Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin's laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3 cardiac fibroblasts and C3ar1 macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad. This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628456 | PMC |
| http://dx.doi.org/10.1186/s13619-024-00213-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microglia-Astroglia-Neuron network following stroke: novel insight into extracellular vesicles communication.
Brain Res Bull
September 2025
Jiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, the 1(st) Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. Electronic address:
Stroke is one of the leading causes of death and disability worldwide, with ischemic stroke accounting for the majority of cases. Intercellular communication is critical to its prognostic impact, and extracellular vesicles (EVs) are an emerging important mechanism. EVs are increasingly recognized as key mediators of crosstalk between neurons and glial cells, affecting processes such as neuroinflammation, oxidative stress and tissue repair.
View Article and Find Full Text PDFAnchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity.
Immunity
August 2025
Molecular Medicine and Gene Therapy, Science for Life Laboratory, Lund Stem Cell Centre, Lund University, BMC A12, Lund 221 84, Sweden; Wallenberg Centre for Molecular Medicine at Lund University, BMC A12, Lund 221 84, Sweden; Centre for Neuroscience and Cell Biology, University of Coimbra, Largo Ma
Transcription factor cooperation is essential for specifying the heterogeneous dendritic cell (DC) lineages that orchestrate adaptive immunity, yet how it drives subset diversification remains poorly understood. Here, we employed a sequential anchored screen of 70 transcription factors using direct cellular reprogramming to identify regulators that specify type 2 conventional DCs (cDC2s) and plasmacytoid DCs (pDCs). We identified PU.
View Article and Find Full Text PDFSevere tenosynovitis with rapidly fluctuating power Doppler activity, a clue for the diagnosis of Blau syndrome: a case report.
Front Pediatr
August 2025
Department of Pediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.
Background: Blau Syndrome is a rare monogenic disorder characterized by granulomatous polyarthritis, dermatitis, and uveitis. The diagnosis can be challenging as symptoms may not always align with the classic triad.
Case Description: An 8-year-old girl presented with fluctuant swellings in the wrists and ankles, strength reduction and stiffness.
Zinc and metformin co-functionalized polyetheretherketone: A novel dental implant material tailored for the elderly.
J Adv Res
August 2025
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China. Electronic address:
Introduction: The rising demand for dental implants among the elderly population is challenged by age-related impairments in osteogenic regeneration, such as Wnt/β-catenin signaling decline, ROS-mediated cellular senescence (compromising osteoblast differentiation), and elevated pro-inflammatory cytokines (e.g. IL-6, TNF-α).
View Article and Find Full Text PDFMachine learning driven semi-automated framework for yeast sporulation efficiency quantification using ilastik segmentation and Fiji nuclear enumeration.
Fungal Genet Biol
August 2025
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, PR China. Electronic address:
Accurate quantification of yeast sporulation efficiency is essential for genetic studies, but manual counting remains time-consuming and susceptible to subjective bias. Although deep learning tools like cellpose provide automated solutions, there exists a compelling need for alternative approaches that enable the quantification of spores. Our methodology employs ilastik's texture-feature optimization to reliably segment sporulating mother cells, intentionally avoiding explicit tetrad discrimination to ensure robustness across diverse spore morphologies.
View Article and Find Full Text PDF