Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Promising Biomarker for Poststroke Depression After Acute Ischemic Stroke.

Background: Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) was reported to induce inflammatory responses, enhance microglial survival, and contribute to the development of neurodegenerative disorders. We aimed to prospectively investigate the association between plasma sTREM2 levels and poststroke depression (PSD).

Methods: We measured plasma sTREM2 levels in 590 patients with ischemic stroke from 7 participating hospitals of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke) trial.

High spatial resolution spectral imaging based on amplitude-phase joint modulation metasurfaces using a global optimization algorithm.

Conventional spectral imaging techniques relying on dispersive spectrometers are limited by the trade-offs in size, cost, imaging speed, and other factors. Currently, metasurface-based spectral imaging has attracted considerable attention owing to its miniaturization, real-time detection, and low cost. However, introducing randomness in the spectral response function utilizing guided resonance in metasurfaces requires a large number of periodic elements, resulting in reduced spatial resolution in spectral imaging.

Research on the effects and alignment of in-plane motion in a segmented solar telescope.

For ground-based segmented telescopes, the active control system primarily adjusts three out-of-plane DOFs: tip, tilt, and piston. In contrast, in-plane DOFs rely on high-precision mechanical alignment. A systematic analysis of the effects of in-plane motion on the optical performance of ring segmented mirror systems is presented, and an analytical relationship between in-plane motion and the higher-order residual aberrations after tilt compensation is derived.

High Plasma Sarcosine Levels Are Associated with Decreased Risks of Adverse Outcomes After Ischemic Stroke: A Multicenter Prospective Study.

Sarcosine has been reported to improve ischemic tolerance in animal models of brain ischemia, but population-based evidence from patients with ischemic stroke is lacking. We conducted a multicenter prospective study to investigate the associations between plasma sarcosine levels and adverse outcomes among patients with ischemic stroke. We measured plasma sarcosine levels among 3473 patients with ischemic stroke from 26 hospitals across China.

Enhancing Visual Analysis in Person Re-Identification With Vision-Language Models.

Image-based person re-identification aims to match individuals across multiple cameras. Despite advances in machine learning, their effectiveness in real-world scenarios remains limited, often leaving users to handle fine-grained matching manually. Recent work has explored textual information as auxiliary cues, but existing methods generate coarse descriptions and fail to integrate them effectively into retrieval workflows.

Geometry-enhanced graph neural networks accelerate circRNA therapeutic target discovery.

Circular RNAs (circRNAs) play pivotal roles in various biological processes and disease progression, particularly in modulating drug responses and resistance mechanisms. Accurate prediction of circRNA-drug associations (CDAs) is essential for biomarker discovery and the advancement of therapeutic strategies. Although several computational approaches have been proposed for identifying novel circRNA therapeutic targets, their performance is often limited by inadequate modeling of higher-order geometric information within circRNA-drug interaction networks.

Novel CD19 Fast-CAR-T cells vs. CD19 conventional CAR-T cells for the treatment of relapsed/refractory CD19-positive B-cell acute lymphoblastic leukemia.

Background: Treatment with chimeric antigen receptor-T (CAR-T) cells has shown promising effectiveness in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL), although the process of preparing for this therapy usually takes a long time. We have recently created CD19 Fast-CAR-T (F-CAR-T) cells, which can be produced within a single day. The objective of this study was to evaluate and contrast the effectiveness and safety of CD19 F-CAR-T cells with those of CD19 conventional CAR-T cells in the management of R/R B-ALL.

Autoimmune glial fibrillary acidic protein astrocytopathy suspected of intracranial infection: A case report.

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is an autoimmune-mediated neurological disease with cerebrospinal fluid GFAP-IgG as a marker. This is a rare disease. This paper reported a GFAP-A patient suspected intracranial infection whose diagnosis and treatment were summarized, and the value of negative metagenomic second-generation sequencing (mNGS) results for the exclusion of infectious diseases and the preferred treatment plan for GFAP-A were discussed.

Liquid metal/ionic liquid lubricants: rational design and tribological performance evaluation.

To improve the performance of lubricants, a liquid metal/ionic liquid 1-hexyl-3-methylimidazole hexafluorophosphate (LM/IL) additive was prepared in this study using a simple ultrasonic dispersion method. The extreme pressure performance, anti-wear, and friction reduction properties of LM/IL were examined using a four-ball tribo-meter. After incorporating 0.

Enhancing the measurement stability of segmented mirror edge height through synchronous measurement in atmospheric turbulence.

Optical interference phase measurement is a crucial technology for measuring the edge height of segments during the co-phased adjustment stage of giant astronomical telescopes equipped with segmented primary mirrors. For the Chinese Giant Solar Telescope (CGST), achieving optical interferometric measurements with a range of 10 m or more is a critical challenge that must be addressed to integrate the the co-focus and phasing adjustment processes. Given the unique requirements of solar observation, CGST intends to implement multi-wavelength technology to tackle the measurement range issue.

Sleep, carotid intima-media thickness, and arterial stiffness: results from a large longitudinal cohort study.

Background: To evaluate the associations of sleep health with carotid intima-media thickness (CIMT) and arterial stiffness.

Methods: A total of 41 465 UK Biobank participants were included. Sleep traits were assessed at baseline via self-reported questionnaires, and a composite sleep score was constructed based on six factors: sleep duration, snoring, insomnia, chronotype, daytime napping, and daytime sleepiness, with higher scores indicating poorer sleep health.

Remnant cholesterol and post-stroke cognitive function: A multicenter prospective study.

Objective: To explore the association between baseline remnant cholesterol (RC) levels and post-stroke cognitive impairment (PSCI) at three months following the event.

Methods: The data utilized in this research originated from a pre-arranged subsidiary investigation of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). RC levels were determined using the formula: RC (mmol/L) = total cholesterol (TC) - low-density lipoprotein cholesterol (LDL-C) - high-density lipoprotein cholesterol (HDL-C), and cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at three months post-stroke.

Increased plasma thrombospondin-1 is associated with poor prognosis in ischemic stroke patients.

Background And Aims: Thrombospondin-1 (THBS1) plays an important role in the modulation of coagulation, inflammatory response, vascular structure, and blood-brain barrier function, but its impact on clinical outcomes after ischemic stroke remains uncertain. We aimed to examine the relationship between plasma THBS1 levels and ischemic stroke prognosis in a multicenter observational study.

Methods And Results: Plasma THBS1 levels at baseline were measured in 3511 ischemic stroke patients enrolled between August 2009 and May 2013 in 26 hospitals across China.

Telemedicine in China: Effective indicators of telemedicine platforms for promoting health and well-being among healthcare consumers.

Objective: Telemedicine platforms played a crucial role during the COVID-19 pandemic, alleviating issues related to the shortage and unequal distribution of healthcare resources. The purpose of this study is to identify key factors affecting the service quality of telemedicine platforms in China, with the dual objectives of advancing patient wellbeing and informing evidence-based service innovations for industry stakeholders.

Methods: To quantitatively assess the impact of these key factors on health and wellbeing from the perspective of healthcare consumers, a total of 25,499 valid online reviews were collected from telemedicine platforms.

Efficacy of immediate anti-hypertensive treatment in patients with acute ischaemic stroke stratified by mean arterial pressure and pulse pressure: a secondary analysis of the China Antihypertensive Trial in Acute Ischemic Stroke trial.

Background: Whether mean arterial pressure (MAP) and pulse pressure (PP), two indicators of cerebral perfusion, could guide the selection of anti-hypertensive strategies after acute ischaemic stroke remains uncertain. Our study was to explore the impact of early anti-hypertensive intervention on adverse clinical outcomes following ischaemic stroke stratified by the levels of MAP and PP based on the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).

Methods: The trial randomised 4071 acute ischaemic stroke patients with elevated systolic blood pressure (SBP) to receive anti-hypertensive treatment (targeting a 10%-25% reduction in SBP during the 24 hours postrandomisation, reaching a BP level <140/90 mm Hg in 7 days, further keeping these levels throughout hospitalisation) or discontinue anti-hypertensive treatment during hospitalisation.

Reprogramming of skin fibroblasts by 3D spheroid culture promotes peripheral nerve regeneration via the ID3/semaphorin7a pathway.

Peripheral nerve injury remains an intractable clinical issue with high morbidity, causing an excessive burden on the economy and society. Peripheral nerve tissue engineering combined with nerve conduits and supporting seed cells is considered a promising strategy for treating of long nerve defects. However, supporting seed cell sources that are easily accessible, capable of rapid expansion, and do not require genetic intervention are still urgently needed.

xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins.

Protein language models have shown remarkable success in learning biological information from protein sequences. However, most existing models are limited by either autoencoding or autoregressive pretraining objectives, which makes them struggle to handle protein understanding and generation tasks concurrently. We propose a unified protein language model, xTrimoPGLM, to address these two types of tasks simultaneously through an innovative pretraining framework.

Development of Duplex Loop-Mediated Isothermal Amplification with Hydroxynaphthol Blue for Detection of Infectious Spleen and Kidney Necrosis Virus and in Chinese Perch ().

Bacterial sepsis caused by () and infectious spleen and kidney necrosis virus disease (ISKNVD) caused by infectious spleen and kidney necrosis virus (ISKNV) frequently result in significant mortality among Chinese perch (). Co-infection of mandarin fish with and ISKNV occurs from time to time. In this study, a visual detection method for ISKNV and was developed, using loop-mediated isothermal amplification (LAMP) and pre-addition of hydroxynaphthol blue.

Case Report: Complete AV block in two patients with a congenital absence of the right coronary artery: an unusual correlation.

Background: Congenital absence of the right coronary artery (RCA) is an extremely rare coronary anomaly with a very low incidence in the general population. The prevalence of complete atrioventricular (AV) block also appears to be low. No previous reports have documented the coexistence of congenital absence of the RCA and complete AV block in the same patient.

High plasma fibroblast growth factor 19 is associated with improved prognosis in patients with acute ischemic stroke.

Objective: To prospectively investigate the relationships between plasma fibroblast growth factor 19 (FGF-19) and clinical outcomes in patients with acute ischemic stroke.

Methods: Plasma FGF-19 levels at baseline were measured for 3048 patients with ischemic stroke, and all patients were followed up at one year after stroke onset. The primary outcome was a combination of death and major disability (modified Rankin Scale score of ≥3) at one year after stroke onset, and secondary outcomes included major disability, death, recurrent stroke, vascular events and the combination of death and vascular events.

Leveraging protein language models for robust antimicrobial peptide detection.

Antimicrobial peptides (AMPs) are promising candidates for addressing the global challenge of antibiotic resistance due to their broad-spectrum antimicrobial properties. Traditional AMP identification methods, while effective, are labor-intensive and time-consuming. Recent advancements in deep learning and large language models (LLMs), especially protein language models (PLMs) present a transformative approach for AMP prediction.

Plasma polyamines levels and post-stroke depression in ischemic stroke patients: A multicenter prospective study.

Background And Aims: Polyamines have been suggested to implicated in inflammation, ischemic stroke, and mental disorders, but the associations of polyamines with post-stroke depression (PSD) remain unclear. We aimed to prospectively investigate the associations of plasma putrescine, spermidine and spermine with PSD among ischemic stroke patients in a multicenter cohort study.

Methods: We measured plasma putrescine, spermidine and spermine levels at baseline among 635 ischemic stroke patients from a preplanned ancillary study of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke).

Update for diagnosis and treatment of syndrome after cardiac injury: a mini-review.

Post-Cardiac Injury Syndrome (PCIS) refers to a collective term encompassing post-myocardial infarction syndrome, post-pericardiotomy syndrome, and post-traumatic pericarditis. With an aging population, the incidence of PCIS is on the rise annually. This condition is considered to be an autoimmune-mediated inflammatory response leading to pericarditis as the primary manifestation of the cardiac disease.

Plasma Osteoprotegerin and Cognitive Impairment after Ischemic Stroke.

Background: Plasma osteoprotegerin (OPG) has been linked to poor prognosis following stroke, but its impact on post-stroke cognitive impairment (PSCI) is unknown. The purpose of our work was to analyze the relationship of OPG with PSCI.

Methods: Our study included 613 ischemic stroke subjects with plasma OPG levels.