Retention of the infrapatellar fat pad does not influence the outcome of total knee arthroplasty: a systematic review.

Introduction: To improve patient satisfaction after total knee arthroplasty (TKA), retention of the infrapatellar fat pad (IPFP) is advocated.

Source Of Data: Recently published literature identified from PubMed, EMBASE, Scopus, and Google Scholar.

Areas Of Agreement: TKA is routinely performed in patients with end-stage joint osteoarthritis, but 18% to 11% of patients are unsatisfied after surgery.

A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.

Aging is the main risk factor for Parkinson's disease (PD), yet our understanding of how age-related mechanisms contribute to PD pathophysiology remains limited. We conducted a longitudinal analysis of blood samples from the Parkinson's Progression Markers Initiative cohort to investigate DNA damage in PD. Patients with PD exhibited disrupted DNA repair pathways and biased suppression of longer transcripts, indicating age-related, transcription-stalling DNA damage.

Transdermal, Infusion, and Surgical Therapies and Effect on Sleep Dysfunction in Parkinson's Disease.

Sleep dysfunction is dominant in patients on oral dopamine replacement therapies as nighttime therapy is suboptimal and often not attempted. Non oral infusion-based Parkinson's disease (PD) therapies, transdermal therapies, as well as deep brain stimulation (DBS) of the subthalamic nucleus (STN) bridge this gap and provide nighttime cover in most cases in PD. DBS of the STN also show significant improvement in PD sleep scale scores and improvement in sleep quality.

Non-motor Subtypes of Parkinson's Disease and Sleep Dysfunction.

Parkinson's disease is a syndrome with many clinical presentations. It is often dominated by visible motor symptoms; however, specific nonmotor features, such as cognitive dysfunction, sleep dysfunction, pain, apathy, dysautonomia, depression, and anxiety, enrich the clinical picture significantly. Proposed non-motor phenotypes segregate to central cholinergic, serotonergic, or noradrenergic dysfunctions, and clinical and biomarker-driven studies support these subtypes.

Outcome of systemic therapy in patients with advanced rare skin cancers: A retrospective multicenter DeCOG study of 209 patients.

Introduction: For rare skin cancers, few data exist on the outcome of systemic therapies, particularly immune checkpoint inhibition (ICI). The present study analysed the real-world use of different systemic therapies including ICI, and its outcome in patients with advanced rare skin cancers.

Methods: This retrospective multicenter study included patients who received systemic therapy for advanced, non-resectable cutaneous angiosarcoma (AS), Kaposi sarcoma (KS), pleomorphic dermal sarcoma (PDS), or cutaneous adnexal carcinoma (CAC).

Antipsychotic Treatment Approaches in Schizophrenia Spectrum and Other Psychotic Disorders: Prescription Patterns in Eight Different Diagnostic Groups.

Background: The objective of this study was to characterize real-world prescription patterns of antipsychotic drugs in patients with various psychiatric disorders with psychotic features.

Method: We analyzed the discharge prescription plans of 59,962 cases with the main diagnoses schizophrenia, schizoaffective disorder, acute transient psychotic disorder, delusional disorder, psychotic bipolar disorder, psychotic depression, organic delusional disorder or substance-induced psychosis. We analyzed the overall use, pharmacological subgroups, the use of long-acting injectable (LAI) formulations, and the frequency of prescription of the singular antipsychotic drugs.

Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry.

Unlabelled: Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants of BTE according to their location and severity in a retrospective analysis of the German ECMO COVID-19 registry. Logistic regression was applied to identify factors influencing ICU survival as well as variables associated with risks of BTE.

Current Situation of Solid Organ Transplantation from HIV-Positive Donors to HIV-Positive Recipients in Europe. The Spanish Perspective.

Objectives: There is limited information on the use of organs from HIV-positive donors (HIV D+) for HIV-positive recipients (HIV R+) in Europe. In some countries the use of HIV D+ organs is prohibited by law. This study aimed to assess the attitudes of Spanish kidney and liver transplant (KT/LT) teams towards HIV D+/R+ KT/LT through a nationwide survey, and to evaluate the current situation across Europe regarding legislation and reported cases.

Acalabrutinib treatment for older (≥80 years old) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial.

Because frail and patients ≥80 years with CLL are still underrepresented in clinical trials, the CLL-Frail trial aimed to evaluate the efficacy and safety of acalabrutinib in these patients. The primary endpoint was the overall response rate (ORR) after 6 cycles of treatment to test the null hypothesis of ORR ≤ 65%.53 patients were included into the trial and 34 patients are still on therapy.

Altered Gating of Two Ca2.1 Variants Linked to Neurodevelopmental Disorders With Epilepsy and Migraine.

P/Q-type (Ca2.1) Ca channels regulate the release of neurotransmitter at central synapses. Missense and nonsense mutations in CACNA1A, the gene that encodes the principal α subunit of the Ca2.

Electrosurgical hysteroscopic metroplasty for septate uterus: a single-center retrospective analysis of safety, adhesion rates, and perioperative outcomes.

Objective: To evaluate the safety, adhesion rates, and perioperative outcomes of monopolar and bipolar electrosurgical hysteroscopic metroplasty in women with a septate uterus.

Methods: We conducted a single-center retrospective analysis of 155 consecutive patients who underwent same-session laparoscopy and hysteroscopic septum resection between January 2021 and January 2025. Procedures were performed under surgeon discretion using either a monopolar loop with glycine distension or a bipolar loop with isotonic Ringer's lactate.

Activation metrics for structural connectivity recruitment in deep brain stimulation.

Comparatively high excitability of myelinated fibres suggests that they represent a major mediator of deep brain stimulation effects. Such effects can be modelled using different levels of abstraction, ranging from simple electric field estimates to complex multicompartment axon models. In this study, we explored three metrics to evaluate axonal activation: electric field magnitudes, electric field projections and pathway activation modelling.

Multi-omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma.

Squamous cell lung carcinoma (SqCC) is the second most common histological subtype of lung cancer. Besides tumor-initiating and promoting DNA, RNA, and epigenetic alterations, aberrant cell metabolism is a hallmark of carcinogenesis. This study aimed to identify SqCC-specific key regulators that could eventually be used as new anticancer targets.

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation.

Aging is a major risk factor for neurodegenerative diseases associated with protein aggregation, including Huntington's disease and amyotrophic lateral sclerosis (ALS). Although these diseases involve different aggregation-prone proteins, their common late onset suggests a link to converging changes resulting from aging. In this study, we found that age-associated hyperactivation of EPS8/RAC signaling in Caenorhabditis elegans promotes the pathological aggregation of Huntington's disease-related polyglutamine repeats and ALS-associated mutant FUS and TDP-43 variants.

Path integration impairments reveal early cognitive changes in subjective cognitive decline.

Path integration, the ability to track one's position using self-motion cues, is critically dependent on the grid cell network in the entorhinal cortex, a region vulnerable to early Alzheimer's disease pathology. In this study, we examined path integration performance in individuals with subjective cognitive decline (SCD), a group at increased risk for Alzheimer's disease, and healthy controls using an immersive virtual reality task. We developed a Bayesian computational model to decompose path integration errors into distinct components.

Cardiovascular health and cognition in older adults: Variations across recruitment models and European countries in the MOPEAD project.

BackgroundThe Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project aimed to identify the most effective and cost-efficient recruitment model for detecting prodromal and mild Alzheimer's disease (AD) across five European countries.ObjectiveTo examine differences in cardiovascular risk factors and cognitive performance among countries and recruitment models using MOPEAD data.MethodsIndividuals aged 65-85 with a high risk for prodromal or mild AD were included.

Implementation of HL7 FHIR-Based Terminology Services for a National Federated Health Research Infrastructure.

Introduction: As part of the German Medical Informatics Initiative (MII) and Network University Medicine (NUM), a central research terminology service (TS) is provided by the Service Unit Terminology Services (SU-TermServ). This HL7 FHIR-based service depends on the timely and comprehensive availability of FHIR terminology resources to provide the necessary interactions for the distributed MII/NUM infrastructure. While German legislation has recently instituted a national terminology service for medical classifications and terminologies, the scope of the MII and NUM extends beyond routine patient care, encompassing the need for supplementary or specialized services and terminologies that are not commonly utilized elsewhere.

Catnip for MedCAT: Optimizing the Input for Automated SNOMED CT Mapping of Clinical Variables.

Introduction: Mapping local medical data assets to international data standards such as medical ontology SNOMED CT fosters data harmonization and, thereby, global progress in medical research. Since its intense resource requirements often hinder manual SNOMED CT mapping, automated mapping tools such as MedCAT have been developed. We investigated how the formulation of study variable names (VNs) influences the efficacy and accuracy of the SNOMED CT concepts identified by MedCAT.

Repeat-associated ataxias in a German patient cohort analysed by targeted parallel long-read sequencing.

Hereditary adult-onset ataxias are a heterogeneous group of phenotypically overlapping conditions, often caused by pathogenic expansions of short tandem repeats. Currently, 18 repeat disorders with a core phenotype of adult-onset ataxia are known. Diagnosis typically relies on sequential PCR-based methods, which are labour-intensive and lack precision.

Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.

An animal's feeding state changes its behavioral priorities and thus influences even nonfeeding-related decisions. How the feeding state information is transmitted to nonfeeding-related circuits and what circuit mechanisms are involved in biasing nonfeeding-related decisions remain open questions. By combining calcium imaging, neuronal manipulations, behavioral analysis and computational modeling, we determined that the competition between different aversive responses to mechanical cues is biased by changes in the feeding state.

Study protocol: neonatal colonisation and infection with in very immature preterm infants born <29 weeks of gestation (NEO-CONSCIOUS) - a prospective multicentre study assessing early life colonisation rates and potentially associated adverse outcomes.

Introduction: Preterm infants, particularly those born before 29 weeks of gestation, are at increased risk of developing bronchopulmonary dysplasia (BPD) and other complications of prematurity. Substantial evidence suggests that respiratory tract colonisation with species significantly contributes to pulmonary inflammation, impaired lung function and subsequent lung disease especially in very immature infants. Moreover, exposure has been implicated in the pathogenesis of other inflammation-related sequelae of prematurity.