Causal Associations Between Oral Microbiota and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.

Background: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. The oral microbiota, influenced by genetic factors, may play a role in GDM development, but the causal association remains unclear.

Methods: We employed a two-sample Mendelian randomization (MR) approach using Genome-Wide Association Study (GWAS) data on GDM from FINN cohort data (ID: finngen_R10_GEST_DIABETES) and GWAS data on the Oral microbiota from the Danish ADDITION-PRO cohort.

Genome-Wide Identification Analysis of the Gene Family in and Its Expression Analysis in .

: RAB11 (RABA) is a type of RAB GTPase. RAB GTPases are key components of membrane trafficking mechanisms, Rab11 is implicated in a variety of biological developmental processes and responses to biotic and abiotic stresses. Nevertheless, the role of Rab11 in the defense mechanisms of cotton against () remains to be elucidated.

Genome-Wide Identification of Gene Family in Ten Cotton Species and Function Analysis of Involved in Cold Stress Response.

Basic Pentacysteine (BPC) represents a class of plant-exclusive transcription factors, serving pivotal roles in orchestrating developmental processes and mediating responses to both biotic and abiotic stressors. However, the genome-wide characteristics and low-temperature response mechanism of the gene family in cotton remain unclear. Employing a genome-wide screening approach, this study characterized 60 distinct BPC transcription factor genes across ten species.

Genome-wide identification of VOZ gene family in ten cotton species and the function analysis of GhVOZ2 involved in heat stress response.

Background: Vascular plant one zinc-finger protein (VOZ) is a type of special transcription factor and plays important roles in regulating various biological processes in plants. However, a genome-wide analysis of VOZ gene family in cotton is still not clear, which greatly limits the further understanding of VOZ gene function and regulatory mechanism.

Results: We identified 44 VOZ family genes in ten cotton species including 3 in Gossypium herbaceum, G.

[Research progress on the biomarkers of sepsis-induced cardiomyopathy].

Sepsis constitutes one of the principal causes of death globally, and the mortality rate of patients complicated with sepsis-induced cardiomyopathy (SIC) surges by over 50%. Early identification of patients with sepsis, particularly SIC, and implementing clinical intervention are vital measures to reduce the mortality. In recent years, biomarkers for the diagnosis and prognosis of SIC have emerged rapidly.

Risk stratification and subgroup analysis of systemic lupus erythematosus patients with pregnancy: based on a 13-year multicenter cohort study.

Objectives: Systemic lupus erythematosus (SLE) presents with heterogeneous clinical manifestations and pregnancy outcomes, complicating its pregnancy management. This study aimed to identify distinct subgroups of pregnant SLE patients and explore their prognostic implications.

Method: In this multicenter cohort study across 45 centers in China, 25 baseline variables were incorporated into a cluster analysis (CA) considering collinearity and clinical relevance.

Urethral rerouting around one side of corpora cavernosus via a perineal approach for treating long-segment, complex posterior urethral strictures.

Objective: To explore the value of urethral repair by using distant urethra rerouting around one side of corpora cavernosus via the transperineal inferior pubectomy approach for treating long-segment, complex posterior urethral strictures (LS-cPUS).

Patients And Methods: The clinical data of 37 LS-cPUS patients who were admitted to our department from May 2006 to June 2023 were retrospectively analyzed. Via a perineal approach, the procedure involved distal urethral mobilization, division of the median septum of corpus cavernosa, resection of the inferior pubic margin, and urethral repair by using distant urethra rerouting around one side of corpora cavernosus.

Multifunctional bacterial cellulose-based hydrogel with tannic acid (TA)-modified MXene for antibacterial photothermal therapy and accelerated wound healing.

This work reports the development of an advanced multifunctional hydrogel system designed to address the challenges of infectious wound healing and tissue regeneration. We constructed a polyvinyl alcohol-borax/GelMA hybrid hydrogel matrix, endowing the photocurable hydrogel with excellent mechanical properties and self-healing capability. Bacterial cellulose (BC), a naturally derived biopolymer synthesized by specific microbial strains, was incorporated into the hydrogel matrix to enhance its mechanical properties, structural stability, and biocompatibility, while also serving as a scaffold for cellular adhesion and proliferation.

Fully Reshapeable and Recyclable Protein Hydrogels.

Hydrogels have emerged as a new generation of functional materials with a broad range of applications in diverse fields. They usually cannot be reshaped or recycled, restricting their ability to respond to evolving demands and emerging applications, and contributing to the accumulation of synthetic polymer waste and associated environmental concerns. Here, a robust and general strategy is reported to engineer fully reshapeable and recyclable protein hydrogels by integrating protein folding-unfolding with reversible disulfide crosslinking.

Genome-Wide Identification of the Gene Family and Expression Analysis of Different Flower Colours and Different Flowering Stages in L.

Safflower ( L.) is a plant in the family of Asteraceae, and the dried tubular flowers are used as medicine, which contain active ingredients such as safflower yellow pigment and safflower glycosides. They play important roles in many fields.

Overexpression of the Gene from the Desert Pioneer Plant Enhances the Drought Tolerance in .

This research centers on the sand-fixing plant known as , from which the β-glucosidase gene was successfully cloned using the molecular cloning method. encodes a hydrophilic and stable protein made up of 193 amino acids, located in the cell membrane. qRT-PCR analysis indicated that the expression of the is closely linked to the drought stress tolerance of .

Profiles of Approaches to Writing and Their Links to Self-Efficacy and LLM Acceptance in L2 Academic Writing.

Approaches to writing play an important role in both the writing processes and outcomes. However, little is known about whether L2 writers adopt different combinations of approaches in academic writing contexts and what factors predict such combinations. Hence, this study aimed to identify different profiles of approaches to writing in an L2 academic context and examine how they are predicted by writing self-efficacy and large language model (LLM) acceptance.

Establishment of a low-temperature immersion method for extracting high-activity and high-purity mitochondria from Syntrichia caninervis Mitt.

Background: Mitochondria are central to plant growth, development, and stress resilience. Despite their importance, mitochondrial research in desiccation-tolerant mosses remains underexplored. To unravel the stress resistance mechanisms of the extremotolerant desert moss, establishing a method to isolate highly active and pure mitochondria is critical.

The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.

Background: Idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune diseases with variable long-term outcomes.

Objective: To determine the prognosis of IIM.

Methods: This multicenter, prospective cohort study included Chinese patients with IIM.

Identification and Expression Pattern Analysis of Gene Family in .

Sugars Will Eventually Be Exported Transporters (SWEETs) are involved in plant growth and development, particularly in resistance to adverse environments. () exhibits rhizosheath formation and demonstrates notable salt and drought tolerance. We identified 31 sugar transporter family genes () from the genome in the NCBI database and performed bioinformatics analyses, including gene structure, subcellular localization, conserved sequences, promoter cis-acting elements, phylogenetic relationships, and chromosomal localization.

Validation and clinical application of 2022 ACR/EULAR criteria for Takayasu arteritis in a large Chinese cohort.

Objective: To validate the performance of the 2022 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for Takayasu arteritis (TAK) in a China cohort and examine its performance in clinical practices.

Methods: 778 patients with TAK and 378 patients with non-TAK were included. The sensitivity, specificity, positive and negative predictive values, accuracy, and AUC of the 2022 ACR/EULAR and 1990 ACR criteria were assessed.

Ionic Crosslinking Improves the Stiffness and Toughness of Protein Hydrogels.

Protein-based hydrogels are promising materials for biomedical and materials science applications. However, engineering hydrogels with both high stiffness and high toughness, a key requirement for many applications, remains challenging. Recently, by using the denatured crosslinking method, we developed highly stiff and tough protein hydrogels based on the polyprotein (FL) via introducing chain entanglements into the hydrogel network, which allow for stiffening the hydrogel without sacrificing toughness.

Tough and biodegradable film from modified carboxymethyl cellulose crosslinked gelatin.

Gelatin's renewable and biodegradable properties establish it as a promising alternative to fossil-based plastics. However, extensive intermolecular hydrogen bonding in gelatin restricts chain mobility, resulting in limited processing capabilities. This study utilizes aldehyde-functionalized carboxymethyl cellulose fibers as a cross-linking agent for gelatin, enhancing intermolecular interactions by substituting hydrogen bonds with dynamic covalent bonds.

Obesity promotes ARDS by modulating ceramide transfer protein-ceramide pathway and exacerbating oxidative stress/apoptosis in alveolar macrophages.

Obesity is an independent risk factor for acute respiratory distress syndrome (ARDS). However, the precise pathway through which obesity amplifies the severity of ARDS remains elusive. Our study embarked on a comprehensive analysis focusing on alterations in the proteomic and metabolomic landscapes of lung tissue extracted from high-fat diet (HFD) mice afflicted with lipopolysaccharide-induced lung injury.

Comparative Efficacy of LDL-C-Lowering Therapies in First-time versus Recurrent Myocardial Infarction Prevention: A Meta-Analysis of Large-scale Randomized Controlled Trials.

Aims: Reducing elevated low-density lipoprotein cholesterol (LDL-C) is central to global efforts to prevent myocardial infarction (MI). While many studies have evaluated LDL-C-lowering therapies in first-time and recurrent MI prevention, direct comparisons of their relative efficacy are lacking. Therefore, we conducted a systematic review and meta-analysis to compare the efficacy of LDL-C-lowering therapies in first-time versus recurrent MI prevention.

Management of newly diagnosed lupus nephritis in China: An implementation study based on the 2023 EULAR recommendations.

Background: Current evidence demonstrates that rigorous adherence to the standardized diagnostic and therapeutic protocols outlined in the European League Against Rheumatism (EULAR) guidelines can markedly enhance renal survival rates in patients with lupus nephritis (LN) and lead to improved overall outcomes. Data on the real-world implementation of LN management guideline in China was limited. This study aimed to examine the implementation of the 2023 EULAR recommendations for systemic lupus erymatosus (SLE) and LN in China.

Ginsenoside Rh2 Exerts a Therapeutic Effect against Myocardial Infarction via Promoting Angiogenesis and Mitochondrial Bioenergetics.

Ginsenoside Rh2 (Rh2), an important phytochemical derived from , has demonstrated anticancer activity, amelioration of ischemic brain injury, and mitigation of doxorubicin-induced cardiac damage. The cardioprotective effects of Rh2 were evaluated in a mouse model of acute myocardial infarction (AMI). Mice received Rh2 treatment for 14 days postsurgery, and the cardiac function was assessed by echocardiography.