Establishing the super-enhancer landscape in chicken adipose tissue.

Enhancers are cis-regulatory elements that control spatiotemporal gene expression patterns. Super-enhancers (SEs), which function as clustered regulatory elements, play crucial roles in establishment and maintenance of cellular identity. Accumulating evidence highlights the importance of SEs in mammalian adipogenesis and fat deposition.

Regulating Interface Chemistry with Topological Insulator for Ultra-Stable and Dendrite-Free Sodium Metal Batteries.

Metallic sodium (Na) is an attractive anode material for sodium metal batteries (SMBs) due to its high theoretical capacity and natural abundance. However, the unstable electrolyte/electrode interface and uncontrollable Na dendrite growth arising from the inhomogeneous Na transfer have significantly restricted its practical feasibility. Herein, the topological insulator of bismuth selenide (BiSe), which has protected conducting states on its surface, is selected as a regulator to guide uniform Na transfer.

A thioether additive as an interfacial regulator for ultra-stable lithium-metal batteries.

Rapid inactive lithium accumulation and severe lithium dendrite growth critically limit the cycle life of metallic lithium anodes. Herein, cyclic thioether 1,3-dithiane is reported as a novel electrolyte additive for fabricating ultra-stable lithium-metal batteries. Through the preferential decomposition of 1,3-dithiane additive and PF anion ions, robust inorganic-rich electrode interphases could be generated at both the anode and the cathode, which is conducive to enhanced kinetics and structural stability of the electrode interface, endowing alleviated active lithium loss and dendrite-free lithium deposition.

Dual-Interface Regulation of Cyclic Thioether Electrolyte Additives for Enhancing the Cycling Stability of High-Voltage Lithium Metal Batteries.

The development of high-energy-density lithium metal batteries (LMBs) using carbonate electrolytes is severely hindered by unstable interfacial chemistry, leading to uncontrolled lithium dendrite growth and rapid performance degradation. Given that the electrode/electrolyte interface property is highly dependent on the interface interactions, this work introduces 1,4-dithiane (1,4-DH), an environmentally benign cyclic thioether, as a multifunctional additive for stabilizing electrode-electrolyte interfaces in conventional carbonate electrolytes without fluorinated solvents. The 1,4-DH additive exhibits preferentially adsorption on both Li metal anodes and NCM811 (LiNiCoMnO) cathodes, displacing solvent molecules from electrode surfaces to suppress solvent decomposition while driving localized PF enrichment at the electrode interfaces via a robust binding interaction.

Bridging Donor Ligands Enable an Ultrastable Graphite Anode for Sodium-Ion Batteries.

Graphite is widely utilized as an anode material in lithium-ion batteries due to its abundance, cost-effectiveness, and excellent structural stability during lithium intercalation and deintercalation, which contribute to a long cycle life. However, graphite is not inherently suitable for sodium-ion batteries (SIBs) due to the limited intercalation properties of sodium ions. To address this, we propose the concept of bridging-donor-ligands, which construct ligand channels and consistently expand the graphite interlayer spacing.

Dynamic Gradient Oxygen Layer Enables Stable Sn Anode for Lithium Storage.

Sn-based anodes are of significant interest due to their high capacity and resource abundance for lithium-ion batteries. However, incomplete lithiation and severe volume expansion result in their low capacity and electrode pulverization. Here, a rationally designed coating layer, composed of disordered SnO (x = 1, 2) lamellar structures, on the Sn particles surface (Sn@SnO) is proposed.

Review on Cooperative Catalysis for Room-Temperature Sodium-Sulfur Batteries.

The low cost and high energy density characteristics of room-temperature sodium-sulfur (RT Na-S) batteries remarkably promote the development of sustainable large-scale energy-storage systems. However, there are serious problems with the shuttle effect and slow conversion kinetics caused by polysulfide dissolution in RT Na-S batteries, which can lead to decreased coulombic efficiency, rapid capacity degradation, and poor rate performance, hindering the practical application of RT Na-S batteries. Recently, numerous multimodal approaches have been attempted to address these issues, thereby promoting cycling stability and raising the energy density of RT Na-S batteries to a higher level.

Unveiling Aqueous Potassium-Ion Batteries with Prussian Blue Analogue Cathodes.

Aqueous rechargeable potassium-ion batteries have considerable advantages and potentials in the application of large-scale energy storage systems, owing to its high safety, abundant potassium resources, and environmental friendliness. However, the practical applications are fraught with numerous challenges. Identification of suitable cathode materials and potassium storage mechanisms are of great significance.

Evidence of Quasi-Na Metallic Clusters in Sodium Ion Batteries through In Situ X-Ray Diffraction.

Carbonaceous materials have been considered the most promising anode in sodium-ion batteries (SIBs) due to their low cost, good electrical conductivity, and structural stability. The main challenge of carbonaceous anodes prior to their commercialization is low initial coulomb efficiencies, derived from a lack of an efficient technique to reveal a fundamental comprehension of sodium storage mechanisms. Here, the direct observation of quasi-Na metallic clusters in carbonaceous anodes during cycling through in situ XRD is reported.

HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.

Background: The mutations of oncogenic epidermal growth factor receptor (EGFR) is an important cause of lung adenocarcinoma (LUAD) malignance. It has been knowm that metabolic reprogramming is an important hallmark of malignant tumors, and purine metabolism is a key metabolic pathway for tumor progression and drug resistance, but its relationship with the EGFR-mutant LUAD is unclear.

Methods: Metabolic reprogramming was studied through capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolic profiling analysis.

Stable Dendrite-Free Room Temperature Sodium-Sulfur Batteries Enabled by a Novel Sodium Thiotellurate Interface.

The practical application of room-temperature sodium-sulfur (RT Na-S) batteries is severely hindered by inhomogeneous sodium deposition and notorious sodium polysulfides (NaPSs) shuttling. Herein, novel sodium thiotellurate (NaTeS) interfaces are constructed both on the cathode and anode for Na-S batteries to simultaneously address the Na dendritic growth and polysulfides shuttling. On the cathode side, a heterostructural sodium sulfide/sodium telluride embedded in a carbon matrix (NaS/NaTe@C) is rationally designed through a facile carbothermal reaction, where the NaTeS interface will be in situ chemically obtained.

A Class of Sodium Transition-Metal Sulfide Cathodes With Anion Redox.

Sodium-ion batteries (SIBs) are entering commercial relevance as a sustainable and low-cost alternative to lithium-ion batteries. Improving the energy density of SIBs is critical to enable their widespread adoption. Here, a new class of cathode materials NaMS (M = Co, Mn, Fe, and Zn) that exhibit high charge-storage capacity is reported.

Association of physical activity pattern and risk of Parkinson's disease.

Increasing evidence suggests an association between exercise duration and Parkinson's disease. However, no high-quality prospective evidence exists confirming whether differences exist between the two modes of exercise, weekend warrior and equal distribution of exercise duration, and Parkinson's risk. Hence, this study aimed to explore the association between different exercise patterns and Parkinson's risk using exercise data from the UK Biobank.

Bortezomib elevates intracellular free Fe by enhancing NCOA4-mediated ferritinophagy and synergizes with RSL-3 to inhibit multiple myeloma cells.

Iron contributes to tumor initiation and progression; however, excessive intracellular free Fe can be toxic to cancer cells. Our findings confirmed that multiple myeloma (MM) cells exhibited elevated intracellular iron levels and increased ferritin, a key protein for iron storage, compared with normal cells. Interestingly, Bortezomib (BTZ) was found to trigger ferritin degradation, increase free intracellular Fe, and promote ferroptosis in MM cells.

Superstructure-Assisted Single-Atom Catalysis on Tungsten Carbides for Bifunctional Oxygen Reactions.

Single-atom catalysis (SAC) attracts wide interest for zinc-air batteries that require high-performance bifunctional electrocatalysts for oxygen reactions. However, catalyst design is still highly challenging because of the insufficient driving force for promoting multiple-electron transfer kinetics. Herein, we report a superstructure-assisted SAC on tungsten carbides for oxygen evolution and reduction reactions.

hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways.

Polycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs.

3D Flower-like Nanospheres Constructed by Transition Metal Telluride Nanosheets as Sulfur Immobilizers for High-Performance Room-Temperature Na-S Batteries.

Room-temperature sodium-sulfur (RT Na-S) batteries hold immense promise as next-generation energy storage systems, owing to their exceptionally high theoretical capacity, abundant resources, eco-friendliness, and affordability. Nevertheless, their practical application is impeded by the shuttling effect of sodium polysulfides (NaPSs) and sluggish sulfur redox kinetics. In this study, an advanced strategy by designing 3D flower-like molybdenum telluride (MoTe) as an efficient catalyst to promote sulfur redox for RT Na-S batteries is presented.

Diallyl disulfide synergizes with melphalan to increase apoptosis and DNA damage through elevation of reactive oxygen species in multiple myeloma cells.

Diallyl disulfide (DADS), one of the main components of garlic, is well known to have anticancer effects on multiple cancers. However, its efficacy in treating multiple myeloma (MM) is yet to be determined. We explored the effects of DADS on MM cells and investigated the synergistic effects of DADS when combined with five anti-MM drugs, including melphalan, bortezomib, carfilzomib, doxorubicin, and lenalidomide.

Intercalation-type catalyst for non-aqueous room temperature sodium-sulfur batteries.

Ambient-temperature sodium-sulfur (Na-S) batteries are potential attractive alternatives to lithium-ion batteries owing to their high theoretical specific energy of 1,274 Wh kg based on the mass of NaS and abundant sulfur resources. However, their practical viability is impeded by sodium polysulfide shuttling. Here, we report an intercalation-conversion hybrid positive electrode material by coupling the intercalation-type catalyst, MoTe, with the conversion-type active material, sulfur.

Tellurium Nanowires for Lithium-Metal Anode Stabilization in High-Performance Anode-Free Li-S Batteries.

Enhancing the reversibility of Li is crucial for extending the cycle life of Li-limited anode-free lithium-sulfur (Li-S) batteries. Incorporating tellurium (Te) in the system has proven to be highly effective by its reaction with polysulfides and forming a passivating interfacial layer on Li surface, which reduces the Li-ion diffusion barrier. However, due to the poor utilization of Te, a significant amount of Te is required to improve cell cycling performance.

Clinical characteristics of hypersensitivity pneumonitis: non-fibrotic and fibrotic subtypes.

Background: The presence of fibrosis is a criterion for subtype classification in the newly updated hypersensitivity pneumonitis (HP) guidelines. The present study aimed to summarize differences in clinical characteristics and prognosis of non-fibrotic hypersensitivity pneumonitis (NFHP) and fibrotic hypersensitivity pneumonitis (FHP) and explore factors associated with the presence of fibrosis.

Methods: In this prospective cohort study, patients diagnosed with HP through a multidisciplinary discussion were enrolled.

Evaluation of total tumor volume reduction ratio in initially unresectable colorectal liver metastases after first-line systemic treatment.

Purpose: Total tumor volume (TTV) may play an essential role in the estimation of tumor burden. This study is aimed to investigate the clinical value of the reduction ratio of TTV as a valuable indicator of clinical outcomes in patients with colorectal liver metastases (CRLM).

Methods: A total of 240 initially unresectable CRLM patients who underwent first-line systemic treatment were enrolled in this study.