Establishing the super-enhancer landscape in chicken adipose tissue.

Enhancers are cis-regulatory elements that control spatiotemporal gene expression patterns. Super-enhancers (SEs), which function as clustered regulatory elements, play crucial roles in establishment and maintenance of cellular identity. Accumulating evidence highlights the importance of SEs in mammalian adipogenesis and fat deposition.

Fault location method for hybrid MTDC system based on LCC signal injection strategy.

A fault location method based on line commutation converter (LCC) signal injection strategy for hybrid multi-terminal direct current (MTDC) system is proposed to deter-mine the fault location after the permanent fault occurs and facilitate the line inspection and maintenance by the staff. Firstly, using the fault control ability of LCC, the additional control strategy is applied to the trigger angle of LCC to realize signal injection. The frequency, duration and amplitude of the injection signal are analyzed and determined, and a signal injection strategy based on LCC is proposed.

Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection.

Background: As a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADAs, especially those treated using hybrid endoscopic submucosal dissection (ESD), are exceedingly rare, and to our knowledge, this condition has not been reported previously.

Cloche/Npas4l is a pro-regenerative platelet factor during zebrafish heart regeneration.

Zebrafish has full capacity of heart regeneration, but little is known about how blood cells, especially platelets, are involved in this regenerative process. Here, we report that cloche/npas4l is a pro-regenerative platelet factor for heart regeneration. We found that haploinsufficiency of npas4l disrupted cardiomyocyte (CM) and endothelial cell (EC) proliferation and heart regeneration after injury.

Systematic Evaluation of Isolation Techniques and Freeze-Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling.

Extracellular vesicles (EVs) are increasingly recognized as promising disease biomarkers and therapeutic carriers. However, standardizing blood-derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field-flow fractionation (AF4), size-exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo-CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze-thawed plasma samples.

Analysis of the efficacy of paclitaxel combined with bevacizumab intraperitoneal instillation in common gastrointestinal malignant peritoneal effusions and screening of prognostic indicators.

Background: This study investigates the efficacy of paclitaxel combined with bevacizumab in the treatment of malignant gastrointestinal tumors with malignant ascites and screens for biomarkers that predict efficacy.

Research Design And Methods: A prospective cohort study was conducted, enrolling 92 eligible patients who received either paclitaxel combined with bevacizumab or paclitaxel monotherapy. Efficacy was assessed, and biomarkers predictive of treatment efficacy were screened using indicators such as disease control rate, objective response rate, LA, LDH, and CD4/CD8 ratios.

Dietary isobutyric acid supplementation improves intestinal mucosal barrier function and meat quality by regulating cecal microbiota and serum metabolites in weaned piglets.

This study aimed to provide evidence for the effects of isobutyric acid on the intestinal mucosal barrier and gut microbiota in weaned piglets. In this study, 30 piglets were divided into two groups: one group was fed a standard diet (CON group), and the other group was fed a diet supplemented with 0.5% isobutyric acid (IB group) for 21 days.

AARS2 ameliorates myocardial ischemia fine-tuning PKM2-mediated metabolism.

AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac function, notable cardiac fibrosis, and cardiomyocyte apoptosis. Cardiomyocyte-specific AARS2 overexpression in mice improved cardiac function and reduced cardiac fibrosis after myocardial infarction (MI), without affecting cardiomyocyte proliferation and coronary angiogenesis.

Nonunit protection based on the ratio of IVRW tangent envelope area for modular multilevel converter based HVDC grid.

In modular multilevel converters-based DC power grid, short faults develop rapidly and have complex characteristics. The power electronic converter has a limited ability to withstand overcurrent. So, protection needs to quickly identify the fault area in an extremely short time.

The Combination of Tunnel Shaped Excision with Radiotherapy and Injection of Type A Botulinum Toxin in the Treatment of Auricular Keloids.

Background: To investigate the clinical effect of the combination of tunnel shaped excision with radiotherapy and injection of type A botulinum toxin in the treatment of auricular keloids.

Methods: From June 2017 to May 2023, a total of 52 cases with auricular keloids were treated with tunnel shaped excision combined with radiotherapy and the injection of type A botulinum toxin. The effects of this sequential treatment were analyzed and evaluated.

Improved active current limiting control for flexible DC power grid to consider the effects of selective and higher fault resistance.

The current limiting control strategy of modular multilevel converters in flexible DC power grids can effectively reduce the requirements for line protection speed and the breaking capacity of DC circuit breakers (DCCB). However, it can easily lead to the interruption of power transmission at non-fault terminals and expanding the scope of the fault impact. Secondly, it did not consider the severity of matching faults, which may lead to excessive suppression of fault currents and reduce the sensitivity of the protection system.

Diversity and Potential Cross-Species Transmission of Rotavirus A in Wild Animals in Yunnan, China.

Rotavirus A (RVA) is the primary enteric pathogen of humans and many other species. However, RVA interspecies transmission remains poorly understood. In this study, we conducted a comprehensive screening and genotyping analysis of RVA in 1706 wild animal samples collected from various regions within Yunnan Province, China.

Association Between Dietary Live Microbe Intake and Chronic Diarrhea and Fecal Incontinence: A Cross-Sectional NHANES 2005-2010 Study.

Objective: We explored potential relationships between dietary live microbe intake and chronic diarrhea (CD) and fecal incontinence (FI).

Methods: We conducted a cross-sectional retrospective study based on the National Health and Nutrition Examination Survey (NHANES) database. Participants were categorized into three groups according to the Sanders classification system (low, medium, and high dietary live microbe groups).

Enhancing lobaplatin sensitivity in lung adenocarcinoma through inhibiting LDHA-targeted metabolic pathways.

Background And Objective: Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), is associated with high incidence and mortality rates. Effective treatment options are limited due to the frequent development of multidrug resistance, making it crucial to identify new therapeutic targets and sensitizing agents. This study investigates the role of Lactate dehydrogenase A (LDHA) in enhancing the chemotherapy sensitivity of Lobaplatin (LBP) in LUAD.

A cellular triad for linking cardiac niche to regeneration.

Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin's laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3 cardiac fibroblasts and C3ar1 macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad.

Debittering and antioxidant improvement of soy protein hydrolysates using curcumin as hydrophobic core.

Background: Protein hydrolysates possess various bioactive functions (e.g. antioxidant), but their bitter taste is unacceptable to most consumers.

Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.

Targeted protein degradation (TPD) utilizes molecular glues or proteolysis-targeting chimeras (PROTACs) to eliminate disease-causing proteins by promoting their interaction with E3 ubiquitin ligases. Current TPD approaches are limited by reliance on a small number of constitutively active E3 ubiquitin ligases. Here, we report that (S)-ACE-OH, a metabolite of the antipsychotic drug acepromazine, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking.

Reliability assessment method of wind power DC collection system based on MLFTA-SMC.

Wind power DC collection system, as a crucial component of wind farms, plays a vital role in ensuring the safe and stable operation of the entire wind farm. This paper proposes a reliability assessment method for wind power DC collection systems based on MLFTA-SMC. Firstly, it analyzes the topology and key equipment of wind power DC collection systems.

Distribution and genetic characterization of hantaviruses in bats and rodents from Yunnan.

Hemorrhagic fever with renal syndrome caused by hantaviruses has long been a serious public health issue in Yunnan Province. Hantaviruses exhibit a high extent of biodiversity in their natural hosts, particularly in mammalian hosts. This study was conducted to screen for hantaviruses in bats and rodents in Yunnan Province and elucidate their genetic characteristics and possible zoonotic disease risk.

Clinical characteristics and prognosis of pancreatitis associated with immune checkpoint inhibitors.

Background And Objective: Immune checkpoint inhibitors (ICIs) have shown remarkable efficacy against various cancers in clinical practice. However, ICIs can cause immune checkpoint inhibitor-associated pancreatic injury, often leading to drug withdrawal, and then patients must go to specialized treatment. The patients, their primary tumors are sensitive to ICIs therapy, may experience treatment delays due to such adverse reactions.

Mulberry Leaf Dietary Supplementation Can Improve the Lipo-Nutritional Quality of Pork and Regulate Gut Microbiota in Pigs: A Comprehensive Multi-Omics Analysis.

Mulberry leaves, a common traditional Chinese medicine, represent a potential nutritional strategy to improve the fat profile, also known as the lipo-nutrition, of pork. However, the effects of mulberry leaves on pork lipo-nutrition and the microorganisms and metabolites in the porcine gut remain unclear. In this study, multi-omics analysis was employed in a Yuxi black pig animal model to explore the possible regulatory mechanism of mulberry leaves on pork quality.

Unveiling new horizons in heart research: the promise of multi-chamber cardiac organoids.

Human cardiac and other organoids have recently emerged as a groundbreaking tool for advancing our understanding the developmental biology of human organs. A recent paper from Sasha Mendjan's laboratory published in the journal Cell on December 7, 2023, reported the generation of multi-chamber cardioids from human pluripotent stem cells, a transformative technology in the field of cardiology. In this short highlight paper, we summarize their findings.

The large-scale group consensus multi-attribute decision-making method based on probabilistic dual hesitant fuzzy sets.

We proposed a novel decision-making method, the large-scale group consensus multi-attribute decision-making method based on probabilistic dual hesitant fuzzy sets, to address the challenge of large-scale group multi-attribute decision-making in fuzzy environments. This method concurrently accounted for the membership and non-membership degrees of decision-making experts in fuzzy environments and the corresponding probabilistic value to quantify expert decision information. Furthermore, it applied to complex scenarios involving groups of 20 or more decision-making experts.