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Objective: Nurses are key in administering oxygen therapy and managing its potential adverse effects in medical settings. This study aimed to investigate the knowledge, attitudes, and practices (KAP) regarding low-flow oxygen therapy and humidification among nurses.
Methods: This cross-sectional study was conducted from January 2024 to March 2024 at Shanghai Xuhui Central Hospital. Demographic data and KAP scores were collected through questionnaires.
Result: A total of 243 valid questionnaires were collected. Among them, 228 (93.8%) were female, and 93 (38.3%) had been working for more than 10 years. The mean scores for knowledge, attitudes, and practices were 11.11 ± 4.30 (Ranging 0-18), 29.14 ± 3.41 (Ranging 7-35), and 28.07 ± 4.73 (Ranging 7-35), respectively. Multivariate logistic regression confirmed that knowledge (OR = 1.302, 95% CI: [1.167-1.453], < 0.001) and attitudes (OR = 1.196, 95% CI: [1.080-1.325], < 0.001) were independently associated with proactive practices. Structural equation modeling (SEM) corroborated the direct influences of training ( = 3.210, < 0.001) and clinical experience ( = 2.044, = 0.002) on knowledge, with knowledge ( = 0.379, < 0.001) and gender ( = -1.642, = 0.037) directly impacting attitudes. Additionally, knowledge (β = 0.395, < 0.001), attitudes ( = 0.340, < 0.001), and equipment utilization ( = 1.098, < 0.001) directly influenced practices.
Conclusion: Nurses demonstrated inadequate knowledge, positive attitudes, and inactive practices toward low-flow oxygen therapy and humidification. Enhanced training and increased clinical experience are recommended to improve nurses' knowledge and practice in this area.
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http://dx.doi.org/10.3389/fmed.2024.1460079 | DOI Listing |
ACS Appl Bio Mater
September 2025
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
The generation of reactive oxygen species (ROS) through nanozyme-mediated sonocatalytic therapy has demonstrated remarkable therapeutic efficacy in the field of cancer. Nevertheless, it remains a significant challenge for nanozymes with a single catalytic active center to generate sufficient ROS via Fenton or Fenton-like reactions to effectively induce tumor cell death. In order to enhance the catalytic efficacy, we devised and synthesized a multiple active centre and mitochondrial-targeted perovskite nanozyme (NCFP), doped with cobalt (Co) element, and incorporated 4-carboxybutyltriphenylphosphonium bromide (TPP) as a mitochondrial targeting marker for ultrasound (US)-assisted enzyme-like catalytic treatment of tumors.
View Article and Find Full Text PDFAnn Am Thorac Soc
September 2025
Brigham and Women's Hospital, Division of Sleep and Circadian Disorders, Boston, Massachusetts, United States.
Rationale: There are insufficient data to inform the management of central sleep apnea (CSA) in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Nocturnal oxygen therapy (NOT) has been postulated to benefit CSA patients with HFrEF, but has not been rigorously studied. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.
View Article and Find Full Text PDFArq Bras Cardiol
September 2025
Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brasil.
Targeted temperature management (TTM) is currently the only potentially neuroprotective intervention recommended for post-cardiac arrest care. However, there are concerns among the scientific community regarding conflicting evidence supporting this recommendation. Moreover, the bulk of trials included in systematic reviews that inform guidelines and recommendations have been conducted in developed countries, with case mix and patient characteristics that significantly differ from the reality of developing countries such as Brazil.
View Article and Find Full Text PDFExp Physiol
September 2025
Department of Hepatobiliary Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Hepatic ischaemia-reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR-induced liver damage, mitochondria-targeted treatment is of the utmost significance for improving outcomes. The present study explored the mitoprotective role of combined ginsenoside-MC1 (GMC1) and irisin administration in diabetic rats with hepatic IR injury.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Cardiac Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Background: Cardiac ischemia reperfusion (I/R) injury is a serious consequence of reperfusion therapy for myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the citrullination of proteins. In previous studies, PAD4 inhibition protected distinct organs from I/R injury by preventing the formation of neutrophil extracellular traps (NETs) and attenuating inflammatory responses.
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