Zinc and metformin co-functionalized polyetheretherketone: A novel dental implant material tailored for the elderly.

Introduction: The rising demand for dental implants among the elderly population is challenged by age-related impairments in osteogenic regeneration, such as Wnt/β-catenin signaling decline, ROS-mediated cellular senescence (compromising osteoblast differentiation), and elevated pro-inflammatory cytokines (e.g. IL-6, TNF-α).

Surface Microstructural Responses of Heterogeneous Green Schist to Femtosecond Laser Grooving with Varying Process Parameters.

The Mount Wudang architectural complex, recognized as a UNESCO World Cultural Heritage site, extensively utilizes green schist as the building material in its rock temple structures. Due to prolonged exposure to weathering and moisture, effective surface protection of these stones is crucial for their preservation. Inspired by the lotus leaf, femtosecond laser fabrication of bioinspired micro/nanostructures offers a promising approach for imparting hydrophobicity to stone surfaces.

Irg1 mediates inhibition of A20-triggered NF-κB signaling cascade in tilapia macrophages during early immune response.

Immune response gene 1 (Irg1) is prominently upregulated during the early phase of macrophage immune response to lipopolysaccharide (LPS) stimulation, concomitant with pronounced inflammatory activity. Prior investigations have identified Irg1 as one of the most rapidly and significantly upregulated immune-related genes in the teleost fish model following pathogenic challenge, suggesting its pivotal role in teleost immune responses. Herein, we investigated how Irg1 modulates early (12 h) inflammatory responses in head kidney-derived macrophages of Oreochromis niloticus (Nile tilapia).

Nasal Delivery of Engineered Exosomes via a Thermo-Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair.

Spinal cord injury (SCI) presents formidable therapeutic challenges due to its multifaceted pathological complexity. Here, this work reports engineered macrophage-derived exosomes overexpressing GNA12 and GNA13 (G12G13MExos) that reprogram macrophages toward the M2c anti-inflammatory phenotype and astrocytes into a neuroprotective phenotype. G12G13MExos enhance astrocyte-mediated clearance of myelin debris, glutamate homeostasis, and synapse formation while fostering astrocyte-neuron crosstalk.

A method for detecting the rate of tobacco leaf loosening in tobacco leaf sorting scenarios.

During the tobacco leaf sorting process, manual factors can lead to non-compliant tobacco leaf loosening, resulting in low-quality tobacco leaf sorting such as mixed leaf parts, mixed grades, and contamination with non-tobacco related materials. Given the absence of established methodologies for monitoring and evaluating tobacco leaf sorting quality, this paper proposes a YOLO-TobaccoStem-based detection model for quantifying tobacco leaf loosening rates. Initially, a darkroom image acquisition system was constructed to create a stable monitoring environment.

Injectable functionalised Lycium barbarum polysaccharide/alginate hydrogel particles for the treatment of bone defects.

The treatment of bone defects presents a number of significant clinical challenges. In recent years, plant-derived hydrogels have demonstrated considerable potential as a means of intervening in bone defects. In this study, a alginate hydrogel (Alg) system containing the Chinese medicinal plant Lycium barbarum was prepared with the objective of promoting the repair of bone defects.

Spin Manipulation of Single Nitroxide Radical on Au(111) by Selective Coordination.

Organic radicals are promising candidates for constructing molecule-based magnetic materials. Despite the achievements of various radical ligand-containing complex materials, tuning the spin state of organic radicals at the single-molecule level on surfaces remains a challenge. In this study, the spin state of the DPBIN molecule, a derivative of 1,4-di(pyridine-3-yl)benzene bearing two imino-nitroxide radicals in para positions, is tuned by selective coordination with Au, Ni, and Fe centers on the Au(111) surface.

Direct anterior approach enhances early recovery outcomes in total hip arthroplasty among elderly individuals with femoral neck fractures: a propensity-matched cohort study.

Objective Enhanced recovery after surgery protocols have been increasingly adopted to optimize postoperative functional restoration. This propensity score-matched cohort study quantified the impact of the direct anterior approach during THA on ERAS efficacy in patients with femoral neck fractures and analyzed outcomes such as functional recovery acceleration and perioperative complications. Methods The consecutive cohort comprised 231 patients who underwent primary arthroplasty for femoral neck fractures and were stratified by surgical approach: direct anterior (DAA, n = 59) versus posterolateral (PLA, n = 172).

Spatiotemporal Targeted Delivery of Biomimetic Bacterial Outer Membrane Nanoparticles for Enhanced Spinal Cord Injury Repair.

Spinal cord injury (SCI) is a complex and dynamic pathological condition characterized by disrupted lipid metabolism and neuroinflammatory responses, posing significant therapeutic challenges. To address these, biomimetic bacterial outer membrane nanoparticles (BM-NPs) are designed by integrating the precise targeting capability of detoxified outer membrane vesicles (dOMVs) with the efficient drug-loading properties of liposomes. BM-NPs exhibit superior targeting efficiency toward peripheral neutrophils and macrophages, enabling spatiotemporal drug delivery via immune cells.

Development of peripheral biomarker-based prognostic nomograms for short-term and long-term survival in immune checkpoint inhibitor-associated myocarditis.

Background: Immune checkpoint inhibitor-associated myocarditis (ICI myocarditis) is a rare but highly fatal immune-related adverse reaction. This study aimed to develop nomogram prognostic models for both short-term and long-term survival outcomes in patients with ICI myocarditis based on key biomarkers in peripheral blood.

Methods: In this single-center retrospective study, we included 90 patients with ICI myocarditis at the Fourth Hospital of Hebei Medical University.

GTPLM-GO: Enhancing Protein Function Prediction Through Dual-Branch Graph Transformer and Protein Language Model Fusing Sequence and Local-Global PPI Information.

Currently, protein-protein interaction (PPI) networks have become an essential data source for protein function prediction. However, methods utilizing graph neural networks (GNNs) face significant challenges in modeling PPI networks. A primary issue is over-smoothing, which occurs when multiple GNN layers are stacked to capture global information.

A pipeline for enabling Nearshore Infrared Video Super-resolution to learn more high-frequency foreground information.

A key challenge in Nearshore Infrared Video Super-resolution (NIVSR) is the limited high-frequency foreground information. The most common approach is to fuse frames in order to learn cross-temporal information. However, existing methods struggle to achieve pixel-level reconstruction of foreground features in infrared video with limited detail.

Injectable glycyrrhizinate-pectin hydrogel wound dressing based on natural ingredients.

Wound healing remains a significant clinical challenge, particularly for chronic and non-healing wounds, which impose substantial burdens on patients and healthcare systems. Despite advances in wound care, traditional dressings lack therapeutic properties and can impede the healing process due to their inability to conform to irregular wound geometries and lack of self-healing capabilities. This study addresses these limitations by introducing an innovative, injectable Glycyrrhizic acid ammonium salt/Pectin@Strontium (GAAS/Pec@Sr) hydrogel dressing.

Regulation of Neuroimmune Microenvironment by PLA/GO/Anti-TNF-α Composite to Enhance Neurological Repair After Spinal Cord Injury.

Introduction: Spinal cord injury (SCI) is a severe neurological condition with limited treatment options. Polylactic acid (PLA)+graphene oxide (GO)+anti-TNF-α (Ab) composites have shown potential in regulating immune responses and promoting neural repair.

Methods: Electrospinning PLA+GO+Ab materials were characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and X-ray diffraction (XRD).

Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.

Thoracic aortic dissection (TAD) is a life-threatening condition with high mortality rates. Recent research suggests a potential link between early-stage TAD and endothelial barrier dysfunction, although the underlying mechanisms remain unclear. Single-cell RNA sequencing data from patients reveal that dysregulated Calpain-2 expression modulates endothelial focal adhesion proteins, serving as an early pathological hallmark and driver of TAD.

Interlaminar Endoscopic Treatment of Adjacent Segment Disease After Posterior Instrumented Lumbar Fusion.

Purpose: This study aimed to investigate the feasibility of interlaminar endoscopic surgery for the treatment of adjacent segment disease (ASD) after posterior instrumented lumbar fusion.

Materials And Methods: Between January 2019 and March 2023, the data of 22 patients with ASD who underwent revision interlaminar technique (R-ILT) endoscopic surgery after posterior instrumented lumbar fusion were retrospectively analyzed. For comparison, the data of 30 patients with single segment lumbar spinal stenosis who underwent primary interlaminar technique (P-ILT) endoscopic surgery were collected.

Application of Smart Packaging in Fruit and Vegetable Preservation: A Review.

The application of smart packaging technology in fruit and vegetable preservation has shown significant potential with the ongoing advancement of science and technology. Smart packaging leverages advanced sensors, smart materials, and Internet of Things (IoT) technologies to monitor and regulate the storage environment of fruits and vegetables in real time. This approach effectively extends shelf life, enhances food safety, and reduces food waste.

SEGT-GO: a graph transformer method based on PPI serialization and explanatory artificial intelligence for protein function prediction.

Background: A massive amount of protein sequences have been obtained, but their functions remain challenging to discern. In recent research on protein function prediction, Protein-Protein Interaction (PPI) Networks have played a crucial role. Uncovering potential function relationships between distant proteins within PPI networks is essential for improving the accuracy of protein function prediction.

IL-4-primed human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate recovery in spinal cord injury via the miR-21-5p/PDCD4-mediated shifting of macrophage M1/M2 polarization.

Spinal cord injury (SCI) represents a significant neurological disorder that profoundly impacts human life. Transplantation of extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUC-MSCs) has emerged as a promising therapeutic strategy. microRNA (miRNA) containing EVs serve as crucial mediators of intercellular communication, playing vital roles in physiological and pathological processes.

A highly transparent cellulose film for shielding ultraviolet and high-energy visible blue light.

The ultraviolet (UV) and high-energy visible blue (HEVB) light can cause damage to the eyes and skin. In this study, a cellulose composite film with UV and HEVB light shielding properties was prepared through the incorporation of a shielding agent into a carboxymethyl cellulose (CMC) solution. The shielding agent was synthesized through a Schiff base reaction between vanillin (VA) and 3-aminopropyltriethoxysilane (APS).

Preparation, characterisation, and application of gelatin/sodium carboxymethyl cellulose/peach gum ternary composite microcapsules for encapsulating sweet orange essential oil.

This study successfully developed a gelatin-sodium carboxymethyl cellulose-peach gum composite microcapsule system using the complex coacervation method. Optimal preparation conditions were determined by turbidity, complex condensate yield and encapsulation efficiency: the ratio of gelatin to sodium carboxymethyl cellulose was 7:1, the ratio of gelatin/sodium carboxymethyl cellulose to peach gum was 4:1, and the pH value was 4.2.

Identification of serum biomarkers and therapeutic targets for aortic diseases in obesity through multi-omics analysis.

Background: Obesity is associated with an increased risk of aortic diseases and operative risks. Currently, there are no effective drugs available to prevent the occurrence and progression of aortic aneurysms or dissections. We investigated potential biomarkers and therapeutic targets using a multi-omics approach.

A novel method for the rapid determination of phenolic compounds based on the nanozyme with laccase-like activity.

Phenolic compounds are prevalent in domestic and industrial effluents, leading a serious environmental hazard. Paper-based analysis device mediated by nanozymes has shown great potential in portable visual determination of phenolic compounds in the environment. In this work, we used nicotinic acid derivatives such as pyridine-2,3-dicarboxylic acid, 2-methylnicotinic acid and 2-aminonicotinic acid by coordinating copper (II) acetate monohydrate coordination to obtain Cu2-COOHNA, Cu2-CHNA, Cu2-ANA nanozymes with laccase-activity.