UIon antagonism strategy for cadmium mitigation in Morchella sextelata: Physiological and metabolomic insights.

Cadmium (Cd) contamination in edible fungi poses a significant threat to food safety. However, targeted strategies to regulate Cd uptake and enhance Cd stress tolerance in Morchella sextelata remain largely unexplored. Given that M.

Research on the construction method and characterization of neutralizing mouse-canine chimeric antibody against canine distemper virus.

Canine distemper (CD) is an acute infectious disease that poses significant health risks to canines. Neutralizing monoclonal antibody (mAb) therapy has demonstrated substantial efficacy in prevent CDV infection. However, immune rejection reactions prevent the use of mouse-derived mAbs in the prophylactic protection of CD.

Multiquadrant presentation of eruption sequestrum: a case report and literature review.

Background: Eruption sequestrum (ES) is an uncommon condition characterized by irregular calcified tissues on the occlusal surfaces of erupting permanent molars, primarily in children. Despite its rarity, ES has been linked to potential complications, including gingivitis, occlusal trauma, and delayed tooth eruption.

Case Presentation: This paper reports a multiquadrant ES case affecting the first molars of bilateral maxillary and mandibular arches in a 6-year-old pediatric patient.

Metal Porphyrin-Terminated Hyperbranched Polyimides for Resistive Switching in Nonvolatile Memory Devices.

Polymer resistive random-access memory (RRAM) holds great promise for flexible wearable electronics and artificial intelligence, yet its development is hindered by chain entanglement and intermolecular interactions, leading to processing challenges, high operating voltages, and unstable switching parameters. Herein, metal-porphyrin-terminated hyperbranched polyimides (ATPP@HBPI, (Zn)ATPP@HBPI, and (Cu)ATPP@HBPI) were synthesized. The hyperbranched structure mitigates intermolecular interactions, while ionic doping modulates conductivity, and the synergistic effect of ions and electrons optimizes resistive switching behavior.

Multiple biomarkers risk score for accurately predicting the long-term prognosis of patients with acute coronary syndrome.

Background: Biomarkers-based prediction of long-term risk of acute coronary syndrome (ACS) is scarce. We aim to develop a risk score integrating clinical routine information (C) and plasma biomarkers (B) for predicting long-term risk of ACS patients.

Methods: We included 2729 ACS patients from the OCEA (Observation of cardiovascular events in ACS patients).

The impact of land use change on ecosystem services in the Huaihai economic zone for evaluation and Spatiotemporal characterization.

A comprehensive understanding of the impact of land use change on ecosystem services is essential for regional sustainable development. This study aims to enhance the accuracy of ecosystem service value (ESV) assessment by accounting for regional differences and to propose a novel approach for quantifying the relationship between land use change and ecosystem services. Based on land use data from the Huaihai Economic Zone (HEZ) during 1995-2020, spatially adjusted equivalence factors were employed to estimate ESV, while the coefficient of improved cross sensitivity (CICS) was developed to measure the linkage between land use and ESV.

Dynamic TOM-TIM23 supercomplex directs mitochondrial protein translocation and sorting.

The mitochondrial translocase of the outer membrane (TOM) and translocase of the inner membrane 23 (TIM23) complexes are coupled to control protein import across the outer and inner membranes, respectively. However, the mechanisms of protein recognition and sorting in the TOM-TIM23 pathway remain unclear. Here we report cryo-electron microscopy structures of a translocating polypeptide substrate captured in the active TOM-TIM23 supercomplex from Saccharomyces cerevisiae.

Timing of surgery for symptomatic choledochal cysts with hyperamylasemia in children: a retrospective analysis.

Purpose: This study aims to investigate the optimal surgical timing for symptomatic choledochal cyst (CDC) with hyperamylasemia in children.

Methods: We retrospectively reviewed 61 symptomatic CDC patients with hyperamylasemia who underwent cyst excision and Roux-en-Y hepaticojejunostomy between July 2020 and November 2021. Patients were either in symptomatic phase or in remission at the time of surgery.

Association between C-reactive protein-triglyceride glucose index and Future cardiovascular disease risk in a population with cardiovascular-Kidney-metabolic syndrome stage 0-3.

Cardiovascular-Kidney-Metabolic (CKM) syndrome, a concept recently introduced by the American Heart Association (AHA), emphasizes the intricate relationships among metabolic, renal, and cardiovascular diseases. The C-reactive protein-triglyceride-glucose index (CTI) has been proposed as an effective biomarker for insulin resistance (IR) and inflammation. Although there is substantial evidence demonstrating an association between the CTI and cardiovascular disease (CVD), its precise role in individuals with CKM syndrome stage 0-3 remains unclear.

Electric Field-Insensitive Solvation Chemistry Stabilizes High-Voltage Lithium Metal Batteries.

Ether based electrolytes are promising for the realization of lithium (Li) metal batteries (LMBs). However, the oxidation chemistry of these electrolytes stemming from the disruption to solvent coordination by interfacial electric-field remains unresolved and challenging. Herein, we demonstrated that reinforcing the interactions between solvent and diluent to decouple solvation dynamics from interfacial electric fields could maintain Li⁺-solvent coordination integrity and drastically diminish uncoordinated solvents, thereby increasing electrolyte anodic stability.

Unlocking Efficient Direct Charge Transfer of Ni-N Bridge 2D N-ZnInS/Ni Single-Atom Photocatalysts for Hydrogen Evolution.

This study reports a strategy for constructing highly efficient single-atom photocatalysts through the formation of Ni-N chemical bonds. By anchoring Ni single atoms on nitrogen-doped ZnInS (N-ZIS), we created a localized charge region that enables directed interfacial charge transfer. The newly formed Ni-N bond plays dual roles of significantly enhancing charge carrier separation and prolonging their lifetime, and serving as an efficient electron transfer pathway from N trap states to Ni active sites.

IFITM1 promotes microglial polarization and NLRP3 inflammasome activation in ischemic stroke through up-regulating c-FOS.

Unlabelled: Microglial polarization and the NLRP3 inflammasome play critical roles in the pathology of ischemic stroke (IS). Regulation of microglial polarization towards M2 type has become a potential therapy approach for M2 type has become a potential therapy approach for treating IS. The current study demonstrated IFITM1 was markedly upregulated in microglia in the Distal middle cerebral artery (dMCAO) model.

MetaDetection: wireless intelligent detection of multiliquids by using space-time-coding metasurface.

The increasing demand for public safety has created an urgent need for high-performance technologies capable of detecting hazardous liquids with high accuracy, efficiency, and cost-effectiveness. Conventional liquid detection methods often fall short in addressing these requirements due to limitations in precision, operational complexity, and scalability. This study introduces a wireless intelligent system for the detection of suspicious liquids, leveraging advancements in programmable metasurface and software defined radio technologies.

Adaptive Covariance Matrix for UAV-Based Visual-Inertial Navigation Systems Using Gaussian Formulas.

In a variety of UAV applications, visual-inertial navigation systems (VINSs) play a crucial role in providing accurate positioning and navigation solutions. However, traditional VINS struggle to adapt flexibly to varying environmental conditions due to fixed covariance matrix settings. This limitation becomes especially acute during high-speed drone operations, where motion blur and fluctuating image clarity can significantly compromise navigation accuracy and system robustness.

ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation.

Gastric cancer (GC) is characterised by a dense stromal microenvironment, lack of therapeutic targets, and limited effective treatment options, collectively leading to a poor prognosis. Here, we identify UL16 binding protein 2 (ULBP2) as a potential therapeutic target in GC. Mechanistically, ULBP2 overexpression activates the TGF-β signalling pathway, promoting the activation of cancer-associated fibroblasts (CAFs) and tumor progression in GC.

Indirect determination of environmental polylactic acid microplastic residues using a single-atom nickel composite electrode.

The widely accepted application of polylactic acid (PLA) films as agricultural mulch films has led to the accumulation of microplastics (MPs) in soil ecosystems, causing severe white pollution. Developing a convenient method to detect PLA in the environment is essential for pollution control. In this study, single-atom nickel-doped nitrogen on carbon nanosheets (Ni-N-C) combined with gold-palladium nanoparticles (AuPdNPs) enabled highly sensitive lactic acid detection.

Resolving Hydraulic Resistances in Thin-Film Composite Polyamide Nanofiltration Membranes.

Thin-film composite (TFC) nanofiltration (NF) membranes are widely used in water treatment and resource recovery. Researchers generally take for granted that the dense polyamide rejection film dictates the overall hydraulic resistance of these membranes, neglecting the contributions of the substrate and the transverse transport of water to reach substrate pores. To address this critical gap, we developed a resistance-in-series model to quantify the resistances from the polyamide film, substrate, and transverse transport.

Obstacle-Immune Microwave Wireless Power Transfer System Based on Amplitude-Dependent Caustic Metasurface.

Rapid advances in the Internet of Everything (IoE) drive microwave wireless power transfer (MWPT) technology for charging wireless smart devices. However, environmental obstacles and safety concerns associated with high-power transmission present new challenges for the technology. To address these problems, an amplitude-dependent caustic metasurface (ADCMs) design method is proposed for generating self-bending radio frequency circular Airy beams (RFCAB).

Effects of core strength training on the technical skill performance of striking combat sport players: a systematic review.

Research Purpose: This review investigated the effects of core strength training on the competitive performance of players participating in striking combat sports. By analyzing karate, taekwondo, boxing, Chinese martial arts, and Muay Thai, the study examined the effects of core strength training on the number of kicks, striking force, and impact speed of players. The aim of this study was to provide a theoretical basis for training methods in striking combat sports and to explore the role of core strength in improving players' actual competitive performance.

Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis.

Background: Acute liver injury (ALI), which can progress to cirrhosis, hepatocellular carcinoma and acute liver failure, has become a global concern and a serious threat to human life and health. Isorhamnetin (ISO) is an O-methylated flavonol from the class of flavonoids. It has a protective effect on various organs, but its effect on ALI is still unclear in current studies.

Cancer-associated fibroblasts secreting IL-6 inhibit the cisplatin and docetaxel killing effect in lung squamous cell carcinoma.

Chemoresistance remains a major obstacle in the treatment of lung squamous cell carcinoma (LUSC), often leading to suboptimal clinical outcomes. Among the key contributors to this resistance are cancer-associated fibroblasts (CAFs), which are increasingly recognized for their tumor-supportive roles. Despite this, the molecular pathways through which CAFs promote chemoresistance in LUSC are not fully elucidated.

Phosphorus Filling Sulfur Vacancies in CoS Optimizes the Electronic Structure and Boosts the Overall Water Splitting in Alkaline Media.

The defective cobalt sulfide (CoS) core-shell hollow spheres are modified by homogeneously distributed phosphorus (P) atoms. P atoms can not only effectively stabilize sulfur vacancies but also form the Co-P coordination with Co active site in the sulfur vacancies, which can modulate the electronic structure of the active site, enabling P-CoS to exhibit much superior oxygen evolution reaction (OER) activity. Furthermore, CoS has been developed as a highly efficient OER electrocatalyst but has poor activity for hydrogen evolution reaction (HER), thus limiting the overall performance of water splitting.

Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis.

Hirschsprung disease (HSCR) is a congenital condition characterized by the improper migration of enteric neural crest cells, leading to aganglionosis most commonly in the rectosigmoid colon. This severe and life-threatening disorder often results in the development of Hirschsprung-associated enterocolitis (HAEC), which can occur either before or after surgical resection of the affected bowel segment. Using colonic tissue from patients with HSCR alongside the well-established endothelin receptor B knockout mouse model, we investigated epithelial regeneration dynamics and stromal-epithelial cross-talk in the distal ganglionic colon, a critical site for HAEC development.

CD248 induces PD-L1 expression on cancer-associated fibroblasts to promote NSCLC immune escape.

Background: Tumor immune escape is a critical step in tumor progression. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) express abundant PD-L1 and suppress the functions of CD8T cells, enablingd immune escape. CD248 is a candidate bioindicator for CAFs associated with non-small cell lung cancer (NSCLC), although its involvement in immune escape is not known.

Polysaccharide nano‑selenium in the regulation of neuroinflammation: A review of mechanisms, functional potential, and activity evaluation.

Neuroinflammation is crucial in the pathogenesis of various neurological disorders, particularly neurodegenerative and inflammatory diseases. Recently, polysaccharides and polysaccharide nano‑selenium have gained attention for their potential in protecting neural tissue from damage. However, there is a lack of comprehensive studies on the role of polysaccharides in modulating neuroinflammation and the structural characteristics that underpin their effects.