused by interfacial reactions during cycling. Herein, a chemical prelithiated composite interlayer, made of lithiophilic silver (Ag) and lithiophobic copper (Cu) in a 3D porous carbon fiber matrix, is applied on a planar Cu current collector to regulate Li plating and stripping and prevent undesired reactions. The Li-rich surface coating of lithium oxide (LiO), lithium carboxylate (RCOLi), lithium carbonates (ROCOLi), and lithium hydride (LiH) is formed by soaking and directly heating the interlayer in -butyllithium hexane solution.

Plasma levels of bactericidal/permeability-increasing protein correlate with systemic inflammation in acute coronary syndrome.

Background: Neutrophils play important roles in atherosclerosis and atherothrombosis. Bactericidal/permeability-increasing protein (BPI) is mainly expressed in the granules of human neutrophils in response to inflammatory stress. This observational, cross-sectional study investigated the plasma level of BPI in patients with acute coronary syndrome (ACS) and its correlation with blood neutrophil counts and circulating inflammatory biomarkers.

Capacity Degradation of Zero-Excess All-Solid-State Li Metal Batteries Using a Poly(ethylene oxide) Based Solid Electrolyte.

Solid-state polymer electrolytes (SPEs), such as poly(ethylene oxide) (PEO), have good flexibility when compared to ceramic-type solid electrolytes. Therefore, it could be an ideal solid electrolyte for zero-excess all-solid-state Li metal battery (ZESSLB), also known as anode-free all-solid-state Li battery, development by offering better contact to the Cu current collector. However, the low Coulombic efficiencies observed from polymer type solid-state Li batteries (SSLBs) raise the concern that PEO may consume the limited amount of Li in ZESSLB to fail the system.

Efficacy and safety of intracoronary pro-urokinase combined with low-pressure balloon pre-dilatation during percutaneous coronary intervention in patients with anterior ST-segment elevation myocardial infarction.

Background: The efficacy and safety of low-pressure balloon pre-dilatation before intracoronary pro-urokinase (pro-UK) in preventing no-reflow during percutaneous coronary intervention (PCI) remains unknown. This study aimed to evaluate the clinical outcomes of intracoronary pro-UK combined with low-pressure balloon pre-dilatation in patients with anterior ST-segment-elevation myocardial infarction (STEMI).

Methods: This was a randomized, single-blind, investigator-initiated trial that included 179 patients diagnosed with acute anterior STEMI.