PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity.

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a gene strongly associated with lupus and other autoimmune diseases. PTPN22 regulates T cell receptor (TCR) signaling through dephosphorylation of the kinases lymphocyte-specific protein tyrosine kinase (LCK) and zeta-chain-associated protein kinase 70 (ZAP70). The regulation of PTPN22 remains poorly understood.

Metal Porphyrin-Terminated Hyperbranched Polyimides for Resistive Switching in Nonvolatile Memory Devices.

Polymer resistive random-access memory (RRAM) holds great promise for flexible wearable electronics and artificial intelligence, yet its development is hindered by chain entanglement and intermolecular interactions, leading to processing challenges, high operating voltages, and unstable switching parameters. Herein, metal-porphyrin-terminated hyperbranched polyimides (ATPP@HBPI, (Zn)ATPP@HBPI, and (Cu)ATPP@HBPI) were synthesized. The hyperbranched structure mitigates intermolecular interactions, while ionic doping modulates conductivity, and the synergistic effect of ions and electrons optimizes resistive switching behavior.

Urban streams as hotspots of carbon dioxide and methane diffusive emissions compared to small ponds.

Streams and ponds significantly contribute to the global freshwater carbon gases budget. To understand the role of urbanization in affecting aquatic carbon emissions, here we examined the carbon dioxide (CO) and methane (CH) concentrations and diffusive emissions from streams and small ponds across three headwater catchments with varied urbanization intensities in the upper Yangtze River. We found that riverine partial pressure of CO (pCO) and dissolved CH concentration (dCH) increased, while pond pCO and dCH decreased as urban land proportion of catchments increased from 1.

Environmental noise exposure and cardiovascular diseases in a Shanghai cohort.

Background: Little is known about the impact of environmental noise on cardiovascular diseases (CVDs) in low- and middle-income countries, where high population density and complex sources of noise are prevalent. This study aimed to explore associations of environmental noise with CVDs and cardiovascular risk factors.

Methods: 27,444 participants aged 18-74 years were included in this study.

Reconfigurable Flexible Plasmonic Hydrogen Sensor Based on Disordered Palladium Nanoparticles: Coupled Optical Modulation and 3D Structural Rearrangement.

Hydrogen, a clean and renewable energy carrier, necessitates advanced sensing technologies for safe and efficient utilization. Here, we present a tunable flexible plasmonic sensor based on a disordered system composed of upper palladium (Pd) nanoparticles (NPs), a poly(methyl methacrylate) (PMMA) spacer, a lower Pd film, and a soft substrate. The contributions of Pd NPs and Pd films to the optical response at various hydrogen concentrations are different.

What do we know about midwife-woman interactions during vaginal childbirth: a scoping review and thematic analysis.

Background: Against the backdrop of changes in the medical model, a clearer awareness among women of their rights, and a deeper emphasis on the "woman-centred" approach, it has become increasingly important to focus on the current state and quality of intrapartum interactions. While midwife-woman interactions during vaginal childbirth are recognized as central to shaping maternal health outcomes and birthing experiences, existing studies offer fragmented insights, with a limited synthesis of how these dynamics influence intrapartum care and support, maternal autonomy in decision-making, and the midwife-woman relationship.

Objectives: To synthesize the existing literature addressing midwife-woman interactions during childbirth and to identify any research gaps.

Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming.

Hepatocellular carcinoma (HCC) causes a significant mortality burden worldwide. Radiotherapy (RT) is the primary locoregional treatment modality for HCC. However, the efficacy of RT in HCC is limited by tumor microenvironment (TME) hypoxia, immunosuppression, and extracellular matrix (ECM) stiffness.

Generation of a human PBMC induced pluripotent stem cell line JXEYi001-A-iPSC from a pediatric patient with ventricular arrhythmias.

This study established an iPSC line, JXEYi001-A, from a 7-year-old male with a KCNJ2 mutation linked to ventricular arrhythmias (VA). KCNJ2 encodes Kir2.1, essential for cardiac repolarization; its mutations can cause short QT syndrome, increasing VA risk.

Robot-assisted surgery for pediatric tumors: A single-center study of 114 cases.

Purpose: Although robot-assisted surgery has been widely adopted for adult malignancies, its application in pediatric oncology remains contentious because of limited evidence. This study aims to assess the safety, feasibility, and surgical indications of robot-assisted surgery in pediatric oncology.

Method: A retrospective analysis was conducted on pediatric patients who underwent robot-assisted surgery at the Department of Surgical Oncology, Beijing Children's Hospital, between June 2021 and January 2024.

Biocontrol of the zearalenone-producer Fusarium ipomoeae on soybean pods using an avirulent Lasiodiplodia theobromae isolate.

Background: Fusarium pod blight is emerging as a destructive disease in soybean-producing regions. Currently, strategies for the management of Fusarium pod blight are lacking. This study aimed to examine the biocontrol activity of a new avirulent Lasiodiplodia theobromae isolate for the management of Fusarium pod blight.

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging.

Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy that increasingly affects the elderly population, with its post-transcriptional landscape remaining largely elusive. Establishing a stable proteomics-based classification system and systematically screening age-related proteins and regulatory networks are crucial for understanding the pathogenesis and outcomes of AML. In this study, we leveraged a multi-omics cohort of 374 newly diagnosed AML patients, integrating proteome, phosphoproteome, genome, transcriptome, and drug screening data.

Tailoring Low-Miller-Index Crystal Facets Realizes Perovskite Solar Cells with Flat Grain-boundary Grooves.

Charge transport and nonradiative recombination loss at the buried interface are important factors, which limit the efficiency and stability of perovskite solar cells (PSCs). Herein, we screen a series of diphosphate Lewis-base molecules, where N,N-bis(diphenylphosphino)amine (N-DPPM) with appropriate alkyl chains and multiple active sites not only can efficiently facilitate carrier transport but also coordinate with undercoordinated Pb and interact with FA through N⋯H bond. These features prompt the formation of high-quality perovskite films along (100)/(200) crystal facets.

Factors associated with symptom relief in patients with irritable bowel syndrome: a retrospective cohort study.

Background: Symptom relief in irritable bowel syndrome (IBS) varies widely, influenced by demographic, clinical, and psychosocial factors. Identifying factors associated with symptom relief can enhance management strategies for IBS patients.

Objective: This study aimed to examine factors associated with symptom relief in a cohort of IBS patients, focusing on the role of demographic, lifestyle, psychological, and physiological characteristics.

CDR clipping-induced heterodimerization: identification of a novel dimerization mechanism in a co-formulated antibody cocktail via a multifaceted mass spectrometry approach.

Co-formulated antibody cocktails are becoming an increasingly popular therapeutic class; however, they present analytical challenges over traditional single monoclonal antibody (mAb) formulations. One paramount concern is the formation of heteromeric species that have unknown impacts on safety and efficacy. Consequently, effective approaches for identifying and characterizing high-molecular weight (HMW) impurities are critical to the successful development of this therapeutic class.

Impact of dietary patterns on the survival outcomes of patients with cardiovascular disease.

Background: This study examines the association between dietary patterns and survival outcomes in patients with cardiovascular disease (CVD).

Methods: A total of 9,101 adults with CVD from the 2005-2018 National Health and Nutrition Examination Survey were included. Dietary patterns were evaluated using five indices: the Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH), Dietary Inflammatory Index (DII), Healthy Eating Index-2020 (HEI-2020), and the Alternative Mediterranean Diet Score (aMED).

Development of a core competency evaluation index system for specialist nurses in robot-assisted surgery: a Delphi study.

Background: The rapid rise of robot-assisted surgery (RAS), especially with the Da Vinci Surgical System (DVSS), has transformed surgical practices, enhanced precision and improving patient outcomes. As this technology becomes more prevalent, operating room nurses have taken on more specialized roles. However, there is a lack of standardized training and competency evaluation for these nurses, leading to inconsistencies in their preparedness.

Study on the dynamics of a single cavitation bubble in a compressible spherical liquid confined by an elastic solid.

Cavitation bubbles within elastic solids are widespread phenomena in both natural environments and technological systems, yet their confinement-dependent dynamics remain not well understood. To systematically study the bubble behavior in these phenomena, we develop a coupled model to study the dynamical behavior of a single cavitation bubble within a spherically constrained compressible liquid domain, incorporating the first-order compressibility correction, within a finite-thickness elastic solid. Linear analysis reveals a fundamental inverse relationship between resonant frequency and inner radius of the elastic solid, which is agree with the experimental results obtained by Vincent when the outer radius of the elastic solid is greater than or equal to twice the inner radius.

Automatically constructing an initial structure of athermal and achromatic optical systems based on particle swarm optimization.

In the design process of athermal and achromatic optical systems, most designers rely on experience to select the initial structure and materials, which leads to relatively low design efficiency. This paper proposes a method for constructing an initial structure of athermal and achromatic optical systems based on particle swarm optimization (PSO). The method automatically selects lens materials and optimizes structural parameters.

A pilot prospective study based on scanning OCT: the intraoperative vault model predicts postoperative vault.

Purpose: To evaluate the correlation between intraoperative vault measured by optical coherence tomography (OCT) and postoperative vault, and to assess dynamic changes in vault following EVO implantable collamer lens (ICL) implantation.

Setting: Eye and ENT Hospital of Fudan University.

Design: Prospective observational study.

In Situ Interface Reaction Enables Efficient Deep-Blue Perovskite Light-Emitting Diodes.

The development of blue perovskite light-emitting diodes (PeLEDs) is critical for advancing next-generation display technologies. However, the fabrication of high-quality mixed-halide blue perovskites remains challenging due to their intrinsic vulnerability to high defect densities, ion migration, and inefficient charge transport. To address this, we introduce a rapid in situ interface reaction at the buried interface between the perovskite layer and the underlying poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) film.

Isolation, identification, and characterization of a marine strain with antimicrobial activity against .

, an opportunistic pathogen commonly found in the food and cosmetics industries, has serious potential to cause severe human infections and industrial contamination. However, compared to traditional physical or chemical antimicrobial treatment, the novel biological antimicrobial strategies against have not been extensively explored. In this study, a strain with antimicrobial activity against was isolated from a marine grouper aquaculture pond and identified as Dys01.

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis.

Highly conserved homeobox genes are closely related to bone formation during embryogenesis, while their role in adult bone resorption remains unclear. In this study, we found that the homeobox gene MSX2 actively participates bone metabolism. Myeloid-specific Msx2 deficiency safeguards bone mass under physiological and pathological conditions.

An Integrated Machine Learning Framework for Developing and Validating a Diagnostic Model of Hub Genes Related to Lipid Metabolism in Chronic Rhinosinusitis.

Purpose: The study aimed to identify key genes related to lipid metabolism in chronic sinusitis and understand their biological implications, considering the growing interest in the association between chronic sinusitis - a complex inflammatory condition - and lipid metabolism due to lipids' role in inflammation and immunity.

Methods: Gene expression data from bulk - RNA sequence was analyzed and intersected with lipid metabolism genes and WGCNA module genes from the MSigDB database. Immune infiltration analysis was conducted.

Residual nephrogenic rests affect the long-term prognosis of Wilms tumor with bilateral nephrogenic rests.

Background/objectives: The progression of nephrogenic rests (NRs) can lead to the development of Wilms tumor (WT). The aim is to explore the factors affecting the poor prognosis associated with WT combined with bilateral NRs.

Methods: We retrospectively analyzed the clinical data of patients with WT combined bilateral NRs admitted to our center from January 2008 to December 2022.