Sectoral linkages and their influence on structural change: The case of China.

Structural change is a fundamental aspect of a country's economic development process. Unlike traditional literature, our research integrates input-output analysis with a multisector general equilibrium model to investigate the role of sectoral input-output linkages throughout this process. By utilizing this framework and applying it to Chinese data, we find that sectoral input-output linkages are as critical as final demand in our analysis.

A Lipid with Lewis Pair-Mediated Targeting and Multiple Stimuli-Responsive Delivery of Antibiotics for Bacterial Infections.

Integrating both targeted delivery and stimulus-responsive release into a single small molecule for drug delivery presents challenges related to synthesis, stability, and efficacy. In this study, single-molecular lipids incorporating a Lewis pair (Lp-lipids) are described, composed of a Lewis acid (phenylboronic acid) and a Lewis base (amine) within a single small molecular structure, to formulate lipid nanoparticles for antibiotic delivery. For targeted delivery to bacterial biofilms, the phenylboronic acid selectively binds to bacteria or biofilms by forming boronate ester bonds with diols in the microbial dextran or peptidoglycan.

Active and passive targeted delivery of anti-ferroptotic therapy for post-resuscitation myocardial dysfunction.

Post-resuscitation myocardial dysfunction (PRMD), associated with ferroptosis, contributes significantly to early mortality post-cardiopulmonary resuscitation. However, ferrostatin-1 (Fer-1), a ferroptosis inhibitor, faces challenges in clinical applicability for critical diseases. Here, we report a reactive oxygen species (ROS)-responsive (passively targeting ferroptosis) and myocardium-targeted drug delivery system that facilitates the on-demand delivery of nanoparticles (NPs) encapsulating a ferroptotic inhibitor as tested in a cardiac arrest model.

Igfbp2 Downregulation in PVT-CeA Glutamatergic Circuits Drives Neonatal Anesthesia-Induced Fear Memory Deficits.

Repeated neonatal general anesthesia results in long-term cognitive dysfunction; however, the underlying mechanisms remain unclear. This study finds that repeated neonatal anesthesia impaired fear memory in adolescent mice of both sexes, along with hypoactivated glutamatergic neurons in the paraventricular thalamus (PVT). Optogenetic activation of PVT glutamatergic neurons rescued fear memory deficits in anesthesia-treated mice, whereas optogenetic inhibition of these neurons recapitulated memory deficits in control mice.

Photonic Nyquist folding receiver using optical pulses with discrete pulse position modulation.

This paper presents a photonic Nyquist folding receiver (NYFR) architecture leveraging discrete pulse position modulation for efficient ultra-wideband radio frequency (RF) signal acquisition and processing. The proposed system integrates a mode-locked laser (MLL) with cascaded Mach-Zehnder modulators (MZMs) to generate non-uniform optical pulse trains with frequency-modulated sampling intervals. These non-uniform pulses serve as optical sampling signals to compress and capture wideband RF signals.

High-temperature-resistant gas pressure sensor based on an all-silica Fabry-Perot interferometer.

A high-temperature-resistant gas pressure sensor based on an all-silica Fabry-Perot interferometer (FPI) structure is proposed. A carbon dioxide () laser is utilized to achieve integrated welding between a silica capillary tube and optical fibers. A cascaded femtosecond laser-inscribed fiber Bragg grating is used to compensate for the influence of temperature.

Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits.

Engram cells storing episodic memories are allocated to separate neuronal ensembles. However, how these ensembles maintain their stability to drive precise memory expression, and whether their destabilization contributes to aging-related memory deficits, remain elusive. Here, we show that during contextual fear memory consolidation, neuronal pentraxin 1 (NPTX1) in Fos transcription-dependent ensemble (F-RAM) of the dentate gyrus (DG) promotes memory expression in the fear context.

Precise rewiring of corticospinal axons and spinal interneurons via near-infrared optogenetics for spinal cord injury treatment.

To date, precise restoration of proper connections between posttrauma axons and neurons following spinal cord injury (SCI) remains a substantial challenge. Here, we developed glutamate-linked upconversion nanoparticles (Glu-UCNP) to facilitate optogenetic control of axonal sprouting in SCI mice. After being specifically uptaken by the postsynaptic interneurons innervated by corticospinal tract (CST) axons, Glu-UCNP not only serves as internal light transducers that convert near-infrared light to visible light but also acts as nanobeacons that guide axonal sprouting toward postsynaptic neurons of glutamatergic synapses.

Quality review of typical value ranges in urodynamic measurements using statistical process control: A single-center retrospective study.

Background: Urodynamic study (UDS) is essential for assessing lower urinary tract function, but quality control methods remain limited. Statistical process control (SPC), a tool originally developed in manufacturing, has shown promise in healthcare for improving quality and reducing variability.

Objective: This study explored the application of SPC to analyze the typical value ranges (TVR) of urodynamic measurements.

CD248 induces PD-L1 expression on cancer-associated fibroblasts to promote NSCLC immune escape.

Background: Tumor immune escape is a critical step in tumor progression. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) express abundant PD-L1 and suppress the functions of CD8T cells, enablingd immune escape. CD248 is a candidate bioindicator for CAFs associated with non-small cell lung cancer (NSCLC), although its involvement in immune escape is not known.

Traditional Chinese medicine formulas alleviated acute pancreatitis via improvement of microcirculation: A systematic review and meta-analysis.

Objective: Microcirculatory disturbance is pathologically critical to acute pancreatitis (AP), which can be effectively alleviated by traditional Chinese medicine (TCM) formulas that activate blood flow. However, there has been no evidence-based research to date. Therefore, a well-designed systematic review and meta-analysis is necessary to elucidate the therapeutic transformative benefit of improving microcirculation during AP.

Decreased Nitrogen and Carbohydrate Metabolism Activity Leads to Grain Yield Reduction in Qingke Under Continuous Cropping.

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The Stress Hyperglycemia Ratio as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Cohort Study.

: The stress hyperglycemia ratio (SHR) has emerged as a promising biomarker for assessing stress-induced hyperglycemia (SH) but has not been evaluated in patients with acute pancreatitis (AP). This study investigates the role of the SHR in predicting adverse clinical outcomes in patients with AP. : Adult patients with AP who were admitted within 72 h of the onset of abdominal pain were screened in the database.

Feasibility and safety assessment of the AGIBOT robotic system in urological surgery: preliminary results from a multicenter study.

Background: Robotic-assisted surgery has become a standard approach for urological procedures, providing enhanced precision, dexterity, and minimally invasive benefits. However, high costs and limited accessibility limits its broader adoption. This study evaluates feasibility and safety of novel AGIBOT robotic system in complex urological surgeries.

Dynamic changes in chromatin accessibility within one month of mouse intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high mortality and disability. Understanding the molecular and cellular mechanisms behind ICH is vital for developing effective therapeutic interventions. We utilized a single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq) to profile changes in chromatin accessibility over the first month following ICH in murine models.

All-Fiber Electronic Skin Based on Asymmetric Wool/PTFE Structure for Energy Harvesting and Self-Powered Sensing.

This paper reports on a fully textile electronic skin (e-skin) based on an asymmetric wool/polytetrafluoroethylene (PTFE) structure, which is fabricated through an innovative filling core yarn and weft interweaving technique, enabling self-driven contact detection and motion sensing functions. The e-skin features a three-layer woven structure, with the outer layer made of PTFE (high dielectric constant, superhydrophobic), the inner layer composed of wool (hygroscopic, skin-friendly), and a middle layer embedded with silver-plated nylon (SPN) conductive yarns forming a flexible electrode array. Benefiting from its asymmetric design, this material exhibits excellent triboelectric performance (open-circuit voltage of 37 V, short-circuit current of 58 nA), breathability (341.

PRMT2-mediated upregulation of miR-323-3p in sensory neurons promotes trigeminal neuropathic pain by targeting Kv2.1 channels.

Herein, we show a molecular pathway driven by an evolutionarily conserved microRNA (miRNA) in sensory neurons to control neuropathic pain. By employing high-throughput sequencing analysis, we find that miRNA-323-3p (miR-323-3p) exhibits the most significant upregulation in injured trigeminal ganglia (TGs). Local inhibition of miR-323-3p in injured TGs suppresses established trigeminal neuropathic pain but has no effect on inflammatory pain.

Inflammatory Biomarker-Based Risk Prediction Model for Endovascular Reconstruction in Acute Lower Limb Ischemia: A Multicenter Development and Validation Study.

Background: Inflammatory markers are associated with poor prognosis of peripheral vascular diseases. We aim to determine the relationship between inflammatory markers and the prognosis of acute lower limb ischemic disease and to construct and verify a prognostic model based on inflammatory indicators.

Methods: We evaluated 295 patients with a diagnosis of acute lower limb ischemia (ALI) from multiple centers between 2020 and 2023.

The size of parapelvic cyst may affect the effect of ureteroscopic laser incision and internal drainage.

Background: To evaluate the efficacy and the safety of flexible ureteroscopic laser incision and internal drainage in the treatment of parapelvic cysts and investigate the key variables affecting the collapse effect after cyst surgery.

Methods: A retrospective analysis was conducted on the clinical data of 45 patients diagnosed with parapelvic cysts and treated with laser incision and internal drainage at West China Hospital of Sichuan University from January 2018 to December 2024. The reduction ratio of the maximum transverse diameter of the cysts pre- and post-operation was utilized as the criterion for assessing therapeutic efficacy.

Application of 5G robotic telesurgery in urology: a multicenter study in the real world.

Background: The current literature still lacks robust real-life evidence to support the practical implications of telesurgery. We conduct the current study to evaluate the safety and effectiveness of telesurgery over a high-speed remote communication network (the 5G network) in the real world.

Methods: A total of 37 patients were enrolled across the participating hospitals from December 2023 to June 2024.

Photonic Disclination Nanocavities with Versatile Rotational Symmetries.

Disclinations, as real-space topological defects, have been extensively studied across condensed matter and classical wave systems. However, their formation is typically restricted by atomic interaction forces or specific lattice symmetries, severely limiting the tunability. Here, we engineer photonic disclination nanocavities with versatile rotational symmetries through a symmetry-unconstrained Volterra process, surpassing natural system limitations.

STING Agonist Drug Delivery by Bacterial Extracellular Vesicles Induces Synergistic Immuno-Oncology Responses and Efficient Inhibition of Tumour Growth.

Bacterial extracellular vesicles are spherical, nanosized structures with lipid bilayer membranes and can suppress tumour growth in cancer models. However, the efficacy of some of these models is limited. One potential way to enhance their effects is by loading the bacterial vesicles with immunostimulatory molecules.

Leaching behavior and release mechanism of arsenic and antimony from different storage duration in a phosphogypsum stack.

Phosphogypsum, a by-product of phosphate fertilizers and phosphoric acid production, is a major solid waste in the chemical industry. This study systematically investigated the leaching behavior of heavy metals (arsenic and antimony) from phosphogypsum stored for various storage durations using sequential chemical extraction, batch experiments, and column experiments. Phosphogypsum were sampled at different storage durations spanning up to 8 years from a large-scale phosphogypsum stockpile.

Self-Powered Multimodal Tactile Sensing Enabled by Hybrid Triboelectric and Magnetoelastic Mechanisms.

Object property perception, as a core component of tactile sensing technology, faces severe challenges due to its inherent complexity and diversity, particularly under the constraints of decoupling difficulty and limited precision. Herein, this paper introduces an innovative approach to object property perception utilizing triboelectric-magnetoelastic sensing. This technology integrates triboelectricity and magnetoelasticity, achieving a self-powered sensing mechanism that requires no external power source for sensing signal generation.

Randomized clinical studies assessing the pharmacokinetics and subjective effects of vuse alto electronic nicotine delivery systems.

The US FDA recommends assessment of abuse liability (AL) for premarket tobacco product applications (PMTAs) to determine whether a new tobacco product is appropriate for the protection of public health (APPH). To assess the AL and nicotine uptake of Vuse Alto electronic nicotine tobacco products (ENDS) which offer e-liquid pods that vary in nicotine concentration, we conducted two clinical laboratory studies. The primary objective of Study 1 was to assess measures of product abuse liability (AL) in real time during and following product use.